Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QGR0_LEIMA

TriTrypDb:

LmjF.12.0330 , LMJLV39_120008700 , LMJSD75_120008500

Length:

857

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGR0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.643
CLV_NRD_NRD_1	249	251	PF00675	0.669
CLV_NRD_NRD_1	302	304	PF00675	0.613
CLV_NRD_NRD_1	386	388	PF00675	0.629
CLV_NRD_NRD_1	841	843	PF00675	0.552
CLV_PCSK_KEX2_1	122	124	PF00082	0.643
CLV_PCSK_KEX2_1	249	251	PF00082	0.669
CLV_PCSK_KEX2_1	302	304	PF00082	0.613
CLV_PCSK_KEX2_1	386	388	PF00082	0.629
CLV_PCSK_KEX2_1	447	449	PF00082	0.707
CLV_PCSK_KEX2_1	841	843	PF00082	0.552
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.661
CLV_PCSK_SKI1_1	239	243	PF00082	0.610
CLV_PCSK_SKI1_1	378	382	PF00082	0.592
CLV_PCSK_SKI1_1	416	420	PF00082	0.551
CLV_PCSK_SKI1_1	583	587	PF00082	0.664
CLV_PCSK_SKI1_1	812	816	PF00082	0.611
CLV_PCSK_SKI1_1	834	838	PF00082	0.569
CLV_Separin_Metazoa	736	740	PF03568	0.544
DEG_APCC_DBOX_1	415	423	PF00400	0.546
DEG_APCC_DBOX_1	811	819	PF00400	0.564
DEG_APCC_DBOX_1	833	841	PF00400	0.555
DEG_Nend_UBRbox_2	1	3	PF02207	0.521
DEG_SPOP_SBC_1	182	186	PF00917	0.577
DEG_SPOP_SBC_1	225	229	PF00917	0.638
DEG_SPOP_SBC_1	269	273	PF00917	0.600
DOC_CYCLIN_RxL_1	413	424	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	208	214	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	748	754	PF00134	0.632
DOC_MAPK_gen_1	583	591	PF00069	0.628
DOC_MAPK_gen_1	832	840	PF00069	0.556
DOC_MAPK_gen_1	841	849	PF00069	0.463
DOC_MAPK_MEF2A_6	151	159	PF00069	0.503
DOC_MAPK_MEF2A_6	832	840	PF00069	0.556
DOC_PP2B_LxvP_1	136	139	PF13499	0.596
DOC_PP2B_LxvP_1	748	751	PF13499	0.609
DOC_PP2B_LxvP_1	813	816	PF13499	0.578
DOC_USP7_MATH_1	104	108	PF00917	0.601
DOC_USP7_MATH_1	181	185	PF00917	0.733
DOC_USP7_MATH_1	225	229	PF00917	0.638
DOC_USP7_MATH_1	251	255	PF00917	0.600
DOC_USP7_MATH_1	256	260	PF00917	0.655
DOC_USP7_MATH_1	263	267	PF00917	0.624
DOC_USP7_MATH_1	269	273	PF00917	0.602
DOC_USP7_MATH_1	275	279	PF00917	0.624
DOC_USP7_MATH_1	337	341	PF00917	0.674
DOC_USP7_MATH_1	348	352	PF00917	0.516
DOC_USP7_MATH_1	391	395	PF00917	0.578
DOC_USP7_MATH_1	425	429	PF00917	0.608
DOC_USP7_MATH_1	455	459	PF00917	0.639
DOC_USP7_MATH_1	469	473	PF00917	0.749
DOC_USP7_MATH_1	515	519	PF00917	0.685
DOC_USP7_MATH_1	523	527	PF00917	0.629
DOC_USP7_MATH_1	555	559	PF00917	0.597
DOC_USP7_MATH_1	632	636	PF00917	0.707
DOC_USP7_MATH_1	658	662	PF00917	0.717
DOC_USP7_MATH_1	681	685	PF00917	0.724
DOC_USP7_MATH_1	776	780	PF00917	0.691
