Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGP8_LEIMA

TriTrypDb:

LmjF.12.0440 , LMJLV39_120009900 , LMJSD75_120009700 , LMJSD75_120009800

Length:

710

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.802
CLV_C14_Caspase3-7	322	326	PF00656	0.725
CLV_C14_Caspase3-7	390	394	PF00656	0.702
CLV_C14_Caspase3-7	423	427	PF00656	0.742
CLV_C14_Caspase3-7	543	547	PF00656	0.515
CLV_NRD_NRD_1	138	140	PF00675	0.548
CLV_NRD_NRD_1	141	143	PF00675	0.563
CLV_NRD_NRD_1	334	336	PF00675	0.720
CLV_NRD_NRD_1	419	421	PF00675	0.625
CLV_NRD_NRD_1	464	466	PF00675	0.623
CLV_NRD_NRD_1	469	471	PF00675	0.639
CLV_NRD_NRD_1	530	532	PF00675	0.482
CLV_NRD_NRD_1	567	569	PF00675	0.653
CLV_NRD_NRD_1	66	68	PF00675	0.629
CLV_NRD_NRD_1	684	686	PF00675	0.657
CLV_NRD_NRD_1	688	690	PF00675	0.644
CLV_NRD_NRD_1	703	705	PF00675	0.628
CLV_PCSK_FUR_1	460	464	PF00082	0.632
CLV_PCSK_FUR_1	685	689	PF00082	0.757
CLV_PCSK_KEX2_1	137	139	PF00082	0.537
CLV_PCSK_KEX2_1	334	336	PF00082	0.720
CLV_PCSK_KEX2_1	419	421	PF00082	0.625
CLV_PCSK_KEX2_1	460	462	PF00082	0.632
CLV_PCSK_KEX2_1	463	465	PF00082	0.638
CLV_PCSK_KEX2_1	469	471	PF00082	0.651
CLV_PCSK_KEX2_1	529	531	PF00082	0.476
CLV_PCSK_KEX2_1	567	569	PF00082	0.663
CLV_PCSK_KEX2_1	65	67	PF00082	0.632
CLV_PCSK_KEX2_1	686	688	PF00082	0.661
CLV_PCSK_KEX2_1	703	705	PF00082	0.703
CLV_PCSK_KEX2_1	75	77	PF00082	0.576
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.632
CLV_PCSK_PC1ET2_1	686	688	PF00082	0.661
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.576
CLV_PCSK_PC7_1	134	140	PF00082	0.530
CLV_PCSK_PC7_1	460	466	PF00082	0.627
CLV_PCSK_PC7_1	62	68	PF00082	0.511
CLV_PCSK_SKI1_1	118	122	PF00082	0.403
CLV_PCSK_SKI1_1	447	451	PF00082	0.677
CLV_PCSK_SKI1_1	517	521	PF00082	0.541
CLV_PCSK_SKI1_1	62	66	PF00082	0.637
CLV_PCSK_SKI1_1	704	708	PF00082	0.632
DEG_APCC_DBOX_1	528	536	PF00400	0.551
DEG_COP1_1	152	162	PF00400	0.539
DEG_SCF_FBW7_1	288	294	PF00400	0.714
DEG_SPOP_SBC_1	220	224	PF00917	0.503
DEG_SPOP_SBC_1	507	511	PF00917	0.707
DOC_CDC14_PxL_1	176	184	PF14671	0.614
DOC_CDC14_PxL_1	624	632	PF14671	0.591
DOC_CKS1_1	288	293	PF01111	0.712
DOC_CYCLIN_yCln2_LP_2	162	168	PF00134	0.529
DOC_MAPK_gen_1	373	380	PF00069	0.616
DOC_PP2B_LxvP_1	162	165	PF13499	0.527
DOC_USP7_MATH_1	146	150	PF00917	0.660
DOC_USP7_MATH_1	263	267	PF00917	0.687
DOC_USP7_MATH_1	291	295	PF00917	0.813
