Mannosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Mannosyltransferase

Gene product:

dolichyl-P-Man:GDP-Man5GlcNAc2-PP-dolichyl alpha-1,2-mannosyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QGS7_LEIMA

TriTrypDb:

LmjF.12.0160 , LMJLV39_120007000 , LMJSD75_120007700

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	10
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QGS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGS7

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	10
GO:0006487	protein N-linked glycosylation	5	2
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	5	2
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	2
GO:0006629	lipid metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043413	macromolecule glycosylation	3	10
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	10
GO:0044255	cellular lipid metabolic process	3	2
GO:0070085	glycosylation	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000026	alpha-1,2-mannosyltransferase activity	6	10
GO:0000030	mannosyltransferase activity	5	10
GO:0003824	catalytic activity	1	10
GO:0016740	transferase activity	2	10
GO:0016757	glycosyltransferase activity	3	10
GO:0016758	hexosyltransferase activity	4	10
GO:0052918	dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity	7	10
GO:0052926	dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity	7	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	397	401	PF00656	0.388
CLV_MEL_PAP_1	172	178	PF00089	0.188
CLV_NRD_NRD_1	349	351	PF00675	0.302
CLV_NRD_NRD_1	392	394	PF00675	0.243
CLV_NRD_NRD_1	523	525	PF00675	0.550
CLV_NRD_NRD_1	747	749	PF00675	0.601
CLV_NRD_NRD_1	771	773	PF00675	0.565
CLV_NRD_NRD_1	808	810	PF00675	0.584
CLV_PCSK_FUR_1	389	393	PF00082	0.188
CLV_PCSK_KEX2_1	349	351	PF00082	0.318
CLV_PCSK_KEX2_1	391	393	PF00082	0.256
CLV_PCSK_KEX2_1	496	498	PF00082	0.557
CLV_PCSK_KEX2_1	523	525	PF00082	0.504
CLV_PCSK_KEX2_1	592	594	PF00082	0.555
CLV_PCSK_KEX2_1	749	751	PF00082	0.619
CLV_PCSK_KEX2_1	771	773	PF00082	0.519
CLV_PCSK_KEX2_1	808	810	PF00082	0.555
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.460
CLV_PCSK_PC1ET2_1	592	594	PF00082	0.595
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.525
CLV_PCSK_SKI1_1	434	438	PF00082	0.271
CLV_PCSK_SKI1_1	61	65	PF00082	0.463
CLV_PCSK_SKI1_1	759	763	PF00082	0.598
DEG_APCC_DBOX_1	433	441	PF00400	0.460
DEG_APCC_DBOX_1	749	757	PF00400	0.327
DEG_COP1_1	501	510	PF00400	0.766
DOC_ANK_TNKS_1	365	372	PF00023	0.442
DOC_CDC14_PxL_1	575	583	PF14671	0.363
