NOT2_3_5 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CCR4-NOT transcription complex subunit 2, putative

Species:

Leishmania major

UniProt:

Q4QGQ8_LEIMA

TriTrypDb:

LmjF.12.0350 , LMJLV39_120008900 , LMJSD75_120008700

Length:

562

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0000932	P-body	5	2
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0030015	CCR4-NOT core complex	3	5
GO:0032991	protein-containing complex	1	5
GO:0035770	ribonucleoprotein granule	3	2
GO:0036464	cytoplasmic ribonucleoprotein granule	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	5

Expansion

Sequence features

Q4QGQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGQ8

Function

Biological processes
Term	Name	Level	Count
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	8	2
GO:0000956	nuclear-transcribed mRNA catabolic process	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006355	regulation of DNA-templated transcription	6	5
GO:0006401	RNA catabolic process	5	2
GO:0006402	mRNA catabolic process	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009889	regulation of biosynthetic process	4	5
GO:0009892	negative regulation of metabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	5
GO:0010556	regulation of macromolecule biosynthetic process	5	5
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010629	negative regulation of gene expression	6	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	5
GO:0019222	regulation of metabolic process	3	5
GO:0019439	aromatic compound catabolic process	4	2
GO:0031323	regulation of cellular metabolic process	4	5
GO:0031326	regulation of cellular biosynthetic process	5	5
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046700	heterocycle catabolic process	4	2
GO:0048519	negative regulation of biological process	3	2
GO:0050789	regulation of biological process	2	5
GO:0050794	regulation of cellular process	3	5
GO:0051171	regulation of nitrogen compound metabolic process	4	5
GO:0051252	regulation of RNA metabolic process	5	5
GO:0060255	regulation of macromolecule metabolic process	4	5
GO:0065007	biological regulation	1	5
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	5
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1903506	regulation of nucleic acid-templated transcription	7	5
GO:2001141	regulation of RNA biosynthetic process	6	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	338	342	PF00656	0.698
CLV_NRD_NRD_1	67	69	PF00675	0.754
CLV_PCSK_KEX2_1	67	69	PF00082	0.754
CLV_PCSK_SKI1_1	425	429	PF00082	0.432
CLV_PCSK_SKI1_1	473	477	PF00082	0.432
CLV_PCSK_SKI1_1	68	72	PF00082	0.754
DEG_COP1_1	318	325	PF00400	0.797
DOC_MAPK_gen_1	124	132	PF00069	0.770
DOC_MAPK_JIP1_4	399	405	PF00069	0.632
DOC_MAPK_MEF2A_6	308	316	PF00069	0.777
DOC_PP2B_LxvP_1	130	133	PF13499	0.777
DOC_PP2B_LxvP_1	49	52	PF13499	0.750
DOC_PP4_FxxP_1	25	28	PF00568	0.839
DOC_PP4_FxxP_1	389	392	PF00568	0.524
DOC_PP4_MxPP_1	12	15	PF00568	0.660
DOC_USP7_MATH_1	264	268	PF00917	0.753
DOC_USP7_MATH_1	377	381	PF00917	0.710
DOC_USP7_MATH_1	542	546	PF00917	0.851
DOC_USP7_MATH_1	558	562	PF00917	0.585
DOC_USP7_UBL2_3	304	308	PF12436	0.731
DOC_USP7_UBL2_3	397	401	PF12436	0.632
DOC_WW_Pin1_4	239	244	PF00397	0.822
DOC_WW_Pin1_4	316	321	PF00397	0.808
DOC_WW_Pin1_4	554	559	PF00397	0.851
LIG_14-3-3_CanoR_1	105	113	PF00244	0.747
LIG_14-3-3_CanoR_1	399	404	PF00244	0.632
LIG_BIR_II_1	1	5	PF00653	0.868
LIG_eIF4E_1	301	307	PF01652	0.720
LIG_FHA_1	317	323	PF00498	0.803
LIG_FHA_1	327	333	PF00498	0.570
LIG_FHA_1	349	355	PF00498	0.668
LIG_FHA_1	373	379	PF00498	0.705
LIG_FHA_1	476	482	PF00498	0.632
LIG_FHA_2	59	65	PF00498	0.727
LIG_LIR_Apic_2	23	28	PF02991	0.847
LIG_LIR_Apic_2	382	387	PF02991	0.700
LIG_LIR_Apic_2	388	392	PF02991	0.427
