Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGT2_LEIMA

TriTrypDb:

LmjF.12.0110 , LMJLV39_120006500 , LMJSD75_120007200

Length:

810

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGT2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.689
CLV_C14_Caspase3-7	255	259	PF00656	0.613
CLV_C14_Caspase3-7	311	315	PF00656	0.555
CLV_C14_Caspase3-7	395	399	PF00656	0.706
CLV_NRD_NRD_1	199	201	PF00675	0.713
CLV_NRD_NRD_1	251	253	PF00675	0.722
CLV_NRD_NRD_1	400	402	PF00675	0.657
CLV_NRD_NRD_1	416	418	PF00675	0.496
CLV_NRD_NRD_1	423	425	PF00675	0.654
CLV_NRD_NRD_1	456	458	PF00675	0.683
CLV_NRD_NRD_1	493	495	PF00675	0.661
CLV_NRD_NRD_1	717	719	PF00675	0.559
CLV_NRD_NRD_1	760	762	PF00675	0.667
CLV_NRD_NRD_1	783	785	PF00675	0.603
CLV_PCSK_FUR_1	197	201	PF00082	0.635
CLV_PCSK_FUR_1	715	719	PF00082	0.559
CLV_PCSK_KEX2_1	111	113	PF00082	0.704
CLV_PCSK_KEX2_1	197	199	PF00082	0.712
CLV_PCSK_KEX2_1	251	253	PF00082	0.803
CLV_PCSK_KEX2_1	256	258	PF00082	0.749
CLV_PCSK_KEX2_1	416	418	PF00082	0.645
CLV_PCSK_KEX2_1	423	425	PF00082	0.652
CLV_PCSK_KEX2_1	493	495	PF00082	0.661
CLV_PCSK_KEX2_1	717	719	PF00082	0.559
CLV_PCSK_KEX2_1	760	762	PF00082	0.676
CLV_PCSK_KEX2_1	767	769	PF00082	0.505
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.704
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.715
CLV_PCSK_PC1ET2_1	767	769	PF00082	0.632
CLV_PCSK_PC7_1	252	258	PF00082	0.720
CLV_PCSK_SKI1_1	117	121	PF00082	0.686
CLV_PCSK_SKI1_1	122	126	PF00082	0.644
CLV_PCSK_SKI1_1	139	143	PF00082	0.408
CLV_PCSK_SKI1_1	147	151	PF00082	0.531
CLV_PCSK_SKI1_1	223	227	PF00082	0.656
CLV_PCSK_SKI1_1	257	261	PF00082	0.629
CLV_PCSK_SKI1_1	266	270	PF00082	0.553
CLV_PCSK_SKI1_1	35	39	PF00082	0.546
CLV_PCSK_SKI1_1	387	391	PF00082	0.666
CLV_PCSK_SKI1_1	440	444	PF00082	0.598
CLV_PCSK_SKI1_1	469	473	PF00082	0.672
CLV_PCSK_SKI1_1	539	543	PF00082	0.554
CLV_PCSK_SKI1_1	556	560	PF00082	0.723
CLV_PCSK_SKI1_1	78	82	PF00082	0.586
DEG_APCC_DBOX_1	233	241	PF00400	0.675
DEG_SCF_FBW7_1	72	77	PF00400	0.653
DEG_SPOP_SBC_1	791	795	PF00917	0.646
DOC_CYCLIN_RxL_1	525	536	PF00134	0.508
DOC_MAPK_gen_1	208	216	PF00069	0.473
DOC_MAPK_gen_1	434	443	PF00069	0.613
DOC_MAPK_gen_1	765	771	PF00069	0.669
DOC_USP7_MATH_1	259	263	PF00917	0.620
