Putative leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein, putative

Species:

Leishmania major

UniProt:

Q4QGS8_LEIMA

TriTrypDb:

LmjF.12.0150 , LMJLV39_120006900 , LMJSD75_120007600

Length:

1025

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

Q4QGS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.599
CLV_C14_Caspase3-7	279	283	PF00656	0.741
CLV_C14_Caspase3-7	405	409	PF00656	0.523
CLV_C14_Caspase3-7	988	992	PF00656	0.683
CLV_C14_Caspase3-7	997	1001	PF00656	0.700
CLV_NRD_NRD_1	207	209	PF00675	0.729
CLV_NRD_NRD_1	293	295	PF00675	0.776
CLV_NRD_NRD_1	346	348	PF00675	0.878
CLV_NRD_NRD_1	395	397	PF00675	0.660
CLV_NRD_NRD_1	449	451	PF00675	0.769
CLV_NRD_NRD_1	640	642	PF00675	0.751
CLV_NRD_NRD_1	835	837	PF00675	0.638
CLV_NRD_NRD_1	929	931	PF00675	0.616
CLV_PCSK_FUR_1	446	450	PF00082	0.802
CLV_PCSK_KEX2_1	116	118	PF00082	0.533
CLV_PCSK_KEX2_1	206	208	PF00082	0.729
CLV_PCSK_KEX2_1	293	295	PF00082	0.776
CLV_PCSK_KEX2_1	346	348	PF00082	0.723
CLV_PCSK_KEX2_1	394	396	PF00082	0.671
CLV_PCSK_KEX2_1	448	450	PF00082	0.793
CLV_PCSK_KEX2_1	639	641	PF00082	0.751
CLV_PCSK_KEX2_1	745	747	PF00082	0.764
CLV_PCSK_KEX2_1	835	837	PF00082	0.638
CLV_PCSK_KEX2_1	929	931	PF00082	0.616
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.533
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.723
CLV_PCSK_PC1ET2_1	745	747	PF00082	0.764
CLV_PCSK_SKI1_1	347	351	PF00082	0.794
CLV_PCSK_SKI1_1	48	52	PF00082	0.502
CLV_PCSK_SKI1_1	741	745	PF00082	0.640
CLV_PCSK_SKI1_1	835	839	PF00082	0.714
CLV_PCSK_SKI1_1	97	101	PF00082	0.674
DEG_APCC_DBOX_1	167	175	PF00400	0.656
DEG_APCC_DBOX_1	311	319	PF00400	0.770
DEG_APCC_DBOX_1	393	401	PF00400	0.620
DEG_SPOP_SBC_1	228	232	PF00917	0.706
DEG_SPOP_SBC_1	616	620	PF00917	0.500
DOC_CKS1_1	355	360	PF01111	0.649
DOC_CKS1_1	803	808	PF01111	0.789
DOC_MAPK_gen_1	42	51	PF00069	0.589
DOC_MAPK_MEF2A_6	173	181	PF00069	0.411
DOC_MAPK_MEF2A_6	42	51	PF00069	0.589
DOC_MAPK_MEF2A_6	479	486	PF00069	0.685
DOC_PP1_RVXF_1	46	52	PF00149	0.574
DOC_PP1_RVXF_1	591	598	PF00149	0.815
DOC_PP1_RVXF_1	834	841	PF00149	0.678
DOC_PP1_RVXF_1	952	958	PF00149	0.604
DOC_PP2B_LxvP_1	8	11	PF13499	0.703
DOC_PP4_FxxP_1	597	600	PF00568	0.758
DOC_PP4_FxxP_1	826	829	PF00568	0.551
DOC_USP7_MATH_1	1021	1025	PF00917	0.594
DOC_USP7_MATH_1	20	24	PF00917	0.630
DOC_USP7_MATH_1	211	215	PF00917	0.741
DOC_USP7_MATH_1	228	232	PF00917	0.596
DOC_USP7_MATH_1	256	260	PF00917	0.771
DOC_USP7_MATH_1	31	35	PF00917	0.434
DOC_USP7_MATH_1	339	343	PF00917	0.711
DOC_USP7_MATH_1	349	353	PF00917	0.694
