Membrane-associated protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QGR9_LEIMA

TriTrypDb:

LmjF.12.0240 , LMJLV39_120007800 , LMJSD75_120005400

Length:

704

Annotations

LeishMANIAdb annotations

This membrane protein has considerable similarity to beta-lactamases found in Streptomyces species. A protein family found in a single copy in parazitic species, while multiple paralogs exist in B.saltans.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 6
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QGR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.301
CLV_C14_Caspase3-7	344	348	PF00656	0.389
CLV_C14_Caspase3-7	620	624	PF00656	0.709
CLV_C14_Caspase3-7	677	681	PF00656	0.720
CLV_NRD_NRD_1	606	608	PF00675	0.428
CLV_NRD_NRD_1	647	649	PF00675	0.609
CLV_NRD_NRD_1	652	654	PF00675	0.632
CLV_PCSK_FUR_1	645	649	PF00082	0.478
CLV_PCSK_FUR_1	650	654	PF00082	0.475
CLV_PCSK_KEX2_1	134	136	PF00082	0.691
CLV_PCSK_KEX2_1	645	647	PF00082	0.610
CLV_PCSK_KEX2_1	650	652	PF00082	0.624
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.691
CLV_PCSK_PC7_1	646	652	PF00082	0.612
CLV_PCSK_SKI1_1	118	122	PF00082	0.573
CLV_PCSK_SKI1_1	335	339	PF00082	0.677
CLV_PCSK_SKI1_1	695	699	PF00082	0.554
CLV_PCSK_SKI1_1	84	88	PF00082	0.595
DEG_APCC_DBOX_1	33	41	PF00400	0.572
DEG_COP1_1	221	231	PF00400	0.322
DEG_SPOP_SBC_1	95	99	PF00917	0.347
DOC_CYCLIN_RxL_1	211	222	PF00134	0.306
DOC_CYCLIN_RxL_1	81	90	PF00134	0.328
DOC_MAPK_DCC_7	32	42	PF00069	0.461
DOC_MAPK_MEF2A_6	576	585	PF00069	0.651
DOC_PP2B_LxvP_1	581	584	PF13499	0.599
DOC_PP4_FxxP_1	121	124	PF00568	0.366
DOC_PP4_FxxP_1	189	192	PF00568	0.312
DOC_USP7_MATH_1	100	104	PF00917	0.336
DOC_USP7_MATH_1	173	177	PF00917	0.443
DOC_USP7_MATH_1	320	324	PF00917	0.501
DOC_USP7_MATH_1	442	446	PF00917	0.453
DOC_USP7_MATH_1	468	472	PF00917	0.353
DOC_USP7_MATH_1	505	509	PF00917	0.304
DOC_USP7_MATH_1	590	594	PF00917	0.670
DOC_USP7_MATH_1	597	601	PF00917	0.775
DOC_USP7_MATH_1	638	642	PF00917	0.699
DOC_WW_Pin1_4	35	40	PF00397	0.550
DOC_WW_Pin1_4	599	604	PF00397	0.730
DOC_WW_Pin1_4	625	630	PF00397	0.762
LIG_14-3-3_CanoR_1	135	143	PF00244	0.424
LIG_14-3-3_CanoR_1	322	332	PF00244	0.554
LIG_14-3-3_CanoR_1	385	391	PF00244	0.371
LIG_14-3-3_CanoR_1	438	444	PF00244	0.438
LIG_14-3-3_CanoR_1	639	645	PF00244	0.732
LIG_14-3-3_CanoR_1	684	692	PF00244	0.761
LIG_BIR_III_2	164	168	PF00653	0.301
