Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QGP5_LEIMA

TriTrypDb:

LmjF.12.0470 , LMJLV39_120010200 , LMJSD75_120010100

Length:

751

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGP5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.674
CLV_C14_Caspase3-7	226	230	PF00656	0.609
CLV_NRD_NRD_1	148	150	PF00675	0.650
CLV_NRD_NRD_1	180	182	PF00675	0.704
CLV_NRD_NRD_1	183	185	PF00675	0.699
CLV_NRD_NRD_1	194	196	PF00675	0.544
CLV_NRD_NRD_1	241	243	PF00675	0.666
CLV_NRD_NRD_1	371	373	PF00675	0.595
CLV_NRD_NRD_1	442	444	PF00675	0.648
CLV_NRD_NRD_1	459	461	PF00675	0.680
CLV_PCSK_FUR_1	181	185	PF00082	0.660
CLV_PCSK_KEX2_1	180	182	PF00082	0.706
CLV_PCSK_KEX2_1	183	185	PF00082	0.697
CLV_PCSK_KEX2_1	194	196	PF00082	0.542
CLV_PCSK_KEX2_1	240	242	PF00082	0.675
CLV_PCSK_KEX2_1	371	373	PF00082	0.593
CLV_PCSK_KEX2_1	442	444	PF00082	0.698
CLV_PCSK_KEX2_1	459	461	PF00082	0.680
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.671
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.675
CLV_PCSK_PC7_1	237	243	PF00082	0.554
CLV_PCSK_SKI1_1	242	246	PF00082	0.660
CLV_PCSK_SKI1_1	429	433	PF00082	0.645
CLV_PCSK_SKI1_1	443	447	PF00082	0.547
CLV_PCSK_SKI1_1	493	497	PF00082	0.561
DEG_SCF_TRCP1_1	265	270	PF00400	0.686
DEG_SPOP_SBC_1	251	255	PF00917	0.560
DEG_SPOP_SBC_1	676	680	PF00917	0.570
DOC_CDC14_PxL_1	394	402	PF14671	0.528
DOC_CKS1_1	502	507	PF01111	0.620
DOC_CKS1_1	704	709	PF01111	0.687
DOC_CYCLIN_RxL_1	237	247	PF00134	0.621
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.567
DOC_MAPK_gen_1	149	159	PF00069	0.640
DOC_MAPK_HePTP_8	353	365	PF00069	0.591
DOC_MAPK_MEF2A_6	356	365	PF00069	0.593
DOC_MAPK_MEF2A_6	578	587	PF00069	0.646
DOC_PP2B_LxvP_1	396	399	PF13499	0.619
DOC_PP2B_LxvP_1	585	588	PF13499	0.632
DOC_USP7_MATH_1	109	113	PF00917	0.707
DOC_USP7_MATH_1	11	15	PF00917	0.640
DOC_USP7_MATH_1	176	180	PF00917	0.700
DOC_USP7_MATH_1	190	194	PF00917	0.546
DOC_USP7_MATH_1	20	24	PF00917	0.593
DOC_USP7_MATH_1	251	255	PF00917	0.705
DOC_USP7_MATH_1	263	267	PF00917	0.718
DOC_USP7_MATH_1	312	316	PF00917	0.663
DOC_USP7_MATH_1	495	499	PF00917	0.547
DOC_USP7_MATH_1	526	530	PF00917	0.654
DOC_USP7_MATH_1	537	541	PF00917	0.553
DOC_USP7_MATH_1	547	551	PF00917	0.532
DOC_USP7_MATH_1	557	561	PF00917	0.539
DOC_USP7_MATH_1	676	680	PF00917	0.661
DOC_USP7_MATH_1	722	726	PF00917	0.682
DOC_USP7_UBL2_3	146	150	PF12436	0.649
DOC_WW_Pin1_4	121	126	PF00397	0.633
