Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Myotubularin-related protein, putative

Species:

Leishmania major

UniProt:

Q4QGR1_LEIMA

TriTrypDb:

LmjF.12.0320 , LMJLV39_120008600 , LMJSD75_120008400

Length:

3246

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0019637	organophosphate metabolic process	3	2
GO:0030258	lipid modification	4	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004438	phosphatidylinositol-3-phosphate phosphatase activity	8	2
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0004725	protein tyrosine phosphatase activity	4	1
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016791	phosphatase activity	5	3
GO:0042578	phosphoric ester hydrolase activity	4	3
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	7	2
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1089	1093	PF00656	0.702
CLV_C14_Caspase3-7	1096	1100	PF00656	0.668
CLV_C14_Caspase3-7	1415	1419	PF00656	0.462
CLV_C14_Caspase3-7	2184	2188	PF00656	0.421
CLV_C14_Caspase3-7	2198	2202	PF00656	0.528
CLV_C14_Caspase3-7	2616	2620	PF00656	0.243
CLV_C14_Caspase3-7	2744	2748	PF00656	0.658
CLV_C14_Caspase3-7	2843	2847	PF00656	0.554
CLV_C14_Caspase3-7	675	679	PF00656	0.579
CLV_MEL_PAP_1	1617	1623	PF00089	0.619

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WRW1	Leishmania donovani	89%	100%
A4H6U8	Leishmania braziliensis	63%	100%
E9AGB9	Leishmania infantum	89%	100%
E9ANV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%

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