LIG_BRCT_BRCA1_1	235	239	PF00533	0.303
LIG_BRCT_BRCA1_1	302	306	PF00533	0.339
LIG_Clathr_ClatBox_1	157	161	PF01394	0.316
LIG_eIF4E_1	550	556	PF01652	0.491
LIG_FHA_1	161	167	PF00498	0.378
LIG_FHA_1	169	175	PF00498	0.344
LIG_FHA_1	194	200	PF00498	0.360
LIG_FHA_1	303	309	PF00498	0.316
LIG_FHA_1	316	322	PF00498	0.384
LIG_FHA_1	341	347	PF00498	0.471
LIG_FHA_1	407	413	PF00498	0.313
LIG_FHA_1	457	463	PF00498	0.437
LIG_FHA_1	539	545	PF00498	0.334
LIG_FHA_1	550	556	PF00498	0.565
LIG_FHA_1	626	632	PF00498	0.776
LIG_FHA_1	96	102	PF00498	0.371
LIG_FHA_2	228	234	PF00498	0.410
LIG_FHA_2	362	368	PF00498	0.297
LIG_FHA_2	441	447	PF00498	0.369
LIG_FHA_2	70	76	PF00498	0.530
LIG_GBD_Chelix_1	547	555	PF00786	0.544
LIG_Integrin_isoDGR_2	609	611	PF01839	0.495
LIG_LIR_Apic_2	119	124	PF02991	0.354
LIG_LIR_Apic_2	188	192	PF02991	0.305
LIG_LIR_Gen_1	279	288	PF02991	0.383
LIG_LIR_Gen_1	290	300	PF02991	0.360
LIG_LIR_Gen_1	357	366	PF02991	0.379
LIG_LIR_Gen_1	422	430	PF02991	0.348
LIG_LIR_Gen_1	473	484	PF02991	0.346
LIG_LIR_LC3C_4	541	544	PF02991	0.355
LIG_LIR_Nem_3	193	197	PF02991	0.361
LIG_LIR_Nem_3	279	285	PF02991	0.385
LIG_LIR_Nem_3	290	296	PF02991	0.324
LIG_LIR_Nem_3	357	362	PF02991	0.307
LIG_LIR_Nem_3	422	428	PF02991	0.378
LIG_LIR_Nem_3	473	479	PF02991	0.344
LIG_LIR_Nem_3	80	86	PF02991	0.362
LIG_LYPXL_yS_3	108	111	PF13949	0.390
LIG_NRBOX	147	153	PF00104	0.256
LIG_NRBOX	200	206	PF00104	0.279
LIG_PALB2_WD40_1	528	536	PF16756	0.262
LIG_Pex14_2	529	533	PF04695	0.262
LIG_PTB_Apo_2	188	195	PF02174	0.294
LIG_SH2_CRK	282	286	PF00017	0.391
LIG_SH2_CRK	3	7	PF00017	0.569
LIG_SH2_CRK	425	429	PF00017	0.397
LIG_SH2_CRK	83	87	PF00017	0.360
LIG_SH2_NCK_1	260	264	PF00017	0.354
LIG_SH2_NCK_1	425	429	PF00017	0.383
LIG_SH2_NCK_1	439	443	PF00017	0.344
LIG_SH2_NCK_1	668	672	PF00017	0.618
LIG_SH2_SRC	159	162	PF00017	0.367
LIG_SH2_SRC	178	181	PF00017	0.378
LIG_SH2_STAP1	328	332	PF00017	0.353
LIG_SH2_STAT3	554	557	PF00017	0.623
LIG_SH2_STAT5	159	162	PF00017	0.292
LIG_SH2_STAT5	178	181	PF00017	0.337
LIG_SH2_STAT5	183	186	PF00017	0.358
LIG_SH2_STAT5	258	261	PF00017	0.306
LIG_SH2_STAT5	270	273	PF00017	0.235
LIG_SH2_STAT5	328	331	PF00017	0.367
LIG_SH2_STAT5	355	358	PF00017	0.312
LIG_SH2_STAT5	404	407	PF00017	0.349
LIG_SH2_STAT5	436	439	PF00017	0.405
LIG_SH2_STAT5	550	553	PF00017	0.556
LIG_SH2_STAT5	554	557	PF00017	0.602
