Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGS5_LEIMA

TriTrypDb:

LmjF.12.0180 , LMJLV39_120007200 , LMJSD75_120007900

Length:

909

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGS5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.594
CLV_C14_Caspase3-7	604	608	PF00656	0.393
CLV_C14_Caspase3-7	618	622	PF00656	0.362
CLV_MEL_PAP_1	11	17	PF00089	0.475
CLV_NRD_NRD_1	168	170	PF00675	0.681
CLV_NRD_NRD_1	183	185	PF00675	0.653
CLV_NRD_NRD_1	221	223	PF00675	0.430
CLV_NRD_NRD_1	247	249	PF00675	0.594
CLV_NRD_NRD_1	255	257	PF00675	0.416
CLV_NRD_NRD_1	290	292	PF00675	0.592
CLV_NRD_NRD_1	293	295	PF00675	0.544
CLV_NRD_NRD_1	385	387	PF00675	0.805
CLV_NRD_NRD_1	503	505	PF00675	0.522
CLV_NRD_NRD_1	527	529	PF00675	0.405
CLV_NRD_NRD_1	655	657	PF00675	0.474
CLV_NRD_NRD_1	726	728	PF00675	0.618
CLV_NRD_NRD_1	733	735	PF00675	0.635
CLV_NRD_NRD_1	749	751	PF00675	0.619
CLV_PCSK_FUR_1	253	257	PF00082	0.317
CLV_PCSK_FUR_1	291	295	PF00082	0.623
CLV_PCSK_FUR_1	653	657	PF00082	0.396
CLV_PCSK_KEX2_1	168	170	PF00082	0.642
CLV_PCSK_KEX2_1	185	187	PF00082	0.649
CLV_PCSK_KEX2_1	221	223	PF00082	0.430
CLV_PCSK_KEX2_1	247	249	PF00082	0.604
CLV_PCSK_KEX2_1	255	257	PF00082	0.416
CLV_PCSK_KEX2_1	290	292	PF00082	0.592
CLV_PCSK_KEX2_1	293	295	PF00082	0.544
CLV_PCSK_KEX2_1	503	505	PF00082	0.522
CLV_PCSK_KEX2_1	527	529	PF00082	0.405
CLV_PCSK_KEX2_1	655	657	PF00082	0.415
CLV_PCSK_KEX2_1	733	735	PF00082	0.715
CLV_PCSK_KEX2_1	749	751	PF00082	0.619
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.703
CLV_PCSK_SKI1_1	101	105	PF00082	0.417
CLV_PCSK_SKI1_1	230	234	PF00082	0.475
CLV_PCSK_SKI1_1	255	259	PF00082	0.349
CLV_PCSK_SKI1_1	268	272	PF00082	0.577
CLV_PCSK_SKI1_1	662	666	PF00082	0.409
CLV_PCSK_SKI1_1	704	708	PF00082	0.457
CLV_PCSK_SKI1_1	903	907	PF00082	0.514
DEG_APCC_DBOX_1	254	262	PF00400	0.418
DEG_APCC_DBOX_1	547	555	PF00400	0.406
DEG_ODPH_VHL_1	317	330	PF01847	0.331
DEG_ODPH_VHL_1	753	765	PF01847	0.615
DEG_SPOP_SBC_1	479	483	PF00917	0.546
DEG_SPOP_SBC_1	566	570	PF00917	0.538
DOC_ANK_TNKS_1	134	141	PF00023	0.520
DOC_ANK_TNKS_1	238	245	PF00023	0.565
DOC_CDC14_PxL_1	751	759	PF14671	0.591
DOC_CYCLIN_RxL_1	656	669	PF00134	0.416
DOC_CYCLIN_RxL_1	841	850	PF00134	0.461
DOC_MAPK_gen_1	251	260	PF00069	0.455
DOC_MAPK_gen_1	290	301	PF00069	0.489