DOC_WW_Pin1_4	131	136	PF00397	0.633
DOC_WW_Pin1_4	276	281	PF00397	0.714
DOC_WW_Pin1_4	365	370	PF00397	0.661
DOC_WW_Pin1_4	376	381	PF00397	0.613
DOC_WW_Pin1_4	399	404	PF00397	0.519
DOC_WW_Pin1_4	468	473	PF00397	0.600
DOC_WW_Pin1_4	501	506	PF00397	0.615
DOC_WW_Pin1_4	7	12	PF00397	0.600
DOC_WW_Pin1_4	703	708	PF00397	0.748
DOC_WW_Pin1_4	718	723	PF00397	0.513
LIG_14-3-3_CanoR_1	144	149	PF00244	0.642
LIG_14-3-3_CanoR_1	184	190	PF00244	0.679
LIG_14-3-3_CanoR_1	241	245	PF00244	0.604
LIG_14-3-3_CanoR_1	252	257	PF00244	0.595
LIG_14-3-3_CanoR_1	281	286	PF00244	0.657
LIG_14-3-3_CanoR_1	459	466	PF00244	0.700
LIG_14-3-3_CanoR_1	546	552	PF00244	0.652
LIG_14-3-3_CanoR_1	610	619	PF00244	0.568
LIG_14-3-3_CanoR_1	652	658	PF00244	0.658
LIG_AP2alpha_2	91	93	PF02296	0.638
LIG_BRCT_BRCA1_1	547	551	PF00533	0.616
LIG_CtBP_PxDLS_1	567	571	PF00389	0.640
LIG_DLG_GKlike_1	578	585	PF00625	0.567
LIG_EVH1_1	587	591	PF00568	0.540
LIG_FHA_1	208	214	PF00498	0.664
LIG_FHA_1	251	257	PF00498	0.580
LIG_FHA_1	356	362	PF00498	0.642
LIG_FHA_1	430	436	PF00498	0.644
LIG_FHA_1	531	537	PF00498	0.532
LIG_FHA_1	694	700	PF00498	0.694
LIG_FHA_1	735	741	PF00498	0.454
LIG_FHA_2	170	176	PF00498	0.658
LIG_FHA_2	224	230	PF00498	0.679
LIG_FHA_2	612	618	PF00498	0.544
LIG_FHA_2	94	100	PF00498	0.619
LIG_LIR_Gen_1	540	549	PF02991	0.628
LIG_LIR_Gen_1	659	668	PF02991	0.593
LIG_LIR_LC3C_4	662	667	PF02991	0.518
LIG_LIR_Nem_3	395	400	PF02991	0.550
LIG_LIR_Nem_3	540	544	PF02991	0.631
LIG_LIR_Nem_3	659	663	PF02991	0.588
LIG_LIR_Nem_3	717	723	PF02991	0.587
LIG_LYPXL_S_1	396	400	PF13949	0.547
LIG_LYPXL_yS_3	397	400	PF13949	0.541
LIG_MYND_3	391	395	PF01753	0.635
LIG_NRBOX	158	164	PF00104	0.554
LIG_NRBOX	85	91	PF00104	0.533
LIG_Pex14_2	551	555	PF04695	0.615
LIG_SH2_CRK	415	419	PF00017	0.554
LIG_SH2_GRB2like	603	606	PF00017	0.547
LIG_SH2_NCK_1	415	419	PF00017	0.528
LIG_SH2_STAP1	330	334	PF00017	0.702
LIG_SH2_STAT5	603	606	PF00017	0.650
LIG_SH3_3	203	209	PF00018	0.698
LIG_SH3_3	447	453	PF00018	0.555
LIG_SH3_3	546	552	PF00018	0.514
LIG_SH3_3	585	591	PF00018	0.550
LIG_SH3_3	605	611	PF00018	0.589
LIG_SH3_3	706	712	PF00018	0.639
LIG_SH3_3	716	722	PF00018	0.526
LIG_SUMO_SIM_anti_2	202	208	PF11976	0.614
LIG_SUMO_SIM_anti_2	696	703	PF11976	0.603
LIG_SUMO_SIM_par_1	357	362	PF11976	0.642
LIG_SUMO_SIM_par_1	430	438	PF11976	0.644
LIG_TRAF2_1	338	341	PF00917	0.660
LIG_TRAF2_1	405	408	PF00917	0.598
LIG_TRAF2_1	614	617	PF00917	0.649
