Putative hydroxyacylglutathione hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glyoxalase II, putative

Species:

Leishmania major

UniProt:

Q4QGS1_LEIMA

TriTrypDb:

LmjF.12.0220 , LMJLV39_120007600 , LMJSD75_120005200

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGS1

PDB structure(s): 2p18_A , 2p1e_A

Function

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Biological processes
Term	Name	Level	Count
GO:0006081	cellular aldehyde metabolic process	3	1
GO:0006082	organic acid metabolic process	3	1
GO:0006089	lactate metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009438	methylglyoxal metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	6	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004416	hydroxyacylglutathione hydrolase activity	5	9
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016790	thiolester hydrolase activity	4	9
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.487
CLV_C14_Caspase3-7	20	24	PF00656	0.496
CLV_PCSK_SKI1_1	47	51	PF00082	0.521
DEG_COP1_1	11	21	PF00400	0.469
DEG_Nend_UBRbox_1	1	4	PF02207	0.484
DOC_CYCLIN_yClb1_LxF_4	229	235	PF00134	0.338
DOC_MAPK_FxFP_2	205	208	PF00069	0.367
DOC_MAPK_gen_1	116	126	PF00069	0.522
DOC_MAPK_MEF2A_6	261	269	PF00069	0.384
DOC_PP1_RVXF_1	200	206	PF00149	0.510

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS53	Leptomonas seymouri	70%	100%
A0A0S4JNU4	Bodo saltans	42%	100%
A0A1X0NMK6	Trypanosomatidae	51%	96%
A0A3S5IRV9	Trypanosoma rangeli	54%	100%
A0A3S7WRZ1	Leishmania donovani	97%	100%
A0KIK2	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	31%	100%
A0KXS9	Shewanella sp. (strain ANA-3)	26%	100%
A0Q7M7	Francisella tularensis subsp. novicida (strain U112)	29%	100%
A1A7Q3	Escherichia coli O1:K1 / APEC	26%	100%
A1IPQ8	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	30%	100%

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