DOC_MAPK_gen_1	527	533	PF00069	0.398
DOC_MAPK_gen_1	653	663	PF00069	0.458
DOC_MAPK_gen_1	78	87	PF00069	0.365
DOC_MAPK_JIP1_4	325	331	PF00069	0.421
DOC_MAPK_MEF2A_6	253	261	PF00069	0.294
DOC_MAPK_MEF2A_6	294	303	PF00069	0.418
DOC_MAPK_MEF2A_6	353	360	PF00069	0.422
DOC_MAPK_MEF2A_6	548	556	PF00069	0.431
DOC_MAPK_MEF2A_6	656	665	PF00069	0.470
DOC_MAPK_MEF2A_6	78	87	PF00069	0.426
DOC_MAPK_MEF2A_6	862	871	PF00069	0.440
DOC_PP1_RVXF_1	266	272	PF00149	0.582
DOC_PP2B_LxvP_1	136	139	PF13499	0.620
DOC_PP2B_LxvP_1	329	332	PF13499	0.366
DOC_PP2B_LxvP_1	854	857	PF13499	0.557
DOC_PP4_FxxP_1	510	513	PF00568	0.444
DOC_PP4_FxxP_1	834	837	PF00568	0.477
DOC_USP7_MATH_1	145	149	PF00917	0.671
DOC_USP7_MATH_1	191	195	PF00917	0.584
DOC_USP7_MATH_1	281	285	PF00917	0.756
DOC_USP7_MATH_1	42	46	PF00917	0.611
DOC_USP7_MATH_1	443	447	PF00917	0.574
DOC_USP7_MATH_1	463	467	PF00917	0.705
DOC_USP7_MATH_1	471	475	PF00917	0.550
DOC_USP7_MATH_1	480	484	PF00917	0.496
DOC_USP7_MATH_1	547	551	PF00917	0.478
DOC_USP7_MATH_1	675	679	PF00917	0.587
DOC_USP7_MATH_1	740	744	PF00917	0.619
DOC_USP7_MATH_1	807	811	PF00917	0.740
DOC_USP7_MATH_1	821	825	PF00917	0.632
DOC_USP7_MATH_1	95	99	PF00917	0.492
DOC_WW_Pin1_4	170	175	PF00397	0.634
DOC_WW_Pin1_4	420	425	PF00397	0.629
DOC_WW_Pin1_4	588	593	PF00397	0.549
LIG_14-3-3_CanoR_1	14	20	PF00244	0.536
LIG_14-3-3_CanoR_1	168	173	PF00244	0.649
LIG_14-3-3_CanoR_1	262	271	PF00244	0.542
LIG_14-3-3_CanoR_1	392	396	PF00244	0.643
LIG_14-3-3_CanoR_1	457	464	PF00244	0.617
LIG_14-3-3_CanoR_1	503	513	PF00244	0.493
LIG_14-3-3_CanoR_1	548	552	PF00244	0.438
LIG_14-3-3_CanoR_1	66	71	PF00244	0.622
LIG_14-3-3_CanoR_1	690	699	PF00244	0.517
LIG_14-3-3_CanoR_1	749	754	PF00244	0.605
LIG_Actin_WH2_2	639	657	PF00022	0.368
LIG_APCC_ABBA_1	712	717	PF00400	0.531
LIG_BIR_II_1	1	5	PF00653	0.508
LIG_BRCT_BRCA1_1	109	113	PF00533	0.418
LIG_BRCT_BRCA1_1	15	19	PF00533	0.495
LIG_BRCT_BRCA1_1	506	510	PF00533	0.460
LIG_deltaCOP1_diTrp_1	162	170	PF00928	0.582
LIG_EH1_1	700	708	PF00400	0.442
LIG_FHA_1	116	122	PF00498	0.406
LIG_FHA_1	391	397	PF00498	0.714
LIG_FHA_1	600	606	PF00498	0.448
LIG_FHA_1	635	641	PF00498	0.377
LIG_FHA_1	88	94	PF00498	0.488
LIG_FHA_2	20	26	PF00498	0.487
LIG_FHA_2	205	211	PF00498	0.499
LIG_FHA_2	309	315	PF00498	0.432
LIG_FHA_2	421	427	PF00498	0.507
