V-type proton ATPase subunit F

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar ATP synthase subunit, putative

Species:

Leishmania major

UniProt:

Q4QGP0_LEIMA

TriTrypDb:

LmjF.12.0520 , LMJLV39_120010800 , LMJSD75_120010700

Length:

137

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0032991	protein-containing complex	1	11
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	11
GO:0033180	proton-transporting V-type ATPase, V1 domain	4	11
GO:0098796	membrane protein complex	2	11
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGP0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005215	transporter activity	1	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0015078	proton transmembrane transporter activity	5	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	11
GO:0015399	primary active transmembrane transporter activity	4	11
GO:0016787	hydrolase activity	2	6
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	11
GO:0022804	active transmembrane transporter activity	3	11
GO:0022853	active monoatomic ion transmembrane transporter activity	4	11
GO:0022857	transmembrane transporter activity	2	11
GO:0022890	inorganic cation transmembrane transporter activity	4	11
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	11
GO:0042626	ATPase-coupled transmembrane transporter activity	2	11
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	11
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	11
GO:0140657	ATP-dependent activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	78	80	PF00675	0.375
CLV_PCSK_KEX2_1	78	80	PF00082	0.275
CLV_PCSK_SKI1_1	36	40	PF00082	0.336
CLV_PCSK_SKI1_1	96	100	PF00082	0.172
DOC_CKS1_1	59	64	PF01111	0.264
DOC_MAPK_gen_1	78	87	PF00069	0.372
DOC_MAPK_MEF2A_6	78	86	PF00069	0.372
DOC_PP2B_LxvP_1	110	113	PF13499	0.238
DOC_WW_Pin1_4	58	63	PF00397	0.246
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_FHA_1	129	135	PF00498	0.496
LIG_FHA_1	23	29	PF00498	0.263
LIG_GBD_Chelix_1	91	99	PF00786	0.300
LIG_SH2_STAT5	58	61	PF00017	0.289
LIG_SH3_3	56	62	PF00018	0.317
LIG_SUMO_SIM_par_1	108	114	PF11976	0.238
LIG_UBA3_1	109	115	PF00899	0.281
LIG_WW_1	54	57	PF00397	0.338
MOD_CK2_1	64	70	PF00069	0.371
MOD_GSK3_1	60	67	PF00069	0.358
MOD_NEK2_1	1	6	PF00069	0.638
MOD_Plk_1	20	26	PF00069	0.238
MOD_Plk_4	101	107	PF00069	0.303
MOD_ProDKin_1	58	64	PF00069	0.246
TRG_ENDOCYTIC_2	57	60	PF00928	0.269
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.281

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I750	Leptomonas seymouri	84%	99%
A0A0S4JD04	Bodo saltans	52%	100%
A0A1X0NNW5	Trypanosomatidae	69%	96%
A0A3Q8I866	Leishmania donovani	93%	100%
A0A3R7LS82	Trypanosoma rangeli	64%	100%
A1DH48	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	40%	100%
A4H6W1	Leishmania braziliensis	91%	100%
A6RRW0	Botryotinia fuckeliana (strain B05.10)	42%	100%
A7TMI5	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	37%	100%
C9ZIT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AGE0	Leishmania infantum	94%	100%
E9ANY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O27037	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	32%	100%
O43046	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
O44091	Drosophila pseudoobscura pseudoobscura	42%	100%
P31478	Manduca sexta	41%	100%
P39111	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
P50408	Rattus norvegicus	44%	100%
Q16864	Homo sapiens	44%	100%
Q17029	Anopheles gambiae	41%	100%
Q1HQK8	Aedes aegypti	41%	100%
Q23680	Caenorhabditis elegans	46%	100%
Q24583	Drosophila melanogaster	41%	100%
Q28029	Bos taurus	44%	100%
Q55AH5	Dictyostelium discoideum	43%	100%
Q9D1K2	Mus musculus	44%	100%
Q9I8H3	Xenopus laevis	47%	100%
Q9Y756	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	42%	100%
Q9ZQX4	Arabidopsis thaliana	40%	100%