Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QGP6_LEIMA

TriTrypDb:

LmjF.12.0460 , LMJLV39_120010100 , LMJSD75_120010000

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.655
CLV_C14_Caspase3-7	279	283	PF00656	0.719
CLV_C14_Caspase3-7	389	393	PF00656	0.680
CLV_C14_Caspase3-7	461	465	PF00656	0.551
CLV_C14_Caspase3-7	546	550	PF00656	0.672
CLV_C14_Caspase3-7	707	711	PF00656	0.809
CLV_NRD_NRD_1	106	108	PF00675	0.790
CLV_NRD_NRD_1	252	254	PF00675	0.752
CLV_NRD_NRD_1	367	369	PF00675	0.786
CLV_NRD_NRD_1	596	598	PF00675	0.715
CLV_NRD_NRD_1	614	616	PF00675	0.502
CLV_NRD_NRD_1	685	687	PF00675	0.705
CLV_PCSK_KEX2_1	106	108	PF00082	0.785
CLV_PCSK_KEX2_1	252	254	PF00082	0.750
CLV_PCSK_KEX2_1	366	368	PF00082	0.794
CLV_PCSK_KEX2_1	596	598	PF00082	0.715
CLV_PCSK_KEX2_1	685	687	PF00082	0.705
CLV_PCSK_PC7_1	248	254	PF00082	0.737
CLV_PCSK_PC7_1	592	598	PF00082	0.706
CLV_PCSK_SKI1_1	110	114	PF00082	0.784
CLV_PCSK_SKI1_1	60	64	PF00082	0.757
CLV_PCSK_SKI1_1	638	642	PF00082	0.670
DEG_APCC_DBOX_1	621	629	PF00400	0.553
DEG_Kelch_Keap1_1	502	507	PF01344	0.757
DEG_Nend_UBRbox_3	1	3	PF02207	0.745
DEG_SCF_FBW7_1	474	481	PF00400	0.750
DEG_SPOP_SBC_1	422	426	PF00917	0.562
DEG_SPOP_SBC_1	694	698	PF00917	0.710
DEG_SPOP_SBC_1	96	100	PF00917	0.737
DOC_ANK_TNKS_1	595	602	PF00023	0.640
DOC_CDC14_PxL_1	187	195	PF14671	0.747
DOC_CKS1_1	144	149	PF01111	0.701
DOC_CKS1_1	475	480	PF01111	0.787
DOC_CYCLIN_RxL_1	106	115	PF00134	0.733
DOC_CYCLIN_yClb3_PxF_3	259	265	PF00134	0.718
DOC_CYCLIN_yCln2_LP_2	209	212	PF00134	0.637
DOC_MAPK_gen_1	106	113	PF00069	0.783
DOC_MAPK_gen_1	635	643	PF00069	0.562
DOC_MAPK_gen_1	758	765	PF00069	0.698
DOC_MAPK_JIP1_4	107	113	PF00069	0.734
DOC_PP2B_LxvP_1	198	201	PF13499	0.805
DOC_PP2B_LxvP_1	209	212	PF13499	0.644
DOC_PP2B_LxvP_1	257	260	PF13499	0.576
DOC_PP2B_LxvP_1	528	531	PF13499	0.779
DOC_PP4_FxxP_1	265	268	PF00568	0.808
DOC_PP4_FxxP_1	4	7	PF00568	0.652
DOC_USP7_MATH_1	112	116	PF00917	0.811
DOC_USP7_MATH_1	122	126	PF00917	0.698
DOC_USP7_MATH_1	153	157	PF00917	0.707
DOC_USP7_MATH_1	169	173	PF00917	0.591
DOC_USP7_MATH_1	201	205	PF00917	0.772
DOC_USP7_MATH_1	413	417	PF00917	0.597
DOC_USP7_MATH_1	478	482	PF00917	0.651
DOC_USP7_MATH_1	488	492	PF00917	0.707