LIG_FHA_2	449	455	PF00498	0.618
LIG_FHA_2	692	698	PF00498	0.524
LIG_FHA_2	798	804	PF00498	0.640
LIG_FHA_2	815	821	PF00498	0.801
LIG_FHA_2	902	908	PF00498	0.577
LIG_Integrin_RGD_1	32	34	PF01839	0.472
LIG_LIR_Apic_2	507	513	PF02991	0.462
LIG_LIR_Gen_1	110	121	PF02991	0.421
LIG_LIR_Gen_1	297	308	PF02991	0.446
LIG_LIR_Gen_1	462	471	PF02991	0.505
LIG_LIR_Gen_1	637	647	PF02991	0.378
LIG_LIR_Nem_3	110	116	PF02991	0.413
LIG_LIR_Nem_3	297	303	PF02991	0.451
LIG_LIR_Nem_3	462	467	PF02991	0.507
LIG_LIR_Nem_3	637	642	PF02991	0.416
LIG_LIR_Nem_3	77	82	PF02991	0.509
LIG_MLH1_MIPbox_1	506	510	PF16413	0.460
LIG_NRBOX	253	259	PF00104	0.430
LIG_NRBOX	605	611	PF00104	0.421
LIG_NRBOX	637	643	PF00104	0.290
LIG_PCNA_PIPBox_1	1	10	PF02747	0.503
LIG_PCNA_PIPBox_1	24	33	PF02747	0.433
LIG_PDZ_Class_3	904	909	PF00595	0.535
LIG_Pex14_1	355	359	PF04695	0.434
LIG_Pex14_2	113	117	PF04695	0.410
LIG_REV1ctd_RIR_1	507	512	PF16727	0.378
LIG_SH2_CRK	835	839	PF00017	0.586
LIG_SH2_GRB2like	7	10	PF00017	0.457
LIG_SH2_NCK_1	205	209	PF00017	0.363
LIG_SH2_NCK_1	716	720	PF00017	0.523
LIG_SH2_SRC	7	10	PF00017	0.474
LIG_SH2_STAP1	205	209	PF00017	0.483
LIG_SH2_STAP1	313	317	PF00017	0.438
LIG_SH2_STAP1	643	647	PF00017	0.340
LIG_SH2_STAP1	716	720	PF00017	0.523
LIG_SH2_STAT5	300	303	PF00017	0.439
LIG_SH2_STAT5	7	10	PF00017	0.474
LIG_SH2_STAT5	847	850	PF00017	0.629
LIG_SH3_3	464	470	PF00018	0.503
LIG_SH3_3	486	492	PF00018	0.543
LIG_SH3_3	530	536	PF00018	0.375
LIG_SH3_3	578	584	PF00018	0.585
LIG_SH3_3	61	67	PF00018	0.651
LIG_SH3_3	705	711	PF00018	0.486
LIG_SH3_3	834	840	PF00018	0.485
LIG_SUMO_SIM_anti_2	118	125	PF11976	0.495
LIG_SUMO_SIM_anti_2	553	558	PF11976	0.311
LIG_SUMO_SIM_anti_2	760	767	PF11976	0.599
LIG_SUMO_SIM_anti_2	876	884	PF11976	0.488
LIG_SUMO_SIM_par_1	327	336	PF11976	0.408
LIG_SUMO_SIM_par_1	436	441	PF11976	0.415
LIG_SUMO_SIM_par_1	624	630	PF11976	0.509
LIG_SUMO_SIM_par_1	880	886	PF11976	0.455
LIG_TRFH_1	509	513	PF08558	0.457
LIG_TYR_ITIM	641	646	PF00017	0.340
LIG_TYR_ITIM	714	719	PF00017	0.518
LIG_UBA3_1	880	885	PF00899	0.446
LIG_WRC_WIRS_1	27	32	PF05994	0.418
MOD_CDK_SPxxK_3	420	427	PF00069	0.567
MOD_CK1_1	148	154	PF00069	0.532
MOD_CK1_1	200	206	PF00069	0.590
MOD_CK1_1	285	291	PF00069	0.637
MOD_CK1_1	400	406	PF00069	0.721
MOD_CK1_1	459	465	PF00069	0.631
