GST N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glutathione S-transferase, N-terminal domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QGQ7_LEIMA

TriTrypDb:

LmjF.12.0360 , LMJLV39_120009000 , LMJSD75_120008800

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QGQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGQ7

Function

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Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003746	translation elongation factor activity	4	3
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	3
GO:0008135	translation factor activity, RNA binding	3	3
GO:0016740	transferase activity	2	1
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.495
CLV_NRD_NRD_1	166	168	PF00675	0.444
CLV_NRD_NRD_1	265	267	PF00675	0.760
CLV_NRD_NRD_1	359	361	PF00675	0.403
CLV_PCSK_KEX2_1	166	168	PF00082	0.508
CLV_PCSK_KEX2_1	265	267	PF00082	0.760
CLV_PCSK_SKI1_1	136	140	PF00082	0.527
CLV_PCSK_SKI1_1	154	158	PF00082	0.499
CLV_PCSK_SKI1_1	16	20	PF00082	0.306
CLV_PCSK_SKI1_1	333	337	PF00082	0.382

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY02	Leptomonas seymouri	69%	99%
A0A1X0NNU8	Trypanosomatidae	36%	92%
A0A3R7MZA1	Trypanosoma rangeli	35%	100%
A0A3S7WRV8	Leishmania donovani	98%	100%
A4H6V1	Leishmania braziliensis	83%	99%
C9ZQA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AGC3	Leishmania infantum	98%	100%
E9ANW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DE18	Trypanosoma cruzi	40%	100%

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