Fe-ADH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Iron-containing alcohol dehydrogenase, putative

Species:

Leishmania major

UniProt:

Q4QGQ0_LEIMA

TriTrypDb:

LmjF.12.0420 , LMJLV39_120009700 , LMJSD75_120009500

Length:

141

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGQ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.549
CLV_NRD_NRD_1	136	138	PF00675	0.743
CLV_NRD_NRD_1	26	28	PF00675	0.549
CLV_NRD_NRD_1	51	53	PF00675	0.549
CLV_NRD_NRD_1	63	65	PF00675	0.339
CLV_NRD_NRD_1	91	93	PF00675	0.549
CLV_PCSK_KEX2_1	136	138	PF00082	0.743
CLV_PCSK_KEX2_1	26	28	PF00082	0.549
CLV_PCSK_KEX2_1	51	53	PF00082	0.549
CLV_PCSK_KEX2_1	91	93	PF00082	0.549
CLV_PCSK_PC7_1	132	138	PF00082	0.778
CLV_PCSK_SKI1_1	92	96	PF00082	0.549
DOC_MAPK_gen_1	96	106	PF00069	0.549
DOC_PP4_FxxP_1	13	16	PF00568	0.735
DOC_PP4_FxxP_1	38	41	PF00568	0.549
DOC_USP7_MATH_1	8	12	PF00917	0.750
LIG_Actin_WH2_2	80	98	PF00022	0.549
LIG_BIR_III_2	113	117	PF00653	0.549
LIG_BRCT_BRCA1_1	34	38	PF00533	0.549
LIG_CSL_BTD_1	138	141	PF09270	0.715
LIG_FHA_1	68	74	PF00498	0.549
LIG_Integrin_isoDGR_2	89	91	PF01839	0.549
LIG_LIR_Apic_2	11	16	PF02991	0.745
LIG_LIR_Apic_2	35	41	PF02991	0.549
LIG_PCNA_yPIPBox_3	81	93	PF02747	0.549
LIG_SH2_STAT5	14	17	PF00017	0.732
LIG_SUMO_SIM_par_1	41	47	PF11976	0.549
MOD_CK1_1	108	114	PF00069	0.549
MOD_CK1_1	22	28	PF00069	0.549
MOD_Cter_Amidation	89	92	PF01082	0.549
MOD_GlcNHglycan	10	13	PF01048	0.765
MOD_GlcNHglycan	21	24	PF01048	0.557
MOD_GlcNHglycan	28	31	PF01048	0.234
MOD_GSK3_1	120	127	PF00069	0.811
MOD_GSK3_1	22	29	PF00069	0.549
MOD_GSK3_1	79	86	PF00069	0.549
MOD_GSK3_1	95	102	PF00069	0.269
MOD_N-GLC_1	80	85	PF02516	0.549
MOD_NEK2_1	1	6	PF00069	0.758
MOD_NEK2_1	95	100	PF00069	0.549
MOD_PK_1	99	105	PF00069	0.549
MOD_PKA_1	26	32	PF00069	0.549
MOD_PKA_2	26	32	PF00069	0.549
MOD_Plk_1	80	86	PF00069	0.549
MOD_Plk_4	68	74	PF00069	0.504
MOD_Plk_4	80	86	PF00069	0.339
MOD_Plk_4	99	105	PF00069	0.217
TRG_DiLeu_LyEn_5	39	44	PF01217	0.549
TRG_ENDOCYTIC_2	14	17	PF00928	0.732
TRG_ER_diArg_1	135	137	PF00400	0.752
TRG_ER_diArg_1	50	52	PF00400	0.549
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
F8DVL8	ZYMMA	36%	37%
P0DJA2	ZYMMO	36%	37%
P37686	ECOLI	36%	37%
Q09669	SCHPO	37%	33%