MOD_CK1_1	482	488	PF00069	0.759
MOD_CK1_1	543	549	PF00069	0.471
MOD_CK1_1	568	574	PF00069	0.618
MOD_CK1_1	824	830	PF00069	0.593
MOD_CK1_1	901	907	PF00069	0.527
MOD_CK1_1	94	100	PF00069	0.571
MOD_CK2_1	204	210	PF00069	0.514
MOD_CK2_1	308	314	PF00069	0.426
MOD_CK2_1	420	426	PF00069	0.523
MOD_CK2_1	448	454	PF00069	0.601
MOD_CK2_1	691	697	PF00069	0.490
MOD_CK2_1	729	735	PF00069	0.644
MOD_CK2_1	768	774	PF00069	0.503
MOD_Cter_Amidation	288	291	PF01082	0.617
MOD_GlcNHglycan	147	150	PF01048	0.695
MOD_GlcNHglycan	15	18	PF01048	0.492
MOD_GlcNHglycan	285	288	PF01048	0.626
MOD_GlcNHglycan	366	369	PF01048	0.676
MOD_GlcNHglycan	399	402	PF01048	0.650
MOD_GlcNHglycan	42	45	PF01048	0.604
MOD_GlcNHglycan	439	443	PF01048	0.472
MOD_GlcNHglycan	445	448	PF01048	0.506
MOD_GlcNHglycan	458	461	PF01048	0.651
MOD_GlcNHglycan	473	476	PF01048	0.650
MOD_GlcNHglycan	482	485	PF01048	0.663
MOD_GlcNHglycan	493	496	PF01048	0.625
MOD_GlcNHglycan	672	675	PF01048	0.502
MOD_GlcNHglycan	810	813	PF01048	0.687
MOD_GlcNHglycan	823	826	PF01048	0.659
MOD_GlcNHglycan	829	832	PF01048	0.568
MOD_GlcNHglycan	900	903	PF01048	0.532
MOD_GlcNHglycan	93	96	PF01048	0.511
MOD_GlcNHglycan	97	100	PF01048	0.530
MOD_GSK3_1	117	124	PF00069	0.491
MOD_GSK3_1	144	151	PF00069	0.560
MOD_GSK3_1	15	22	PF00069	0.502
MOD_GSK3_1	168	175	PF00069	0.712
MOD_GSK3_1	186	193	PF00069	0.512
MOD_GSK3_1	200	207	PF00069	0.414
MOD_GSK3_1	281	288	PF00069	0.749
MOD_GSK3_1	333	340	PF00069	0.543
MOD_GSK3_1	359	366	PF00069	0.524
MOD_GSK3_1	396	403	PF00069	0.721
MOD_GSK3_1	42	49	PF00069	0.641
MOD_GSK3_1	443	450	PF00069	0.602
MOD_GSK3_1	459	466	PF00069	0.637
MOD_GSK3_1	478	485	PF00069	0.685
MOD_GSK3_1	487	494	PF00069	0.665
MOD_GSK3_1	51	58	PF00069	0.715
MOD_GSK3_1	543	550	PF00069	0.479
MOD_GSK3_1	568	575	PF00069	0.542
MOD_GSK3_1	87	94	PF00069	0.448
MOD_GSK3_1	892	899	PF00069	0.523
MOD_GSK3_1	901	908	PF00069	0.577
MOD_NEK2_1	107	112	PF00069	0.436
MOD_NEK2_1	117	122	PF00069	0.437
MOD_NEK2_1	163	168	PF00069	0.602
MOD_NEK2_1	438	443	PF00069	0.457
MOD_NEK2_1	456	461	PF00069	0.765
MOD_NEK2_1	565	570	PF00069	0.548
MOD_NEK2_1	74	79	PF00069	0.558
MOD_NEK2_1	757	762	PF00069	0.544
MOD_NEK2_1	768	773	PF00069	0.555
MOD_NEK2_1	892	897	PF00069	0.514
MOD_NEK2_2	308	313	PF00069	0.438
MOD_PIKK_1	163	169	PF00454	0.606
MOD_PIKK_1	824	830	PF00454	0.627