LIG_WRC_WIRS_1	692	697	PF05994	0.640
LIG_WW_2	588	591	PF00397	0.531
MOD_CDK_SPK_2	276	281	PF00069	0.614
MOD_CDK_SPK_2	7	12	PF00069	0.600
MOD_CDK_SPxK_1	365	371	PF00069	0.637
MOD_CDK_SPxxK_3	121	128	PF00069	0.554
MOD_CDK_SPxxK_3	365	372	PF00069	0.562
MOD_CK1_1	114	120	PF00069	0.676
MOD_CK1_1	166	172	PF00069	0.632
MOD_CK1_1	188	194	PF00069	0.622
MOD_CK1_1	254	260	PF00069	0.675
MOD_CK1_1	266	272	PF00069	0.763
MOD_CK1_1	279	285	PF00069	0.618
MOD_CK1_1	288	294	PF00069	0.655
MOD_CK1_1	298	304	PF00069	0.533
MOD_CK1_1	321	327	PF00069	0.674
MOD_CK1_1	329	335	PF00069	0.651
MOD_CK1_1	355	361	PF00069	0.662
MOD_CK1_1	402	408	PF00069	0.517
MOD_CK1_1	455	461	PF00069	0.650
MOD_CK1_1	471	477	PF00069	0.520
MOD_CK1_1	486	492	PF00069	0.579
MOD_CK1_1	507	513	PF00069	0.698
MOD_CK1_1	529	535	PF00069	0.665
MOD_CK1_1	550	556	PF00069	0.551
MOD_CK1_1	569	575	PF00069	0.569
MOD_CK1_1	656	662	PF00069	0.623
MOD_CK1_1	708	714	PF00069	0.703
MOD_CK2_1	150	156	PF00069	0.652
MOD_CK2_1	169	175	PF00069	0.493
MOD_CK2_1	199	205	PF00069	0.696
MOD_CK2_1	376	382	PF00069	0.689
MOD_CK2_1	401	407	PF00069	0.623
MOD_CK2_1	537	543	PF00069	0.607
MOD_CK2_1	611	617	PF00069	0.542
MOD_CK2_1	676	682	PF00069	0.570
MOD_GlcNHglycan	105	108	PF01048	0.668
MOD_GlcNHglycan	111	114	PF01048	0.684
MOD_GlcNHglycan	118	121	PF01048	0.628
MOD_GlcNHglycan	125	128	PF01048	0.503
MOD_GlcNHglycan	152	155	PF01048	0.669
MOD_GlcNHglycan	22	25	PF01048	0.623
MOD_GlcNHglycan	265	268	PF01048	0.731
MOD_GlcNHglycan	291	294	PF01048	0.608
MOD_GlcNHglycan	376	379	PF01048	0.754
MOD_GlcNHglycan	418	421	PF01048	0.604
MOD_GlcNHglycan	473	476	PF01048	0.601
MOD_GlcNHglycan	480	483	PF01048	0.653
MOD_GlcNHglycan	509	512	PF01048	0.738
MOD_GlcNHglycan	528	531	PF01048	0.468
MOD_GlcNHglycan	555	558	PF01048	0.629
MOD_GlcNHglycan	559	562	PF01048	0.604
MOD_GlcNHglycan	563	566	PF01048	0.578
MOD_GlcNHglycan	649	652	PF01048	0.585
MOD_GlcNHglycan	737	740	PF01048	0.572
MOD_GSK3_1	105	112	PF00069	0.706
MOD_GSK3_1	144	151	PF00069	0.690
MOD_GSK3_1	15	22	PF00069	0.588
MOD_GSK3_1	162	169	PF00069	0.482
MOD_GSK3_1	184	191	PF00069	0.713
MOD_GSK3_1	219	226	PF00069	0.654
MOD_GSK3_1	240	247	PF00069	0.744
MOD_GSK3_1	250	257	PF00069	0.643
MOD_GSK3_1	263	270	PF00069	0.823
MOD_GSK3_1	279	286	PF00069	0.544
MOD_GSK3_1	291	298	PF00069	0.622
MOD_GSK3_1	306	313	PF00069	0.675
MOD_GSK3_1	318	325	PF00069	0.669
MOD_GSK3_1	340	347	PF00069	0.796
MOD_GSK3_1	355	362	PF00069	0.532
