Plus3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania major

UniProt:

Q4QGT3_LEIMA

TriTrypDb:

LmjF.12.0100 , LMJLV39_120006400 , LMJSD75_120007100

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGT3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	14
GO:0003677	DNA binding	4	14
GO:0005488	binding	1	14
GO:0097159	organic cyclic compound binding	2	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.472
CLV_NRD_NRD_1	151	153	PF00675	0.612
CLV_NRD_NRD_1	172	174	PF00675	0.623
CLV_NRD_NRD_1	188	190	PF00675	0.649
CLV_NRD_NRD_1	43	45	PF00675	0.373
CLV_PCSK_KEX2_1	151	153	PF00082	0.614
CLV_PCSK_KEX2_1	172	174	PF00082	0.635
CLV_PCSK_KEX2_1	188	190	PF00082	0.649
CLV_PCSK_KEX2_1	43	45	PF00082	0.412
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.637
CLV_PCSK_SKI1_1	174	178	PF00082	0.596
CLV_PCSK_SKI1_1	206	210	PF00082	0.468
CLV_PCSK_SKI1_1	224	228	PF00082	0.255
CLV_PCSK_SKI1_1	31	35	PF00082	0.343
DEG_APCC_DBOX_1	205	213	PF00400	0.478
DEG_Nend_Nbox_1	1	3	PF02207	0.289
DOC_CDC14_PxL_1	125	133	PF14671	0.570
DOC_CYCLIN_RxL_1	188	200	PF00134	0.628
DOC_CYCLIN_RxL_1	26	38	PF00134	0.341
DOC_MAPK_gen_1	172	182	PF00069	0.572
DOC_PP1_RVXF_1	119	126	PF00149	0.667
DOC_USP7_UBL2_3	247	251	PF12436	0.493
DOC_WW_Pin1_4	100	105	PF00397	0.358
DOC_WW_Pin1_4	144	149	PF00397	0.557
DOC_WW_Pin1_4	261	266	PF00397	0.337
DOC_WW_Pin1_4	43	48	PF00397	0.490
LIG_14-3-3_CanoR_1	173	182	PF00244	0.688
LIG_14-3-3_CanoR_1	231	239	PF00244	0.374
LIG_14-3-3_CanoR_1	87	95	PF00244	0.358
LIG_14-3-3_CanoR_1	9	13	PF00244	0.388
LIG_deltaCOP1_diTrp_1	17	21	PF00928	0.368
LIG_FHA_1	118	124	PF00498	0.680
LIG_FHA_1	175	181	PF00498	0.590
LIG_LIR_Gen_1	48	58	PF02991	0.493
LIG_LIR_Gen_1	73	84	PF02991	0.369
LIG_LIR_Nem_3	122	128	PF02991	0.645
LIG_LIR_Nem_3	17	21	PF02991	0.352
LIG_LIR_Nem_3	269	273	PF02991	0.469
LIG_LIR_Nem_3	48	54	PF02991	0.459
LIG_LIR_Nem_3	73	79	PF02991	0.376
LIG_PTB_Apo_2	99	106	PF02174	0.358
LIG_SH2_GRB2like	110	113	PF00017	0.493
LIG_SH2_PTP2	29	32	PF00017	0.388
LIG_SH2_PTP2	51	54	PF00017	0.493
LIG_SH2_STAP1	268	272	PF00017	0.586
LIG_SH2_STAT5	268	271	PF00017	0.584
LIG_SH2_STAT5	29	32	PF00017	0.388
LIG_SH2_STAT5	51	54	PF00017	0.342
LIG_SH3_3	123	129	PF00018	0.634
LIG_SUMO_SIM_anti_2	207	213	PF11976	0.614
LIG_SUMO_SIM_par_1	207	213	PF11976	0.587
LIG_TRAF2_1	168	171	PF00917	0.607
LIG_TRAF2_1	38	41	PF00917	0.448
MOD_CDC14_SPxK_1	103	106	PF00782	0.374
MOD_CDK_SPxK_1	100	106	PF00069	0.374
MOD_CDK_SPxxK_3	144	151	PF00069	0.567
MOD_CK1_1	124	130	PF00069	0.628
MOD_CK1_1	65	71	PF00069	0.360
MOD_CK2_1	215	221	PF00069	0.477
MOD_CK2_1	35	41	PF00069	0.498
MOD_GlcNHglycan	64	67	PF01048	0.386
MOD_GSK3_1	117	124	PF00069	0.649
MOD_GSK3_1	96	103	PF00069	0.345
MOD_LATS_1	229	235	PF00433	0.393
MOD_N-GLC_1	117	122	PF02516	0.629
MOD_N-GLC_1	19	24	PF02516	0.492
MOD_NEK2_1	7	12	PF00069	0.358
MOD_NEK2_1	86	91	PF00069	0.358
MOD_NEK2_2	249	254	PF00069	0.481
MOD_PIKK_1	86	92	PF00454	0.361
MOD_PKA_1	174	180	PF00069	0.516
MOD_PKA_2	174	180	PF00069	0.533
MOD_PKA_2	215	221	PF00069	0.457
MOD_PKA_2	36	42	PF00069	0.361
MOD_PKA_2	8	14	PF00069	0.388
MOD_PKA_2	86	92	PF00069	0.358
MOD_Plk_1	121	127	PF00069	0.660
MOD_Plk_4	8	14	PF00069	0.393
MOD_ProDKin_1	100	106	PF00069	0.358
MOD_ProDKin_1	144	150	PF00069	0.565
MOD_ProDKin_1	261	267	PF00069	0.337
MOD_ProDKin_1	43	49	PF00069	0.490
TRG_DiLeu_BaEn_1	207	212	PF01217	0.616
TRG_ENDOCYTIC_2	29	32	PF00928	0.388
TRG_ENDOCYTIC_2	51	54	PF00928	0.415
TRG_ENDOCYTIC_2	64	67	PF00928	0.261
TRG_ER_diArg_1	150	152	PF00400	0.602
TRG_ER_diArg_1	173	176	PF00400	0.636
TRG_ER_diArg_1	187	189	PF00400	0.660
TRG_ER_diArg_1	253	256	PF00400	0.337
TRG_NES_CRM1_1	207	221	PF08389	0.490
TRG_NLS_MonoExtC_3	172	178	PF00514	0.625
TRG_NLS_MonoExtN_4	172	177	PF00514	0.622
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T3	Leptomonas seymouri	88%	94%
A0A0S4JCN1	Bodo saltans	27%	85%
A0A0S4JLV2	Bodo saltans	54%	95%
A0A1X0NMT4	Trypanosomatidae	68%	94%
A0A3R7KK47	Trypanosoma rangeli	67%	94%
A0A3S5H6K3	Leishmania donovani	98%	100%
A4H6S6	Leishmania braziliensis	92%	95%
A4HV54	Leishmania infantum	98%	94%
C9ZQD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	94%
D0A9C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	68%
E9ANT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BHW6	Trypanosoma cruzi	66%	94%