SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGR6_LEIMA

TriTrypDb:

LmjF.12.0270 , LMJLV39_120008100 , LMJSD75_120005700

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QGR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGR6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.724
CLV_C14_Caspase3-7	326	330	PF00656	0.715
CLV_NRD_NRD_1	113	115	PF00675	0.507
CLV_NRD_NRD_1	18	20	PF00675	0.632
CLV_NRD_NRD_1	221	223	PF00675	0.547
CLV_NRD_NRD_1	301	303	PF00675	0.625
CLV_NRD_NRD_1	543	545	PF00675	0.438
CLV_PCSK_FUR_1	19	23	PF00082	0.624
CLV_PCSK_FUR_1	299	303	PF00082	0.576
CLV_PCSK_KEX2_1	112	114	PF00082	0.566
CLV_PCSK_KEX2_1	18	20	PF00082	0.633
CLV_PCSK_KEX2_1	21	23	PF00082	0.624
CLV_PCSK_KEX2_1	221	223	PF00082	0.547
CLV_PCSK_KEX2_1	301	303	PF00082	0.625
CLV_PCSK_KEX2_1	543	545	PF00082	0.440
CLV_PCSK_KEX2_1	547	549	PF00082	0.454
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.623
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.473
CLV_PCSK_PC7_1	543	549	PF00082	0.466
CLV_PCSK_SKI1_1	202	206	PF00082	0.405
CLV_PCSK_SKI1_1	222	226	PF00082	0.209
CLV_PCSK_SKI1_1	455	459	PF00082	0.518
CLV_PCSK_SKI1_1	543	547	PF00082	0.447
CLV_PCSK_SKI1_1	548	552	PF00082	0.437
CLV_PCSK_SKI1_1	555	559	PF00082	0.406
CLV_PCSK_SKI1_1	72	76	PF00082	0.560
DEG_SPOP_SBC_1	332	336	PF00917	0.621
DOC_CKS1_1	81	86	PF01111	0.434
DOC_CYCLIN_RxL_1	469	481	PF00134	0.446
DOC_CYCLIN_RxL_1	543	552	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	458	464	PF00134	0.481
DOC_MAPK_gen_1	112	121	PF00069	0.508
DOC_MAPK_gen_1	418	427	PF00069	0.370
DOC_MAPK_HePTP_8	109	121	PF00069	0.526
DOC_MAPK_MEF2A_6	112	121	PF00069	0.547
DOC_MAPK_MEF2A_6	418	427	PF00069	0.370
DOC_MAPK_MEF2A_6	72	80	PF00069	0.584
DOC_PP2B_LxvP_1	160	163	PF13499	0.580
DOC_PP2B_LxvP_1	225	228	PF13499	0.506
DOC_USP7_MATH_1	125	129	PF00917	0.761
DOC_USP7_MATH_1	148	152	PF00917	0.702
DOC_USP7_MATH_1	172	176	PF00917	0.767
DOC_USP7_MATH_1	198	202	PF00917	0.451
DOC_USP7_MATH_1	332	336	PF00917	0.708
DOC_USP7_MATH_1	343	347	PF00917	0.515
DOC_USP7_MATH_1	390	394	PF00917	0.596
DOC_USP7_MATH_1	396	400	PF00917	0.553
DOC_USP7_MATH_1	421	425	PF00917	0.527
DOC_USP7_MATH_1	489	493	PF00917	0.548
DOC_USP7_MATH_1	503	507	PF00917	0.452
DOC_WW_Pin1_4	164	169	PF00397	0.779
DOC_WW_Pin1_4	194	199	PF00397	0.430
DOC_WW_Pin1_4	44	49	PF00397	0.805
DOC_WW_Pin1_4	80	85	PF00397	0.431
LIG_14-3-3_CanoR_1	22	26	PF00244	0.737
LIG_14-3-3_CanoR_1	221	225	PF00244	0.527
LIG_14-3-3_CanoR_1	455	461	PF00244	0.515
LIG_14-3-3_CanoR_1	512	517	PF00244	0.629
LIG_14-3-3_CanoR_1	548	558	PF00244	0.460
LIG_14-3-3_CanoR_1	61	66	PF00244	0.615
LIG_14-3-3_CanoR_1	72	77	PF00244	0.445
