Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGQ6_LEIMA

TriTrypDb:

LmjF.12.0370 , LMJLV39_120009100 , LMJSD75_120008900

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	6
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QGQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.710
CLV_NRD_NRD_1	215	217	PF00675	0.497
CLV_NRD_NRD_1	279	281	PF00675	0.490
CLV_NRD_NRD_1	90	92	PF00675	0.639
CLV_PCSK_KEX2_1	221	223	PF00082	0.519
CLV_PCSK_KEX2_1	279	281	PF00082	0.490
CLV_PCSK_KEX2_1	90	92	PF00082	0.534
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.519
CLV_PCSK_PC7_1	275	281	PF00082	0.563
CLV_PCSK_SKI1_1	47	51	PF00082	0.373
CLV_PCSK_SKI1_1	91	95	PF00082	0.442
DEG_SPOP_SBC_1	163	167	PF00917	0.793
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.334
DOC_MAPK_gen_1	126	135	PF00069	0.658
DOC_PP1_RVXF_1	45	52	PF00149	0.491
DOC_PP2B_LxvP_1	210	213	PF13499	0.747
DOC_USP7_MATH_1	162	166	PF00917	0.791
DOC_USP7_MATH_1	19	23	PF00917	0.502
DOC_USP7_MATH_1	2	6	PF00917	0.675
DOC_USP7_UBL2_3	217	221	PF12436	0.704
DOC_WW_Pin1_4	109	114	PF00397	0.343
DOC_WW_Pin1_4	169	174	PF00397	0.790
LIG_14-3-3_CanoR_1	53	61	PF00244	0.380
LIG_BRCT_BRCA1_1	98	102	PF00533	0.334
LIG_CaM_NSCaTE_8	51	58	PF13499	0.399
LIG_deltaCOP1_diTrp_1	194	199	PF00928	0.700
LIG_FHA_1	125	131	PF00498	0.580
LIG_FHA_1	176	182	PF00498	0.774
LIG_FHA_1	286	292	PF00498	0.642
LIG_FHA_1	308	314	PF00498	0.703
LIG_FHA_2	229	235	PF00498	0.797
LIG_LIR_Nem_3	141	147	PF02991	0.572
LIG_PCNA_yPIPBox_3	74	88	PF02747	0.440
LIG_PTB_Apo_2	103	110	PF02174	0.399
LIG_SH2_STAP1	44	48	PF00017	0.650
LIG_SH2_STAT3	71	74	PF00017	0.419
LIG_SH3_3	167	173	PF00018	0.749
LIG_SH3_3	200	206	PF00018	0.660
LIG_UBA3_1	116	122	PF00899	0.548
LIG_UBA3_1	209	217	PF00899	0.691
MOD_CK1_1	12	18	PF00069	0.631
MOD_CK1_1	165	171	PF00069	0.771
MOD_CK1_1	263	269	PF00069	0.753
MOD_CK1_1	56	62	PF00069	0.449
MOD_CK2_1	264	270	PF00069	0.835
MOD_GlcNHglycan	12	15	PF01048	0.416
MOD_GlcNHglycan	257	260	PF01048	0.534
MOD_GlcNHglycan	266	269	PF01048	0.518
MOD_GlcNHglycan	5	8	PF01048	0.552
MOD_GlcNHglycan	55	58	PF01048	0.325
MOD_GlcNHglycan	98	101	PF01048	0.350
MOD_GSK3_1	165	172	PF00069	0.742
MOD_GSK3_1	249	256	PF00069	0.791
MOD_GSK3_1	260	267	PF00069	0.680
MOD_GSK3_1	31	38	PF00069	0.513
MOD_GSK3_1	49	56	PF00069	0.449
MOD_LATS_1	120	126	PF00433	0.622
MOD_N-GLC_1	3	8	PF02516	0.519
MOD_N-GLC_1	31	36	PF02516	0.308
MOD_NEK2_1	124	129	PF00069	0.588
MOD_NEK2_1	98	103	PF00069	0.333
MOD_PIKK_1	215	221	PF00454	0.708
MOD_PIKK_1	243	249	PF00454	0.739
MOD_PKA_2	215	221	PF00069	0.687
MOD_PKA_2	270	276	PF00069	0.675
MOD_Plk_1	3	9	PF00069	0.602
MOD_Plk_1	307	313	PF00069	0.698
MOD_Plk_4	56	62	PF00069	0.401
MOD_ProDKin_1	109	115	PF00069	0.343
MOD_ProDKin_1	169	175	PF00069	0.791
MOD_SUMO_for_1	294	297	PF00179	0.665
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.647
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.468
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.298
TRG_ER_diArg_1	278	280	PF00400	0.690
TRG_ER_diArg_1	81	84	PF00400	0.408
TRG_ER_diArg_1	89	91	PF00400	0.331
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL14	Leptomonas seymouri	38%	95%
A0A3S7WRY6	Leishmania donovani	91%	100%
A4H6V2	Leishmania braziliensis	67%	92%
E9AGC4	Leishmania infantum	91%	100%
E9ANW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%