Putative ornithine decarboxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ornithine decarboxylase, putative

Species:

Leishmania major

UniProt:

Q4QGR5_LEIMA

TriTrypDb:

LmjF.12.0280 , LMJLV39_120008200 , LMJSD75_120005800

Length:

707

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGR5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006520	amino acid metabolic process	3	2
GO:0006576	biogenic amine metabolic process	5	8
GO:0006591	ornithine metabolic process	5	2
GO:0006595	polyamine metabolic process	6	8
GO:0006596	polyamine biosynthetic process	7	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	8
GO:0009308	amine metabolic process	4	8
GO:0009309	amine biosynthetic process	5	8
GO:0009445	putrescine metabolic process	7	2
GO:0009446	putrescine biosynthetic process	8	2
GO:0009987	cellular process	1	8
GO:0019752	carboxylic acid metabolic process	5	2
GO:0033387	putrescine biosynthetic process from ornithine	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0042401	biogenic amine biosynthetic process	6	8
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	8
GO:0044271	cellular nitrogen compound biosynthetic process	4	8
GO:0044281	small molecule metabolic process	2	2
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901566	organonitrogen compound biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8
GO:1901605	alpha-amino acid metabolic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004586	ornithine decarboxylase activity	5	6
GO:0016829	lyase activity	2	8
GO:0016830	carbon-carbon lyase activity	3	8
GO:0016831	carboxy-lyase activity	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	396	400	PF00656	0.429
CLV_C14_Caspase3-7	575	579	PF00656	0.564
CLV_C14_Caspase3-7	88	92	PF00656	0.713
CLV_NRD_NRD_1	162	164	PF00675	0.480
CLV_NRD_NRD_1	191	193	PF00675	0.613
CLV_NRD_NRD_1	217	219	PF00675	0.461
CLV_NRD_NRD_1	616	618	PF00675	0.319
CLV_NRD_NRD_1	621	623	PF00675	0.327
CLV_NRD_NRD_1	678	680	PF00675	0.447
CLV_NRD_NRD_1	69	71	PF00675	0.638
CLV_NRD_NRD_1	95	97	PF00675	0.638
CLV_PCSK_KEX2_1	162	164	PF00082	0.480
CLV_PCSK_KEX2_1	191	193	PF00082	0.637
CLV_PCSK_KEX2_1	217	219	PF00082	0.454
CLV_PCSK_KEX2_1	615	617	PF00082	0.323
CLV_PCSK_KEX2_1	621	623	PF00082	0.338
CLV_PCSK_KEX2_1	677	679	PF00082	0.408
CLV_PCSK_KEX2_1	69	71	PF00082	0.679
CLV_PCSK_PC7_1	617	623	PF00082	0.306
CLV_PCSK_SKI1_1	226	230	PF00082	0.464
CLV_PCSK_SKI1_1	481	485	PF00082	0.335
CLV_PCSK_SKI1_1	501	505	PF00082	0.323
CLV_PCSK_SKI1_1	529	533	PF00082	0.318
CLV_PCSK_SKI1_1	69	73	PF00082	0.621
DEG_APCC_DBOX_1	274	282	PF00400	0.533
DEG_APCC_DBOX_1	480	488	PF00400	0.523
DEG_SPOP_SBC_1	237	241	PF00917	0.511
DOC_CYCLIN_RxL_1	515	526	PF00134	0.486
DOC_CYCLIN_RxL_1	63	73	PF00134	0.649
DOC_MAPK_gen_1	217	224	PF00069	0.438
DOC_MAPK_gen_1	403	412	PF00069	0.449
DOC_MAPK_gen_1	518	527	PF00069	0.468
DOC_MAPK_MEF2A_6	403	412	PF00069	0.484
DOC_PP2B_LxvP_1	655	658	PF13499	0.464
DOC_PP4_FxxP_1	331	334	PF00568	0.523
DOC_PP4_FxxP_1	391	394	PF00568	0.564
DOC_PP4_MxPP_1	48	51	PF00568	0.766
DOC_USP7_MATH_1	114	118	PF00917	0.675
DOC_USP7_MATH_1	286	290	PF00917	0.571
