Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QGP4_LEIMA

TriTrypDb:

LmjF.12.0480 , LMJLV39_120010300 , LMJSD75_120010200

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.579
CLV_C14_Caspase3-7	256	260	PF00656	0.645
CLV_C14_Caspase3-7	591	595	PF00656	0.610
CLV_NRD_NRD_1	395	397	PF00675	0.684
CLV_PCSK_FUR_1	393	397	PF00082	0.636
CLV_PCSK_KEX2_1	217	219	PF00082	0.656
CLV_PCSK_KEX2_1	392	394	PF00082	0.667
CLV_PCSK_KEX2_1	395	397	PF00082	0.660
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.564
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.627
CLV_PCSK_SKI1_1	389	393	PF00082	0.548
DEG_APCC_DBOX_1	472	480	PF00400	0.682
DEG_SCF_FBW7_1	89	96	PF00400	0.536
DEG_SPOP_SBC_1	195	199	PF00917	0.579
DOC_CKS1_1	559	564	PF01111	0.623
DOC_PP1_RVXF_1	350	356	PF00149	0.616
DOC_PP1_RVXF_1	546	553	PF00149	0.551
DOC_USP7_MATH_1	140	144	PF00917	0.650
DOC_USP7_MATH_1	153	157	PF00917	0.697
DOC_USP7_MATH_1	166	170	PF00917	0.595
DOC_USP7_MATH_1	194	198	PF00917	0.627
DOC_USP7_MATH_1	203	207	PF00917	0.623
DOC_USP7_MATH_1	286	290	PF00917	0.791
DOC_USP7_MATH_1	40	44	PF00917	0.677
DOC_USP7_MATH_1	442	446	PF00917	0.603
DOC_USP7_MATH_1	512	516	PF00917	0.663
DOC_USP7_MATH_1	551	555	PF00917	0.674
DOC_USP7_MATH_1	583	587	PF00917	0.652
DOC_USP7_MATH_1	72	76	PF00917	0.646
DOC_USP7_MATH_1	80	84	PF00917	0.612
DOC_USP7_MATH_1	93	97	PF00917	0.542
DOC_WW_Pin1_4	184	189	PF00397	0.649
DOC_WW_Pin1_4	196	201	PF00397	0.685
DOC_WW_Pin1_4	23	28	PF00397	0.643
DOC_WW_Pin1_4	36	41	PF00397	0.537
DOC_WW_Pin1_4	558	563	PF00397	0.663
DOC_WW_Pin1_4	76	81	PF00397	0.678
DOC_WW_Pin1_4	89	94	PF00397	0.561
LIG_14-3-3_CanoR_1	110	119	PF00244	0.539
LIG_14-3-3_CanoR_1	218	224	PF00244	0.662
LIG_14-3-3_CanoR_1	276	280	PF00244	0.591
LIG_14-3-3_CanoR_1	395	403	PF00244	0.687
LIG_14-3-3_CanoR_1	411	417	PF00244	0.543
LIG_14-3-3_CanoR_1	441	450	PF00244	0.628
LIG_14-3-3_CanoR_1	521	526	PF00244	0.687
LIG_14-3-3_CanoR_1	542	552	PF00244	0.646
LIG_BIR_III_4	428	432	PF00653	0.588
LIG_BRCT_BRCA1_1	207	211	PF00533	0.655
LIG_BRCT_BRCA1_1	46	50	PF00533	0.676
LIG_BRCT_BRCA1_1	82	86	PF00533	0.589
LIG_EVH1_2	526	530	PF00568	0.593
LIG_FHA_1	18	24	PF00498	0.599
LIG_FHA_1	235	241	PF00498	0.547
LIG_FHA_1	421	427	PF00498	0.664
LIG_FHA_1	483	489	PF00498	0.588
LIG_FHA_1	559	565	PF00498	0.630
LIG_FHA_1	573	579	PF00498	0.551
LIG_FHA_1	80	86	PF00498	0.693
LIG_FHA_2	321	327	PF00498	0.639
LIG_FHA_2	451	457	PF00498	0.747
LIG_FHA_2	572	578	PF00498	0.691
LIG_LIR_Apic_2	381	386	PF02991	0.636
LIG_LIR_Gen_1	52	62	PF02991	0.591
LIG_LIR_Gen_1	83	94	PF02991	0.539