DOC_USP7_MATH_1	801	805	PF00917	0.624
DOC_USP7_MATH_2	347	353	PF00917	0.696
DOC_USP7_UBL2_3	447	451	PF12436	0.587
DOC_WW_Pin1_4	127	132	PF00397	0.670
DOC_WW_Pin1_4	252	257	PF00397	0.629
DOC_WW_Pin1_4	261	266	PF00397	0.568
DOC_WW_Pin1_4	270	275	PF00397	0.517
DOC_WW_Pin1_4	421	426	PF00397	0.576
DOC_WW_Pin1_4	461	466	PF00397	0.725
DOC_WW_Pin1_4	519	524	PF00397	0.627
DOC_WW_Pin1_4	537	542	PF00397	0.656
DOC_WW_Pin1_4	566	571	PF00397	0.623
DOC_WW_Pin1_4	59	64	PF00397	0.641
DOC_WW_Pin1_4	593	598	PF00397	0.713
DOC_WW_Pin1_4	672	677	PF00397	0.793
DOC_WW_Pin1_4	757	762	PF00397	0.692
DOC_WW_Pin1_4	769	774	PF00397	0.587
LIG_14-3-3_CanoR_1	122	129	PF00244	0.560
LIG_14-3-3_CanoR_1	193	202	PF00244	0.574
LIG_14-3-3_CanoR_1	638	644	PF00244	0.643
LIG_14-3-3_CanoR_1	753	762	PF00244	0.686
LIG_14-3-3_CanoR_1	841	850	PF00244	0.552
LIG_Actin_WH2_2	570	585	PF00022	0.627
LIG_Actin_WH2_2	737	755	PF00022	0.582
LIG_BRCT_BRCA1_1	29	33	PF00533	0.555
LIG_Clathr_ClatBox_1	318	322	PF01394	0.613
LIG_FHA_1	101	107	PF00498	0.595
LIG_FHA_1	193	199	PF00498	0.541
LIG_FHA_1	291	297	PF00498	0.588
LIG_FHA_1	383	389	PF00498	0.664
LIG_FHA_1	394	400	PF00498	0.525
LIG_FHA_1	500	506	PF00498	0.623
LIG_FHA_1	527	533	PF00498	0.691
LIG_FHA_1	611	617	PF00498	0.635
LIG_FHA_1	66	72	PF00498	0.530
LIG_FHA_1	724	730	PF00498	0.586
LIG_FHA_1	747	753	PF00498	0.529
LIG_FHA_1	833	839	PF00498	0.558
LIG_FHA_2	465	471	PF00498	0.638
LIG_FHA_2	588	594	PF00498	0.686
LIG_FHA_2	707	713	PF00498	0.610
LIG_FHA_2	83	89	PF00498	0.548
LIG_GBD_Chelix_1	487	495	PF00786	0.576
LIG_LIR_Apic_2	243	248	PF02991	0.638
LIG_LIR_Gen_1	150	160	PF02991	0.504
LIG_LIR_Gen_1	649	659	PF02991	0.635
LIG_LIR_Gen_1	740	750	PF02991	0.557
LIG_LIR_Nem_3	150	156	PF02991	0.504
LIG_LIR_Nem_3	240	245	PF02991	0.612
LIG_LIR_Nem_3	368	373	PF02991	0.659
LIG_LIR_Nem_3	649	655	PF02991	0.766
LIG_LIR_Nem_3	740	745	PF02991	0.535
LIG_LIR_Nem_3	846	852	PF02991	0.564
LIG_NRBOX	414	420	PF00104	0.544
LIG_PCNA_PIPBox_1	20	29	PF02747	0.558
LIG_RPA_C_Fungi	307	319	PF08784	0.554
LIG_SH2_CRK	129	133	PF00017	0.638
LIG_SH2_CRK	245	249	PF00017	0.651
LIG_SH2_CRK	370	374	PF00017	0.664
LIG_SH2_CRK	652	656	PF00017	0.635
LIG_SH2_SRC	314	317	PF00017	0.741
LIG_SH2_STAP1	314	318	PF00017	0.606
LIG_SH2_STAP1	628	632	PF00017	0.743
LIG_SH2_STAT5	26	29	PF00017	0.548
LIG_SH2_STAT5	405	408	PF00017	0.614
LIG_SH3_1	250	256	PF00018	0.636
LIG_SH3_3	125	131	PF00018	0.773
LIG_SH3_3	165	171	PF00018	0.634
LIG_SH3_3	250	256	PF00018	0.644
LIG_SH3_3	371	377	PF00018	0.675
LIG_SH3_3	509	515	PF00018	0.790