DOC_USP7_MATH_1	520	524	PF00917	0.698
DOC_USP7_MATH_1	633	637	PF00917	0.600
DOC_USP7_MATH_1	664	668	PF00917	0.587
DOC_USP7_MATH_1	73	77	PF00917	0.800
DOC_USP7_MATH_1	741	745	PF00917	0.779
DOC_USP7_MATH_1	746	750	PF00917	0.772
DOC_USP7_MATH_1	761	765	PF00917	0.514
DOC_USP7_MATH_1	91	95	PF00917	0.604
DOC_WW_Pin1_4	140	145	PF00397	0.828
DOC_WW_Pin1_4	246	251	PF00397	0.779
DOC_WW_Pin1_4	259	264	PF00397	0.749
DOC_WW_Pin1_4	26	31	PF00397	0.748
DOC_WW_Pin1_4	270	275	PF00397	0.733
DOC_WW_Pin1_4	282	287	PF00397	0.586
DOC_WW_Pin1_4	293	298	PF00397	0.622
DOC_WW_Pin1_4	299	304	PF00397	0.610
DOC_WW_Pin1_4	306	311	PF00397	0.623
DOC_WW_Pin1_4	398	403	PF00397	0.804
DOC_WW_Pin1_4	426	431	PF00397	0.792
DOC_WW_Pin1_4	432	437	PF00397	0.708
DOC_WW_Pin1_4	44	49	PF00397	0.613
DOC_WW_Pin1_4	474	479	PF00397	0.839
DOC_WW_Pin1_4	515	520	PF00397	0.594
DOC_WW_Pin1_4	695	700	PF00397	0.694
DOC_WW_Pin1_4	713	718	PF00397	0.674
DOC_WW_Pin1_4	97	102	PF00397	0.741
LIG_14-3-3_CanoR_1	185	191	PF00244	0.824
LIG_14-3-3_CanoR_1	19	27	PF00244	0.694
LIG_14-3-3_CanoR_1	192	198	PF00244	0.795
LIG_14-3-3_CanoR_1	231	236	PF00244	0.815
LIG_14-3-3_CanoR_1	252	257	PF00244	0.726
LIG_14-3-3_CanoR_1	332	340	PF00244	0.807
LIG_14-3-3_CanoR_1	366	372	PF00244	0.783
LIG_14-3-3_CanoR_1	405	414	PF00244	0.752
LIG_14-3-3_CanoR_1	441	449	PF00244	0.771
LIG_14-3-3_CanoR_1	450	456	PF00244	0.629
LIG_14-3-3_CanoR_1	60	67	PF00244	0.787
LIG_14-3-3_CanoR_1	673	682	PF00244	0.694
LIG_14-3-3_CanoR_1	686	692	PF00244	0.594
LIG_14-3-3_CanoR_1	740	750	PF00244	0.653
LIG_14-3-3_CanoR_1	758	764	PF00244	0.675
LIG_BIR_III_2	152	156	PF00653	0.582
LIG_BIR_III_2	663	667	PF00653	0.648
LIG_BIR_III_4	224	228	PF00653	0.581
LIG_BRCT_BRCA1_1	261	265	PF00533	0.616
LIG_BRCT_BRCA1_1	297	301	PF00533	0.669
LIG_BRCT_BRCA1_1	725	729	PF00533	0.710
LIG_BRCT_BRCA1_1	761	765	PF00533	0.698
LIG_BRCT_BRCA1_2	725	731	PF00533	0.708
LIG_EVH1_1	210	214	PF00568	0.632
LIG_EVH1_1	257	261	PF00568	0.574
LIG_FHA_1	204	210	PF00498	0.709
LIG_FHA_1	23	29	PF00498	0.716
LIG_FHA_1	232	238	PF00498	0.719
LIG_FHA_1	522	528	PF00498	0.674
LIG_FHA_1	56	62	PF00498	0.612
LIG_FHA_1	655	661	PF00498	0.764
LIG_FHA_2	688	694	PF00498	0.773
LIG_FHA_2	698	704	PF00498	0.718