DOC_USP7_MATH_1	52	56	PF00917	0.677
DOC_USP7_MATH_1	531	535	PF00917	0.567
DOC_USP7_MATH_1	588	592	PF00917	0.499
DOC_WW_Pin1_4	146	151	PF00397	0.658
DOC_WW_Pin1_4	179	184	PF00397	0.580
DOC_WW_Pin1_4	322	327	PF00397	0.526
DOC_WW_Pin1_4	99	104	PF00397	0.775
LIG_14-3-3_CanoR_1	195	204	PF00244	0.624
LIG_14-3-3_CanoR_1	38	46	PF00244	0.593
LIG_14-3-3_CanoR_1	501	510	PF00244	0.497
LIG_14-3-3_CanoR_1	521	527	PF00244	0.514
LIG_14-3-3_CanoR_1	615	620	PF00244	0.509
LIG_14-3-3_CanoR_1	625	632	PF00244	0.454
LIG_14-3-3_CterR_2	703	707	PF00244	0.603
LIG_Actin_WH2_2	507	523	PF00022	0.442
LIG_AP2alpha_2	257	259	PF02296	0.437
LIG_BRCT_BRCA1_1	387	391	PF00533	0.480
LIG_Clathr_ClatBox_1	134	138	PF01394	0.524
LIG_FHA_1	126	132	PF00498	0.451
LIG_FHA_1	460	466	PF00498	0.518
LIG_FHA_1	517	523	PF00498	0.578
LIG_FHA_1	565	571	PF00498	0.527
LIG_FHA_2	156	162	PF00498	0.611
LIG_FHA_2	25	31	PF00498	0.738
LIG_FHA_2	449	455	PF00498	0.523
LIG_FHA_2	469	475	PF00498	0.551
LIG_LIR_Apic_2	328	334	PF02991	0.480
LIG_LIR_Apic_2	388	394	PF02991	0.564
LIG_LIR_Gen_1	350	358	PF02991	0.485
LIG_LIR_Gen_1	435	444	PF02991	0.564
LIG_LIR_Gen_1	471	480	PF02991	0.482
LIG_LIR_Gen_1	550	561	PF02991	0.480
LIG_LIR_Gen_1	653	660	PF02991	0.480
LIG_LIR_Nem_3	149	154	PF02991	0.553
LIG_LIR_Nem_3	168	173	PF02991	0.474
LIG_LIR_Nem_3	21	25	PF02991	0.565
LIG_LIR_Nem_3	213	219	PF02991	0.458
LIG_LIR_Nem_3	256	262	PF02991	0.392
LIG_LIR_Nem_3	350	354	PF02991	0.485
LIG_LIR_Nem_3	435	440	PF02991	0.523
LIG_LIR_Nem_3	471	476	PF02991	0.482
LIG_LIR_Nem_3	542	547	PF02991	0.496
LIG_LIR_Nem_3	550	556	PF02991	0.461
LIG_LIR_Nem_3	653	657	PF02991	0.480
LIG_PCNA_yPIPBox_3	288	299	PF02747	0.515
LIG_Pex14_2	387	391	PF04695	0.480
LIG_Pex14_2	609	613	PF04695	0.506
LIG_Pex14_2	670	674	PF04695	0.462
LIG_SH2_CRK	173	177	PF00017	0.504
LIG_SH2_GRB2like	547	550	PF00017	0.480
LIG_SH2_NCK_1	14	18	PF00017	0.608
LIG_SH2_NCK_1	173	177	PF00017	0.567
LIG_SH2_NCK_1	663	667	PF00017	0.389
LIG_SH2_PTP2	351	354	PF00017	0.523
LIG_SH2_SRC	561	564	PF00017	0.428
LIG_SH2_STAP1	663	667	PF00017	0.389
LIG_SH2_STAT5	223	226	PF00017	0.471
LIG_SH2_STAT5	260	263	PF00017	0.447
LIG_SH2_STAT5	284	287	PF00017	0.564
LIG_SH2_STAT5	351	354	PF00017	0.480
LIG_SH2_STAT5	429	432	PF00017	0.486
LIG_SH2_STAT5	502	505	PF00017	0.523
LIG_SH2_STAT5	547	550	PF00017	0.480
LIG_SH2_STAT5	663	666	PF00017	0.381
LIG_SH2_STAT5	695	698	PF00017	0.609
LIG_SH3_3	177	183	PF00018	0.556
LIG_SH3_3	20	26	PF00018	0.642
LIG_SH3_3	245	251	PF00018	0.628
LIG_SH3_3	252	258	PF00018	0.469
LIG_SH3_3	320	326	PF00018	0.564
LIG_SH3_3	351	357	PF00018	0.518
LIG_SH3_3	601	607	PF00018	0.432
LIG_SUMO_SIM_anti_2	492	498	PF11976	0.523
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.523
LIG_SUMO_SIM_par_1	294	300	PF11976	0.496
LIG_SUMO_SIM_par_1	567	573	PF11976	0.523
LIG_TRAF2_1	158	161	PF00917	0.566
LIG_TRAF2_1	310	313	PF00917	0.518
LIG_TRAF2_1	59	62	PF00917	0.713
LIG_TRAF2_1	591	594	PF00917	0.496
LIG_TYR_ITIM	349	354	PF00017	0.523
LIG_UBA3_1	373	377	PF00899	0.454
LIG_WRC_WIRS_1	553	558	PF05994	0.480
MOD_CK1_1	468	474	PF00069	0.561
MOD_CK1_1	534	540	PF00069	0.518
MOD_CK1_1	662	668	PF00069	0.392
