WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WW domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QGP1_LEIMA

TriTrypDb:

LmjF.12.0510 , LMJLV39_280032000 , LMJSD75_280031600

Length:

970

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QGP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGP1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.784
CLV_C14_Caspase3-7	268	272	PF00656	0.546
CLV_C14_Caspase3-7	299	303	PF00656	0.591
CLV_C14_Caspase3-7	434	438	PF00656	0.664
CLV_C14_Caspase3-7	951	955	PF00656	0.647
CLV_NRD_NRD_1	107	109	PF00675	0.693
CLV_NRD_NRD_1	292	294	PF00675	0.480
CLV_NRD_NRD_1	349	351	PF00675	0.562
CLV_NRD_NRD_1	460	462	PF00675	0.641
CLV_NRD_NRD_1	554	556	PF00675	0.671
CLV_NRD_NRD_1	600	602	PF00675	0.674
CLV_NRD_NRD_1	725	727	PF00675	0.446
CLV_NRD_NRD_1	737	739	PF00675	0.408
CLV_NRD_NRD_1	743	745	PF00675	0.343
CLV_NRD_NRD_1	895	897	PF00675	0.701
CLV_NRD_NRD_1	926	928	PF00675	0.629
CLV_NRD_NRD_1	944	946	PF00675	0.678
CLV_NRD_NRD_1	957	959	PF00675	0.597
CLV_PCSK_FUR_1	365	369	PF00082	0.528
CLV_PCSK_KEX2_1	106	108	PF00082	0.692
CLV_PCSK_KEX2_1	264	266	PF00082	0.533
CLV_PCSK_KEX2_1	279	281	PF00082	0.387
CLV_PCSK_KEX2_1	291	293	PF00082	0.484
CLV_PCSK_KEX2_1	349	351	PF00082	0.540
CLV_PCSK_KEX2_1	367	369	PF00082	0.360
CLV_PCSK_KEX2_1	460	462	PF00082	0.445
CLV_PCSK_KEX2_1	554	556	PF00082	0.671
CLV_PCSK_KEX2_1	600	602	PF00082	0.526
CLV_PCSK_KEX2_1	725	727	PF00082	0.344
CLV_PCSK_KEX2_1	743	745	PF00082	0.597
CLV_PCSK_KEX2_1	757	759	PF00082	0.595
CLV_PCSK_KEX2_1	895	897	PF00082	0.625
CLV_PCSK_KEX2_1	926	928	PF00082	0.667
CLV_PCSK_KEX2_1	944	946	PF00082	0.678
CLV_PCSK_KEX2_1	957	959	PF00082	0.597
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.692
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.587
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.381
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.523
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.468
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.527
CLV_PCSK_PC1ET2_1	757	759	PF00082	0.501
CLV_PCSK_SKI1_1	102	106	PF00082	0.610
CLV_PCSK_SKI1_1	131	135	PF00082	0.532
CLV_PCSK_SKI1_1	231	235	PF00082	0.775
CLV_PCSK_SKI1_1	387	391	PF00082	0.495
CLV_PCSK_SKI1_1	600	604	PF00082	0.703
CLV_PCSK_SKI1_1	634	638	PF00082	0.429
CLV_PCSK_SKI1_1	65	69	PF00082	0.421
CLV_PCSK_SKI1_1	805	809	PF00082	0.439