LIG_LIR_Apic_2	393	398	PF02991	0.504
LIG_LIR_Gen_1	344	354	PF02991	0.674
LIG_LIR_Gen_1	407	416	PF02991	0.632
LIG_LIR_Gen_1	476	484	PF02991	0.632
LIG_LIR_Nem_3	344	350	PF02991	0.678
LIG_LIR_Nem_3	379	384	PF02991	0.719
LIG_LIR_Nem_3	407	411	PF02991	0.632
LIG_LIR_Nem_3	414	420	PF02991	0.550
LIG_LIR_Nem_3	476	482	PF02991	0.526
LIG_LIR_Nem_3	486	490	PF02991	0.504
LIG_PCNA_yPIPBox_3	194	205	PF02747	0.744
LIG_SH2_CRK	395	399	PF00017	0.632
LIG_SH2_CRK	421	425	PF00017	0.632
LIG_SH2_PTP2	384	387	PF00017	0.688
LIG_SH2_SRC	321	324	PF00017	0.790
LIG_SH2_STAP1	381	385	PF00017	0.622
LIG_SH2_STAT3	173	176	PF00017	0.735
LIG_SH2_STAT5	321	324	PF00017	0.752
LIG_SH2_STAT5	384	387	PF00017	0.628
LIG_SH2_STAT5	418	421	PF00017	0.637
LIG_SH2_STAT5	479	482	PF00017	0.632
LIG_SH3_3	265	271	PF00018	0.831
LIG_SH3_3	306	312	PF00018	0.639
LIG_SH3_3	317	323	PF00018	0.593
LIG_SH3_3	325	331	PF00018	0.429
LIG_SH3_3	478	484	PF00018	0.632
LIG_SH3_3	8	14	PF00018	0.662
LIG_SH3_4	397	404	PF00018	0.632
LIG_SUMO_SIM_anti_2	110	115	PF11976	0.728
LIG_TRAF2_1	512	515	PF00917	0.718
LIG_WRC_WIRS_1	405	410	PF05994	0.632
LIG_WW_2	312	315	PF00397	0.783
MOD_CK1_1	404	410	PF00069	0.632
MOD_CK2_1	104	110	PF00069	0.761
MOD_CK2_1	321	327	PF00069	0.785
MOD_CK2_1	359	365	PF00069	0.691
MOD_CK2_1	457	463	PF00069	0.632
MOD_CK2_1	58	64	PF00069	0.725
MOD_GlcNHglycan	106	109	PF01048	0.750
MOD_GlcNHglycan	227	230	PF01048	0.802
MOD_GlcNHglycan	248	251	PF01048	0.718
MOD_GlcNHglycan	258	261	PF01048	0.726
MOD_GlcNHglycan	323	326	PF01048	0.709
MOD_GlcNHglycan	332	335	PF01048	0.617
MOD_GlcNHglycan	504	509	PF01048	0.680
MOD_GlcNHglycan	537	540	PF01048	0.823
MOD_GlcNHglycan	551	554	PF01048	0.626
MOD_GlcNHglycan	558	561	PF01048	0.649
MOD_GSK3_1	175	182	PF00069	0.734
MOD_GSK3_1	248	255	PF00069	0.648
MOD_GSK3_1	326	333	PF00069	0.754
MOD_GSK3_1	368	375	PF00069	0.699
MOD_GSK3_1	473	480	PF00069	0.637
MOD_GSK3_1	554	561	PF00069	0.799
MOD_N-GLC_1	146	151	PF02516	0.758
MOD_N-GLC_1	156	161	PF02516	0.554
MOD_N-GLC_1	256	261	PF02516	0.839
MOD_N-GLC_1	345	350	PF02516	0.675
MOD_N-GLC_1	548	553	PF02516	0.688
MOD_N-GLC_1	554	559	PF02516	0.710
MOD_N-GLC_2	444	446	PF02516	0.289
MOD_NEK2_1	224	229	PF00069	0.809
MOD_NEK2_1	345	350	PF00069	0.675
MOD_NEK2_1	369	374	PF00069	0.693
MOD_NEK2_1	462	467	PF00069	0.545
MOD_NEK2_1	475	480	PF00069	0.504
MOD_NEK2_1	58	63	PF00069	0.723
MOD_NEK2_2	477	482	PF00069	0.632
MOD_PIKK_1	175	181	PF00454	0.734
MOD_PIKK_1	189	195	PF00454	0.519
MOD_PIKK_1	28	34	PF00454	0.750
MOD_PIKK_1	335	341	PF00454	0.723
MOD_PIKK_1	354	360	PF00454	0.372
MOD_PIKK_1	489	495	PF00454	0.632
MOD_PIKK_1	518	524	PF00454	0.621
MOD_PKA_2	104	110	PF00069	0.761
MOD_Plk_1	156	162	PF00069	0.723
MOD_Plk_1	256	262	PF00069	0.834
MOD_Plk_1	345	351	PF00069	0.673
MOD_Plk_1	354	360	PF00069	0.535
MOD_Plk_1	412	418	PF00069	0.632
MOD_Plk_1	504	510	PF00069	0.685
MOD_Plk_2-3	457	463	PF00069	0.632
MOD_Plk_4	20	26	PF00069	0.860
MOD_Plk_4	412	418	PF00069	0.574
MOD_Plk_4	457	463	PF00069	0.632
MOD_Plk_4	477	483	PF00069	0.400
MOD_ProDKin_1	239	245	PF00069	0.823
MOD_ProDKin_1	316	322	PF00069	0.807
MOD_ProDKin_1	554	560	PF00069	0.848
MOD_SUMO_for_1	411	414	PF00179	0.632
MOD_SUMO_rev_2	382	392	PF00179	0.680
TRG_DiLeu_BaEn_1	505	510	PF01217	0.694
TRG_ENDOCYTIC_2	383	386	PF00928	0.702
TRG_ENDOCYTIC_2	479	482	PF00928	0.632
TRG_ER_diArg_1	126	129	PF00400	0.771
TRG_NLS_MonoCore_2	395	400	PF00514	0.632
TRG_NLS_MonoExtC_3	395	400	PF00514	0.632
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.764
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.729
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WRX6	Leishmania donovani	95%	100%
E9AGC2	Leishmania infantum	95%	100%
E9ANW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	98%