DOC_USP7_MATH_1	361	365	PF00917	0.750
DOC_USP7_MATH_1	466	470	PF00917	0.609
DOC_USP7_MATH_1	495	499	PF00917	0.671
DOC_USP7_MATH_1	616	620	PF00917	0.659
DOC_USP7_MATH_1	62	66	PF00917	0.380
DOC_USP7_MATH_1	635	639	PF00917	0.459
DOC_USP7_MATH_1	643	647	PF00917	0.636
DOC_USP7_MATH_1	676	680	PF00917	0.687
DOC_USP7_MATH_1	787	791	PF00917	0.575
DOC_USP7_MATH_1	811	815	PF00917	0.760
DOC_USP7_MATH_1	892	896	PF00917	0.624
DOC_USP7_MATH_1	935	939	PF00917	0.766
DOC_USP7_MATH_1	985	989	PF00917	0.590
DOC_USP7_UBL2_3	741	745	PF12436	0.757
DOC_WW_Pin1_4	11	16	PF00397	0.677
DOC_WW_Pin1_4	199	204	PF00397	0.688
DOC_WW_Pin1_4	322	327	PF00397	0.780
DOC_WW_Pin1_4	340	345	PF00397	0.564
DOC_WW_Pin1_4	354	359	PF00397	0.591
DOC_WW_Pin1_4	523	528	PF00397	0.780
DOC_WW_Pin1_4	579	584	PF00397	0.836
DOC_WW_Pin1_4	60	65	PF00397	0.489
DOC_WW_Pin1_4	612	617	PF00397	0.590
DOC_WW_Pin1_4	666	671	PF00397	0.755
DOC_WW_Pin1_4	697	702	PF00397	0.718
DOC_WW_Pin1_4	766	771	PF00397	0.619
DOC_WW_Pin1_4	792	797	PF00397	0.765
DOC_WW_Pin1_4	802	807	PF00397	0.633
DOC_WW_Pin1_4	886	891	PF00397	0.698
DOC_WW_Pin1_4	975	980	PF00397	0.699
LIG_14-3-3_CanoR_1	293	302	PF00244	0.745
LIG_14-3-3_CanoR_1	347	355	PF00244	0.834
LIG_14-3-3_CanoR_1	42	48	PF00244	0.594
LIG_14-3-3_CanoR_1	450	458	PF00244	0.701
LIG_14-3-3_CanoR_1	53	58	PF00244	0.427
LIG_14-3-3_CanoR_1	715	720	PF00244	0.736
LIG_14-3-3_CanoR_1	841	848	PF00244	0.684
LIG_14-3-3_CanoR_1	97	102	PF00244	0.675
LIG_Actin_WH2_2	34	50	PF00022	0.595
LIG_Actin_WH2_2	752	769	PF00022	0.718
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_BIR_III_2	1009	1013	PF00653	0.591
LIG_BIR_III_4	408	412	PF00653	0.715
LIG_BIR_III_4	984	988	PF00653	0.785
LIG_BRCT_BRCA1_1	233	237	PF00533	0.593
LIG_CtBP_PxDLS_1	770	774	PF00389	0.749
LIG_FHA_1	120	126	PF00498	0.457
LIG_FHA_1	224	230	PF00498	0.755
LIG_FHA_1	348	354	PF00498	0.771
LIG_FHA_1	355	361	PF00498	0.679
LIG_FHA_1	534	540	PF00498	0.586
LIG_FHA_1	618	624	PF00498	0.565
LIG_FHA_1	78	84	PF00498	0.623
LIG_FHA_1	795	801	PF00498	0.729
LIG_FHA_1	818	824	PF00498	0.650
LIG_FHA_1	950	956	PF00498	0.659
LIG_FHA_2	173	179	PF00498	0.636
LIG_FHA_2	192	198	PF00498	0.382
LIG_FHA_2	330	336	PF00498	0.794
LIG_FHA_2	948	954	PF00498	0.794
LIG_GSK3_LRP6_1	354	359	PF00069	0.644
LIG_Integrin_isoDGR_2	273	275	PF01839	0.790
LIG_Integrin_RGD_1	215	217	PF01839	0.623
LIG_LIR_Apic_2	824	829	PF02991	0.559
LIG_LIR_Gen_1	132	143	PF02991	0.544
LIG_LIR_Gen_1	144	153	PF02991	0.475
LIG_LIR_Gen_1	23	32	PF02991	0.379
LIG_LIR_Gen_1	387	397	PF02991	0.573
