Sulfatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGN3_LEIMA

TriTrypDb:

LmjF.12.0600 , LMJLV39_120011500 , LMJSD75_120011400

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QGN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGN3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008484	sulfuric ester hydrolase activity	4	1
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.532
CLV_NRD_NRD_1	287	289	PF00675	0.610
CLV_NRD_NRD_1	497	499	PF00675	0.689
CLV_PCSK_KEX2_1	216	218	PF00082	0.598
CLV_PCSK_KEX2_1	440	442	PF00082	0.623
CLV_PCSK_KEX2_1	497	499	PF00082	0.651
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.617
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.678
CLV_PCSK_PC7_1	493	499	PF00082	0.640
CLV_PCSK_SKI1_1	216	220	PF00082	0.651
CLV_PCSK_SKI1_1	288	292	PF00082	0.522
CLV_PCSK_SKI1_1	441	445	PF00082	0.580
CLV_PCSK_SKI1_1	450	454	PF00082	0.513
CLV_PCSK_SKI1_1	49	53	PF00082	0.525
CLV_Separin_Metazoa	260	264	PF03568	0.516
DEG_APCC_KENBOX_2	396	400	PF00400	0.359
DEG_Nend_Nbox_1	1	3	PF02207	0.752
DEG_ODPH_VHL_1	445	457	PF01847	0.429
DEG_SPOP_SBC_1	420	424	PF00917	0.470
DOC_MAPK_DCC_7	75	83	PF00069	0.408
DOC_MAPK_gen_1	216	225	PF00069	0.437
DOC_MAPK_gen_1	394	403	PF00069	0.357
DOC_MAPK_JIP1_4	246	252	PF00069	0.303
DOC_MAPK_MEF2A_6	219	227	PF00069	0.438
DOC_MAPK_MEF2A_6	397	405	PF00069	0.410
DOC_MAPK_MEF2A_6	75	83	PF00069	0.335
DOC_USP7_MATH_1	150	154	PF00917	0.444
DOC_USP7_MATH_1	178	182	PF00917	0.340
DOC_USP7_MATH_1	205	209	PF00917	0.401
DOC_USP7_MATH_1	233	237	PF00917	0.415
DOC_USP7_MATH_1	240	244	PF00917	0.436
DOC_USP7_MATH_1	279	283	PF00917	0.430
DOC_USP7_MATH_1	34	38	PF00917	0.739
DOC_USP7_MATH_1	472	476	PF00917	0.456
DOC_WW_Pin1_4	103	108	PF00397	0.457
DOC_WW_Pin1_4	184	189	PF00397	0.381
DOC_WW_Pin1_4	25	30	PF00397	0.725
DOC_WW_Pin1_4	289	294	PF00397	0.512
DOC_WW_Pin1_4	484	489	PF00397	0.458
LIG_14-3-3_CanoR_1	20	29	PF00244	0.694
LIG_14-3-3_CanoR_1	263	267	PF00244	0.480
LIG_14-3-3_CanoR_1	288	293	PF00244	0.361
LIG_14-3-3_CanoR_1	353	359	PF00244	0.443
LIG_14-3-3_CanoR_1	392	401	PF00244	0.420
LIG_14-3-3_CanoR_1	441	446	PF00244	0.395
LIG_14-3-3_CanoR_1	450	459	PF00244	0.294
LIG_BRCT_BRCA1_1	73	77	PF00533	0.551
LIG_eIF4E_1	376	382	PF01652	0.422
LIG_FHA_1	21	27	PF00498	0.776
LIG_FHA_1	307	313	PF00498	0.351
LIG_FHA_1	472	478	PF00498	0.476
LIG_FHA_2	165	171	PF00498	0.481
LIG_FHA_2	22	28	PF00498	0.792
LIG_FHA_2	331	337	PF00498	0.543