CLV_PCSK_SKI1_1	85	89	PF00082	0.476
DEG_APCC_DBOX_1	554	562	PF00400	0.633
DEG_APCC_KENBOX_2	162	166	PF00400	0.517
DEG_APCC_KENBOX_2	77	81	PF00400	0.629
DEG_SCF_FBW7_1	656	662	PF00400	0.700
DEG_SCF_FBW7_1	667	672	PF00400	0.717
DEG_SCF_FBW7_1	87	92	PF00400	0.649
DEG_SPOP_SBC_1	232	236	PF00917	0.623
DEG_SPOP_SBC_1	761	765	PF00917	0.537
DOC_ANK_TNKS_1	710	717	PF00023	0.485
DOC_ANK_TNKS_1	935	942	PF00023	0.641
DOC_CKS1_1	656	661	PF01111	0.709
DOC_CYCLIN_RxL_1	62	71	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	685	688	PF00134	0.788
DOC_MAPK_gen_1	551	560	PF00069	0.605
DOC_PP2B_LxvP_1	203	206	PF13499	0.498
DOC_PP2B_LxvP_1	26	29	PF13499	0.419
DOC_PP2B_LxvP_1	685	688	PF13499	0.801
DOC_PP4_FxxP_1	642	645	PF00568	0.521
DOC_PP4_FxxP_1	701	704	PF00568	0.590
DOC_PP4_FxxP_1	844	847	PF00568	0.512
DOC_USP7_MATH_1	180	184	PF00917	0.652
DOC_USP7_MATH_1	204	208	PF00917	0.600
DOC_USP7_MATH_1	331	335	PF00917	0.331
DOC_USP7_MATH_1	36	40	PF00917	0.287
DOC_USP7_MATH_1	385	389	PF00917	0.496
DOC_USP7_MATH_1	661	665	PF00917	0.683
DOC_USP7_MATH_1	669	673	PF00917	0.669
DOC_USP7_MATH_1	848	852	PF00917	0.580
DOC_USP7_MATH_1	868	872	PF00917	0.453
DOC_USP7_MATH_1	89	93	PF00917	0.765
DOC_USP7_UBL2_3	102	106	PF12436	0.685
DOC_USP7_UBL2_3	477	481	PF12436	0.487
DOC_USP7_UBL2_3	529	533	PF12436	0.520
DOC_USP7_UBL2_3	74	78	PF12436	0.580
DOC_WW_Pin1_4	225	230	PF00397	0.639
DOC_WW_Pin1_4	567	572	PF00397	0.670
DOC_WW_Pin1_4	617	622	PF00397	0.653
DOC_WW_Pin1_4	637	642	PF00397	0.379
DOC_WW_Pin1_4	643	648	PF00397	0.569
DOC_WW_Pin1_4	655	660	PF00397	0.617
DOC_WW_Pin1_4	665	670	PF00397	0.693
DOC_WW_Pin1_4	85	90	PF00397	0.715
DOC_WW_Pin1_4	880	885	PF00397	0.646
DOC_WW_Pin1_4	929	934	PF00397	0.698
LIG_14-3-3_CanoR_1	182	188	PF00244	0.654
LIG_14-3-3_CanoR_1	518	525	PF00244	0.478
LIG_14-3-3_CanoR_1	554	559	PF00244	0.579
LIG_14-3-3_CanoR_1	605	609	PF00244	0.715
LIG_14-3-3_CanoR_1	762	770	PF00244	0.456
LIG_14-3-3_CanoR_1	775	779	PF00244	0.360
LIG_14-3-3_CanoR_1	805	810	PF00244	0.405
LIG_14-3-3_CanoR_1	926	932	PF00244	0.661
LIG_Actin_WH2_2	462	479	PF00022	0.524
LIG_Actin_WH2_2	621	636	PF00022	0.489
LIG_BIR_III_2	201	205	PF00653	0.612
LIG_BRCT_BRCA1_1	378	382	PF00533	0.517
LIG_BRCT_BRCA1_1	395	399	PF00533	0.309
LIG_BRCT_BRCA1_1	697	701	PF00533	0.641
LIG_Clathr_ClatBox_1	806	810	PF01394	0.481
LIG_FHA_1	128	134	PF00498	0.637
LIG_FHA_1	628	634	PF00498	0.463