LIG_LIR_Gen_1	718	725	PF02991	0.758
LIG_LIR_Gen_1	727	738	PF02991	0.453
LIG_LIR_Nem_3	132	138	PF02991	0.545
LIG_LIR_Nem_3	144	148	PF02991	0.473
LIG_LIR_Nem_3	23	27	PF02991	0.375
LIG_LIR_Nem_3	387	392	PF02991	0.572
LIG_LIR_Nem_3	621	627	PF02991	0.675
LIG_LIR_Nem_3	718	722	PF02991	0.772
LIG_LIR_Nem_3	727	733	PF02991	0.432
LIG_MYND_1	576	580	PF01753	0.774
LIG_NRBOX	728	734	PF00104	0.751
LIG_NRBOX	78	84	PF00104	0.623
LIG_Pex14_1	726	730	PF04695	0.735
LIG_PTAP_UEV_1	735	740	PF05743	0.575
LIG_SH2_CRK	719	723	PF00017	0.764
LIG_SH2_CRK	730	734	PF00017	0.761
LIG_SH2_GRB2like	552	555	PF00017	0.684
LIG_SH2_NCK_1	19	23	PF00017	0.639
LIG_SH2_SRC	19	22	PF00017	0.641
LIG_SH2_SRC	552	555	PF00017	0.684
LIG_SH2_STAP1	382	386	PF00017	0.631
LIG_SH2_STAP1	472	476	PF00017	0.704
LIG_SH2_STAP1	503	507	PF00017	0.524
LIG_SH2_STAP1	730	734	PF00017	0.761
LIG_SH2_STAT5	143	146	PF00017	0.524
LIG_SH2_STAT5	626	629	PF00017	0.644
LIG_SH2_STAT5	648	651	PF00017	0.771
LIG_SH2_STAT5	719	722	PF00017	0.769
LIG_SH3_2	326	331	PF14604	0.776
LIG_SH3_2	736	741	PF14604	0.621
LIG_SH3_3	323	329	PF00018	0.773
LIG_SH3_3	352	358	PF00018	0.846
LIG_SH3_3	522	528	PF00018	0.807
LIG_SH3_3	574	580	PF00018	0.856
LIG_SH3_3	689	695	PF00018	0.657
LIG_SH3_3	733	739	PF00018	0.601
LIG_SH3_3	744	750	PF00018	0.690
LIG_SH3_3	793	799	PF00018	0.798
LIG_SH3_3	96	102	PF00018	0.667
LIG_SH3_4	923	930	PF00018	0.814
LIG_SUMO_SIM_par_1	423	431	PF11976	0.661
LIG_SUMO_SIM_par_1	481	487	PF11976	0.663
LIG_SUMO_SIM_par_1	70	76	PF11976	0.586
LIG_TRAF2_1	244	247	PF00917	0.841
LIG_TRAF2_1	277	280	PF00917	0.778
LIG_TRAF2_1	872	875	PF00917	0.733
LIG_TRAF2_1	902	905	PF00917	0.627
LIG_TYR_ITIM	501	506	PF00017	0.602
LIG_TYR_ITIM	728	733	PF00017	0.749
LIG_WRC_WIRS_1	142	147	PF05994	0.603
MOD_CDC14_SPxK_1	343	346	PF00782	0.618
MOD_CDK_SPK_2	322	327	PF00069	0.625
MOD_CDK_SPxK_1	340	346	PF00069	0.625
MOD_CDK_SPxxK_3	199	206	PF00069	0.701
MOD_CDK_SPxxK_3	340	347	PF00069	0.783
MOD_CDK_SPxxK_3	697	704	PF00069	0.757
MOD_CK1_1	231	237	PF00069	0.741
MOD_CK1_1	295	301	PF00069	0.779
MOD_CK1_1	308	314	PF00069	0.598
MOD_CK1_1	342	348	PF00069	0.679
MOD_CK1_1	4	10	PF00069	0.708
MOD_CK1_1	407	413	PF00069	0.738
MOD_CK1_1	417	423	PF00069	0.533
MOD_CK1_1	532	538	PF00069	0.698
MOD_CK1_1	618	624	PF00069	0.703
MOD_CK1_1	664	670	PF00069	0.772
MOD_CK1_1	814	820	PF00069	0.612
MOD_CK1_1	821	827	PF00069	0.645
MOD_CK1_1	918	924	PF00069	0.704
MOD_CK1_1	931	937	PF00069	0.559
MOD_CK1_1	940	946	PF00069	0.606
MOD_CK1_1	961	967	PF00069	0.669