LIG_GSK3_LRP6_1	259	264	PF00069	0.609
LIG_LIR_Apic_2	262	268	PF02991	0.630
LIG_LIR_Apic_2	3	7	PF02991	0.649
LIG_LIR_Apic_2	429	434	PF02991	0.790
LIG_LIR_Apic_2	539	545	PF02991	0.735
LIG_LIR_Apic_2	619	624	PF02991	0.684
LIG_LIR_Gen_1	523	532	PF02991	0.567
LIG_LIR_Nem_3	298	304	PF02991	0.681
LIG_LIR_Nem_3	523	528	PF02991	0.678
LIG_MYND_1	101	105	PF01753	0.735
LIG_MYND_1	310	314	PF01753	0.554
LIG_SH2_CRK	431	435	PF00017	0.798
LIG_SH2_CRK	525	529	PF00017	0.686
LIG_SH2_NCK_1	431	435	PF00017	0.798
LIG_SH2_STAP1	288	292	PF00017	0.761
LIG_SH2_STAP1	451	455	PF00017	0.654
LIG_SH2_STAP1	772	776	PF00017	0.713
LIG_SH2_STAT5	371	374	PF00017	0.763
LIG_SH2_STAT5	431	434	PF00017	0.763
LIG_SH2_STAT5	566	569	PF00017	0.485
LIG_SH3_2	101	106	PF14604	0.737
LIG_SH3_2	630	635	PF14604	0.547
LIG_SH3_3	116	122	PF00018	0.580
LIG_SH3_3	141	147	PF00018	0.738
LIG_SH3_3	208	214	PF00018	0.784
LIG_SH3_3	24	30	PF00018	0.730
LIG_SH3_3	253	259	PF00018	0.789
LIG_SH3_3	265	271	PF00018	0.708
LIG_SH3_3	305	311	PF00018	0.588
LIG_SH3_3	353	359	PF00018	0.680
LIG_SH3_3	516	522	PF00018	0.560
LIG_SH3_3	542	548	PF00018	0.529
LIG_SH3_3	627	633	PF00018	0.601
LIG_SH3_3	711	717	PF00018	0.728
LIG_SH3_3	747	753	PF00018	0.734
LIG_SH3_3	98	104	PF00018	0.711
LIG_SUMO_SIM_par_1	233	238	PF11976	0.574
LIG_SUMO_SIM_par_1	639	645	PF11976	0.738
LIG_TRAF2_1	779	782	PF00917	0.663
LIG_WRC_WIRS_1	1	6	PF05994	0.656
LIG_WRC_WIRS_1	378	383	PF05994	0.699
LIG_WW_3	103	107	PF00397	0.736
MOD_CDC14_SPxK_1	249	252	PF00782	0.765
MOD_CDK_SPxK_1	246	252	PF00069	0.764
MOD_CDK_SPxK_1	695	701	PF00069	0.618
MOD_CDK_SPxxK_3	246	253	PF00069	0.698
MOD_CDK_SPxxK_3	398	405	PF00069	0.732
MOD_CDK_SPxxK_3	713	720	PF00069	0.684
MOD_CK1_1	138	144	PF00069	0.738
MOD_CK1_1	18	24	PF00069	0.727
MOD_CK1_1	246	252	PF00069	0.823
MOD_CK1_1	293	299	PF00069	0.769
MOD_CK1_1	302	308	PF00069	0.661
MOD_CK1_1	37	43	PF00069	0.559
MOD_CK1_1	370	376	PF00069	0.800
MOD_CK1_1	406	412	PF00069	0.739
MOD_CK1_1	435	441	PF00069	0.623
MOD_CK1_1	476	482	PF00069	0.790
MOD_CK1_1	649	655	PF00069	0.780
MOD_CK1_1	697	703	PF00069	0.828
MOD_CK1_1	759	765	PF00069	0.770
MOD_CK1_1	768	774	PF00069	0.592
MOD_CK1_1	87	93	PF00069	0.718
MOD_CK2_1	220	226	PF00069	0.750
MOD_CK2_1	687	693	PF00069	0.769
