AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGR2_LEIMA

TriTrypDb:

LmjF.12.0310 , LMJLV39_120008500 , LMJSD75_120008300

Length:

644

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QGR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGR2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	611	615	PF00656	0.681
CLV_NRD_NRD_1	306	308	PF00675	0.576
CLV_NRD_NRD_1	48	50	PF00675	0.503
CLV_PCSK_KEX2_1	241	243	PF00082	0.446
CLV_PCSK_KEX2_1	273	275	PF00082	0.469
CLV_PCSK_KEX2_1	297	299	PF00082	0.588
CLV_PCSK_KEX2_1	305	307	PF00082	0.549
CLV_PCSK_KEX2_1	48	50	PF00082	0.503
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.446
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.469
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.555
CLV_PCSK_SKI1_1	176	180	PF00082	0.461
CLV_PCSK_SKI1_1	25	29	PF00082	0.422
CLV_PCSK_SKI1_1	270	274	PF00082	0.506
CLV_PCSK_SKI1_1	281	285	PF00082	0.458
DEG_APCC_DBOX_1	455	463	PF00400	0.641
DEG_COP1_1	471	480	PF00400	0.613
DEG_Nend_UBRbox_4	1	3	PF02207	0.424
DEG_SCF_FBW7_1	157	164	PF00400	0.673
DOC_CDC14_PxL_1	240	248	PF14671	0.721
DOC_CKS1_1	158	163	PF01111	0.763
DOC_CKS1_1	26	31	PF01111	0.703
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.697
DOC_CYCLIN_yCln2_LP_2	335	341	PF00134	0.638
DOC_MAPK_DCC_7	344	353	PF00069	0.661
DOC_MAPK_HePTP_8	341	353	PF00069	0.678
DOC_MAPK_MEF2A_6	344	353	PF00069	0.683
DOC_PP2B_LxvP_1	121	124	PF13499	0.559
DOC_PP2B_LxvP_1	13	16	PF13499	0.350
DOC_PP2B_LxvP_1	141	144	PF13499	0.527
DOC_PP2B_LxvP_1	335	338	PF13499	0.642
DOC_PP2B_LxvP_1	346	349	PF13499	0.647
DOC_PP4_FxxP_1	113	116	PF00568	0.633
DOC_USP7_MATH_1	104	108	PF00917	0.606
DOC_USP7_MATH_1	161	165	PF00917	0.678
DOC_USP7_MATH_1	211	215	PF00917	0.793
DOC_USP7_MATH_1	318	322	PF00917	0.634
DOC_USP7_MATH_1	349	353	PF00917	0.733
DOC_USP7_MATH_1	37	41	PF00917	0.644
DOC_USP7_MATH_1	370	374	PF00917	0.706
DOC_USP7_MATH_1	454	458	PF00917	0.631
DOC_USP7_MATH_1	484	488	PF00917	0.666
DOC_USP7_MATH_1	5	9	PF00917	0.471
DOC_USP7_MATH_1	500	504	PF00917	0.644
DOC_USP7_MATH_1	507	511	PF00917	0.603
DOC_USP7_MATH_1	87	91	PF00917	0.687
DOC_USP7_UBL2_3	414	418	PF12436	0.633
DOC_USP7_UBL2_3	595	599	PF12436	0.683
DOC_WW_Pin1_4	157	162	PF00397	0.727
DOC_WW_Pin1_4	207	212	PF00397	0.730
DOC_WW_Pin1_4	25	30	PF00397	0.623
DOC_WW_Pin1_4	312	317	PF00397	0.802
DOC_WW_Pin1_4	344	349	PF00397	0.654
DOC_WW_Pin1_4	61	66	PF00397	0.640
LIG_14-3-3_CanoR_1	377	383	PF00244	0.706
LIG_14-3-3_CanoR_1	456	464	PF00244	0.644
LIG_14-3-3_CanoR_1	542	552	PF00244	0.337
LIG_Actin_WH2_2	226	243	PF00022	0.675
LIG_Actin_WH2_2	69	87	PF00022	0.547
