Semialdhyde_dh domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGQ4_LEIMA

TriTrypDb:

LmjF.12.0390 , LMJLV39_120009300 , LMJSD75_120009100

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGQ4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0009987	cellular process	1	2
GO:0046907	intracellular transport	3	2
GO:0051169	nuclear transport	4	2
GO:0051170	import into nucleus	6	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.657
CLV_C14_Caspase3-7	155	159	PF00656	0.392
CLV_C14_Caspase3-7	61	65	PF00656	0.535
CLV_NRD_NRD_1	155	157	PF00675	0.402
CLV_NRD_NRD_1	370	372	PF00675	0.644
CLV_NRD_NRD_1	69	71	PF00675	0.574
CLV_PCSK_KEX2_1	108	110	PF00082	0.487
CLV_PCSK_KEX2_1	69	71	PF00082	0.608
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.622
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.608
CLV_PCSK_SKI1_1	139	143	PF00082	0.402
CLV_PCSK_SKI1_1	163	167	PF00082	0.388
CLV_PCSK_SKI1_1	274	278	PF00082	0.475
CLV_PCSK_SKI1_1	306	310	PF00082	0.538
CLV_PCSK_SKI1_1	92	96	PF00082	0.447
DEG_APCC_KENBOX_2	360	364	PF00400	0.508
DEG_SPOP_SBC_1	246	250	PF00917	0.422
DEG_SPOP_SBC_1	340	344	PF00917	0.605
DOC_CYCLIN_yCln2_LP_2	375	381	PF00134	0.485
DOC_USP7_MATH_1	107	111	PF00917	0.599
DOC_USP7_MATH_1	114	118	PF00917	0.627
DOC_USP7_MATH_1	228	232	PF00917	0.523
DOC_USP7_MATH_1	246	250	PF00917	0.281
DOC_USP7_MATH_1	261	265	PF00917	0.351
DOC_USP7_MATH_1	323	327	PF00917	0.351
DOC_USP7_UBL2_3	383	387	PF12436	0.567
DOC_WW_Pin1_4	187	192	PF00397	0.578
DOC_WW_Pin1_4	280	285	PF00397	0.478
DOC_WW_Pin1_4	370	375	PF00397	0.668
DOC_WW_Pin1_4	73	78	PF00397	0.699
DOC_WW_Pin1_4	81	86	PF00397	0.511
LIG_14-3-3_CanoR_1	302	310	PF00244	0.637
LIG_14-3-3_CanoR_1	35	44	PF00244	0.413
LIG_14-3-3_CanoR_1	92	97	PF00244	0.424
LIG_14-3-3_CterR_2	413	416	PF00244	0.484
LIG_BRCT_BRCA1_1	248	252	PF00533	0.484
LIG_deltaCOP1_diTrp_1	97	105	PF00928	0.360
LIG_FHA_1	175	181	PF00498	0.428
LIG_FHA_1	232	238	PF00498	0.504
LIG_FHA_1	255	261	PF00498	0.442
LIG_FHA_1	380	386	PF00498	0.582
LIG_FHA_1	8	14	PF00498	0.327
LIG_FHA_2	153	159	PF00498	0.388
LIG_FHA_2	164	170	PF00498	0.333
LIG_FHA_2	82	88	PF00498	0.471
LIG_Integrin_RGD_1	62	64	PF01839	0.496
LIG_LIR_Gen_1	146	152	PF02991	0.385
LIG_LIR_Gen_1	169	176	PF02991	0.332
LIG_LIR_Gen_1	249	260	PF02991	0.450
LIG_LIR_Gen_1	304	315	PF02991	0.473
LIG_LIR_Gen_1	42	52	PF02991	0.477
LIG_LIR_Gen_1	95	106	PF02991	0.361
LIG_LIR_Nem_3	135	141	PF02991	0.403
LIG_LIR_Nem_3	169	173	PF02991	0.338
LIG_LIR_Nem_3	248	254	PF02991	0.445
LIG_LIR_Nem_3	304	310	PF02991	0.505
LIG_LIR_Nem_3	42	47	PF02991	0.484
LIG_LIR_Nem_3	95	101	PF02991	0.351
LIG_PCNA_yPIPBox_3	24	37	PF02747	0.491
LIG_PDZ_Class_2	411	416	PF00595	0.468
LIG_Pex14_2	101	105	PF04695	0.360
LIG_SH2_CRK	138	142	PF00017	0.434
LIG_SH2_CRK	170	174	PF00017	0.355
LIG_SH2_CRK	183	187	PF00017	0.203