LIG_SH3_3	52	58	PF00018	0.644
LIG_SH3_3	562	568	PF00018	0.679
LIG_SH3_3	673	679	PF00018	0.794
LIG_SH3_3	768	774	PF00018	0.587
LIG_SH3_3	849	855	PF00018	0.577
LIG_SH3_3	88	94	PF00018	0.601
LIG_SUMO_SIM_anti_2	728	733	PF11976	0.468
LIG_SUMO_SIM_anti_2	835	841	PF11976	0.550
LIG_SUMO_SIM_par_1	103	110	PF11976	0.562
LIG_SUMO_SIM_par_1	316	322	PF11976	0.580
LIG_SUMO_SIM_par_1	61	68	PF11976	0.560
LIG_SUMO_SIM_par_1	730	736	PF11976	0.556
LIG_TRAF2_1	347	350	PF00917	0.700
LIG_TRAF2_1	37	40	PF00917	0.537
LIG_TRAF2_1	557	560	PF00917	0.686
LIG_TRAF2_1	709	712	PF00917	0.613
LIG_Vh1_VBS_1	399	417	PF01044	0.552
LIG_WRC_WIRS_1	159	164	PF05994	0.505
MOD_CDK_SPxK_1	537	543	PF00069	0.731
MOD_CDK_SPxxK_3	566	573	PF00069	0.620
MOD_CK1_1	107	113	PF00069	0.604
MOD_CK1_1	226	232	PF00069	0.704
MOD_CK1_1	255	261	PF00069	0.675
MOD_CK1_1	264	270	PF00069	0.616
MOD_CK1_1	273	279	PF00069	0.533
MOD_CK1_1	392	398	PF00069	0.654
MOD_CK1_1	460	466	PF00069	0.825
MOD_CK1_1	490	496	PF00069	0.575
MOD_CK1_1	526	532	PF00069	0.714
MOD_CK1_1	566	572	PF00069	0.621
MOD_CK1_1	627	633	PF00069	0.755
MOD_CK1_1	639	645	PF00069	0.729
MOD_CK1_1	756	762	PF00069	0.690
MOD_CK1_1	784	790	PF00069	0.687
MOD_CK1_1	804	810	PF00069	0.423
MOD_CK2_1	158	164	PF00069	0.512
MOD_CK2_1	464	470	PF00069	0.639
MOD_CK2_1	553	559	PF00069	0.691
MOD_CK2_1	706	712	PF00069	0.610
MOD_CK2_1	804	810	PF00069	0.552
MOD_GlcNHglycan	201	205	PF01048	0.580
MOD_GlcNHglycan	258	261	PF01048	0.691
MOD_GlcNHglycan	267	270	PF01048	0.614
MOD_GlcNHglycan	277	280	PF01048	0.549
MOD_GlcNHglycan	389	392	PF01048	0.715
MOD_GlcNHglycan	400	403	PF01048	0.537
MOD_GlcNHglycan	427	430	PF01048	0.636
MOD_GlcNHglycan	457	460	PF01048	0.777
MOD_GlcNHglycan	492	495	PF01048	0.670
MOD_GlcNHglycan	517	520	PF01048	0.664
MOD_GlcNHglycan	537	540	PF01048	0.570
MOD_GlcNHglycan	555	558	PF01048	0.681
MOD_GlcNHglycan	648	651	PF01048	0.638
MOD_GlcNHglycan	671	675	PF01048	0.708
MOD_GlcNHglycan	783	786	PF01048	0.618
MOD_GlcNHglycan	791	794	PF01048	0.602
MOD_GlcNHglycan	803	806	PF01048	0.573
MOD_GSK3_1	100	107	PF00069	0.599
MOD_GSK3_1	223	230	PF00069	0.627
MOD_GSK3_1	251	258	PF00069	0.623
MOD_GSK3_1	261	268	PF00069	0.603
MOD_GSK3_1	269	276	PF00069	0.532
MOD_GSK3_1	378	385	PF00069	0.691
MOD_GSK3_1	387	394	PF00069	0.662
MOD_GSK3_1	421	428	PF00069	0.665
MOD_GSK3_1	453	460	PF00069	0.849
MOD_GSK3_1	490	497	PF00069	0.573
MOD_GSK3_1	515	522	PF00069	0.694
MOD_GSK3_1	523	530	PF00069	0.632
MOD_GSK3_1	531	538	PF00069	0.577
MOD_GSK3_1	623	630	PF00069	0.779
MOD_GSK3_1	632	639	PF00069	0.748