LIG_Actin_WH2_2	29	47	PF00022	0.547
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_BRCT_BRCA1_1	174	178	PF00533	0.739
LIG_BRCT_BRCA1_1	279	283	PF00533	0.397
LIG_EH1_1	468	476	PF00400	0.491
LIG_FHA_1	212	218	PF00498	0.425
LIG_FHA_1	249	255	PF00498	0.438
LIG_FHA_1	36	42	PF00498	0.670
LIG_FHA_1	366	372	PF00498	0.384
LIG_FHA_1	73	79	PF00498	0.464
LIG_FHA_1	81	87	PF00498	0.403
LIG_FHA_1	88	94	PF00498	0.347
LIG_FHA_2	280	286	PF00498	0.548
LIG_LIR_Apic_2	244	250	PF02991	0.482
LIG_LIR_Nem_3	354	359	PF02991	0.460
LIG_LIR_Nem_3	552	557	PF02991	0.503
LIG_MYND_1	164	168	PF01753	0.587
LIG_NRBOX	73	79	PF00104	0.544
LIG_REV1ctd_RIR_1	363	373	PF16727	0.400
LIG_SH2_CRK	247	251	PF00017	0.551
LIG_SH2_CRK	500	504	PF00017	0.525
LIG_SH2_CRK	554	558	PF00017	0.559
LIG_SH2_NCK_1	247	251	PF00017	0.451
LIG_SH2_NCK_1	25	29	PF00017	0.693
LIG_SH2_SRC	25	28	PF00017	0.644
LIG_SH2_SRC	498	501	PF00017	0.497
LIG_SH2_STAP1	381	385	PF00017	0.413
LIG_SH2_STAP1	99	103	PF00017	0.522
LIG_SH2_STAT3	556	559	PF00017	0.332
LIG_SH2_STAT5	102	105	PF00017	0.322
LIG_SH2_STAT5	193	196	PF00017	0.452
LIG_SH2_STAT5	247	250	PF00017	0.459
LIG_SH2_STAT5	358	361	PF00017	0.387
LIG_SH2_STAT5	415	418	PF00017	0.447
LIG_SH2_STAT5	498	501	PF00017	0.454
LIG_SH2_STAT5	556	559	PF00017	0.524
LIG_SH2_STAT5	85	88	PF00017	0.500
LIG_SH3_2	450	455	PF14604	0.532
LIG_SH3_3	413	419	PF00018	0.559
LIG_SH3_3	447	453	PF00018	0.678
LIG_SUMO_SIM_anti_2	480	487	PF11976	0.434
LIG_SUMO_SIM_par_1	117	124	PF11976	0.567
LIG_SUMO_SIM_par_1	253	259	PF11976	0.449
LIG_SUMO_SIM_par_1	480	487	PF11976	0.397
LIG_SUMO_SIM_par_1	535	541	PF11976	0.393
LIG_TRAF2_1	373	376	PF00917	0.483
LIG_WW_3	162	166	PF00397	0.588
MOD_CDK_SPK_2	44	49	PF00069	0.558
MOD_CK1_1	17	23	PF00069	0.613
MOD_CK1_1	2	8	PF00069	0.753
MOD_CK1_1	220	226	PF00069	0.478
MOD_CK1_1	277	283	PF00069	0.447
MOD_CK1_1	300	306	PF00069	0.701
MOD_CK1_1	311	317	PF00069	0.673
MOD_CK1_1	328	334	PF00069	0.698
MOD_CK1_1	335	341	PF00069	0.680
MOD_CK1_1	52	58	PF00069	0.668
MOD_CK1_1	64	70	PF00069	0.603
MOD_CK1_1	9	15	PF00069	0.696
MOD_CK2_1	124	130	PF00069	0.743
MOD_CK2_1	279	285	PF00069	0.541
MOD_GlcNHglycan	114	117	PF01048	0.469
MOD_GlcNHglycan	14	17	PF01048	0.761
MOD_GlcNHglycan	150	153	PF01048	0.714
MOD_GlcNHglycan	154	157	PF01048	0.683
MOD_GlcNHglycan	158	163	PF01048	0.675
MOD_GlcNHglycan	276	279	PF01048	0.433
MOD_GlcNHglycan	302	305	PF01048	0.617
MOD_GlcNHglycan	345	348	PF01048	0.553
MOD_GlcNHglycan	392	395	PF01048	0.578
MOD_GlcNHglycan	443	446	PF01048	0.621
MOD_GlcNHglycan	491	494	PF01048	0.544
MOD_GlcNHglycan	525	528	PF01048	0.768
MOD_GlcNHglycan	8	11	PF01048	0.802
MOD_GSK3_1	1	8	PF00069	0.692