LIG_SH2_GRB2like	44	47	PF00017	0.281
LIG_SH2_NCK_1	183	187	PF00017	0.410
LIG_SH2_SRC	170	173	PF00017	0.316
LIG_SH2_SRC	398	401	PF00017	0.316
LIG_SH2_STAP1	170	174	PF00017	0.290
LIG_SH2_STAP1	44	48	PF00017	0.471
LIG_SH2_STAT3	20	23	PF00017	0.337
LIG_SH2_STAT5	172	175	PF00017	0.302
LIG_SH2_STAT5	379	382	PF00017	0.372
LIG_SH2_STAT5	398	401	PF00017	0.459
LIG_SH3_3	389	395	PF00018	0.390
LIG_SUMO_SIM_anti_2	217	222	PF11976	0.510
LIG_SUMO_SIM_par_1	28	34	PF11976	0.337
MOD_CDC14_SPxK_1	190	193	PF00782	0.457
MOD_CDK_SPxK_1	187	193	PF00069	0.435
MOD_CDK_SPxxK_3	370	377	PF00069	0.455
MOD_CK1_1	110	116	PF00069	0.624
MOD_CK1_1	161	167	PF00069	0.392
MOD_CK1_1	231	237	PF00069	0.503
MOD_CK1_1	244	250	PF00069	0.518
MOD_CK2_1	261	267	PF00069	0.434
MOD_CK2_1	341	347	PF00069	0.749
MOD_CK2_1	39	45	PF00069	0.564
MOD_CK2_1	81	87	PF00069	0.443
MOD_GlcNHglycan	112	115	PF01048	0.587
MOD_GlcNHglycan	116	119	PF01048	0.586
MOD_GlcNHglycan	160	163	PF01048	0.429
MOD_GlcNHglycan	183	186	PF01048	0.327
MOD_GlcNHglycan	231	234	PF01048	0.435
MOD_GlcNHglycan	325	328	PF01048	0.419
MOD_GlcNHglycan	343	346	PF01048	0.692
MOD_GlcNHglycan	73	76	PF01048	0.622
MOD_GSK3_1	110	117	PF00069	0.521
MOD_GSK3_1	240	247	PF00069	0.534
MOD_GSK3_1	323	330	PF00069	0.411
MOD_GSK3_1	405	412	PF00069	0.500
MOD_GSK3_1	73	80	PF00069	0.629
MOD_LATS_1	272	278	PF00433	0.478
MOD_N-GLC_1	244	249	PF02516	0.443
MOD_N-GLC_1	362	367	PF02516	0.500
MOD_N-GLC_2	273	275	PF02516	0.334
MOD_NEK2_1	152	157	PF00069	0.416
MOD_NEK2_1	181	186	PF00069	0.390
MOD_NEK2_1	310	315	PF00069	0.549
MOD_NEK2_1	36	41	PF00069	0.414
MOD_PIKK_1	99	105	PF00454	0.560
MOD_PKA_1	108	114	PF00069	0.508
MOD_PKA_1	71	77	PF00069	0.496
MOD_PKA_2	108	114	PF00069	0.627
MOD_PKA_2	301	307	PF00069	0.563
MOD_PKA_2	36	42	PF00069	0.392
MOD_Plk_1	261	267	PF00069	0.404
MOD_Plk_1	362	368	PF00069	0.693
MOD_Plk_1	99	105	PF00069	0.440
MOD_Plk_2-3	262	268	PF00069	0.483
MOD_Plk_4	247	253	PF00069	0.393
MOD_ProDKin_1	187	193	PF00069	0.586
MOD_ProDKin_1	280	286	PF00069	0.469
MOD_ProDKin_1	370	376	PF00069	0.651
MOD_ProDKin_1	73	79	PF00069	0.686
MOD_ProDKin_1	81	87	PF00069	0.505
TRG_DiLeu_BaEn_4	99	105	PF01217	0.440
TRG_ENDOCYTIC_2	138	141	PF00928	0.367
TRG_ENDOCYTIC_2	147	150	PF00928	0.314
TRG_ENDOCYTIC_2	170	173	PF00928	0.316
TRG_ENDOCYTIC_2	44	47	PF00928	0.478
TRG_NLS_MonoCore_2	68	73	PF00514	0.513
TRG_NLS_MonoExtN_4	69	74	PF00514	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D9	Leptomonas seymouri	49%	100%
A0A1X0NR33	Trypanosomatidae	34%	100%
A0A3S7WRX1	Leishmania donovani	94%	100%
A0A422NA30	Trypanosoma rangeli	34%	100%
A4H6V4	Leishmania braziliensis	72%	100%
C9ZUI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AGC6	Leishmania infantum	93%	100%
E9ANW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BTJ4	Trypanosoma cruzi	36%	100%