MOD_GSK3_1	374	381	PF00069	0.611
MOD_GSK3_1	448	455	PF00069	0.673
MOD_GSK3_1	464	471	PF00069	0.624
MOD_GSK3_1	526	533	PF00069	0.691
MOD_GSK3_1	547	554	PF00069	0.616
MOD_GSK3_1	557	564	PF00069	0.581
MOD_GSK3_1	568	575	PF00069	0.554
MOD_GSK3_1	652	659	PF00069	0.644
MOD_GSK3_1	7	14	PF00069	0.673
MOD_GSK3_1	708	715	PF00069	0.671
MOD_GSK3_1	718	725	PF00069	0.473
MOD_LATS_1	287	293	PF00433	0.679
MOD_N-GLC_1	526	531	PF02516	0.594
MOD_N-GLC_2	274	276	PF02516	0.666
MOD_NEK2_1	105	110	PF00069	0.671
MOD_NEK2_1	162	167	PF00069	0.579
MOD_NEK2_1	2	7	PF00069	0.680
MOD_NEK2_1	283	288	PF00069	0.773
MOD_NEK2_1	31	36	PF00069	0.692
MOD_NEK2_1	359	364	PF00069	0.650
MOD_NEK2_1	477	482	PF00069	0.660
MOD_NEK2_1	583	588	PF00069	0.647
MOD_PIKK_1	29	35	PF00454	0.680
MOD_PIKK_1	458	464	PF00454	0.693
MOD_PKA_1	194	200	PF00069	0.659
MOD_PKA_1	240	246	PF00069	0.591
MOD_PKA_2	11	17	PF00069	0.594
MOD_PKA_2	148	154	PF00069	0.683
MOD_PKA_2	194	200	PF00069	0.659
MOD_PKA_2	240	246	PF00069	0.606
MOD_PKA_2	251	257	PF00069	0.598
MOD_PKA_2	294	300	PF00069	0.573
MOD_PKA_2	458	464	PF00069	0.703
MOD_PKA_2	545	551	PF00069	0.660
MOD_Plk_1	306	312	PF00069	0.656
MOD_Plk_1	429	435	PF00069	0.682
MOD_Plk_1	572	578	PF00069	0.544
MOD_Plk_1	591	597	PF00069	0.520
MOD_Plk_2-3	677	683	PF00069	0.554
MOD_Plk_4	244	250	PF00069	0.650
MOD_Plk_4	306	312	PF00069	0.723
MOD_Plk_4	355	361	PF00069	0.677
MOD_Plk_4	578	584	PF00069	0.670
MOD_Plk_4	722	728	PF00069	0.593
MOD_ProDKin_1	121	127	PF00069	0.628
MOD_ProDKin_1	131	137	PF00069	0.632
MOD_ProDKin_1	276	282	PF00069	0.715
MOD_ProDKin_1	365	371	PF00069	0.664
MOD_ProDKin_1	376	382	PF00069	0.614
MOD_ProDKin_1	399	405	PF00069	0.519
MOD_ProDKin_1	468	474	PF00069	0.601
MOD_ProDKin_1	501	507	PF00069	0.617
MOD_ProDKin_1	7	13	PF00069	0.598
MOD_ProDKin_1	703	709	PF00069	0.744
MOD_ProDKin_1	718	724	PF00069	0.510
TRG_ENDOCYTIC_2	397	400	PF00928	0.541
TRG_ENDOCYTIC_2	633	636	PF00928	0.563
TRG_ER_diArg_1	181	184	PF00400	0.705
TRG_ER_diArg_1	496	499	PF00400	0.610
TRG_NLS_MonoCore_2	179	184	PF00514	0.653
TRG_NLS_MonoExtC_3	179	184	PF00514	0.679
TRG_NLS_MonoExtN_4	146	153	PF00514	0.647
TRG_NLS_MonoExtN_4	180	186	PF00514	0.679
TRG_NLS_MonoExtN_4	237	244	PF00514	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I993	Leishmania donovani	79%	100%
A4H6X0	Leishmania braziliensis	50%	97%
E9AGD5	Leishmania infantum	79%	100%
E9ANX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%