DOC_CKS1_1	648	653	PF01111	0.403
DOC_CKS1_1	661	666	PF01111	0.398
DOC_CYCLIN_RxL_1	756	766	PF00134	0.418
DOC_CYCLIN_yCln2_LP_2	338	344	PF00134	0.252
DOC_CYCLIN_yCln2_LP_2	648	654	PF00134	0.264
DOC_CYCLIN_yCln2_LP_2	800	806	PF00134	0.324
DOC_MAPK_gen_1	429	439	PF00069	0.453
DOC_MAPK_gen_1	523	529	PF00069	0.660
DOC_MAPK_MEF2A_6	121	129	PF00069	0.272
DOC_MAPK_MEF2A_6	65	72	PF00069	0.260
DOC_MAPK_NFAT4_5	65	73	PF00069	0.260
DOC_PP1_RVXF_1	220	227	PF00149	0.460
DOC_PP1_RVXF_1	88	94	PF00149	0.281
DOC_PP2B_LxvP_1	338	341	PF13499	0.370
DOC_PP2B_LxvP_1	345	348	PF13499	0.408
DOC_PP2B_LxvP_1	673	676	PF13499	0.444
DOC_PP2B_LxvP_1	733	736	PF13499	0.441
DOC_PP4_FxxP_1	40	43	PF00568	0.236
DOC_PP4_FxxP_1	459	462	PF00568	0.229
DOC_PP4_FxxP_1	661	664	PF00568	0.413
DOC_PP4_MxPP_1	198	201	PF00568	0.388
DOC_USP7_MATH_1	139	143	PF00917	0.260
DOC_USP7_MATH_1	201	205	PF00917	0.434
DOC_USP7_MATH_1	353	357	PF00917	0.494
DOC_USP7_MATH_1	376	380	PF00917	0.478
DOC_USP7_MATH_1	425	429	PF00917	0.494
DOC_USP7_MATH_1	600	604	PF00917	0.435
DOC_USP7_MATH_1	63	67	PF00917	0.223
DOC_USP7_MATH_1	686	690	PF00917	0.590
DOC_USP7_MATH_1	742	746	PF00917	0.421
DOC_WW_Pin1_4	199	204	PF00397	0.582
DOC_WW_Pin1_4	212	217	PF00397	0.449
DOC_WW_Pin1_4	379	384	PF00397	0.480
DOC_WW_Pin1_4	404	409	PF00397	0.510
DOC_WW_Pin1_4	458	463	PF00397	0.318
DOC_WW_Pin1_4	491	496	PF00397	0.683
DOC_WW_Pin1_4	498	503	PF00397	0.669
DOC_WW_Pin1_4	531	536	PF00397	0.613
DOC_WW_Pin1_4	598	603	PF00397	0.530
DOC_WW_Pin1_4	647	652	PF00397	0.328
DOC_WW_Pin1_4	660	665	PF00397	0.371
DOC_WW_Pin1_4	684	689	PF00397	0.601
DOC_WW_Pin1_4	790	795	PF00397	0.305
LIG_14-3-3_CanoR_1	162	167	PF00244	0.452
LIG_14-3-3_CanoR_1	290	300	PF00244	0.279
LIG_14-3-3_CanoR_1	4	11	PF00244	0.525
LIG_14-3-3_CanoR_1	618	624	PF00244	0.330
LIG_14-3-3_CanoR_1	631	637	PF00244	0.220
LIG_14-3-3_CanoR_1	697	707	PF00244	0.398
LIG_14-3-3_CanoR_1	81	87	PF00244	0.388
LIG_BIR_III_4	360	364	PF00653	0.388
LIG_BIR_III_4	400	404	PF00653	0.388
LIG_BIR_III_4	511	515	PF00653	0.596
LIG_BRCT_BRCA1_1	112	116	PF00533	0.315
LIG_BRCT_BRCA1_1	533	537	PF00533	0.589
LIG_BRCT_BRCA1_1	633	637	PF00533	0.255
LIG_BRCT_BRCA1_1	65	69	PF00533	0.236
LIG_Clathr_ClatBox_1	252	256	PF01394	0.306
LIG_Clathr_ClatBox_1	313	317	PF01394	0.260
LIG_deltaCOP1_diTrp_1	628	636	PF00928	0.254
LIG_eIF4E_1	575	581	PF01652	0.302
LIG_FHA_1	190	196	PF00498	0.406
LIG_FHA_1	353	359	PF00498	0.428
LIG_FHA_1	382	388	PF00498	0.492
LIG_FHA_1	4	10	PF00498	0.529
LIG_FHA_1	421	427	PF00498	0.462
