Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGS9_LEIMA

TriTrypDb:

LmjF.12.0140 , LMJLV39_120006800 , LMJSD75_120007500

Length:

460

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	9
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0070765	gamma-secretase complex	3	2
GO:0098796	membrane protein complex	2	2
GO:0098797	plasma membrane protein complex	3	2
GO:0110165	cellular anatomical entity	1	9
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q4QGS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGS9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0016485	protein processing	5	9
GO:0019538	protein metabolic process	3	9
GO:0043085	positive regulation of catalytic activity	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044093	positive regulation of molecular function	3	9
GO:0044238	primary metabolic process	2	9
GO:0050790	regulation of catalytic activity	3	9
GO:0051604	protein maturation	4	9
GO:0065007	biological regulation	1	9
GO:0065009	regulation of molecular function	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.656
CLV_NRD_NRD_1	213	215	PF00675	0.433
CLV_NRD_NRD_1	286	288	PF00675	0.552
CLV_NRD_NRD_1	415	417	PF00675	0.651
CLV_PCSK_KEX2_1	286	288	PF00082	0.552
CLV_PCSK_KEX2_1	345	347	PF00082	0.475
CLV_PCSK_KEX2_1	415	417	PF00082	0.651
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.475
CLV_PCSK_SKI1_1	142	146	PF00082	0.664
DEG_APCC_DBOX_1	106	114	PF00400	0.559
DEG_SPOP_SBC_1	150	154	PF00917	0.452
DEG_SPOP_SBC_1	231	235	PF00917	0.688
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.647
DOC_MAPK_DCC_7	105	115	PF00069	0.545
DOC_MAPK_gen_1	105	113	PF00069	0.545
DOC_MAPK_MEF2A_6	105	113	PF00069	0.559
DOC_MAPK_MEF2A_6	82	90	PF00069	0.598
DOC_PP1_RVXF_1	92	98	PF00149	0.627
DOC_PP2B_LxvP_1	13	16	PF13499	0.438
DOC_USP7_MATH_1	122	126	PF00917	0.424
DOC_USP7_MATH_1	251	255	PF00917	0.759
DOC_USP7_MATH_1	281	285	PF00917	0.733
DOC_USP7_MATH_1	302	306	PF00917	0.706
DOC_USP7_MATH_1	330	334	PF00917	0.777
DOC_USP7_MATH_1	337	341	PF00917	0.777
DOC_USP7_MATH_1	353	357	PF00917	0.696
DOC_USP7_MATH_1	399	403	PF00917	0.453
DOC_WW_Pin1_4	349	354	PF00397	0.740
LIG_14-3-3_CanoR_1	149	156	PF00244	0.521
LIG_14-3-3_CanoR_1	175	185	PF00244	0.445
LIG_14-3-3_CanoR_1	307	315	PF00244	0.731
LIG_14-3-3_CanoR_1	339	349	PF00244	0.772
LIG_14-3-3_CanoR_1	415	422	PF00244	0.470
LIG_14-3-3_CanoR_1	446	452	PF00244	0.668
LIG_Actin_WH2_2	41	59	PF00022	0.490
LIG_BIR_II_1	1	5	PF00653	0.408
LIG_Clathr_ClatBox_1	262	266	PF01394	0.732
LIG_FHA_1	151	157	PF00498	0.531
LIG_FHA_1	224	230	PF00498	0.802
LIG_FHA_1	257	263	PF00498	0.705
LIG_FHA_1	3	9	PF00498	0.334
LIG_FHA_1	448	454	PF00498	0.719
LIG_FHA_1	47	53	PF00498	0.457
LIG_FHA_1	83	89	PF00498	0.561
LIG_FHA_2	233	239	PF00498	0.706
LIG_LIR_Gen_1	2	8	PF02991	0.407
LIG_LIR_Gen_1	450	458	PF02991	0.698
LIG_LIR_Gen_1	66	76	PF02991	0.468
LIG_LIR_Nem_3	106	111	PF02991	0.624
LIG_LIR_Nem_3	2	6	PF02991	0.407
LIG_LIR_Nem_3	450	454	PF02991	0.688
LIG_LIR_Nem_3	66	72	PF02991	0.454
LIG_NRBOX	172	178	PF00104	0.480
LIG_PCNA_yPIPBox_3	416	430	PF02747	0.303
LIG_Pex14_2	181	185	PF04695	0.396
LIG_SH2_CRK	3	7	PF00017	0.310
LIG_SH2_CRK	310	314	PF00017	0.638