MOD_CK2_1	697	703	PF00069	0.721
MOD_CK2_1	713	719	PF00069	0.651
MOD_CK2_1	739	745	PF00069	0.805
MOD_DYRK1A_RPxSP_1	26	30	PF00069	0.568
MOD_GlcNHglycan	114	117	PF01048	0.814
MOD_GlcNHglycan	129	132	PF01048	0.643
MOD_GlcNHglycan	198	201	PF01048	0.756
MOD_GlcNHglycan	21	24	PF01048	0.532
MOD_GlcNHglycan	237	240	PF01048	0.690
MOD_GlcNHglycan	340	343	PF01048	0.750
MOD_GlcNHglycan	372	375	PF01048	0.702
MOD_GlcNHglycan	415	418	PF01048	0.789
MOD_GlcNHglycan	426	429	PF01048	0.754
MOD_GlcNHglycan	443	446	PF01048	0.656
MOD_GlcNHglycan	464	468	PF01048	0.691
MOD_GlcNHglycan	490	493	PF01048	0.783
MOD_GlcNHglycan	617	621	PF01048	0.691
MOD_GlcNHglycan	648	651	PF01048	0.707
MOD_GlcNHglycan	7	10	PF01048	0.723
MOD_GlcNHglycan	724	728	PF01048	0.777
MOD_GlcNHglycan	730	734	PF01048	0.702
MOD_GlcNHglycan	89	92	PF01048	0.603
MOD_GSK3_1	11	18	PF00069	0.700
MOD_GSK3_1	22	29	PF00069	0.619
MOD_GSK3_1	231	238	PF00069	0.773
MOD_GSK3_1	240	247	PF00069	0.690
MOD_GSK3_1	270	277	PF00069	0.721
MOD_GSK3_1	282	289	PF00069	0.745
MOD_GSK3_1	295	302	PF00069	0.617
MOD_GSK3_1	306	313	PF00069	0.647
MOD_GSK3_1	334	341	PF00069	0.667
MOD_GSK3_1	346	353	PF00069	0.707
MOD_GSK3_1	366	373	PF00069	0.756
MOD_GSK3_1	377	384	PF00069	0.633
MOD_GSK3_1	405	412	PF00069	0.748
MOD_GSK3_1	422	429	PF00069	0.763
MOD_GSK3_1	432	439	PF00069	0.668
MOD_GSK3_1	450	457	PF00069	0.553
MOD_GSK3_1	459	466	PF00069	0.697
MOD_GSK3_1	474	481	PF00069	0.810
MOD_GSK3_1	488	495	PF00069	0.626
MOD_GSK3_1	51	58	PF00069	0.712
MOD_GSK3_1	526	533	PF00069	0.728
MOD_GSK3_1	534	541	PF00069	0.585
MOD_GSK3_1	61	68	PF00069	0.715
MOD_GSK3_1	645	652	PF00069	0.773
MOD_GSK3_1	693	700	PF00069	0.615
MOD_GSK3_1	73	80	PF00069	0.603
MOD_GSK3_1	761	768	PF00069	0.759
MOD_GSK3_1	86	93	PF00069	0.699
MOD_GSK3_1	95	102	PF00069	0.690
MOD_N-GLC_1	127	132	PF02516	0.791
MOD_N-GLC_1	282	287	PF02516	0.780
MOD_N-GLC_1	406	411	PF02516	0.739
MOD_NEK2_1	11	16	PF00069	0.613
MOD_NEK2_1	235	240	PF00069	0.698
MOD_NEK2_1	244	249	PF00069	0.647
MOD_NEK2_1	347	352	PF00069	0.678
MOD_NEK2_1	377	382	PF00069	0.751
MOD_NEK2_1	403	408	PF00069	0.823
MOD_NEK2_1	423	428	PF00069	0.629
MOD_NEK2_1	674	679	PF00069	0.657
MOD_NEK2_1	729	734	PF00069	0.684
MOD_NEK2_1	765	770	PF00069	0.672