LIG_BRCT_BRCA1_1	109	113	PF00533	0.639
LIG_BRCT_BRCA1_1	326	330	PF00533	0.602
LIG_BRCT_BRCA1_1	518	522	PF00533	0.489
LIG_CtBP_PxDLS_1	124	128	PF00389	0.607
LIG_EH1_1	551	559	PF00400	0.332
LIG_eIF4E_1	552	558	PF01652	0.332
LIG_FHA_1	227	233	PF00498	0.655
LIG_FHA_1	249	255	PF00498	0.711
LIG_FHA_1	26	32	PF00498	0.619
LIG_FHA_1	282	288	PF00498	0.698
LIG_FHA_1	321	327	PF00498	0.614
LIG_FHA_1	459	465	PF00498	0.661
LIG_FHA_1	557	563	PF00498	0.457
LIG_FHA_2	392	398	PF00498	0.739
LIG_FHA_2	458	464	PF00498	0.680
LIG_FHA_2	632	638	PF00498	0.715
LIG_LIR_Apic_2	110	116	PF02991	0.633
LIG_LIR_Gen_1	10	20	PF02991	0.350
LIG_LIR_Gen_1	261	268	PF02991	0.618
LIG_LIR_Gen_1	332	341	PF02991	0.649
LIG_LIR_Gen_1	510	518	PF02991	0.580
LIG_LIR_Gen_1	545	555	PF02991	0.289
LIG_LIR_Nem_3	10	15	PF02991	0.350
LIG_LIR_Nem_3	261	266	PF02991	0.681
LIG_LIR_Nem_3	327	333	PF02991	0.659
LIG_LIR_Nem_3	381	385	PF02991	0.736
LIG_LIR_Nem_3	417	423	PF02991	0.728
LIG_LIR_Nem_3	466	470	PF02991	0.671
LIG_LIR_Nem_3	510	514	PF02991	0.586
LIG_LIR_Nem_3	545	551	PF02991	0.343
LIG_NRBOX	30	36	PF00104	0.703
LIG_Pex14_1	263	267	PF04695	0.627
LIG_Pex14_1	548	552	PF04695	0.289
LIG_SH2_CRK	333	337	PF00017	0.652
LIG_SH2_CRK	421	425	PF00017	0.625
LIG_SH2_CRK	552	556	PF00017	0.332
LIG_SH2_NCK_1	552	556	PF00017	0.332
LIG_SH2_PTP2	23	26	PF00017	0.642
LIG_SH2_STAP1	333	337	PF00017	0.652
LIG_SH2_STAP1	511	515	PF00017	0.584
LIG_SH2_STAT5	137	140	PF00017	0.612
LIG_SH2_STAT5	23	26	PF00017	0.532
LIG_SH2_STAT5	267	270	PF00017	0.639
LIG_SH2_STAT5	480	483	PF00017	0.761
LIG_SH2_STAT5	537	540	PF00017	0.402
LIG_SH2_STAT5	75	78	PF00017	0.685
LIG_SH3_3	113	119	PF00018	0.734
LIG_SH3_3	210	216	PF00018	0.747
LIG_SH3_3	342	348	PF00018	0.726
LIG_SH3_3	466	472	PF00018	0.664
LIG_SUMO_SIM_anti_2	251	256	PF11976	0.620
LIG_SUMO_SIM_par_1	258	264	PF11976	0.568
LIG_SUMO_SIM_par_1	460	466	PF11976	0.713
LIG_TRAF2_1	167	170	PF00917	0.777
LIG_TRAF2_1	362	365	PF00917	0.719
LIG_TRAF2_1	450	453	PF00917	0.656
LIG_TYR_ITSM	548	555	PF00017	0.289
MOD_CK1_1	107	113	PF00069	0.702
MOD_CK1_1	261	267	PF00069	0.702
MOD_CK1_1	372	378	PF00069	0.721
MOD_CK1_1	441	447	PF00069	0.701
MOD_CK1_1	457	463	PF00069	0.631
MOD_CK1_1	501	507	PF00069	0.696
MOD_CK1_1	7	13	PF00069	0.378
MOD_CK2_1	318	324	PF00069	0.682
MOD_CK2_1	37	43	PF00069	0.713
MOD_CK2_1	457	463	PF00069	0.592
MOD_CK2_1	63	69	PF00069	0.677
MOD_DYRK1A_RPxSP_1	344	348	PF00069	0.706
MOD_GlcNHglycan	372	375	PF01048	0.573
MOD_GlcNHglycan	39	42	PF01048	0.422
MOD_GlcNHglycan	424	427	PF01048	0.519
MOD_GlcNHglycan	440	443	PF01048	0.486
MOD_GlcNHglycan	444	447	PF01048	0.459