DOC_USP7_MATH_1	339	343	PF00917	0.666
DOC_USP7_MATH_1	505	509	PF00917	0.809
DOC_USP7_MATH_1	522	526	PF00917	0.447
DOC_USP7_MATH_1	586	590	PF00917	0.710
DOC_USP7_MATH_1	651	655	PF00917	0.702
DOC_USP7_MATH_1	93	97	PF00917	0.604
DOC_WW_Pin1_4	180	185	PF00397	0.468
DOC_WW_Pin1_4	214	219	PF00397	0.668
DOC_WW_Pin1_4	287	292	PF00397	0.821
DOC_WW_Pin1_4	293	298	PF00397	0.766
DOC_WW_Pin1_4	337	342	PF00397	0.823
DOC_WW_Pin1_4	385	390	PF00397	0.606
DOC_WW_Pin1_4	449	454	PF00397	0.741
DOC_WW_Pin1_4	503	508	PF00397	0.717
DOC_WW_Pin1_4	51	56	PF00397	0.528
DOC_WW_Pin1_4	512	517	PF00397	0.576
DOC_WW_Pin1_4	533	538	PF00397	0.612
DOC_WW_Pin1_4	607	612	PF00397	0.740
DOC_WW_Pin1_4	667	672	PF00397	0.706
DOC_WW_Pin1_4	89	94	PF00397	0.512
DOC_WW_Pin1_4	95	100	PF00397	0.544
LIG_14-3-3_CanoR_1	305	313	PF00244	0.685
LIG_14-3-3_CanoR_1	363	367	PF00244	0.758
LIG_14-3-3_CanoR_1	436	441	PF00244	0.534
LIG_14-3-3_CanoR_1	447	452	PF00244	0.676
LIG_14-3-3_CanoR_1	540	548	PF00244	0.494
LIG_14-3-3_CanoR_1	594	599	PF00244	0.665
LIG_14-3-3_CanoR_1	603	608	PF00244	0.717
LIG_14-3-3_CanoR_1	79	87	PF00244	0.581
LIG_Actin_WH2_2	525	542	PF00022	0.465
LIG_APCC_ABBA_1	440	445	PF00400	0.695
LIG_BRCT_BRCA1_1	22	26	PF00533	0.438
LIG_BRCT_BRCA1_1	313	317	PF00533	0.625
LIG_BRCT_BRCA1_1	341	345	PF00533	0.749
LIG_BRCT_BRCA1_1	603	607	PF00533	0.823
LIG_BRCT_BRCA1_1	93	97	PF00533	0.621
LIG_deltaCOP1_diTrp_1	310	317	PF00928	0.682
LIG_FHA_1	14	20	PF00498	0.458
LIG_FHA_1	253	259	PF00498	0.675
LIG_FHA_1	516	522	PF00498	0.566
LIG_FHA_1	534	540	PF00498	0.483
LIG_FHA_1	618	624	PF00498	0.754
LIG_FHA_2	305	311	PF00498	0.706
LIG_FHA_2	320	326	PF00498	0.551
LIG_FHA_2	346	352	PF00498	0.593
LIG_FHA_2	397	403	PF00498	0.636
LIG_FHA_2	541	547	PF00498	0.496
LIG_FHA_2	641	647	PF00498	0.575
LIG_LIR_Gen_1	105	116	PF02991	0.422
LIG_LIR_Gen_1	15	22	PF02991	0.440
LIG_LIR_Gen_1	23	34	PF02991	0.455
LIG_LIR_Gen_1	348	357	PF02991	0.558
LIG_LIR_Nem_3	105	111	PF02991	0.448
LIG_LIR_Nem_3	15	20	PF02991	0.445
LIG_LIR_Nem_3	226	231	PF02991	0.464
LIG_LIR_Nem_3	23	29	PF02991	0.452
LIG_LIR_Nem_3	314	320	PF02991	0.701
LIG_LIR_Nem_3	348	352	PF02991	0.604
LIG_LIR_Nem_3	4	9	PF02991	0.424
LIG_MYND_1	180	184	PF01753	0.587
LIG_NRBOX	187	193	PF00104	0.531
LIG_NRBOX	4	10	PF00104	0.472
LIG_Pex14_2	345	349	PF04695	0.746
LIG_SH2_CRK	108	112	PF00017	0.404
LIG_SH2_STAT3	451	454	PF00017	0.743
LIG_SH2_STAT5	231	234	PF00017	0.433
