Alanine transaminase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alanine aminotransferase

Species:

Leishmania major

UniProt:

Q4QGN0_LEIMA

TriTrypDb:

LmjF.12.0630 , LMJLV39_120011800 , LMJSD75_120011700

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGN0

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	13
GO:0006520	amino acid metabolic process	3	13
GO:0006522	alanine metabolic process	6	13
GO:0006524	alanine catabolic process	5	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009056	catabolic process	2	13
GO:0009058	biosynthetic process	2	13
GO:0009063	amino acid catabolic process	4	13
GO:0009078	pyruvate family amino acid metabolic process	5	13
GO:0009080	pyruvate family amino acid catabolic process	6	13
GO:0009987	cellular process	1	13
GO:0016054	organic acid catabolic process	4	13
GO:0019752	carboxylic acid metabolic process	5	13
GO:0042851	L-alanine metabolic process	7	13
GO:0042853	L-alanine catabolic process	6	13
GO:0043436	oxoacid metabolic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044248	cellular catabolic process	3	13
GO:0044281	small molecule metabolic process	2	13
GO:0044282	small molecule catabolic process	3	13
GO:0046395	carboxylic acid catabolic process	5	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901565	organonitrogen compound catabolic process	4	13
GO:1901575	organic substance catabolic process	3	13
GO:1901605	alpha-amino acid metabolic process	4	13
GO:1901606	alpha-amino acid catabolic process	5	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004021	L-alanine:2-oxoglutarate aminotransferase activity	6	5
GO:0005488	binding	1	13
GO:0008483	transaminase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016769	transferase activity, transferring nitrogenous groups	3	13
GO:0019842	vitamin binding	3	13
GO:0030170	pyridoxal phosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0047635	alanine-oxo-acid transaminase activity	5	5
GO:0070279	vitamin B6 binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.310
CLV_NRD_NRD_1	279	281	PF00675	0.348
CLV_NRD_NRD_1	317	319	PF00675	0.322
CLV_NRD_NRD_1	371	373	PF00675	0.406
CLV_PCSK_FUR_1	102	106	PF00082	0.310
CLV_PCSK_KEX2_1	104	106	PF00082	0.310
CLV_PCSK_KEX2_1	278	280	PF00082	0.342
CLV_PCSK_KEX2_1	317	319	PF00082	0.322
CLV_PCSK_KEX2_1	371	373	PF00082	0.385
CLV_PCSK_SKI1_1	161	165	PF00082	0.330
CLV_PCSK_SKI1_1	220	224	PF00082	0.405
CLV_PCSK_SKI1_1	260	264	PF00082	0.455
CLV_PCSK_SKI1_1	279	283	PF00082	0.173
CLV_PCSK_SKI1_1	412	416	PF00082	0.472
CLV_PCSK_SKI1_1	439	443	PF00082	0.273
DEG_APCC_DBOX_1	103	111	PF00400	0.355
DEG_APCC_DBOX_1	438	446	PF00400	0.282
DEG_Nend_Nbox_1	1	3	PF02207	0.616
DOC_CDC14_PxL_1	469	477	PF14671	0.310
DOC_CDC14_PxL_1	79	87	PF14671	0.345
DOC_CYCLIN_RxL_1	277	286	PF00134	0.310
DOC_CYCLIN_yClb5_NLxxxL_5	322	331	PF00134	0.435
DOC_MAPK_gen_1	278	284	PF00069	0.427
DOC_MAPK_MEF2A_6	161	168	PF00069	0.289
DOC_MAPK_NFAT4_5	161	169	PF00069	0.332
DOC_PP1_RVXF_1	278	285	PF00149	0.332
DOC_PP2B_LxvP_1	289	292	PF13499	0.282
DOC_USP7_MATH_1	294	298	PF00917	0.310
DOC_WW_Pin1_4	139	144	PF00397	0.419
DOC_WW_Pin1_4	14	19	PF00397	0.356