MOD_GSK3_1	642	649	PF00069	0.566
MOD_GSK3_1	65	72	PF00069	0.537
MOD_GSK3_1	670	677	PF00069	0.763
MOD_GSK3_1	719	726	PF00069	0.660
MOD_GSK3_1	753	760	PF00069	0.683
MOD_N-GLC_1	599	604	PF02516	0.616
MOD_NEK2_1	118	123	PF00069	0.763
MOD_NEK2_1	27	32	PF00069	0.555
MOD_NEK2_1	420	425	PF00069	0.483
MOD_NEK2_1	646	651	PF00069	0.628
MOD_NEK2_1	65	70	PF00069	0.540
MOD_NEK2_1	781	786	PF00069	0.698
MOD_NEK2_1	82	87	PF00069	0.370
MOD_NEK2_2	297	302	PF00069	0.596
MOD_PIKK_1	193	199	PF00454	0.582
MOD_PIKK_1	27	33	PF00454	0.584
MOD_PIKK_1	282	288	PF00454	0.629
MOD_PIKK_1	464	470	PF00454	0.639
MOD_PIKK_1	500	506	PF00454	0.497
MOD_PIKK_1	723	729	PF00454	0.732
MOD_PKA_2	121	127	PF00069	0.559
MOD_PKA_2	192	198	PF00069	0.590
MOD_PKA_2	637	643	PF00069	0.644
MOD_PKA_2	795	801	PF00069	0.658
MOD_PKB_1	191	199	PF00069	0.574
MOD_Plk_1	832	838	PF00069	0.566
MOD_Plk_4	104	110	PF00069	0.484
MOD_Plk_4	158	164	PF00069	0.512
MOD_Plk_4	410	416	PF00069	0.536
MOD_Plk_4	441	447	PF00069	0.755
MOD_Plk_4	776	782	PF00069	0.702
MOD_Plk_4	795	801	PF00069	0.478
MOD_Plk_4	82	88	PF00069	0.535
MOD_Plk_4	93	99	PF00069	0.507
MOD_ProDKin_1	127	133	PF00069	0.668
MOD_ProDKin_1	252	258	PF00069	0.632
MOD_ProDKin_1	261	267	PF00069	0.567
MOD_ProDKin_1	270	276	PF00069	0.512
MOD_ProDKin_1	421	427	PF00069	0.579
MOD_ProDKin_1	461	467	PF00069	0.726
MOD_ProDKin_1	519	525	PF00069	0.627
MOD_ProDKin_1	537	543	PF00069	0.659
MOD_ProDKin_1	566	572	PF00069	0.621
MOD_ProDKin_1	59	65	PF00069	0.638
MOD_ProDKin_1	593	599	PF00069	0.713
MOD_ProDKin_1	672	678	PF00069	0.794
MOD_ProDKin_1	757	763	PF00069	0.695
MOD_ProDKin_1	769	775	PF00069	0.586
TRG_DiLeu_BaEn_1	559	564	PF01217	0.687
TRG_DiLeu_BaEn_4	559	565	PF01217	0.687
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.590
TRG_ENDOCYTIC_2	129	132	PF00928	0.640
TRG_ENDOCYTIC_2	370	373	PF00928	0.664
TRG_ENDOCYTIC_2	652	655	PF00928	0.690
TRG_ER_diArg_1	248	250	PF00400	0.671
TRG_ER_diArg_1	301	303	PF00400	0.613
TRG_ER_diArg_1	309	312	PF00400	0.568
TRG_ER_diArg_1	386	388	PF00400	0.629
TRG_ER_diArg_1	659	662	PF00400	0.652
TRG_ER_diArg_1	840	842	PF00400	0.552
TRG_NES_CRM1_1	316	330	PF08389	0.614
TRG_NES_CRM1_1	496	509	PF08389	0.608
TRG_Pf-PMV_PEXEL_1	16	21	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	239	244	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	841	846	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I855	Leishmania donovani	89%	99%
E9AGC0	Leishmania infantum	89%	66%
E9ANW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	94%