LIG_LIR_Nem_3	236	242	PF02991	0.547
LIG_LIR_Nem_3	48	54	PF02991	0.573
LIG_LIR_Nem_3	83	89	PF02991	0.543
LIG_MLH1_MIPbox_1	47	51	PF16413	0.533
LIG_PTB_Apo_2	278	285	PF02174	0.573
LIG_SH2_CRK	383	387	PF00017	0.638
LIG_SH2_CRK	54	58	PF00017	0.605
LIG_SH2_NCK_1	54	58	PF00017	0.605
LIG_SH2_SRC	455	458	PF00017	0.588
LIG_SH2_STAT5	239	242	PF00017	0.642
LIG_SH2_STAT5	383	386	PF00017	0.634
LIG_SH3_3	118	124	PF00018	0.593
LIG_SH3_3	21	27	PF00018	0.665
LIG_SH3_3	324	330	PF00018	0.611
LIG_SH3_3	338	344	PF00018	0.509
LIG_SH3_3	444	450	PF00018	0.637
LIG_SH3_3	58	64	PF00018	0.603
LIG_SH3_3	584	590	PF00018	0.630
LIG_SUMO_SIM_par_1	117	122	PF11976	0.552
LIG_SUMO_SIM_par_1	19	26	PF11976	0.556
LIG_SUMO_SIM_par_1	573	579	PF11976	0.644
LIG_TRAF2_1	596	599	PF00917	0.581
LIG_TYR_ITSM	50	57	PF00017	0.607
LIG_WRC_WIRS_1	109	114	PF05994	0.634
MOD_CK1_1	111	117	PF00069	0.529
MOD_CK1_1	143	149	PF00069	0.621
MOD_CK1_1	212	218	PF00069	0.745
MOD_CK1_1	225	231	PF00069	0.598
MOD_CK1_1	245	251	PF00069	0.549
MOD_CK1_1	299	305	PF00069	0.619
MOD_CK1_1	314	320	PF00069	0.628
MOD_CK1_1	469	475	PF00069	0.698
MOD_CK1_1	510	516	PF00069	0.669
MOD_CK1_1	543	549	PF00069	0.668
MOD_CK1_1	55	61	PF00069	0.598
MOD_CK1_1	558	564	PF00069	0.545
MOD_CK1_1	568	574	PF00069	0.600
MOD_CK1_1	79	85	PF00069	0.693
MOD_CK1_1	88	94	PF00069	0.588
MOD_CK1_1	97	103	PF00069	0.506
MOD_CK2_1	398	404	PF00069	0.698
MOD_CK2_1	564	570	PF00069	0.699
MOD_CK2_1	592	598	PF00069	0.589
MOD_GlcNHglycan	114	117	PF01048	0.632
MOD_GlcNHglycan	155	158	PF01048	0.799
MOD_GlcNHglycan	168	171	PF01048	0.629
MOD_GlcNHglycan	207	210	PF01048	0.797
MOD_GlcNHglycan	211	214	PF01048	0.779
MOD_GlcNHglycan	224	227	PF01048	0.574
MOD_GlcNHglycan	244	247	PF01048	0.664
MOD_GlcNHglycan	253	256	PF01048	0.691
MOD_GlcNHglycan	298	301	PF01048	0.640
MOD_GlcNHglycan	398	401	PF01048	0.724
MOD_GlcNHglycan	416	419	PF01048	0.636
MOD_GlcNHglycan	444	447	PF01048	0.644
MOD_GlcNHglycan	47	50	PF01048	0.666
MOD_GlcNHglycan	473	476	PF01048	0.742
MOD_GlcNHglycan	523	526	PF01048	0.671
MOD_GlcNHglycan	537	540	PF01048	0.572
MOD_GlcNHglycan	57	60	PF01048	0.559
MOD_GlcNHglycan	570	573	PF01048	0.691
MOD_GlcNHglycan	579	583	PF01048	0.600
MOD_GlcNHglycan	594	597	PF01048	0.478
MOD_GlcNHglycan	69	72	PF01048	0.567
MOD_GlcNHglycan	82	85	PF01048	0.586
MOD_GSK3_1	108	115	PF00069	0.589
MOD_GSK3_1	134	141	PF00069	0.774
MOD_GSK3_1	190	197	PF00069	0.622
MOD_GSK3_1	203	210	PF00069	0.650
MOD_GSK3_1	213	220	PF00069	0.607
MOD_GSK3_1	294	301	PF00069	0.690
MOD_GSK3_1	307	314	PF00069	0.548
MOD_GSK3_1	316	323	PF00069	0.653