DOC_USP7_MATH_1	326	330	PF00917	0.739
DOC_USP7_MATH_1	74	78	PF00917	0.692
DOC_USP7_MATH_1	79	83	PF00917	0.665
DOC_USP7_MATH_1	790	794	PF00917	0.686
DOC_USP7_MATH_1	93	97	PF00917	0.571
DOC_USP7_UBL2_3	122	126	PF12436	0.686
DOC_USP7_UBL2_3	18	22	PF12436	0.627
DOC_USP7_UBL2_3	41	45	PF12436	0.691
DOC_WW_Pin1_4	649	654	PF00397	0.636
DOC_WW_Pin1_4	70	75	PF00397	0.770
LIG_14-3-3_CanoR_1	429	436	PF00244	0.450
LIG_14-3-3_CanoR_1	593	601	PF00244	0.595
LIG_14-3-3_CanoR_1	742	749	PF00244	0.596
LIG_14-3-3_CanoR_1	774	780	PF00244	0.502
LIG_14-3-3_CanoR_1	78	84	PF00244	0.747
LIG_BIR_II_1	1	5	PF00653	0.548
LIG_Clathr_ClatBox_1	668	672	PF01394	0.682
LIG_deltaCOP1_diTrp_1	697	702	PF00928	0.605
LIG_FHA_1	148	154	PF00498	0.612
LIG_FHA_1	294	300	PF00498	0.692
LIG_FHA_1	470	476	PF00498	0.460
LIG_FHA_1	557	563	PF00498	0.710
LIG_FHA_1	704	710	PF00498	0.669
LIG_FHA_1	729	735	PF00498	0.693
LIG_FHA_1	743	749	PF00498	0.442
LIG_FHA_2	118	124	PF00498	0.684
LIG_FHA_2	309	315	PF00498	0.575
LIG_FHA_2	562	568	PF00498	0.716
LIG_FHA_2	573	579	PF00498	0.649
LIG_FHA_2	584	590	PF00498	0.534
LIG_FHA_2	623	629	PF00498	0.690
LIG_FHA_2	639	645	PF00498	0.496
LIG_FHA_2	731	737	PF00498	0.545
LIG_FHA_2	793	799	PF00498	0.737
LIG_FHA_2	93	99	PF00498	0.648
LIG_LIR_Gen_1	154	161	PF02991	0.614
LIG_LIR_Gen_1	663	671	PF02991	0.615
LIG_LIR_Gen_1	697	705	PF02991	0.673
LIG_LIR_Nem_3	154	160	PF02991	0.615
LIG_LIR_Nem_3	663	668	PF02991	0.698
LIG_LIR_Nem_3	684	688	PF02991	0.531
LIG_LIR_Nem_3	697	701	PF02991	0.516
LIG_PCNA_PIPBox_1	623	632	PF02747	0.461
LIG_PCNA_PIPBox_1	679	688	PF02747	0.442
LIG_PCNA_yPIPBox_3	325	334	PF02747	0.690
LIG_PCNA_yPIPBox_3	623	633	PF02747	0.463
LIG_Pex14_1	507	511	PF04695	0.449
LIG_Pex14_1	698	702	PF04695	0.605
LIG_Pex14_2	157	161	PF04695	0.611
LIG_RPA_C_Fungi	489	501	PF08784	0.608
LIG_SH2_CRK	665	669	PF00017	0.695
LIG_SH2_CRK	691	695	PF00017	0.674
LIG_SH2_NCK_1	691	695	PF00017	0.674
LIG_SH2_NCK_1	777	781	PF00017	0.583
LIG_SH2_STAP1	201	205	PF00017	0.696
LIG_SH2_STAP1	630	634	PF00017	0.476
LIG_SH2_STAP1	686	690	PF00017	0.685
LIG_SH2_STAT5	777	780	PF00017	0.542
LIG_SH3_3	642	648	PF00018	0.626
LIG_SUMO_SIM_anti_2	98	105	PF11976	0.502
LIG_TRAF2_1	141	144	PF00917	0.644
LIG_TRAF2_1	271	274	PF00917	0.765