LIG_FHA_1	835	841	PF00498	0.456
LIG_FHA_1	899	905	PF00498	0.579
LIG_FHA_2	511	517	PF00498	0.493
LIG_FHA_2	580	586	PF00498	0.703
LIG_FHA_2	775	781	PF00498	0.474
LIG_FHA_2	958	964	PF00498	0.648
LIG_IRF3_LxIS_1	145	152	PF10401	0.584
LIG_LIR_Apic_2	54	59	PF02991	0.295
LIG_LIR_Apic_2	640	645	PF02991	0.494
LIG_LIR_Apic_2	698	704	PF02991	0.615
LIG_LIR_Apic_2	842	848	PF02991	0.482
LIG_LIR_Apic_2	963	968	PF02991	0.662
LIG_LIR_Gen_1	419	426	PF02991	0.430
LIG_LIR_Nem_3	419	424	PF02991	0.429
LIG_LIR_Nem_3	43	49	PF02991	0.287
LIG_LIR_Nem_3	61	67	PF02991	0.290
LIG_PCNA_yPIPBox_3	535	548	PF02747	0.609
LIG_PCNA_yPIPBox_3	622	634	PF02747	0.548
LIG_Pex14_2	395	399	PF04695	0.474
LIG_REV1ctd_RIR_1	842	846	PF16727	0.520
LIG_RPA_C_Fungi	165	177	PF08784	0.591
LIG_SH2_CRK	866	870	PF00017	0.770
LIG_SH2_GRB2like	46	49	PF00017	0.287
LIG_SH2_PTP2	727	730	PF00017	0.509
LIG_SH2_SRC	281	284	PF00017	0.388
LIG_SH2_STAP1	403	407	PF00017	0.472
LIG_SH2_STAT3	255	258	PF00017	0.493
LIG_SH2_STAT5	46	49	PF00017	0.287
LIG_SH2_STAT5	727	730	PF00017	0.509
LIG_SH2_STAT5	942	945	PF00017	0.604
LIG_SH3_1	653	659	PF00018	0.713
LIG_SH3_3	615	621	PF00018	0.578
LIG_SH3_3	653	659	PF00018	0.713
LIG_SH3_4	120	127	PF00018	0.633
LIG_SUMO_SIM_anti_2	556	562	PF11976	0.633
LIG_SUMO_SIM_par_1	805	810	PF11976	0.574
LIG_TRAF2_1	138	141	PF00917	0.522
LIG_TRAF2_1	381	384	PF00917	0.539
LIG_TRAF2_1	536	539	PF00917	0.520
LIG_TRAF2_1	607	610	PF00917	0.663
LIG_TRAF2_1	706	709	PF00917	0.432
LIG_TRAF2_1	777	780	PF00917	0.492
LIG_UBA3_1	543	551	PF00899	0.656
LIG_UBA3_1	806	811	PF00899	0.414
LIG_WRC_WIRS_1	360	365	PF05994	0.457
LIG_WW_3	846	850	PF00397	0.610
MOD_CDC14_SPxK_1	228	231	PF00782	0.643
MOD_CDK_SPK_2	567	572	PF00069	0.670
MOD_CDK_SPxK_1	225	231	PF00069	0.647
MOD_CDK_SPxK_1	665	671	PF00069	0.674
MOD_CDK_SPxxK_3	929	936	PF00069	0.644
MOD_CK1_1	178	184	PF00069	0.675
MOD_CK1_1	186	192	PF00069	0.681
MOD_CK1_1	553	559	PF00069	0.578
MOD_CK1_1	646	652	PF00069	0.678
MOD_CK1_1	834	840	PF00069	0.459
MOD_CK1_1	851	857	PF00069	0.673
MOD_CK1_1	929	935	PF00069	0.666
MOD_CK2_1	224	230	PF00069	0.758
MOD_CK2_1	416	422	PF00069	0.595
MOD_CK2_1	510	516	PF00069	0.518
MOD_CK2_1	604	610	PF00069	0.687
MOD_CK2_1	703	709	PF00069	0.450
MOD_CK2_1	774	780	PF00069	0.497
MOD_CK2_1	888	894	PF00069	0.577
MOD_Cter_Amidation	723	726	PF01082	0.414
MOD_GlcNHglycan	307	310	PF01048	0.492
MOD_GlcNHglycan	396	399	PF01048	0.415