MOD_GSK3_1	36	43	PF00069	0.680
MOD_GSK3_1	394	401	PF00069	0.692
MOD_GSK3_1	412	419	PF00069	0.607
MOD_GSK3_1	45	52	PF00069	0.594
MOD_GSK3_1	478	485	PF00069	0.622
MOD_GSK3_1	507	514	PF00069	0.685
MOD_GSK3_1	540	547	PF00069	0.639
MOD_GSK3_1	551	558	PF00069	0.578
MOD_GSK3_1	564	571	PF00069	0.595
MOD_GSK3_1	578	585	PF00069	0.543
MOD_GSK3_1	588	595	PF00069	0.559
MOD_GSK3_1	72	79	PF00069	0.694
MOD_GSK3_1	85	92	PF00069	0.551
MOD_GSK3_1	93	100	PF00069	0.603
MOD_LATS_1	464	470	PF00433	0.574
MOD_N-GLC_1	112	117	PF02516	0.680
MOD_N-GLC_1	280	285	PF02516	0.569
MOD_N-GLC_1	314	319	PF02516	0.635
MOD_NEK2_1	112	117	PF00069	0.508
MOD_NEK2_1	133	138	PF00069	0.655
MOD_NEK2_1	231	236	PF00069	0.772
MOD_NEK2_1	242	247	PF00069	0.682
MOD_NEK2_1	293	298	PF00069	0.544
MOD_NEK2_1	398	403	PF00069	0.700
MOD_NEK2_1	44	49	PF00069	0.675
MOD_NEK2_1	50	55	PF00069	0.617
MOD_NEK2_1	516	521	PF00069	0.617
MOD_NEK2_1	544	549	PF00069	0.685
MOD_NEK2_1	564	569	PF00069	0.498
MOD_NEK2_1	578	583	PF00069	0.550
MOD_NEK2_1	94	99	PF00069	0.666
MOD_NEK2_2	450	455	PF00069	0.577
MOD_OFUCOSY	484	490	PF10250	0.629
MOD_PIKK_1	176	182	PF00454	0.783
MOD_PIKK_1	231	237	PF00454	0.694
MOD_PIKK_1	294	300	PF00454	0.707
MOD_PIKK_1	514	520	PF00454	0.577
MOD_PKA_1	217	223	PF00069	0.565
MOD_PKA_2	143	149	PF00069	0.642
MOD_PKA_2	217	223	PF00069	0.618
MOD_PKA_2	265	271	PF00069	0.607
MOD_PKA_2	275	281	PF00069	0.621
MOD_PKA_2	394	400	PF00069	0.692
MOD_Plk_1	280	286	PF00069	0.574
MOD_Plk_1	420	426	PF00069	0.657
MOD_Plk_1	572	578	PF00069	0.642
MOD_Plk_2-3	404	410	PF00069	0.547
MOD_Plk_2-3	588	594	PF00069	0.545
MOD_Plk_4	102	108	PF00069	0.661
MOD_Plk_4	114	120	PF00069	0.590
MOD_Plk_4	450	456	PF00069	0.560
MOD_Plk_4	555	561	PF00069	0.681
MOD_ProDKin_1	184	190	PF00069	0.649
MOD_ProDKin_1	196	202	PF00069	0.683
MOD_ProDKin_1	23	29	PF00069	0.645
MOD_ProDKin_1	36	42	PF00069	0.534
MOD_ProDKin_1	558	564	PF00069	0.667
MOD_ProDKin_1	76	82	PF00069	0.678
MOD_ProDKin_1	89	95	PF00069	0.562
MOD_SUMO_for_1	333	336	PF00179	0.526
MOD_SUMO_for_1	391	394	PF00179	0.621
MOD_SUMO_for_1	405	408	PF00179	0.601
MOD_SUMO_rev_2	25	34	PF00179	0.661
MOD_SUMO_rev_2	399	407	PF00179	0.623
MOD_SUMO_rev_2	428	435	PF00179	0.618
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.547
TRG_ENDOCYTIC_2	239	242	PF00928	0.546
TRG_ENDOCYTIC_2	54	57	PF00928	0.607
TRG_ER_diArg_1	5	8	PF00400	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WRY4	Leishmania donovani	83%	100%
A4H6W9	Leishmania braziliensis	51%	100%
E9AGD6	Leishmania infantum	83%	100%
E9ANX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%