MOD_CK2_1	191	197	PF00069	0.456
MOD_CK2_1	241	247	PF00069	0.845
MOD_CK2_1	329	335	PF00069	0.792
MOD_CK2_1	417	423	PF00069	0.695
MOD_CK2_1	468	474	PF00069	0.597
MOD_CK2_1	568	574	PF00069	0.733
MOD_CK2_1	734	740	PF00069	0.802
MOD_CK2_1	846	852	PF00069	0.681
MOD_CK2_1	869	875	PF00069	0.766
MOD_CK2_1	899	905	PF00069	0.601
MOD_DYRK1A_RPxSP_1	579	583	PF00069	0.858
MOD_GlcNHglycan	139	142	PF01048	0.599
MOD_GlcNHglycan	209	212	PF01048	0.798
MOD_GlcNHglycan	219	223	PF01048	0.710
MOD_GlcNHglycan	234	237	PF01048	0.591
MOD_GlcNHglycan	284	287	PF01048	0.766
MOD_GlcNHglycan	289	292	PF01048	0.721
MOD_GlcNHglycan	297	300	PF01048	0.625
MOD_GlcNHglycan	335	338	PF01048	0.725
MOD_GlcNHglycan	363	366	PF01048	0.788
MOD_GlcNHglycan	408	412	PF01048	0.617
MOD_GlcNHglycan	489	492	PF01048	0.595
MOD_GlcNHglycan	519	522	PF01048	0.627
MOD_GlcNHglycan	570	573	PF01048	0.748
MOD_GlcNHglycan	620	623	PF01048	0.690
MOD_GlcNHglycan	736	739	PF01048	0.634
MOD_GlcNHglycan	782	786	PF01048	0.691
MOD_GlcNHglycan	813	816	PF01048	0.832
MOD_GlcNHglycan	820	823	PF01048	0.682
MOD_GlcNHglycan	83	86	PF01048	0.492
MOD_GlcNHglycan	871	874	PF01048	0.761
MOD_GlcNHglycan	900	904	PF01048	0.662
MOD_GlcNHglycan	920	923	PF01048	0.632
MOD_GlcNHglycan	932	936	PF01048	0.687
MOD_GlcNHglycan	939	942	PF01048	0.638
MOD_GSK3_1	100	107	PF00069	0.707
MOD_GSK3_1	1017	1024	PF00069	0.690
MOD_GSK3_1	137	144	PF00069	0.615
MOD_GSK3_1	207	214	PF00069	0.754
MOD_GSK3_1	223	230	PF00069	0.710
MOD_GSK3_1	329	336	PF00069	0.798
MOD_GSK3_1	349	356	PF00069	0.603
MOD_GSK3_1	361	368	PF00069	0.730
MOD_GSK3_1	380	387	PF00069	0.363
MOD_GSK3_1	410	417	PF00069	0.675
MOD_GSK3_1	424	431	PF00069	0.446
MOD_GSK3_1	464	471	PF00069	0.632
MOD_GSK3_1	529	536	PF00069	0.810
MOD_GSK3_1	612	619	PF00069	0.730
MOD_GSK3_1	664	671	PF00069	0.782
MOD_GSK3_1	73	80	PF00069	0.452
MOD_GSK3_1	788	795	PF00069	0.580
MOD_GSK3_1	805	812	PF00069	0.652
MOD_GSK3_1	814	821	PF00069	0.663
MOD_GSK3_1	911	918	PF00069	0.808
MOD_GSK3_1	931	938	PF00069	0.748
MOD_GSK3_1	943	950	PF00069	0.588
MOD_GSK3_1	958	965	PF00069	0.552
MOD_LATS_1	205	211	PF00433	0.749
MOD_N-GLC_1	287	292	PF02516	0.776
MOD_N-GLC_1	308	313	PF02516	0.721
MOD_N-GLC_1	553	558	PF02516	0.780
MOD_N-GLC_1	643	648	PF02516	0.648
MOD_N-GLC_1	676	681	PF02516	0.785
MOD_N-GLC_1	817	822	PF02516	0.636
MOD_NEK2_1	1	6	PF00069	0.710
MOD_NEK2_1	151	156	PF00069	0.539
MOD_NEK2_1	177	182	PF00069	0.558
MOD_NEK2_1	229	234	PF00069	0.705
MOD_NEK2_1	25	30	PF00069	0.606
MOD_NEK2_1	424	429	PF00069	0.646
MOD_NEK2_1	484	489	PF00069	0.644