LIG_SH3_2	558	563	PF14604	0.718
LIG_SH3_3	103	109	PF00018	0.494
LIG_SH3_3	121	127	PF00018	0.423
LIG_SH3_3	189	195	PF00018	0.294
LIG_SH3_3	292	298	PF00018	0.332
LIG_SH3_3	372	378	PF00018	0.354
LIG_SH3_3	462	468	PF00018	0.405
LIG_SH3_3	555	561	PF00018	0.644
LIG_SUMO_SIM_anti_2	459	466	PF11976	0.370
LIG_SUMO_SIM_anti_2	541	547	PF11976	0.324
LIG_SUMO_SIM_par_1	395	401	PF11976	0.381
LIG_SUMO_SIM_par_1	543	549	PF11976	0.316
LIG_TYR_ITIM	106	111	PF00017	0.392
LIG_TYR_ITSM	421	428	PF00017	0.375
LIG_UBA3_1	68	76	PF00899	0.450
MOD_CK1_1	193	199	PF00069	0.344
MOD_CK1_1	209	215	PF00069	0.318
MOD_CK1_1	237	243	PF00069	0.341
MOD_CK1_1	283	289	PF00069	0.327
MOD_CK1_1	323	329	PF00069	0.455
MOD_CK1_1	440	446	PF00069	0.405
MOD_CK1_1	522	528	PF00069	0.443
MOD_CK1_1	549	555	PF00069	0.528
MOD_CK1_1	602	608	PF00069	0.697
MOD_CK1_1	664	670	PF00069	0.773
MOD_CK1_1	686	692	PF00069	0.768
MOD_CK2_1	440	446	PF00069	0.336
MOD_GlcNHglycan	224	227	PF01048	0.660
MOD_GlcNHglycan	247	250	PF01048	0.605
MOD_GlcNHglycan	282	285	PF01048	0.569
MOD_GlcNHglycan	322	325	PF01048	0.695
MOD_GlcNHglycan	347	350	PF01048	0.682
MOD_GlcNHglycan	415	418	PF01048	0.629
MOD_GlcNHglycan	430	433	PF01048	0.486
MOD_GlcNHglycan	440	443	PF01048	0.608
MOD_GlcNHglycan	446	449	PF01048	0.619
MOD_GlcNHglycan	456	459	PF01048	0.465
MOD_GlcNHglycan	484	487	PF01048	0.619
MOD_GlcNHglycan	576	579	PF01048	0.558
MOD_GlcNHglycan	619	622	PF01048	0.624
MOD_GlcNHglycan	633	636	PF01048	0.520
MOD_GlcNHglycan	669	672	PF01048	0.506
MOD_GSK3_1	181	188	PF00069	0.450
MOD_GSK3_1	193	200	PF00069	0.325
MOD_GSK3_1	2	9	PF00069	0.574
MOD_GSK3_1	229	236	PF00069	0.341
MOD_GSK3_1	237	244	PF00069	0.331
MOD_GSK3_1	252	259	PF00069	0.308
MOD_GSK3_1	276	283	PF00069	0.367
MOD_GSK3_1	322	329	PF00069	0.509
MOD_GSK3_1	398	405	PF00069	0.378
MOD_GSK3_1	438	445	PF00069	0.415
MOD_GSK3_1	468	475	PF00069	0.341
MOD_GSK3_1	480	487	PF00069	0.323
MOD_GSK3_1	518	525	PF00069	0.479
MOD_GSK3_1	625	632	PF00069	0.634
MOD_GSK3_1	85	92	PF00069	0.371
MOD_GSK3_1	95	102	PF00069	0.348
MOD_N-GLC_1	280	285	PF02516	0.621
MOD_N-GLC_1	339	344	PF02516	0.609
MOD_N-GLC_1	69	74	PF02516	0.648
MOD_NEK2_1	168	173	PF00069	0.351
MOD_NEK2_1	234	239	PF00069	0.300
MOD_NEK2_1	247	252	PF00069	0.361
MOD_NEK2_1	254	259	PF00069	0.319
MOD_NEK2_1	276	281	PF00069	0.368
MOD_NEK2_1	291	296	PF00069	0.222
MOD_NEK2_1	300	305	PF00069	0.303