MOD_GlcNHglycan	495	498	PF01048	0.564
MOD_GlcNHglycan	579	582	PF01048	0.702
MOD_GlcNHglycan	609	613	PF01048	0.617
MOD_GlcNHglycan	663	666	PF01048	0.719
MOD_GlcNHglycan	671	674	PF01048	0.677
MOD_GlcNHglycan	690	693	PF01048	0.583
MOD_GlcNHglycan	697	700	PF01048	0.638
MOD_GlcNHglycan	826	830	PF01048	0.664
MOD_GlcNHglycan	870	873	PF01048	0.718
MOD_GlcNHglycan	99	102	PF01048	0.686
MOD_GSK3_1	145	152	PF00069	0.651
MOD_GSK3_1	171	178	PF00069	0.670
MOD_GSK3_1	182	189	PF00069	0.651
MOD_GSK3_1	489	496	PF00069	0.401
MOD_GSK3_1	550	557	PF00069	0.640
MOD_GSK3_1	563	570	PF00069	0.635
MOD_GSK3_1	573	580	PF00069	0.626
MOD_GSK3_1	604	611	PF00069	0.661
MOD_GSK3_1	651	658	PF00069	0.644
MOD_GSK3_1	659	666	PF00069	0.655
MOD_GSK3_1	688	695	PF00069	0.634
MOD_GSK3_1	85	92	PF00069	0.684
MOD_GSK3_1	880	887	PF00069	0.625
MOD_GSK3_1	922	929	PF00069	0.755
MOD_GSK3_1	944	951	PF00069	0.681
MOD_N-GLC_1	831	836	PF02516	0.572
MOD_N-GLC_2	831	833	PF02516	0.556
MOD_NEK2_1	149	154	PF00069	0.748
MOD_NEK2_1	176	181	PF00069	0.624
MOD_NEK2_1	224	229	PF00069	0.670
MOD_NEK2_1	359	364	PF00069	0.400
MOD_NEK2_1	476	481	PF00069	0.487
MOD_NEK2_1	510	515	PF00069	0.486
MOD_NEK2_1	573	578	PF00069	0.687
MOD_NEK2_1	676	681	PF00069	0.699
MOD_NEK2_1	742	747	PF00069	0.518
MOD_NEK2_1	792	797	PF00069	0.490
MOD_PIKK_1	376	382	PF00454	0.540
MOD_PIKK_1	476	482	PF00454	0.485
MOD_PIKK_1	501	507	PF00454	0.628
MOD_PIKK_1	517	523	PF00454	0.393
MOD_PIKK_1	792	798	PF00454	0.491
MOD_PIKK_1	910	916	PF00454	0.738
MOD_PK_1	129	135	PF00069	0.645
MOD_PKA_1	106	112	PF00069	0.686
MOD_PKA_1	554	560	PF00069	0.632
MOD_PKA_1	926	932	PF00069	0.665
MOD_PKA_1	944	950	PF00069	0.680
MOD_PKA_1	957	963	PF00069	0.587
MOD_PKA_2	106	112	PF00069	0.636
MOD_PKA_2	517	523	PF00069	0.471
MOD_PKA_2	553	559	PF00069	0.692
MOD_PKA_2	604	610	PF00069	0.661
MOD_PKA_2	676	682	PF00069	0.623
MOD_PKA_2	742	748	PF00069	0.483
MOD_PKA_2	761	767	PF00069	0.336
MOD_PKA_2	774	780	PF00069	0.367
MOD_PKA_2	792	798	PF00069	0.315
MOD_PKA_2	848	854	PF00069	0.659
MOD_PKA_2	926	932	PF00069	0.620
MOD_PKA_2	943	949	PF00069	0.575
MOD_PKA_2	957	963	PF00069	0.679
MOD_Plk_1	716	722	PF00069	0.472
MOD_Plk_1	825	831	PF00069	0.553
MOD_Plk_1	898	904	PF00069	0.522
MOD_Plk_2-3	416	422	PF00069	0.420
MOD_Plk_2-3	57	63	PF00069	0.503
MOD_Plk_2-3	709	715	PF00069	0.641
MOD_Plk_4	150	156	PF00069	0.618
MOD_Plk_4	183	189	PF00069	0.609