LIG_FHA_1	470	476	PF00498	0.365
LIG_FHA_1	499	505	PF00498	0.785
LIG_FHA_1	53	59	PF00498	0.262
LIG_FHA_1	612	618	PF00498	0.358
LIG_FHA_1	620	626	PF00498	0.248
LIG_FHA_1	756	762	PF00498	0.366
LIG_FHA_2	395	401	PF00498	0.388
LIG_GBD_Chelix_1	266	274	PF00786	0.306
LIG_GBD_Chelix_1	546	554	PF00786	0.281
LIG_HCF-1_HBM_1	639	642	PF13415	0.298
LIG_HP1_1	341	345	PF01393	0.388
LIG_LIR_Apic_2	37	43	PF02991	0.244
LIG_LIR_Apic_2	456	462	PF02991	0.223
LIG_LIR_Apic_2	628	633	PF02991	0.261
LIG_LIR_Apic_2	660	664	PF02991	0.408
LIG_LIR_Gen_1	146	156	PF02991	0.259
LIG_LIR_Gen_1	294	304	PF02991	0.238
LIG_LIR_Gen_1	35	46	PF02991	0.236
LIG_LIR_Gen_1	6	16	PF02991	0.442
LIG_LIR_Gen_1	66	77	PF02991	0.223
LIG_LIR_Gen_1	727	736	PF02991	0.331
LIG_LIR_Gen_1	783	792	PF02991	0.334
LIG_LIR_Gen_1	793	804	PF02991	0.291
LIG_LIR_Nem_3	113	118	PF02991	0.330
LIG_LIR_Nem_3	26	31	PF02991	0.298
LIG_LIR_Nem_3	294	299	PF02991	0.238
LIG_LIR_Nem_3	35	41	PF02991	0.217
LIG_LIR_Nem_3	382	388	PF02991	0.388
LIG_LIR_Nem_3	576	581	PF02991	0.296
LIG_LIR_Nem_3	628	632	PF02991	0.262
LIG_LIR_Nem_3	639	645	PF02991	0.269
LIG_LIR_Nem_3	66	72	PF02991	0.220
LIG_LIR_Nem_3	716	721	PF02991	0.371
LIG_LIR_Nem_3	727	733	PF02991	0.263
LIG_LIR_Nem_3	783	788	PF02991	0.322
LIG_LIR_Nem_3	793	799	PF02991	0.261
LIG_LYPXL_yS_3	464	467	PF13949	0.297
LIG_LYPXL_yS_3	578	581	PF13949	0.358
LIG_MLH1_MIPbox_1	633	637	PF16413	0.255
LIG_NRBOX	126	132	PF00104	0.276
LIG_NRBOX	254	260	PF00104	0.306
LIG_NRBOX	269	275	PF00104	0.185
LIG_Pex14_2	24	28	PF04695	0.326
LIG_Pex14_2	330	334	PF04695	0.388
LIG_Pex14_2	442	446	PF04695	0.243
LIG_Pex14_2	548	552	PF04695	0.388
LIG_Pex14_2	632	636	PF04695	0.249
LIG_PTAP_UEV_1	216	221	PF05743	0.388
LIG_REV1ctd_RIR_1	318	328	PF16727	0.271
LIG_SH2_CRK	385	389	PF00017	0.388
LIG_SH2_CRK	630	634	PF00017	0.261
LIG_SH2_STAP1	621	625	PF00017	0.272
LIG_SH2_STAT3	134	137	PF00017	0.206
LIG_SH2_STAT5	23	26	PF00017	0.208
LIG_SH2_STAT5	288	291	PF00017	0.269
LIG_SH2_STAT5	46	49	PF00017	0.316
LIG_SH2_STAT5	564	567	PF00017	0.339
LIG_SH2_STAT5	621	624	PF00017	0.256
LIG_SH2_STAT5	652	655	PF00017	0.333
LIG_SH2_STAT5	718	721	PF00017	0.369
LIG_SH2_STAT5	8	11	PF00017	0.586
LIG_SH2_STAT5	92	95	PF00017	0.255
LIG_SH3_2	217	222	PF14604	0.406
LIG_SH3_3	197	203	PF00018	0.405
LIG_SH3_3	214	220	PF00018	0.354
LIG_SH3_3	411	417	PF00018	0.498
LIG_SH3_3	459	465	PF00018	0.259
LIG_SH3_3	502	508	PF00018	0.769
LIG_SH3_3	519	525	PF00018	0.629
LIG_SH3_3	659	665	PF00018	0.351
LIG_SH3_3	716	722	PF00018	0.384
LIG_SH3_3	809	815	PF00018	0.427