MOD_NEK2_1	360	365	PF00069	0.293
MOD_NEK2_1	381	386	PF00069	0.357
MOD_NEK2_1	413	418	PF00069	0.391
MOD_NEK2_1	420	425	PF00069	0.370
MOD_NEK2_1	453	458	PF00069	0.366
MOD_NEK2_1	482	487	PF00069	0.387
MOD_NEK2_1	51	56	PF00069	0.411
MOD_NEK2_1	6	11	PF00069	0.606
MOD_NEK2_1	631	636	PF00069	0.776
MOD_NEK2_1	69	74	PF00069	0.345
MOD_NEK2_1	94	99	PF00069	0.332
MOD_NEK2_2	116	121	PF00069	0.360
MOD_NEK2_2	242	247	PF00069	0.285
MOD_NEK2_2	640	645	PF00069	0.704
MOD_PIKK_1	247	253	PF00454	0.392
MOD_PIKK_1	519	525	PF00454	0.382
MOD_PIKK_1	568	574	PF00454	0.605
MOD_PIKK_1	686	692	PF00454	0.752
MOD_PIKK_1	85	91	PF00454	0.336
MOD_PKA_1	134	140	PF00069	0.339
MOD_PKA_2	134	140	PF00069	0.426
MOD_PKA_2	340	346	PF00069	0.425
MOD_PKA_2	402	408	PF00069	0.340
MOD_PKA_2	437	443	PF00069	0.261
MOD_PKA_2	617	623	PF00069	0.812
MOD_PKA_2	638	644	PF00069	0.697
MOD_PKA_2	683	689	PF00069	0.742
MOD_Plk_1	280	286	PF00069	0.415
MOD_Plk_1	315	321	PF00069	0.352
MOD_Plk_1	89	95	PF00069	0.373
MOD_Plk_4	174	180	PF00069	0.379
MOD_Plk_4	185	191	PF00069	0.365
MOD_Plk_4	234	240	PF00069	0.307
MOD_Plk_4	242	248	PF00069	0.364
MOD_Plk_4	302	308	PF00069	0.357
MOD_Plk_4	386	392	PF00069	0.389
MOD_Plk_4	420	426	PF00069	0.380
MOD_Plk_4	538	544	PF00069	0.315
MOD_Plk_4	546	552	PF00069	0.354
MOD_Plk_4	61	67	PF00069	0.527
MOD_Plk_4	89	95	PF00069	0.368
MOD_ProDKin_1	35	41	PF00069	0.550
MOD_ProDKin_1	599	605	PF00069	0.729
MOD_ProDKin_1	625	631	PF00069	0.763
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.545
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.459
TRG_ENDOCYTIC_2	108	111	PF00928	0.437
TRG_ENDOCYTIC_2	282	285	PF00928	0.384
TRG_ENDOCYTIC_2	3	6	PF00928	0.643
TRG_ENDOCYTIC_2	359	362	PF00928	0.352
TRG_ENDOCYTIC_2	425	428	PF00928	0.386
TRG_ENDOCYTIC_2	82	85	PF00928	0.359
TRG_ER_diArg_1	34	37	PF00400	0.738
TRG_ER_diArg_1	644	647	PF00400	0.794
TRG_ER_diArg_1	648	651	PF00400	0.781
TRG_ER_diArg_1	652	655	PF00400	0.786
TRG_NES_CRM1_1	146	161	PF08389	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZA5	Leptomonas seymouri	43%	100%
A0A0S4JQ75	Bodo saltans	28%	100%
A0A1X0NMU7	Trypanosomatidae	29%	100%
A0A3S7WRU5	Leishmania donovani	89%	100%
A0A422NUF1	Trypanosoma rangeli	30%	100%
A4H6T9	Leishmania braziliensis	62%	100%
E9AGB3	Leishmania infantum	88%	100%
E9ANV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BD98	Trypanosoma cruzi	29%	100%