LIG_TRAF2_1	339	342	PF00917	0.617
LIG_TRAF2_1	449	452	PF00917	0.450
LIG_TRAF2_1	471	474	PF00917	0.616
LIG_TRAF2_1	489	492	PF00917	0.443
LIG_TRAF2_1	569	572	PF00917	0.712
LIG_WRC_WIRS_1	682	687	PF05994	0.489
MOD_CDC14_SPxK_1	652	655	PF00782	0.697
MOD_CDK_SPxK_1	649	655	PF00069	0.702
MOD_CK1_1	329	335	PF00069	0.471
MOD_CK1_1	595	601	PF00069	0.591
MOD_CK1_1	684	690	PF00069	0.607
MOD_CK1_1	70	76	PF00069	0.726
MOD_CK1_1	704	710	PF00069	0.612
MOD_CK1_1	775	781	PF00069	0.632
MOD_CK1_1	96	102	PF00069	0.682
MOD_CK2_1	156	162	PF00069	0.606
MOD_CK2_1	268	274	PF00069	0.646
MOD_CK2_1	375	381	PF00069	0.657
MOD_CK2_1	432	438	PF00069	0.651
MOD_CK2_1	445	451	PF00069	0.515
MOD_CK2_1	561	567	PF00069	0.721
MOD_CK2_1	572	578	PF00069	0.648
MOD_CK2_1	622	628	PF00069	0.688
MOD_CK2_1	730	736	PF00069	0.691
MOD_CK2_1	792	798	PF00069	0.597
MOD_CK2_1	92	98	PF00069	0.655
MOD_Cter_Amidation	249	252	PF01082	0.598
MOD_GlcNHglycan	128	131	PF01048	0.518
MOD_GlcNHglycan	242	245	PF01048	0.626
MOD_GlcNHglycan	356	359	PF01048	0.617
MOD_GlcNHglycan	394	397	PF01048	0.663
MOD_GlcNHglycan	447	450	PF01048	0.592
MOD_GlcNHglycan	508	511	PF01048	0.635
MOD_GlcNHglycan	544	547	PF01048	0.466
MOD_GlcNHglycan	567	570	PF01048	0.520
MOD_GlcNHglycan	596	600	PF01048	0.707
MOD_GlcNHglycan	69	72	PF01048	0.559
MOD_GlcNHglycan	801	804	PF01048	0.749
MOD_GlcNHglycan	95	98	PF01048	0.755
MOD_GSK3_1	147	154	PF00069	0.661
MOD_GSK3_1	293	300	PF00069	0.631
MOD_GSK3_1	40	47	PF00069	0.689
MOD_GSK3_1	428	435	PF00069	0.640
MOD_GSK3_1	561	568	PF00069	0.640
MOD_GSK3_1	588	595	PF00069	0.715
MOD_GSK3_1	70	77	PF00069	0.758
MOD_GSK3_1	701	708	PF00069	0.607
MOD_GSK3_1	92	99	PF00069	0.551
MOD_LATS_1	76	82	PF00433	0.587
MOD_N-GLC_1	728	733	PF02516	0.633
MOD_N-GLC_1	91	96	PF02516	0.773
MOD_NEK2_1	240	245	PF00069	0.691
MOD_NEK2_1	418	423	PF00069	0.609
MOD_NEK2_1	44	49	PF00069	0.521
MOD_NEK2_1	542	547	PF00069	0.463
MOD_NEK2_1	583	588	PF00069	0.709
MOD_NEK2_1	629	634	PF00069	0.593
MOD_NEK2_1	705	710	PF00069	0.708
MOD_NEK2_1	727	732	PF00069	0.696
MOD_NEK2_1	772	777	PF00069	0.434
MOD_NEK2_2	79	84	PF00069	0.702
MOD_PIKK_1	259	265	PF00454	0.814
MOD_PIKK_1	298	304	PF00454	0.647
MOD_PIKK_1	387	393	PF00454	0.651
MOD_PIKK_1	418	424	PF00454	0.546