LIG_SH3_1	285	291	PF00018	0.720
LIG_SH3_3	16	22	PF00018	0.448
LIG_SH3_3	257	263	PF00018	0.753
LIG_SH3_3	285	291	PF00018	0.720
LIG_SH3_3	435	441	PF00018	0.551
LIG_SH3_3	510	516	PF00018	0.650
LIG_SH3_3	596	602	PF00018	0.617
LIG_SH3_3	608	614	PF00018	0.620
LIG_SH3_3	644	650	PF00018	0.701
LIG_SUMO_SIM_anti_2	362	371	PF11976	0.576
LIG_TRAF2_1	348	351	PF00917	0.597
LIG_WW_3	296	300	PF00397	0.601
LIG_WW_3	600	604	PF00397	0.581
MOD_CDK_SPK_2	512	517	PF00069	0.739
MOD_CDK_SPxK_1	293	299	PF00069	0.599
MOD_CDK_SPxxK_3	533	540	PF00069	0.595
MOD_CK1_1	100	106	PF00069	0.589
MOD_CK1_1	250	256	PF00069	0.754
MOD_CK1_1	279	285	PF00069	0.662
MOD_CK1_1	362	368	PF00069	0.574
MOD_CK1_1	508	514	PF00069	0.700
MOD_CK1_1	515	521	PF00069	0.518
MOD_CK1_1	57	63	PF00069	0.551
MOD_CK1_1	580	586	PF00069	0.648
MOD_CK1_1	670	676	PF00069	0.745
MOD_CK1_1	91	97	PF00069	0.692
MOD_CK2_1	146	152	PF00069	0.628
MOD_CK2_1	304	310	PF00069	0.768
MOD_CK2_1	345	351	PF00069	0.601
MOD_CK2_1	396	402	PF00069	0.656
MOD_CK2_1	640	646	PF00069	0.572
MOD_Cter_Amidation	417	420	PF01082	0.598
MOD_DYRK1A_RPxSP_1	287	291	PF00069	0.714
MOD_GlcNHglycan	148	151	PF01048	0.662
MOD_GlcNHglycan	159	162	PF01048	0.598
MOD_GlcNHglycan	205	208	PF01048	0.629
MOD_GlcNHglycan	249	252	PF01048	0.801
MOD_GlcNHglycan	278	281	PF01048	0.697
MOD_GlcNHglycan	313	316	PF01048	0.641
MOD_GlcNHglycan	329	332	PF01048	0.620
MOD_GlcNHglycan	341	344	PF01048	0.675
MOD_GlcNHglycan	384	388	PF01048	0.708
MOD_GlcNHglycan	426	430	PF01048	0.721
MOD_GlcNHglycan	432	435	PF01048	0.516
MOD_GlcNHglycan	603	606	PF01048	0.821
MOD_GlcNHglycan	81	84	PF01048	0.573
MOD_GlcNHglycan	99	102	PF01048	0.625
MOD_GSK3_1	146	153	PF00069	0.659
MOD_GSK3_1	199	206	PF00069	0.616
MOD_GSK3_1	219	226	PF00069	0.554
MOD_GSK3_1	246	253	PF00069	0.600
MOD_GSK3_1	258	265	PF00069	0.631
MOD_GSK3_1	276	283	PF00069	0.737
MOD_GSK3_1	287	294	PF00069	0.714
MOD_GSK3_1	319	326	PF00069	0.684
MOD_GSK3_1	362	369	PF00069	0.738
MOD_GSK3_1	50	57	PF00069	0.563
MOD_GSK3_1	503	510	PF00069	0.686
MOD_GSK3_1	601	608	PF00069	0.771
MOD_GSK3_1	615	622	PF00069	0.612
MOD_GSK3_1	87	94	PF00069	0.694
MOD_N-GLC_1	263	268	PF02516	0.739
MOD_N-GLC_1	412	417	PF02516	0.588
MOD_N-GLC_1	577	582	PF02516	0.669
MOD_N-GLC_2	401	403	PF02516	0.533
MOD_NEK2_1	1	6	PF00069	0.439
MOD_NEK2_1	313	318	PF00069	0.693
MOD_NEK2_1	323	328	PF00069	0.630