DOC_WW_Pin1_4	225	230	PF00397	0.282
DOC_WW_Pin1_4	355	360	PF00397	0.282
DOC_WW_Pin1_4	7	12	PF00397	0.512
LIG_14-3-3_CanoR_1	220	229	PF00244	0.290
LIG_14-3-3_CanoR_1	279	285	PF00244	0.335
LIG_14-3-3_CanoR_1	396	403	PF00244	0.421
LIG_BRCT_BRCA1_1	119	123	PF00533	0.213
LIG_EH1_1	24	32	PF00400	0.406
LIG_eIF4E_1	25	31	PF01652	0.427
LIG_eIF4E_1	49	55	PF01652	0.462
LIG_FHA_1	226	232	PF00498	0.297
LIG_FHA_1	239	245	PF00498	0.153
LIG_FHA_1	297	303	PF00498	0.288
LIG_FHA_2	144	150	PF00498	0.443
LIG_LIR_Gen_1	373	381	PF02991	0.266
LIG_LIR_Gen_1	48	59	PF02991	0.408
LIG_LIR_Nem_3	283	287	PF02991	0.311
LIG_LIR_Nem_3	373	377	PF02991	0.261
LIG_LIR_Nem_3	48	54	PF02991	0.416
LIG_LIR_Nem_3	490	496	PF02991	0.391
LIG_LIR_Nem_3	71	76	PF02991	0.328
LIG_MYND_3	472	476	PF01753	0.286
LIG_Pex14_2	121	125	PF04695	0.358
LIG_SH2_CRK	408	412	PF00017	0.298
LIG_SH2_CRK	56	60	PF00017	0.367
LIG_SH2_CRK	73	77	PF00017	0.460
LIG_SH2_NCK_1	374	378	PF00017	0.344
LIG_SH2_PTP2	15	18	PF00017	0.465
LIG_SH2_SRC	374	377	PF00017	0.213
LIG_SH2_STAP1	117	121	PF00017	0.311
LIG_SH2_STAP1	185	189	PF00017	0.312
LIG_SH2_STAP1	218	222	PF00017	0.360
LIG_SH2_STAP1	374	378	PF00017	0.238
LIG_SH2_STAP1	493	497	PF00017	0.394
LIG_SH2_STAT3	185	188	PF00017	0.295
LIG_SH2_STAT5	106	109	PF00017	0.270
LIG_SH2_STAT5	117	120	PF00017	0.308
LIG_SH2_STAT5	15	18	PF00017	0.465
LIG_SH2_STAT5	295	298	PF00017	0.358
LIG_SH2_STAT5	321	324	PF00017	0.311
LIG_SH2_STAT5	56	59	PF00017	0.373
LIG_SH3_3	172	178	PF00018	0.282
LIG_SH3_3	192	198	PF00018	0.154
LIG_SH3_3	234	240	PF00018	0.344
LIG_SH3_3	448	454	PF00018	0.282
LIG_SH3_3	77	83	PF00018	0.349
LIG_SUMO_SIM_anti_2	446	454	PF11976	0.286
LIG_SUMO_SIM_par_1	261	268	PF11976	0.435
LIG_SUMO_SIM_par_1	297	308	PF11976	0.354
LIG_SUMO_SIM_par_1	76	81	PF11976	0.243
LIG_TYR_ITIM	54	59	PF00017	0.366
LIG_TYR_ITSM	69	76	PF00017	0.440
LIG_UBA3_1	300	309	PF00899	0.427
LIG_UBA3_1	377	382	PF00899	0.282
LIG_WRC_WIRS_1	281	286	PF05994	0.295
LIG_WW_3	358	362	PF00397	0.388
MOD_CDC14_SPxK_1	358	361	PF00782	0.355
MOD_CDK_SPK_2	14	19	PF00069	0.356
MOD_CDK_SPK_2	225	230	PF00069	0.282
MOD_CDK_SPK_2	7	12	PF00069	0.505
MOD_CDK_SPxK_1	355	361	PF00069	0.355
MOD_CK1_1	225	231	PF00069	0.427
MOD_CK1_1	303	309	PF00069	0.319
MOD_CK1_1	50	56	PF00069	0.515
MOD_CK2_1	280	286	PF00069	0.355
MOD_Cter_Amidation	315	318	PF01082	0.351
MOD_GlcNHglycan	185	188	PF01048	0.478
MOD_GlcNHglycan	224	227	PF01048	0.334
MOD_GlcNHglycan	446	450	PF01048	0.339
MOD_GlcNHglycan	455	458	PF01048	0.243
MOD_GSK3_1	105	112	PF00069	0.319
MOD_GSK3_1	139	146	PF00069	0.342
MOD_GSK3_1	150	157	PF00069	0.280
MOD_GSK3_1	296	303	PF00069	0.324
MOD_GSK3_1	41	48	PF00069	0.427
MOD_N-GLC_2	342	344	PF02516	0.311
MOD_NEK2_1	300	305	PF00069	0.341
MOD_NEK2_1	322	327	PF00069	0.320
MOD_NEK2_1	444	449	PF00069	0.297
MOD_NEK2_1	467	472	PF00069	0.282
MOD_PK_1	337	343	PF00069	0.295
MOD_PKA_2	467	473	PF00069	0.282
MOD_PKB_1	278	286	PF00069	0.310
MOD_Plk_1	363	369	PF00069	0.295
MOD_Plk_4	296	302	PF00069	0.330
MOD_Plk_4	50	56	PF00069	0.420
MOD_Plk_4	68	74	PF00069	0.317
MOD_ProDKin_1	139	145	PF00069	0.419
MOD_ProDKin_1	14	20	PF00069	0.354