LIG_SH3_CIN85_PxpxPR_1	217	222	PF14604	0.406
LIG_SUMO_SIM_anti_2	235	241	PF11976	0.231
LIG_SUMO_SIM_par_1	16	21	PF11976	0.330
LIG_SUMO_SIM_par_1	235	241	PF11976	0.430
LIG_SUMO_SIM_par_1	503	509	PF11976	0.641
LIG_SUMO_SIM_par_1	786	791	PF11976	0.379
LIG_TRAF2_1	666	669	PF00917	0.387
LIG_UBA3_1	447	455	PF00899	0.305
LIG_WW_3	219	223	PF00397	0.460
LIG_WW_3	520	524	PF00397	0.649
MOD_CDC14_SPxK_1	687	690	PF00782	0.428
MOD_CDK_SPK_2	491	496	PF00069	0.776
MOD_CDK_SPxK_1	491	497	PF00069	0.735
MOD_CDK_SPxK_1	684	690	PF00069	0.428
MOD_CK1_1	165	171	PF00069	0.470
MOD_CK1_1	202	208	PF00069	0.570
MOD_CK1_1	212	218	PF00069	0.486
MOD_CK1_1	356	362	PF00069	0.482
MOD_CK1_1	379	385	PF00069	0.507
MOD_CK1_1	428	434	PF00069	0.513
MOD_CK1_1	601	607	PF00069	0.539
MOD_CK1_1	660	666	PF00069	0.429
MOD_CK1_1	689	695	PF00069	0.500
MOD_CK1_1	698	704	PF00069	0.348
MOD_CK1_1	85	91	PF00069	0.336
MOD_CK2_1	565	571	PF00069	0.336
MOD_GlcNHglycan	118	121	PF01048	0.301
MOD_GlcNHglycan	169	172	PF01048	0.279
MOD_GlcNHglycan	204	207	PF01048	0.191
MOD_GlcNHglycan	212	215	PF01048	0.211
MOD_GlcNHglycan	217	220	PF01048	0.213
MOD_GlcNHglycan	249	252	PF01048	0.250
MOD_GlcNHglycan	306	309	PF01048	0.504
MOD_GlcNHglycan	355	358	PF01048	0.330
MOD_GlcNHglycan	370	374	PF01048	0.270
MOD_GlcNHglycan	378	381	PF01048	0.292
MOD_GlcNHglycan	394	397	PF01048	0.191
MOD_GlcNHglycan	489	492	PF01048	0.493
MOD_GlcNHglycan	50	53	PF01048	0.453
MOD_GlcNHglycan	567	570	PF01048	0.543
MOD_GlcNHglycan	669	672	PF01048	0.625
MOD_GSK3_1	110	117	PF00069	0.380
MOD_GSK3_1	139	146	PF00069	0.255
MOD_GSK3_1	156	163	PF00069	0.255
MOD_GSK3_1	167	174	PF00069	0.466
MOD_GSK3_1	189	196	PF00069	0.588
MOD_GSK3_1	201	208	PF00069	0.584
MOD_GSK3_1	262	269	PF00069	0.453
MOD_GSK3_1	352	359	PF00069	0.456
MOD_GSK3_1	379	386	PF00069	0.539
MOD_GSK3_1	387	394	PF00069	0.449
MOD_GSK3_1	48	55	PF00069	0.236
MOD_GSK3_1	487	494	PF00069	0.668
MOD_GSK3_1	607	614	PF00069	0.381
MOD_GSK3_1	675	682	PF00069	0.558
MOD_GSK3_1	684	691	PF00069	0.454
MOD_N-GLC_1	762	767	PF02516	0.633
MOD_N-GLC_2	99	101	PF02516	0.260
MOD_NEK2_1	110	115	PF00069	0.297
MOD_NEK2_1	116	121	PF00069	0.297
MOD_NEK2_1	16	21	PF00069	0.341
MOD_NEK2_1	209	214	PF00069	0.493
MOD_NEK2_1	232	237	PF00069	0.371
MOD_NEK2_1	24	29	PF00069	0.318
MOD_NEK2_1	266	271	PF00069	0.282
MOD_NEK2_1	304	309	PF00069	0.361
MOD_NEK2_1	352	357	PF00069	0.463
MOD_NEK2_1	387	392	PF00069	0.518
MOD_NEK2_1	448	453	PF00069	0.336
MOD_NEK2_1	469	474	PF00069	0.286
MOD_NEK2_1	48	53	PF00069	0.236
MOD_NEK2_1	553	558	PF00069	0.339
