Sulfatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGN3_LEIMA

TriTrypDb:

LmjF.12.0600 , LMJLV39_120011500 , LMJSD75_120011400

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

Q4QGN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGN3

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008484	sulfuric ester hydrolase activity	4	1
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.532
CLV_NRD_NRD_1	287	289	PF00675	0.610
CLV_NRD_NRD_1	497	499	PF00675	0.689
CLV_PCSK_KEX2_1	216	218	PF00082	0.598
CLV_PCSK_KEX2_1	440	442	PF00082	0.623
CLV_PCSK_KEX2_1	497	499	PF00082	0.651
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.617
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.678
CLV_PCSK_PC7_1	493	499	PF00082	0.640
CLV_PCSK_SKI1_1	216	220	PF00082	0.651

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I453	Leptomonas seymouri	62%	99%
A0A1X0NM85	Trypanosomatidae	38%	87%
A0A3Q8IHP7	Leishmania donovani	93%	100%
A0A422NA33	Trypanosoma rangeli	37%	97%
A4H6X3	Leishmania braziliensis	79%	100%
E9AGE7	Leishmania infantum	93%	100%
E9ANY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5AZS1	Trypanosoma cruzi	36%	95%

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