MOD_Plk_4	416	422	PF00069	0.420
MOD_Plk_4	51	57	PF00069	0.381
MOD_Plk_4	556	562	PF00069	0.622
MOD_Plk_4	899	905	PF00069	0.525
MOD_ProDKin_1	225	231	PF00069	0.641
MOD_ProDKin_1	567	573	PF00069	0.675
MOD_ProDKin_1	617	623	PF00069	0.645
MOD_ProDKin_1	637	643	PF00069	0.387
MOD_ProDKin_1	655	661	PF00069	0.616
MOD_ProDKin_1	665	671	PF00069	0.694
MOD_ProDKin_1	85	91	PF00069	0.717
MOD_ProDKin_1	880	886	PF00069	0.641
MOD_ProDKin_1	929	935	PF00069	0.598
MOD_SUMO_for_1	373	376	PF00179	0.449
MOD_SUMO_for_1	68	71	PF00179	0.512
MOD_SUMO_for_1	756	759	PF00179	0.431
MOD_SUMO_rev_2	113	121	PF00179	0.633
MOD_SUMO_rev_2	135	145	PF00179	0.664
MOD_SUMO_rev_2	314	320	PF00179	0.618
MOD_SUMO_rev_2	325	331	PF00179	0.406
MOD_SUMO_rev_2	388	395	PF00179	0.548
MOD_SUMO_rev_2	470	479	PF00179	0.530
MOD_SUMO_rev_2	620	628	PF00179	0.555
TRG_DiLeu_BaEn_1	709	714	PF01217	0.425
TRG_DiLeu_BaEn_2	505	511	PF01217	0.536
TRG_DiLeu_BaEn_3	538	544	PF01217	0.627
TRG_DiLeu_BaEn_4	814	820	PF01217	0.560
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.461
TRG_DiLeu_BaLyEn_6	598	603	PF01217	0.524
TRG_DiLeu_BaLyEn_6	802	807	PF01217	0.399
TRG_ENDOCYTIC_2	46	49	PF00928	0.287
TRG_ENDOCYTIC_2	64	67	PF00928	0.287
TRG_ENDOCYTIC_2	727	730	PF00928	0.509
TRG_ENDOCYTIC_2	866	869	PF00928	0.771
TRG_ER_diArg_1	460	462	PF00400	0.367
TRG_ER_diArg_1	600	602	PF00400	0.526
TRG_ER_diArg_1	718	721	PF00400	0.456
TRG_ER_diArg_1	725	727	PF00400	0.429
TRG_ER_diArg_1	742	744	PF00400	0.589
TRG_ER_diArg_1	819	822	PF00400	0.517
TRG_ER_diArg_1	895	897	PF00400	0.592
TRG_ER_diArg_1	943	945	PF00400	0.748
TRG_ER_diArg_1	956	958	PF00400	0.599
TRG_NLS_Bipartite_1	279	295	PF00514	0.469
TRG_NLS_MonoCore_2	104	109	PF00514	0.682
TRG_NLS_MonoExtC_3	105	110	PF00514	0.686
TRG_NLS_MonoExtC_3	287	292	PF00514	0.528
TRG_NLS_MonoExtN_4	102	109	PF00514	0.710
TRG_NLS_MonoExtN_4	288	295	PF00514	0.529
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.650
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	711	715	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	895	899	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL16	Leptomonas seymouri	56%	93%
A0A3R7KNZ4	Trypanosoma rangeli	31%	100%
A0A3S7WRX9	Leishmania donovani	95%	100%
A4H6W6	Leishmania braziliensis	84%	100%
E9AGD9	Leishmania infantum	94%	100%
E9ANX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5AMQ0	Trypanosoma cruzi	31%	100%