GST N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glutathione S-transferase, N-terminal domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QGQ7_LEIMA

TriTrypDb:

LmjF.12.0360 , LMJLV39_120009000 , LMJSD75_120008800

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGQ7

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0003676	nucleic acid binding	3	3
GO:0003746	translation elongation factor activity	4	3
GO:0005488	binding	1	3
GO:0008135	translation factor activity, RNA binding	3	3
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.495
CLV_NRD_NRD_1	166	168	PF00675	0.444
CLV_NRD_NRD_1	265	267	PF00675	0.760
CLV_NRD_NRD_1	359	361	PF00675	0.403
CLV_PCSK_KEX2_1	166	168	PF00082	0.508
CLV_PCSK_KEX2_1	265	267	PF00082	0.760
CLV_PCSK_SKI1_1	136	140	PF00082	0.527
CLV_PCSK_SKI1_1	154	158	PF00082	0.499
CLV_PCSK_SKI1_1	16	20	PF00082	0.306
CLV_PCSK_SKI1_1	333	337	PF00082	0.382
CLV_PCSK_SKI1_1	348	352	PF00082	0.249
DEG_APCC_DBOX_1	300	308	PF00400	0.563
DEG_SCF_FBW7_1	276	283	PF00400	0.682
DOC_CYCLIN_RxL_1	233	246	PF00134	0.621
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.493
DOC_MAPK_gen_1	233	243	PF00069	0.623
DOC_MAPK_gen_1	345	355	PF00069	0.524
DOC_MAPK_gen_1	360	367	PF00069	0.330
DOC_MAPK_MEF2A_6	348	355	PF00069	0.489
DOC_MAPK_MEF2A_6	360	367	PF00069	0.351
DOC_MAPK_MEF2A_6	76	84	PF00069	0.609
DOC_MAPK_NFAT4_5	348	356	PF00069	0.517
DOC_MAPK_NFAT4_5	360	368	PF00069	0.477
DOC_PP1_RVXF_1	128	134	PF00149	0.482
DOC_PP2B_LxvP_1	351	354	PF13499	0.475
DOC_USP7_MATH_1	267	271	PF00917	0.644
DOC_USP7_MATH_1	280	284	PF00917	0.545
DOC_USP7_UBL2_3	144	148	PF12436	0.470
DOC_WW_Pin1_4	276	281	PF00397	0.642
DOC_WW_Pin1_4	8	13	PF00397	0.414
LIG_14-3-3_CanoR_1	188	198	PF00244	0.705
LIG_14-3-3_CanoR_1	213	218	PF00244	0.557
LIG_14-3-3_CanoR_1	281	285	PF00244	0.647
LIG_14-3-3_CanoR_1	289	293	PF00244	0.649
LIG_Actin_WH2_2	157	174	PF00022	0.462
LIG_Actin_WH2_2	319	335	PF00022	0.551
LIG_BIR_III_4	249	253	PF00653	0.461
LIG_deltaCOP1_diTrp_1	121	126	PF00928	0.360
LIG_eIF4E_1	13	19	PF01652	0.433
LIG_eIF4E_1	346	352	PF01652	0.538
LIG_FHA_1	15	21	PF00498	0.451
LIG_FHA_2	116	122	PF00498	0.432
LIG_FHA_2	127	133	PF00498	0.324
LIG_FHA_2	190	196	PF00498	0.665
LIG_FHA_2	244	250	PF00498	0.615
LIG_FHA_2	311	317	PF00498	0.461
LIG_LIR_Gen_1	121	131	PF02991	0.356
LIG_LIR_Nem_3	121	126	PF02991	0.383
LIG_LIR_Nem_3	135	141	PF02991	0.415
LIG_LIR_Nem_3	337	343	PF02991	0.525
LIG_LYPXL_yS_3	340	343	PF13949	0.443
LIG_Rb_LxCxE_1	322	338	PF01857	0.552
LIG_SH2_CRK	23	27	PF00017	0.475
LIG_SH2_CRK	347	351	PF00017	0.552
LIG_SH2_NCK_1	218	222	PF00017	0.627
LIG_SH2_STAP1	134	138	PF00017	0.483
LIG_SH2_STAT3	134	137	PF00017	0.471