MOD_PIKK_1	428	434	PF00454	0.660
MOD_PIKK_1	469	475	PF00454	0.454
MOD_PIKK_1	556	562	PF00454	0.711
MOD_PIKK_1	696	702	PF00454	0.683
MOD_PIKK_1	742	748	PF00454	0.596
MOD_PK_1	717	723	PF00069	0.480
MOD_PKA_1	126	132	PF00069	0.676
MOD_PKA_1	717	723	PF00069	0.480
MOD_PKA_2	250	256	PF00069	0.679
MOD_PKA_2	308	314	PF00069	0.699
MOD_PKA_2	392	398	PF00069	0.703
MOD_PKA_2	428	434	PF00069	0.455
MOD_PKA_2	492	498	PF00069	0.621
MOD_PKA_2	572	578	PF00069	0.555
MOD_PKA_2	583	589	PF00069	0.587
MOD_PKA_2	592	598	PF00069	0.384
MOD_PKA_2	717	723	PF00069	0.554
MOD_PKB_1	554	562	PF00069	0.728
MOD_PKB_1	715	723	PF00069	0.546
MOD_Plk_1	117	123	PF00069	0.660
MOD_Plk_1	432	438	PF00069	0.624
MOD_Plk_1	696	702	PF00069	0.606
MOD_Plk_1	791	797	PF00069	0.683
MOD_Plk_2-3	792	798	PF00069	0.721
MOD_Plk_4	156	162	PF00069	0.691
MOD_Plk_4	329	335	PF00069	0.471
MOD_Plk_4	681	687	PF00069	0.604
MOD_ProDKin_1	649	655	PF00069	0.635
MOD_ProDKin_1	70	76	PF00069	0.772
MOD_SUMO_for_1	339	342	PF00179	0.617
MOD_SUMO_for_1	533	536	PF00179	0.445
MOD_SUMO_rev_2	261	271	PF00179	0.692
MOD_SUMO_rev_2	29	37	PF00179	0.665
MOD_SUMO_rev_2	433	442	PF00179	0.616
TRG_DiLeu_BaEn_1	32	37	PF01217	0.719
TRG_DiLeu_BaEn_1	363	368	PF01217	0.618
TRG_DiLeu_BaEn_4	163	169	PF01217	0.681
TRG_DiLeu_BaEn_4	32	38	PF01217	0.679
TRG_DiLeu_BaEn_4	438	444	PF01217	0.608
TRG_DiLeu_BaEn_4	596	602	PF01217	0.704
TRG_ENDOCYTIC_2	201	204	PF00928	0.698
TRG_ENDOCYTIC_2	665	668	PF00928	0.702
TRG_ENDOCYTIC_2	691	694	PF00928	0.673
TRG_ER_diArg_1	165	168	PF00400	0.661
TRG_ER_diArg_1	197	200	PF00400	0.713
TRG_ER_diArg_1	415	417	PF00400	0.560
TRG_ER_diArg_1	493	496	PF00400	0.630
TRG_ER_diArg_1	715	718	PF00400	0.559
TRG_ER_diArg_1	741	744	PF00400	0.512
TRG_ER_diArg_1	760	762	PF00400	0.529
TRG_NES_CRM1_1	42	56	PF08389	0.686
TRG_NLS_MonoCore_2	108	113	PF00514	0.705
TRG_NLS_MonoExtC_3	109	115	PF00514	0.703
TRG_NLS_MonoExtN_4	109	114	PF00514	0.705
TRG_Pf-PMV_PEXEL_1	228	233	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	613	617	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WRW5	Leishmania donovani	86%	100%
A4H6S7	Leishmania braziliensis	69%	100%
A4HV55	Leishmania infantum	87%	90%
E9ANT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%