LIG_FHA_2	451	457	PF00498	0.310
LIG_FHA_2	55	61	PF00498	0.662
LIG_FHA_2	97	103	PF00498	0.492
LIG_GBD_Chelix_1	334	342	PF00786	0.595
LIG_HP1_1	107	111	PF01393	0.345
LIG_LIR_Apic_2	412	418	PF02991	0.488
LIG_LIR_Gen_1	120	130	PF02991	0.352
LIG_LIR_Gen_1	398	405	PF02991	0.366
LIG_LIR_Gen_1	463	472	PF02991	0.449
LIG_LIR_Nem_3	120	125	PF02991	0.330
LIG_LIR_Nem_3	180	186	PF02991	0.372
LIG_LIR_Nem_3	314	319	PF02991	0.362
LIG_LIR_Nem_3	398	403	PF02991	0.324
LIG_LIR_Nem_3	463	467	PF02991	0.421
LIG_LIR_Nem_3	74	80	PF02991	0.474
LIG_Pex14_2	343	347	PF04695	0.377
LIG_PTB_Apo_2	337	344	PF02174	0.273
LIG_SH2_CRK	415	419	PF00017	0.520
LIG_SH2_GRB2like	204	207	PF00017	0.403
LIG_SH2_GRB2like	435	438	PF00017	0.280
LIG_SH2_NCK_1	415	419	PF00017	0.419
LIG_SH2_SRC	415	418	PF00017	0.422
LIG_SH2_SRC	6	9	PF00017	0.732
LIG_SH2_STAP1	435	439	PF00017	0.425
LIG_SH2_STAT3	321	324	PF00017	0.472
LIG_SH2_STAT3	371	374	PF00017	0.335
LIG_SH2_STAT5	172	175	PF00017	0.376
LIG_SH2_STAT5	21	24	PF00017	0.691
LIG_SH2_STAT5	358	361	PF00017	0.492
LIG_SH2_STAT5	371	374	PF00017	0.321
LIG_SH2_STAT5	376	379	PF00017	0.246
LIG_SH2_STAT5	388	391	PF00017	0.348
LIG_SH2_STAT5	435	438	PF00017	0.346
LIG_SH2_STAT5	6	9	PF00017	0.787
LIG_SH2_STAT5	95	98	PF00017	0.469
LIG_SH3_3	127	133	PF00018	0.441
LIG_SH3_3	290	296	PF00018	0.525
LIG_SUMO_SIM_anti_2	453	460	PF11976	0.401
LIG_SUMO_SIM_par_1	110	115	PF11976	0.413
LIG_TRAF2_1	257	260	PF00917	0.449
MOD_CDK_SPK_2	103	108	PF00069	0.491
MOD_CDK_SPK_2	184	189	PF00069	0.396
MOD_CK1_1	152	158	PF00069	0.451
MOD_CK1_1	181	187	PF00069	0.343
MOD_CK1_1	197	203	PF00069	0.364
MOD_CK1_1	322	328	PF00069	0.555
MOD_CK1_1	424	430	PF00069	0.373
MOD_CK1_1	475	481	PF00069	0.359
MOD_CK1_1	510	516	PF00069	0.498
MOD_CK1_1	9	15	PF00069	0.779
MOD_CK2_1	164	170	PF00069	0.452
MOD_CK2_1	184	190	PF00069	0.221
MOD_CK2_1	2	8	PF00069	0.780
MOD_CK2_1	21	27	PF00069	0.795
MOD_CK2_1	254	260	PF00069	0.503
MOD_CK2_1	262	268	PF00069	0.497
MOD_CK2_1	364	370	PF00069	0.434
MOD_CK2_1	392	398	PF00069	0.402
MOD_CK2_1	419	425	PF00069	0.435
MOD_CK2_1	47	53	PF00069	0.668
MOD_CK2_1	54	60	PF00069	0.651
MOD_CK2_1	96	102	PF00069	0.481
MOD_GlcNHglycan	117	120	PF01048	0.604
MOD_GlcNHglycan	127	130	PF01048	0.658
MOD_GlcNHglycan	166	170	PF01048	0.598
MOD_GlcNHglycan	173	176	PF01048	0.497
MOD_GlcNHglycan	183	186	PF01048	0.454
MOD_GlcNHglycan	267	272	PF01048	0.659
MOD_GlcNHglycan	300	303	PF01048	0.652
MOD_GlcNHglycan	38	41	PF01048	0.487