MOD_GlcNHglycan	488	491	PF01048	0.495
MOD_GlcNHglycan	500	503	PF01048	0.489
MOD_GlcNHglycan	611	614	PF01048	0.513
MOD_GlcNHglycan	619	622	PF01048	0.435
MOD_GSK3_1	104	111	PF00069	0.782
MOD_GSK3_1	157	164	PF00069	0.748
MOD_GSK3_1	207	214	PF00069	0.715
MOD_GSK3_1	281	288	PF00069	0.667
MOD_GSK3_1	320	327	PF00069	0.614
MOD_GSK3_1	438	445	PF00069	0.708
MOD_GSK3_1	454	461	PF00069	0.611
MOD_GSK3_1	494	501	PF00069	0.729
MOD_GSK3_1	503	510	PF00069	0.605
MOD_GSK3_1	543	550	PF00069	0.351
MOD_GSK3_1	59	66	PF00069	0.662
MOD_GSK3_1	633	640	PF00069	0.676
MOD_NEK2_1	108	113	PF00069	0.651
MOD_NEK2_1	283	288	PF00069	0.725
MOD_NEK2_1	527	532	PF00069	0.332
MOD_NEK2_1	59	64	PF00069	0.649
MOD_NEK2_1	600	605	PF00069	0.688
MOD_PIKK_1	161	167	PF00454	0.774
MOD_PIKK_1	211	217	PF00454	0.764
MOD_PIKK_1	59	65	PF00454	0.649
MOD_PIKK_1	75	81	PF00454	0.578
MOD_PIKK_1	87	93	PF00454	0.682
MOD_PK_1	516	522	PF00069	0.489
MOD_PKA_2	401	407	PF00069	0.642
MOD_PKA_2	455	461	PF00069	0.638
MOD_PKB_1	474	482	PF00069	0.688
MOD_Plk_1	104	110	PF00069	0.637
MOD_Plk_1	139	145	PF00069	0.605
MOD_Plk_1	484	490	PF00069	0.693
MOD_Plk_1	516	522	PF00069	0.489
MOD_Plk_4	117	123	PF00069	0.651
MOD_Plk_4	258	264	PF00069	0.620
MOD_Plk_4	476	482	PF00069	0.690
MOD_Plk_4	547	553	PF00069	0.302
MOD_Plk_4	556	562	PF00069	0.360
MOD_Plk_4	7	13	PF00069	0.310
MOD_ProDKin_1	157	163	PF00069	0.725
MOD_ProDKin_1	207	213	PF00069	0.729
MOD_ProDKin_1	25	31	PF00069	0.622
MOD_ProDKin_1	312	318	PF00069	0.799
MOD_ProDKin_1	344	350	PF00069	0.655
MOD_ProDKin_1	61	67	PF00069	0.636
MOD_SUMO_for_1	181	184	PF00179	0.739
TRG_DiLeu_BaEn_1	596	601	PF01217	0.566
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.637
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.721
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.636
TRG_ENDOCYTIC_2	23	26	PF00928	0.642
TRG_ENDOCYTIC_2	333	336	PF00928	0.655
TRG_ENDOCYTIC_2	420	423	PF00928	0.611
TRG_ENDOCYTIC_2	467	470	PF00928	0.668
TRG_ENDOCYTIC_2	511	514	PF00928	0.586
TRG_ENDOCYTIC_2	552	555	PF00928	0.332
TRG_ER_diArg_1	201	204	PF00400	0.693
TRG_ER_diArg_1	304	307	PF00400	0.728
TRG_ER_diArg_1	309	312	PF00400	0.698
TRG_ER_diArg_1	474	477	PF00400	0.640
TRG_ER_diArg_1	583	586	PF00400	0.610
TRG_ER_diLys_1	641	644	PF00400	0.727
TRG_NES_CRM1_1	258	271	PF08389	0.570
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	542	547	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZL0	Leptomonas seymouri	49%	100%
A0A3S7WS03	Leishmania donovani	90%	100%
A4H6U7	Leishmania braziliensis	71%	100%
E9AGB8	Leishmania infantum	89%	100%
E9ANV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%