MOD_NEK2_1	72	77	PF00069	0.510
MOD_NEK2_2	43	48	PF00069	0.585
MOD_OFUCOSY	939	944	PF10250	0.627
MOD_PIKK_1	1	7	PF00454	0.677
MOD_PIKK_1	100	106	PF00454	0.705
MOD_PIKK_1	143	149	PF00454	0.604
MOD_PIKK_1	365	371	PF00454	0.673
MOD_PIKK_1	841	847	PF00454	0.758
MOD_PIKK_1	876	882	PF00454	0.625
MOD_PIKK_1	911	917	PF00454	0.687
MOD_PIKK_1	923	929	PF00454	0.733
MOD_PKA_1	207	213	PF00069	0.723
MOD_PKA_1	293	299	PF00069	0.777
MOD_PKA_1	347	353	PF00069	0.791
MOD_PKA_2	151	157	PF00069	0.542
MOD_PKA_2	207	213	PF00069	0.723
MOD_PKA_2	292	298	PF00069	0.773
MOD_PKA_2	311	317	PF00069	0.529
MOD_PKA_2	402	408	PF00069	0.581
MOD_PKA_2	52	58	PF00069	0.563
MOD_PKA_2	568	574	PF00069	0.811
MOD_PKA_2	734	740	PF00069	0.802
MOD_PKA_2	928	934	PF00069	0.692
MOD_PKB_1	213	221	PF00069	0.694
MOD_Plk_1	177	183	PF00069	0.642
MOD_Plk_1	384	390	PF00069	0.554
MOD_Plk_1	739	745	PF00069	0.752
MOD_Plk_2-3	905	911	PF00069	0.604
MOD_Plk_4	20	26	PF00069	0.340
MOD_Plk_4	311	317	PF00069	0.769
MOD_Plk_4	384	390	PF00069	0.515
MOD_Plk_4	4	10	PF00069	0.694
MOD_ProDKin_1	11	17	PF00069	0.670
MOD_ProDKin_1	199	205	PF00069	0.694
MOD_ProDKin_1	322	328	PF00069	0.775
MOD_ProDKin_1	340	346	PF00069	0.565
MOD_ProDKin_1	354	360	PF00069	0.593
MOD_ProDKin_1	523	529	PF00069	0.778
MOD_ProDKin_1	579	585	PF00069	0.835
MOD_ProDKin_1	60	66	PF00069	0.486
MOD_ProDKin_1	612	618	PF00069	0.579
MOD_ProDKin_1	666	672	PF00069	0.750
MOD_ProDKin_1	697	703	PF00069	0.715
MOD_ProDKin_1	766	772	PF00069	0.612
MOD_ProDKin_1	792	798	PF00069	0.767
MOD_ProDKin_1	802	808	PF00069	0.634
MOD_ProDKin_1	886	892	PF00069	0.701
MOD_ProDKin_1	975	981	PF00069	0.700
TRG_DiLeu_BaEn_1	497	502	PF01217	0.554
TRG_DiLeu_BaLyEn_6	479	484	PF01217	0.697
TRG_DiLeu_BaLyEn_6	751	756	PF01217	0.738
TRG_ENDOCYTIC_2	120	123	PF00928	0.660
TRG_ENDOCYTIC_2	19	22	PF00928	0.641
TRG_ENDOCYTIC_2	503	506	PF00928	0.600
TRG_ENDOCYTIC_2	719	722	PF00928	0.769
TRG_ENDOCYTIC_2	730	733	PF00928	0.761
TRG_ER_diArg_1	123	126	PF00400	0.426
TRG_ER_diArg_1	206	208	PF00400	0.723
TRG_ER_diArg_1	393	396	PF00400	0.657
TRG_ER_diArg_1	447	450	PF00400	0.800
TRG_ER_diArg_1	629	632	PF00400	0.663
TRG_ER_diArg_1	639	641	PF00400	0.592
TRG_ER_diArg_1	703	706	PF00400	0.703
TRG_ER_diArg_1	834	836	PF00400	0.635
TRG_ER_diArg_1	928	930	PF00400	0.624
TRG_NLS_MonoExtN_4	344	350	PF00514	0.710
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I844	Leishmania donovani	84%	96%
A4H6T1	Leishmania braziliensis	60%	82%
A4HV59	Leishmania infantum	84%	75%
E9ANU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	97%