MOD_GlcNHglycan	473	477	PF01048	0.661
MOD_GlcNHglycan	509	512	PF01048	0.619
MOD_GlcNHglycan	63	67	PF01048	0.507
MOD_GlcNHglycan	8	11	PF01048	0.505
MOD_GlcNHglycan	96	99	PF01048	0.574
MOD_GSK3_1	148	155	PF00069	0.458
MOD_GSK3_1	177	184	PF00069	0.353
MOD_GSK3_1	2	9	PF00069	0.726
MOD_GSK3_1	21	28	PF00069	0.716
MOD_GSK3_1	223	230	PF00069	0.403
MOD_GSK3_1	284	291	PF00069	0.404
MOD_GSK3_1	420	427	PF00069	0.430
MOD_GSK3_1	471	478	PF00069	0.481
MOD_GSK3_1	480	487	PF00069	0.507
MOD_GSK3_1	506	513	PF00069	0.464
MOD_GSK3_1	94	101	PF00069	0.542
MOD_N-GLC_1	164	169	PF02516	0.648
MOD_N-GLC_1	194	199	PF02516	0.604
MOD_N-GLC_1	205	210	PF02516	0.578
MOD_N-GLC_1	364	369	PF02516	0.608
MOD_N-GLC_1	481	486	PF02516	0.689
MOD_NEK2_1	117	122	PF00069	0.332
MOD_NEK2_1	125	130	PF00069	0.372
MOD_NEK2_1	138	143	PF00069	0.357
MOD_NEK2_1	2	7	PF00069	0.751
MOD_NEK2_1	223	228	PF00069	0.412
MOD_NEK2_1	278	283	PF00069	0.405
MOD_NEK2_1	319	324	PF00069	0.519
MOD_NEK2_1	330	335	PF00069	0.500
MOD_NEK2_1	338	343	PF00069	0.253
MOD_NEK2_1	431	436	PF00069	0.314
MOD_NEK2_2	178	183	PF00069	0.357
MOD_OFUCOSY	277	283	PF10250	0.569
MOD_PIKK_1	138	144	PF00454	0.437
MOD_PIKK_1	150	156	PF00454	0.385
MOD_PIKK_1	320	326	PF00454	0.505
MOD_PIKK_1	392	398	PF00454	0.431
MOD_PIKK_1	450	456	PF00454	0.415
MOD_PKA_1	288	294	PF00069	0.393
MOD_PKA_2	19	25	PF00069	0.690
MOD_PKA_2	262	268	PF00069	0.539
MOD_PKB_1	390	398	PF00069	0.433
MOD_Plk_1	338	344	PF00069	0.340
MOD_Plk_1	424	430	PF00069	0.415
MOD_Plk_1	472	478	PF00069	0.451
MOD_Plk_4	117	123	PF00069	0.364
MOD_Plk_4	178	184	PF00069	0.325
MOD_Plk_4	199	205	PF00069	0.437
MOD_Plk_4	2	8	PF00069	0.782
MOD_Plk_4	223	229	PF00069	0.410
MOD_Plk_4	311	317	PF00069	0.415
MOD_Plk_4	338	344	PF00069	0.348
MOD_Plk_4	354	360	PF00069	0.398
MOD_Plk_4	457	463	PF00069	0.330
MOD_ProDKin_1	103	109	PF00069	0.447
MOD_ProDKin_1	184	190	PF00069	0.386
MOD_ProDKin_1	25	31	PF00069	0.724
MOD_ProDKin_1	289	295	PF00069	0.517
MOD_ProDKin_1	484	490	PF00069	0.452
MOD_SUMO_rev_2	406	414	PF00179	0.316
TRG_NES_CRM1_1	456	471	PF08389	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I453	Leptomonas seymouri	62%	99%
A0A1X0NM85	Trypanosomatidae	38%	87%
A0A3Q8IHP7	Leishmania donovani	93%	100%
A0A422NA33	Trypanosoma rangeli	37%	97%
A4H6X3	Leishmania braziliensis	79%	100%
E9AGE7	Leishmania infantum	93%	100%
E9ANY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5AZS1	Trypanosoma cruzi	36%	95%