Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGS6_LEIMA

TriTrypDb:

LmjF.12.0170 , LMJLV39_120007100 , LMJSD75_120007800

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGS6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.787
CLV_C14_Caspase3-7	317	321	PF00656	0.534
CLV_C14_Caspase3-7	350	354	PF00656	0.509
CLV_NRD_NRD_1	297	299	PF00675	0.745
CLV_NRD_NRD_1	72	74	PF00675	0.536
CLV_PCSK_KEX2_1	297	299	PF00082	0.715
CLV_PCSK_KEX2_1	72	74	PF00082	0.540
CLV_PCSK_SKI1_1	239	243	PF00082	0.704
CLV_PCSK_SKI1_1	72	76	PF00082	0.491
DEG_Nend_Nbox_1	1	3	PF02207	0.514
DEG_SPOP_SBC_1	23	27	PF00917	0.607
DEG_SPOP_SBC_1	312	316	PF00917	0.637
DEG_SPOP_SBC_1	32	36	PF00917	0.604
DOC_CYCLIN_RxL_1	100	112	PF00134	0.555
DOC_CYCLIN_RxL_1	66	78	PF00134	0.506
DOC_MAPK_DCC_7	180	189	PF00069	0.599
DOC_MAPK_gen_1	180	189	PF00069	0.574
DOC_MAPK_gen_1	297	306	PF00069	0.542
DOC_MAPK_HePTP_8	294	306	PF00069	0.537
DOC_MAPK_MEF2A_6	180	189	PF00069	0.623
DOC_MAPK_MEF2A_6	297	306	PF00069	0.542
DOC_MAPK_RevD_3	283	298	PF00069	0.621
DOC_PP1_RVXF_1	70	77	PF00149	0.484
DOC_USP7_MATH_1	103	107	PF00917	0.574
DOC_USP7_MATH_1	128	132	PF00917	0.553
DOC_USP7_MATH_1	135	139	PF00917	0.479
DOC_USP7_MATH_1	157	161	PF00917	0.732
DOC_USP7_MATH_1	174	178	PF00917	0.612
DOC_USP7_MATH_1	23	27	PF00917	0.684
DOC_USP7_MATH_1	259	263	PF00917	0.580
DOC_USP7_MATH_1	266	270	PF00917	0.595
DOC_USP7_MATH_1	32	36	PF00917	0.670
DOC_WW_Pin1_4	141	146	PF00397	0.541
DOC_WW_Pin1_4	180	185	PF00397	0.605
DOC_WW_Pin1_4	260	265	PF00397	0.539
DOC_WW_Pin1_4	8	13	PF00397	0.605
LIG_14-3-3_CanoR_1	105	110	PF00244	0.551
LIG_14-3-3_CanoR_1	121	128	PF00244	0.625
LIG_14-3-3_CanoR_1	151	158	PF00244	0.627
LIG_14-3-3_CanoR_1	87	92	PF00244	0.621
LIG_APCC_ABBA_1	185	190	PF00400	0.557
LIG_APCC_ABBA_1	302	307	PF00400	0.546
LIG_APCC_ABBAyCdc20_2	72	78	PF00400	0.486
LIG_eIF4E_1	70	76	PF01652	0.556
LIG_FHA_1	170	176	PF00498	0.625
LIG_FHA_1	328	334	PF00498	0.522
LIG_FHA_1	69	75	PF00498	0.489
LIG_FHA_2	348	354	PF00498	0.510
LIG_FHA_2	380	386	PF00498	0.634
LIG_FHA_2	9	15	PF00498	0.588
LIG_LIR_Gen_1	206	213	PF02991	0.639
LIG_LIR_Gen_1	48	59	PF02991	0.693
LIG_LIR_Nem_3	206	212	PF02991	0.632
LIG_LIR_Nem_3	48	54	PF02991	0.700
LIG_SH2_SRC	2	5	PF00017	0.516
LIG_SH2_STAP1	55	59	PF00017	0.570
LIG_SH2_STAP1	70	74	PF00017	0.501
LIG_SH2_STAT5	142	145	PF00017	0.621
LIG_SH2_STAT5	2	5	PF00017	0.560
LIG_SH2_STAT5	230	233	PF00017	0.602
LIG_SH2_STAT5	376	379	PF00017	0.438
LIG_SH2_STAT5	388	391	PF00017	0.445
LIG_SH2_STAT5	70	73	PF00017	0.588
LIG_SH3_3	178	184	PF00018	0.648
LIG_SH3_3	283	289	PF00018	0.618
LIG_SH3_3	341	347	PF00018	0.445
LIG_SH3_3	389	395	PF00018	0.407
LIG_SUMO_SIM_anti_2	279	287	PF11976	0.645