MOD_PKA_1	168	174	PF00069	0.615
MOD_PKA_1	749	755	PF00069	0.614
MOD_PKA_2	13	19	PF00069	0.532
MOD_PKA_2	168	174	PF00069	0.633
MOD_PKA_2	203	209	PF00069	0.513
MOD_PKA_2	391	397	PF00069	0.632
MOD_PKA_2	456	462	PF00069	0.607
MOD_PKA_2	487	493	PF00069	0.612
MOD_PKA_2	511	517	PF00069	0.428
MOD_PKA_2	547	553	PF00069	0.480
MOD_PKA_2	65	71	PF00069	0.587
MOD_PKA_2	749	755	PF00069	0.576
MOD_PKA_2	814	820	PF00069	0.731
MOD_PKB_1	184	192	PF00069	0.685
MOD_Plk_1	197	203	PF00069	0.504
MOD_Plk_1	333	339	PF00069	0.493
MOD_Plk_4	117	123	PF00069	0.503
MOD_Plk_4	15	21	PF00069	0.514
MOD_Plk_4	26	32	PF00069	0.443
MOD_Plk_4	308	314	PF00069	0.399
MOD_Plk_4	337	343	PF00069	0.517
MOD_Plk_4	391	397	PF00069	0.733
MOD_Plk_4	408	414	PF00069	0.711
MOD_Plk_4	547	553	PF00069	0.521
MOD_Plk_4	582	588	PF00069	0.703
MOD_Plk_4	594	600	PF00069	0.446
MOD_Plk_4	634	640	PF00069	0.367
MOD_Plk_4	758	764	PF00069	0.564
MOD_Plk_4	768	774	PF00069	0.472
MOD_Plk_4	88	94	PF00069	0.449
MOD_ProDKin_1	170	176	PF00069	0.635
MOD_ProDKin_1	420	426	PF00069	0.620
MOD_ProDKin_1	588	594	PF00069	0.540
TRG_DiLeu_BaEn_1	228	233	PF01217	0.499
TRG_DiLeu_BaEn_1	878	883	PF01217	0.461
TRG_DiLeu_BaEn_4	228	234	PF01217	0.504
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.436
TRG_ENDOCYTIC_2	300	303	PF00928	0.436
TRG_ENDOCYTIC_2	643	646	PF00928	0.339
TRG_ENDOCYTIC_2	716	719	PF00928	0.521
TRG_ENDOCYTIC_2	835	838	PF00928	0.602
TRG_ER_diArg_1	168	170	PF00400	0.669
TRG_ER_diArg_1	221	223	PF00400	0.430
TRG_ER_diArg_1	253	256	PF00400	0.459
TRG_ER_diArg_1	290	293	PF00400	0.587
TRG_ER_diArg_1	413	416	PF00400	0.667
TRG_ER_diArg_1	502	504	PF00400	0.516
TRG_ER_diArg_1	526	528	PF00400	0.390
TRG_ER_diArg_1	653	656	PF00400	0.465
TRG_ER_diArg_1	748	750	PF00400	0.622
TRG_NES_CRM1_1	604	619	PF08389	0.431
TRG_NLS_Bipartite_1	168	189	PF00514	0.538
TRG_NLS_MonoExtC_3	183	188	PF00514	0.700
TRG_NLS_MonoExtN_4	184	189	PF00514	0.697
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	903	907	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWE7	Leptomonas seymouri	50%	100%
A0A3S5H6K4	Leishmania donovani	91%	100%
A4H6T3	Leishmania braziliensis	74%	100%
C9ZQC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AGA7	Leishmania infantum	91%	100%
E9ANU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%