LIG_SH2_STAT5	13	16	PF00017	0.433
LIG_SH2_STAT5	134	137	PF00017	0.487
LIG_SH2_STAT5	170	173	PF00017	0.528
LIG_SH2_STAT5	63	66	PF00017	0.306
LIG_SH2_STAT5	73	76	PF00017	0.306
LIG_SH3_2	260	265	PF14604	0.558
LIG_SH3_3	257	263	PF00018	0.750
LIG_SH3_3	98	104	PF00018	0.679
LIG_SUMO_SIM_anti_2	77	83	PF11976	0.646
LIG_SUMO_SIM_par_1	80	85	PF11976	0.592
LIG_TRAF2_1	192	195	PF00917	0.606
LIG_UBA3_1	240	245	PF00899	0.621
MOD_CDK_SPK_2	276	281	PF00069	0.642
MOD_CK1_1	184	190	PF00069	0.692
MOD_CK1_1	206	212	PF00069	0.589
MOD_CK1_1	270	276	PF00069	0.652
MOD_CK1_1	287	293	PF00069	0.695
MOD_CK2_1	110	116	PF00069	0.420
MOD_CK2_1	189	195	PF00069	0.606
MOD_GlcNHglycan	181	184	PF01048	0.558
MOD_GlcNHglycan	276	279	PF01048	0.620
MOD_GlcNHglycan	286	289	PF01048	0.582
MOD_GlcNHglycan	293	296	PF01048	0.497
MOD_GlcNHglycan	84	87	PF01048	0.674
MOD_GlcNHglycan	89	92	PF01048	0.703
MOD_GSK3_1	110	117	PF00069	0.520
MOD_GSK3_1	179	186	PF00069	0.609
MOD_GSK3_1	209	216	PF00069	0.577
MOD_GSK3_1	261	268	PF00069	0.695
MOD_GSK3_1	270	277	PF00069	0.600
MOD_GSK3_1	280	287	PF00069	0.559
MOD_N-GLC_1	38	43	PF02516	0.325
MOD_NEK2_1	1	6	PF00069	0.391
MOD_NEK2_1	114	119	PF00069	0.525
MOD_NEK2_1	126	131	PF00069	0.484
MOD_NEK2_1	274	279	PF00069	0.726
MOD_NEK2_1	319	324	PF00069	0.506
MOD_NEK2_1	64	69	PF00069	0.306
MOD_NEK2_1	80	85	PF00069	0.521
MOD_PIKK_1	115	121	PF00454	0.498
MOD_PK_1	213	219	PF00069	0.624
MOD_PK_1	265	271	PF00069	0.655
MOD_PKA_1	244	250	PF00069	0.612
MOD_PKA_1	265	271	PF00069	0.752
MOD_PKA_2	206	212	PF00069	0.555
MOD_PKA_2	265	271	PF00069	0.677
MOD_PKA_2	280	286	PF00069	0.462
MOD_PKA_2	288	294	PF00069	0.672
MOD_PKA_2	363	369	PF00069	0.433
MOD_Plk_1	115	121	PF00069	0.495
MOD_Plk_2-3	38	44	PF00069	0.430
MOD_Plk_4	1	7	PF00069	0.382
MOD_Plk_4	110	116	PF00069	0.472
MOD_Plk_4	119	125	PF00069	0.395
MOD_Plk_4	152	158	PF00069	0.426
MOD_Plk_4	213	219	PF00069	0.594
MOD_Plk_4	280	286	PF00069	0.717
MOD_Plk_4	346	352	PF00069	0.526
MOD_Plk_4	363	369	PF00069	0.496
MOD_ProDKin_1	276	282	PF00069	0.640
MOD_ProDKin_1	8	14	PF00069	0.414
TRG_ENDOCYTIC_2	23	26	PF00928	0.430
TRG_ENDOCYTIC_2	340	343	PF00928	0.469
TRG_ENDOCYTIC_2	347	350	PF00928	0.481
TRG_ER_diArg_1	166	168	PF00400	0.531
TRG_ER_diArg_1	224	227	PF00400	0.668
TRG_ER_diArg_1	265	267	PF00400	0.760
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY02	Leptomonas seymouri	69%	99%
A0A1X0NNU8	Trypanosomatidae	36%	92%
A0A3R7MZA1	Trypanosoma rangeli	35%	100%
A0A3S7WRV8	Leishmania donovani	98%	100%
A4H6V1	Leishmania braziliensis	83%	99%
C9ZQA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AGC3	Leishmania infantum	98%	100%
E9ANW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DE18	Trypanosoma cruzi	40%	100%