LIG_TRAF2_1	153	156	PF00917	0.527
LIG_TRAF2_1	45	48	PF00917	0.585
MOD_CDK_SPxxK_3	8	15	PF00069	0.515
MOD_CK1_1	131	137	PF00069	0.567
MOD_CK1_1	24	30	PF00069	0.646
MOD_CK1_1	262	268	PF00069	0.696
MOD_CK1_1	271	277	PF00069	0.558
MOD_CK1_1	308	314	PF00069	0.637
MOD_CK1_1	31	37	PF00069	0.615
MOD_CK1_1	49	55	PF00069	0.600
MOD_CK1_1	83	89	PF00069	0.485
MOD_CK1_1	90	96	PF00069	0.568
MOD_CK2_1	131	137	PF00069	0.736
MOD_CK2_1	8	14	PF00069	0.585
MOD_DYRK1A_RPxSP_1	180	184	PF00069	0.544
MOD_GlcNHglycan	115	118	PF01048	0.685
MOD_GlcNHglycan	122	125	PF01048	0.540
MOD_GlcNHglycan	133	136	PF01048	0.551
MOD_GlcNHglycan	147	150	PF01048	0.686
MOD_GlcNHglycan	160	163	PF01048	0.627
MOD_GlcNHglycan	172	175	PF01048	0.689
MOD_GlcNHglycan	243	246	PF01048	0.595
MOD_GlcNHglycan	264	267	PF01048	0.558
MOD_GlcNHglycan	30	33	PF01048	0.721
MOD_GlcNHglycan	339	343	PF01048	0.498
MOD_GlcNHglycan	62	65	PF01048	0.591
MOD_GSK3_1	103	110	PF00069	0.543
MOD_GSK3_1	131	138	PF00069	0.526
MOD_GSK3_1	141	148	PF00069	0.566
MOD_GSK3_1	17	24	PF00069	0.695
MOD_GSK3_1	170	177	PF00069	0.716
MOD_GSK3_1	255	262	PF00069	0.529
MOD_GSK3_1	268	275	PF00069	0.591
MOD_GSK3_1	28	35	PF00069	0.603
MOD_GSK3_1	308	315	PF00069	0.687
MOD_GSK3_1	327	334	PF00069	0.490
MOD_GSK3_1	379	386	PF00069	0.481
MOD_GSK3_1	79	86	PF00069	0.496
MOD_N-GLC_1	271	276	PF02516	0.680
MOD_N-GLC_1	60	65	PF02516	0.532
MOD_N-GLC_1	68	73	PF02516	0.498
MOD_NEK2_1	158	163	PF00069	0.538
MOD_NEK2_1	372	377	PF00069	0.432
MOD_PIKK_1	122	128	PF00454	0.558
MOD_PIKK_1	151	157	PF00454	0.645
MOD_PIKK_1	87	93	PF00454	0.625
MOD_PKA_2	120	126	PF00069	0.674
MOD_PKA_2	259	265	PF00069	0.530
MOD_PKA_2	327	333	PF00069	0.637
MOD_PKA_2	49	55	PF00069	0.552
MOD_Plk_1	129	135	PF00069	0.581
MOD_Plk_1	17	23	PF00069	0.611
MOD_Plk_1	266	272	PF00069	0.671
MOD_Plk_1	281	287	PF00069	0.504
MOD_Plk_1	319	325	PF00069	0.600
MOD_Plk_1	328	334	PF00069	0.428
MOD_Plk_1	46	52	PF00069	0.600
MOD_Plk_1	60	66	PF00069	0.468
MOD_Plk_4	272	278	PF00069	0.585
MOD_Plk_4	314	320	PF00069	0.582
MOD_ProDKin_1	141	147	PF00069	0.542
MOD_ProDKin_1	180	186	PF00069	0.606
MOD_ProDKin_1	260	266	PF00069	0.539
MOD_ProDKin_1	8	14	PF00069	0.609
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.506
TRG_ENDOCYTIC_2	2	5	PF00928	0.516
TRG_ENDOCYTIC_2	209	212	PF00928	0.662
TRG_ER_diArg_1	179	182	PF00400	0.566
TRG_ER_diArg_1	297	300	PF00400	0.632
TRG_ER_diArg_1	72	74	PF00400	0.540
TRG_ER_diArg_1	97	100	PF00400	0.579
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD33	Leptomonas seymouri	28%	85%
A0A3S7WRT8	Leishmania donovani	81%	100%
A4H6T2	Leishmania braziliensis	63%	94%
E9AGA6	Leishmania infantum	81%	100%
E9ANU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%