MOD_NEK2_1	565	570	PF00069	0.275
MOD_NEK2_1	757	762	PF00069	0.370
MOD_NEK2_1	804	809	PF00069	0.417
MOD_PIKK_1	160	166	PF00454	0.460
MOD_PIKK_1	178	184	PF00454	0.375
MOD_PIKK_1	611	617	PF00454	0.426
MOD_PK_1	523	529	PF00069	0.584
MOD_PKA_1	391	397	PF00069	0.388
MOD_PKA_1	523	529	PF00069	0.779
MOD_PKA_2	178	184	PF00069	0.478
MOD_PKA_2	289	295	PF00069	0.293
MOD_PKA_2	3	9	PF00069	0.535
MOD_PKA_2	391	397	PF00069	0.581
MOD_PKA_2	428	434	PF00069	0.460
MOD_PKA_2	523	529	PF00069	0.714
MOD_PKA_2	696	702	PF00069	0.421
MOD_PKB_1	389	397	PF00069	0.442
MOD_Plk_1	34	40	PF00069	0.253
MOD_Plk_1	762	768	PF00069	0.428
MOD_Plk_4	110	116	PF00069	0.283
MOD_Plk_4	139	145	PF00069	0.306
MOD_Plk_4	156	162	PF00069	0.203
MOD_Plk_4	193	199	PF00069	0.405
MOD_Plk_4	24	30	PF00069	0.343
MOD_Plk_4	269	275	PF00069	0.342
MOD_Plk_4	383	389	PF00069	0.557
MOD_Plk_4	632	638	PF00069	0.272
MOD_Plk_4	657	663	PF00069	0.417
MOD_Plk_4	752	758	PF00069	0.439
MOD_ProDKin_1	199	205	PF00069	0.582
MOD_ProDKin_1	212	218	PF00069	0.449
MOD_ProDKin_1	379	385	PF00069	0.480
MOD_ProDKin_1	404	410	PF00069	0.510
MOD_ProDKin_1	458	464	PF00069	0.318
MOD_ProDKin_1	491	497	PF00069	0.683
MOD_ProDKin_1	498	504	PF00069	0.669
MOD_ProDKin_1	531	537	PF00069	0.608
MOD_ProDKin_1	598	604	PF00069	0.533
MOD_ProDKin_1	647	653	PF00069	0.329
MOD_ProDKin_1	660	666	PF00069	0.375
MOD_ProDKin_1	684	690	PF00069	0.600
MOD_ProDKin_1	790	796	PF00069	0.308
MOD_SUMO_for_1	495	498	PF00179	0.661
MOD_SUMO_rev_2	745	751	PF00179	0.322
TRG_DiLeu_BaEn_2	35	41	PF01217	0.236
TRG_DiLeu_BaLyEn_6	576	581	PF01217	0.231
TRG_ENDOCYTIC_2	301	304	PF00928	0.253
TRG_ENDOCYTIC_2	385	388	PF00928	0.388
TRG_ENDOCYTIC_2	464	467	PF00928	0.297
TRG_ENDOCYTIC_2	578	581	PF00928	0.283
TRG_ENDOCYTIC_2	620	623	PF00928	0.343
TRG_ENDOCYTIC_2	645	648	PF00928	0.285
TRG_ENDOCYTIC_2	785	788	PF00928	0.332
TRG_ENDOCYTIC_2	8	11	PF00928	0.593
TRG_ENDOCYTIC_2	801	804	PF00928	0.278
TRG_ENDOCYTIC_2	92	95	PF00928	0.270
TRG_ER_diArg_1	348	350	PF00400	0.494
TRG_ER_diArg_1	388	391	PF00400	0.543
TRG_ER_diArg_1	522	524	PF00400	0.790
TRG_ER_diArg_1	748	751	PF00400	0.375
TRG_ER_diArg_1	770	772	PF00400	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C3	Leptomonas seymouri	51%	100%
A0A0S4ITY5	Bodo saltans	27%	100%
A0A1X0NM38	Trypanosomatidae	36%	100%
A0A3Q8IBE5	Leishmania donovani	80%	100%
A0A422NUF2	Trypanosoma rangeli	37%	100%
C9ZQC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AGA5	Leishmania infantum	80%	100%
E9ANU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%