MOD_NEK2_1	520	525	PF00069	0.440
MOD_NEK2_1	539	544	PF00069	0.478
MOD_NEK2_1	81	86	PF00069	0.579
MOD_OFUCOSY	25	32	PF10250	0.459
MOD_PIKK_1	520	526	PF00454	0.446
MOD_PKA_1	463	469	PF00069	0.582
MOD_PKA_2	304	310	PF00069	0.650
MOD_PKA_2	362	368	PF00069	0.587
MOD_PKA_2	463	469	PF00069	0.582
MOD_PKA_2	539	545	PF00069	0.487
MOD_PKA_2	552	558	PF00069	0.590
MOD_PKA_2	593	599	PF00069	0.776
MOD_PKB_1	201	209	PF00069	0.541
MOD_PKB_1	461	469	PF00069	0.638
MOD_Plk_1	112	118	PF00069	0.387
MOD_Plk_1	220	226	PF00069	0.458
MOD_Plk_1	263	269	PF00069	0.742
MOD_Plk_1	412	418	PF00069	0.634
MOD_Plk_1	577	583	PF00069	0.631
MOD_Plk_2-3	376	382	PF00069	0.570
MOD_Plk_4	1	7	PF00069	0.474
MOD_Plk_4	112	118	PF00069	0.387
MOD_Plk_4	120	126	PF00069	0.411
MOD_Plk_4	263	269	PF00069	0.711
MOD_Plk_4	412	418	PF00069	0.571
MOD_Plk_4	619	625	PF00069	0.627
MOD_ProDKin_1	180	186	PF00069	0.466
MOD_ProDKin_1	214	220	PF00069	0.662
MOD_ProDKin_1	287	293	PF00069	0.821
MOD_ProDKin_1	337	343	PF00069	0.823
MOD_ProDKin_1	385	391	PF00069	0.606
MOD_ProDKin_1	449	455	PF00069	0.739
MOD_ProDKin_1	503	509	PF00069	0.716
MOD_ProDKin_1	51	57	PF00069	0.529
MOD_ProDKin_1	512	518	PF00069	0.568
MOD_ProDKin_1	533	539	PF00069	0.601
MOD_ProDKin_1	607	613	PF00069	0.739
MOD_ProDKin_1	667	673	PF00069	0.704
MOD_ProDKin_1	89	95	PF00069	0.517
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.472
TRG_DiLeu_BaLyEn_6	534	539	PF01217	0.598
TRG_ENDOCYTIC_2	108	111	PF00928	0.411
TRG_ER_diArg_1	137	139	PF00400	0.552
TRG_ER_diArg_1	201	204	PF00400	0.535
TRG_ER_diArg_1	285	288	PF00400	0.724
TRG_ER_diArg_1	419	422	PF00400	0.632
TRG_ER_diArg_1	460	463	PF00400	0.647
TRG_ER_diArg_1	528	531	PF00400	0.460
TRG_ER_diArg_1	567	569	PF00400	0.756
TRG_ER_diArg_1	66	68	PF00400	0.629
TRG_ER_diArg_1	685	688	PF00400	0.760
TRG_NLS_Bipartite_1	685	704	PF00514	0.642
TRG_NLS_MonoCore_2	685	690	PF00514	0.756
TRG_NLS_MonoExtC_3	138	143	PF00514	0.586
TRG_NLS_MonoExtC_3	698	703	PF00514	0.746
TRG_NLS_MonoExtN_4	137	143	PF00514	0.523
TRG_NLS_MonoExtN_4	62	69	PF00514	0.509
TRG_NLS_MonoExtN_4	685	690	PF00514	0.657
TRG_NLS_MonoExtN_4	699	704	PF00514	0.681
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2D5	Leptomonas seymouri	37%	100%
A0A3S7WRY8	Leishmania donovani	87%	100%
A4H6V9	Leishmania braziliensis	68%	98%
E9AGD2	Leishmania infantum	87%	100%
E9ANX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%