LIG_SH2_CRK	451	455	PF00017	0.663
LIG_SH2_SRC	14	17	PF00017	0.490
LIG_SH2_STAP1	201	205	PF00017	0.566
LIG_SH2_STAP1	3	7	PF00017	0.404
LIG_SH3_3	106	112	PF00018	0.570
LIG_SH3_3	243	249	PF00018	0.691
LIG_SH3_3	265	271	PF00018	0.734
LIG_SUMO_SIM_anti_2	261	267	PF11976	0.668
LIG_SUMO_SIM_anti_2	431	437	PF11976	0.394
LIG_SUMO_SIM_par_1	261	267	PF11976	0.730
LIG_SUMO_SIM_par_1	29	35	PF11976	0.596
LIG_SUMO_SIM_par_1	4	10	PF11976	0.301
LIG_SUMO_SIM_par_1	440	445	PF11976	0.493
LIG_TRAF2_1	298	301	PF00917	0.797
LIG_TRFH_1	108	112	PF08558	0.596
LIG_TRFH_1	390	394	PF08558	0.438
LIG_TYR_ITIM	308	313	PF00017	0.638
MOD_CK1_1	151	157	PF00069	0.546
MOD_CK1_1	2	8	PF00069	0.334
MOD_CK1_1	329	335	PF00069	0.736
MOD_CK1_1	340	346	PF00069	0.756
MOD_CK1_1	351	357	PF00069	0.733
MOD_CK1_1	404	410	PF00069	0.474
MOD_CK2_1	232	238	PF00069	0.747
MOD_CK2_1	251	257	PF00069	0.784
MOD_CK2_1	330	336	PF00069	0.771
MOD_CK2_1	352	358	PF00069	0.727
MOD_GlcNHglycan	129	132	PF01048	0.382
MOD_GlcNHglycan	146	149	PF01048	0.566
MOD_GlcNHglycan	166	169	PF01048	0.701
MOD_GlcNHglycan	241	244	PF01048	0.594
MOD_GlcNHglycan	310	313	PF01048	0.596
MOD_GlcNHglycan	316	320	PF01048	0.517
MOD_GlcNHglycan	328	331	PF01048	0.607
MOD_GlcNHglycan	342	345	PF01048	0.464
MOD_GlcNHglycan	355	358	PF01048	0.493
MOD_GlcNHglycan	401	404	PF01048	0.627
MOD_GSK3_1	144	151	PF00069	0.532
MOD_GSK3_1	277	284	PF00069	0.778
MOD_GSK3_1	326	333	PF00069	0.790
MOD_GSK3_1	335	342	PF00069	0.760
MOD_GSK3_1	347	354	PF00069	0.793
MOD_GSK3_1	404	411	PF00069	0.518
MOD_GSK3_1	453	460	PF00069	0.621
MOD_GSK3_1	78	85	PF00069	0.593
MOD_N-GLC_1	422	427	PF02516	0.359
MOD_N-GLC_1	78	83	PF02516	0.435
MOD_NEK2_1	1	6	PF00069	0.386
MOD_NEK2_1	103	108	PF00069	0.625
MOD_NEK2_1	127	132	PF00069	0.325
MOD_NEK2_1	144	149	PF00069	0.437
MOD_NEK2_1	163	168	PF00069	0.460
MOD_NEK2_1	176	181	PF00069	0.301
MOD_NEK2_1	315	320	PF00069	0.769
MOD_NEK2_1	421	426	PF00069	0.321
MOD_NEK2_1	453	458	PF00069	0.586
MOD_NEK2_1	46	51	PF00069	0.402
MOD_NEK2_2	251	256	PF00069	0.821
MOD_NEK2_2	281	286	PF00069	0.781
MOD_PIKK_1	302	308	PF00454	0.702
MOD_PKA_1	214	220	PF00069	0.627
MOD_PKA_2	148	154	PF00069	0.532
MOD_PKA_2	171	177	PF00069	0.442
MOD_PKA_2	338	344	PF00069	0.761
MOD_PKA_2	414	420	PF00069	0.475
MOD_Plk_1	251	257	PF00069	0.795
MOD_Plk_1	422	428	PF00069	0.412
MOD_Plk_1	78	84	PF00069	0.601
MOD_Plk_4	122	128	PF00069	0.379
MOD_Plk_4	181	187	PF00069	0.394
MOD_Plk_4	32	38	PF00069	0.423
MOD_Plk_4	364	370	PF00069	0.579
MOD_Plk_4	428	434	PF00069	0.396
MOD_ProDKin_1	349	355	PF00069	0.736
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.413
TRG_ENDOCYTIC_2	201	204	PF00928	0.591
TRG_ENDOCYTIC_2	3	6	PF00928	0.310
TRG_ENDOCYTIC_2	310	313	PF00928	0.746
TRG_ENDOCYTIC_2	451	454	PF00928	0.688
TRG_ER_diArg_1	104	107	PF00400	0.652
TRG_ER_diArg_1	285	287	PF00400	0.779
TRG_ER_diArg_1	414	416	PF00400	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY04	Leptomonas seymouri	42%	96%
A0A3S7WRT9	Leishmania donovani	87%	100%
A0A422NUD7	Trypanosoma rangeli	27%	100%
A4H6T0	Leishmania braziliensis	66%	100%
A4HV58	Leishmania infantum	88%	68%
E9ANU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5BDA4	Trypanosoma cruzi	24%	100%