MOD_GSK3_1	108	115	PF00069	0.417
MOD_GSK3_1	120	127	PF00069	0.595
MOD_GSK3_1	148	155	PF00069	0.707
MOD_GSK3_1	17	24	PF00069	0.648
MOD_GSK3_1	172	179	PF00069	0.719
MOD_GSK3_1	194	201	PF00069	0.438
MOD_GSK3_1	241	248	PF00069	0.501
MOD_GSK3_1	328	335	PF00069	0.718
MOD_GSK3_1	361	368	PF00069	0.377
MOD_GSK3_1	375	382	PF00069	0.404
MOD_GSK3_1	484	491	PF00069	0.399
MOD_GSK3_1	508	515	PF00069	0.655
MOD_N-GLC_1	267	272	PF02516	0.408
MOD_N-GLC_2	274	276	PF02516	0.378
MOD_NEK2_1	1	6	PF00069	0.801
MOD_NEK2_1	267	272	PF00069	0.508
MOD_NEK2_1	279	284	PF00069	0.500
MOD_NEK2_1	379	384	PF00069	0.415
MOD_NEK2_1	533	538	PF00069	0.499
MOD_NEK2_2	421	426	PF00069	0.370
MOD_NEK2_2	87	92	PF00069	0.575
MOD_PIKK_1	140	146	PF00454	0.690
MOD_PIKK_1	245	251	PF00454	0.517
MOD_PIKK_1	256	262	PF00454	0.377
MOD_PIKK_1	308	314	PF00454	0.525
MOD_PIKK_1	438	444	PF00454	0.750
MOD_PIKK_1	549	555	PF00454	0.333
MOD_PK_1	49	55	PF00069	0.658
MOD_PKA_1	112	118	PF00069	0.371
MOD_PKA_1	21	27	PF00069	0.711
MOD_PKA_1	543	549	PF00069	0.540
MOD_PKA_2	112	118	PF00069	0.368
MOD_PKA_2	148	154	PF00069	0.712
MOD_PKA_2	17	23	PF00069	0.604
MOD_PKA_2	211	217	PF00069	0.437
MOD_PKA_2	220	226	PF00069	0.414
MOD_PKA_2	300	306	PF00069	0.669
MOD_PKA_2	351	357	PF00069	0.531
MOD_PKA_2	438	444	PF00069	0.580
MOD_PKA_2	5	11	PF00069	0.695
MOD_PKA_2	508	514	PF00069	0.706
MOD_PKA_2	543	549	PF00069	0.447
MOD_Plk_1	314	320	PF00069	0.559
MOD_Plk_1	375	381	PF00069	0.403
MOD_Plk_1	421	427	PF00069	0.480
MOD_Plk_2-3	375	381	PF00069	0.502
MOD_Plk_4	103	109	PF00069	0.447
MOD_Plk_4	172	178	PF00069	0.734
MOD_Plk_4	229	235	PF00069	0.559
MOD_Plk_4	27	33	PF00069	0.517
MOD_Plk_4	279	285	PF00069	0.546
MOD_Plk_4	361	367	PF00069	0.364
MOD_Plk_4	421	427	PF00069	0.510
MOD_Plk_4	533	539	PF00069	0.443
MOD_Plk_4	72	78	PF00069	0.542
MOD_ProDKin_1	164	170	PF00069	0.778
MOD_ProDKin_1	194	200	PF00069	0.435
MOD_ProDKin_1	44	50	PF00069	0.803
MOD_ProDKin_1	80	86	PF00069	0.431
MOD_SUMO_for_1	419	422	PF00179	0.500
TRG_DiLeu_BaEn_2	421	427	PF01217	0.561
TRG_ENDOCYTIC_2	554	557	PF00928	0.412
TRG_ER_diArg_1	112	114	PF00400	0.573
TRG_ER_diArg_1	299	302	PF00400	0.662
TRG_ER_diArg_1	542	544	PF00400	0.511
TRG_ER_diArg_1	65	68	PF00400	0.602
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	548	553	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7U7	Leptomonas seymouri	47%	99%
A0A1X0NNV4	Trypanosomatidae	38%	100%
A0A3Q8I958	Leishmania donovani	87%	100%
A4H6U2	Leishmania braziliensis	71%	99%
A4HV71	Leishmania infantum	88%	83%
C9ZQA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ANV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
V5BD95	Trypanosoma cruzi	32%	100%