MOD_CK2_1	155	161	PF00069	0.623
MOD_CK2_1	204	210	PF00069	0.598
MOD_CK2_1	29	35	PF00069	0.635
MOD_CK2_1	307	313	PF00069	0.480
MOD_CK2_1	38	44	PF00069	0.612
MOD_CK2_1	468	474	PF00069	0.495
MOD_CK2_1	520	526	PF00069	0.460
MOD_CK2_1	534	540	PF00069	0.447
MOD_CK2_1	588	594	PF00069	0.465
MOD_Cter_Amidation	94	97	PF01082	0.609
MOD_GlcNHglycan	198	201	PF01048	0.642
MOD_GlcNHglycan	299	302	PF01048	0.367
MOD_GlcNHglycan	368	371	PF01048	0.302
MOD_GlcNHglycan	420	423	PF01048	0.286
MOD_GlcNHglycan	424	429	PF01048	0.292
MOD_GlcNHglycan	430	433	PF01048	0.305
MOD_GlcNHglycan	467	470	PF01048	0.321
MOD_GlcNHglycan	52	55	PF01048	0.763
MOD_GlcNHglycan	581	584	PF01048	0.332
MOD_GlcNHglycan	599	602	PF01048	0.361
MOD_GlcNHglycan	610	613	PF01048	0.280
MOD_GlcNHglycan	91	94	PF01048	0.718
MOD_GSK3_1	204	211	PF00069	0.587
MOD_GSK3_1	236	243	PF00069	0.504
MOD_GSK3_1	29	36	PF00069	0.703
MOD_GSK3_1	424	431	PF00069	0.520
MOD_GSK3_1	465	472	PF00069	0.530
MOD_GSK3_1	516	523	PF00069	0.473
MOD_GSK3_1	85	92	PF00069	0.693
MOD_N-GLC_1	204	209	PF02516	0.597
MOD_N-GLC_1	378	383	PF02516	0.323
MOD_N-GLC_1	469	474	PF02516	0.318
MOD_N-GLC_2	686	688	PF02516	0.446
MOD_NEK2_1	137	142	PF00069	0.524
MOD_NEK2_1	448	453	PF00069	0.523
MOD_NEK2_1	552	557	PF00069	0.493
MOD_NEK2_1	597	602	PF00069	0.529
MOD_NEK2_1	608	613	PF00069	0.496
MOD_NEK2_1	624	629	PF00069	0.558
MOD_NEK2_2	33	38	PF00069	0.681
MOD_NEK2_2	413	418	PF00069	0.510
MOD_NEK2_2	516	521	PF00069	0.452
MOD_PIKK_1	125	131	PF00454	0.601
MOD_PIKK_1	137	143	PF00454	0.557
MOD_PKA_1	191	197	PF00069	0.605
MOD_PKA_1	217	223	PF00069	0.457
MOD_PKA_1	615	621	PF00069	0.518
MOD_PKA_2	191	197	PF00069	0.636
MOD_PKA_2	217	223	PF00069	0.463
MOD_PKA_2	520	526	PF00069	0.513
MOD_PKA_2	615	621	PF00069	0.550
MOD_PKA_2	624	630	PF00069	0.497
MOD_Plk_1	204	210	PF00069	0.598
MOD_Plk_1	424	430	PF00069	0.465
MOD_Plk_1	469	475	PF00069	0.531
MOD_Plk_1	491	497	PF00069	0.523
MOD_Plk_4	204	210	PF00069	0.480
MOD_Plk_4	347	353	PF00069	0.523
MOD_Plk_4	448	454	PF00069	0.523
MOD_Plk_4	491	497	PF00069	0.523
MOD_Plk_4	531	537	PF00069	0.564
MOD_Plk_4	564	570	PF00069	0.496
MOD_Plk_4	625	631	PF00069	0.480
MOD_ProDKin_1	146	152	PF00069	0.661
MOD_ProDKin_1	179	185	PF00069	0.583
MOD_ProDKin_1	322	328	PF00069	0.526
MOD_ProDKin_1	99	105	PF00069	0.775
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.670
TRG_ENDOCYTIC_2	173	176	PF00928	0.538
TRG_ENDOCYTIC_2	19	22	PF00928	0.663
TRG_ENDOCYTIC_2	284	287	PF00928	0.564
TRG_ENDOCYTIC_2	351	354	PF00928	0.480
TRG_ENDOCYTIC_2	437	440	PF00928	0.523
TRG_ENDOCYTIC_2	553	556	PF00928	0.480
TRG_ER_diArg_1	216	218	PF00400	0.451
TRG_ER_diArg_1	45	48	PF00400	0.709
TRG_ER_diArg_1	615	617	PF00400	0.520
TRG_ER_diArg_1	621	623	PF00400	0.526
TRG_ER_diArg_1	677	679	PF00400	0.467
TRG_ER_diArg_1	69	71	PF00400	0.683
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I681	Leptomonas seymouri	62%	98%
A0A0S4JJ84	Bodo saltans	43%	100%
A0A3S5H6K6	Leishmania donovani	91%	100%
A4H6U3	Leishmania braziliensis	70%	100%
E9AGB5	Leishmania infantum	92%	100%
E9ANV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
P27116	Leishmania donovani	92%	100%