MOD_PIKK_1	302	308	PF00454	0.628
MOD_PIKK_1	436	442	PF00454	0.611
MOD_PIKK_1	476	482	PF00454	0.749
MOD_PIKK_1	687	693	PF00454	0.734
MOD_PIKK_1	734	740	PF00454	0.791
MOD_PIKK_1	77	83	PF00454	0.601
MOD_PK_1	252	258	PF00069	0.706
MOD_PK_1	334	340	PF00069	0.593
MOD_PKA_1	252	258	PF00069	0.739
MOD_PKA_1	366	372	PF00069	0.783
MOD_PKA_1	685	691	PF00069	0.730
MOD_PKA_2	18	24	PF00069	0.710
MOD_PKA_2	191	197	PF00069	0.747
MOD_PKA_2	252	258	PF00069	0.730
MOD_PKA_2	322	328	PF00069	0.730
MOD_PKA_2	366	372	PF00069	0.783
MOD_PKA_2	409	415	PF00069	0.780
MOD_PKA_2	685	691	PF00069	0.800
MOD_PKA_2	739	745	PF00069	0.805
MOD_PKA_2	759	765	PF00069	0.490
MOD_PKB_1	332	340	PF00069	0.597
MOD_PKB_1	441	449	PF00069	0.705
MOD_Plk_1	538	544	PF00069	0.669
MOD_Plk_1	616	622	PF00069	0.677
MOD_Plk_1	654	660	PF00069	0.572
MOD_Plk_1	723	729	PF00069	0.774
MOD_Plk_2-3	160	166	PF00069	0.744
MOD_Plk_2-3	459	465	PF00069	0.551
MOD_Plk_4	252	258	PF00069	0.599
MOD_Plk_4	367	373	PF00069	0.821
MOD_Plk_4	451	457	PF00069	0.650
MOD_Plk_4	538	544	PF00069	0.677
MOD_Plk_4	551	557	PF00069	0.565
MOD_Plk_4	761	767	PF00069	0.693
MOD_ProDKin_1	140	146	PF00069	0.829
MOD_ProDKin_1	246	252	PF00069	0.783
MOD_ProDKin_1	259	265	PF00069	0.752
MOD_ProDKin_1	26	32	PF00069	0.749
MOD_ProDKin_1	270	276	PF00069	0.735
MOD_ProDKin_1	282	288	PF00069	0.692
MOD_ProDKin_1	293	299	PF00069	0.619
MOD_ProDKin_1	306	312	PF00069	0.624
MOD_ProDKin_1	398	404	PF00069	0.800
MOD_ProDKin_1	426	432	PF00069	0.793
MOD_ProDKin_1	44	50	PF00069	0.614
MOD_ProDKin_1	474	480	PF00069	0.840
MOD_ProDKin_1	515	521	PF00069	0.595
MOD_ProDKin_1	695	701	PF00069	0.695
MOD_ProDKin_1	713	719	PF00069	0.671
MOD_ProDKin_1	97	103	PF00069	0.741
MOD_SUMO_rev_2	644	649	PF00179	0.649
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.604
TRG_ENDOCYTIC_2	525	528	PF00928	0.688
TRG_ER_diArg_1	105	107	PF00400	0.784
TRG_ER_diArg_1	366	368	PF00400	0.689
TRG_ER_diArg_1	595	597	PF00400	0.696
TRG_ER_diArg_1	684	686	PF00400	0.704
TRG_ER_diArg_1	757	760	PF00400	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9B3	Leishmania donovani	83%	100%
A4H707	Leishmania braziliensis	56%	100%
E9AGD4	Leishmania infantum	83%	100%
E9ANX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%