MOD_ProDKin_1	225	231	PF00069	0.282
MOD_ProDKin_1	355	361	PF00069	0.282
MOD_ProDKin_1	7	13	PF00069	0.507
MOD_SUMO_rev_2	36	40	PF00179	0.495
TRG_DiLeu_BaEn_1	259	264	PF01217	0.358
TRG_DiLeu_BaEn_1	383	388	PF01217	0.451
TRG_ENDOCYTIC_2	321	324	PF00928	0.295
TRG_ENDOCYTIC_2	374	377	PF00928	0.247
TRG_ENDOCYTIC_2	56	59	PF00928	0.373
TRG_ENDOCYTIC_2	73	76	PF00928	0.435
TRG_ER_diArg_1	102	105	PF00400	0.419
TRG_ER_diArg_1	278	280	PF00400	0.437
TRG_NES_CRM1_1	67	81	PF08389	0.252
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	483	487	PF00026	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P4	Leptomonas seymouri	23%	100%
A0A0N1I393	Leptomonas seymouri	25%	100%
A0A0P0VI36	Oryza sativa subsp. japonica	23%	100%
A0A0S4IKK8	Bodo saltans	60%	100%
A0A0S4IU18	Bodo saltans	48%	98%
A0A0S4KND1	Bodo saltans	53%	100%
A0A1X0NME9	Trypanosomatidae	66%	100%
A0A1X0P7X4	Trypanosomatidae	25%	100%
A0A3Q8I9A2	Leishmania donovani	95%	100%
A0A3Q8INT3	Leishmania donovani	24%	100%
A0A3R7LIW3	Trypanosoma rangeli	64%	100%
A0A3S5IRA0	Trypanosoma rangeli	24%	100%
A4H6X6	Leishmania braziliensis	82%	100%
A4HPA3	Leishmania braziliensis	24%	100%
A4IDL0	Leishmania infantum	24%	100%
A4IFH5	Bos taurus	41%	100%
B8IZX8	Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949 / MB)	24%	100%
C6C2Z3	Musicola paradisiaca (strain Ech703)	23%	100%
C9ZIU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	99%
E9AGF0	Leishmania infantum	95%	100%
E9ANZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AT13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
F4I7I0	Arabidopsis thaliana	42%	92%
H3ZPU1	Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)	26%	100%
O67781	Aquifex aeolicus (strain VF5)	27%	100%
O86459	Rhizobium leguminosarum bv. phaseoli	26%	100%
P04694	Rattus norvegicus	25%	100%
P0A959	Escherichia coli (strain K12)	26%	100%
P0A960	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	26%	100%
P0A961	Shigella flexneri	26%	100%
P14909	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	24%	100%
P16524	Bacillus subtilis (strain 168)	24%	100%
P23034	Bacillus sp. (strain YM-2)	24%	100%
P24298	Homo sapiens	43%	100%
P25409	Rattus norvegicus	42%	100%
P29535	Solanum lycopersicum	23%	100%
P33447	Trypanosoma cruzi	25%	100%
P34106	Panicum miliaceum	45%	100%
P52892	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	98%
P52893	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	84%
P52894	Hordeum vulgare	45%	100%
P53001	Bacillus subtilis (strain 168)	23%	100%
P58350	Rhizobium meliloti (strain 1021)	26%	100%
P63499	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	28%	100%
P71348	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	26%	100%
P9WQ90	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	28%	100%
P9WQ91	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
Q00379	Cucurbita pepo	22%	100%
Q10334	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	98%
Q28DB5	Xenopus tropicalis	41%	95%
Q3MDN5	Trichormus variabilis (strain ATCC 29413 / PCC 7937)	23%	100%
Q42881	Solanum lycopersicum	21%	100%
Q4J8X2	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	24%	100%
Q4Q1I5	Leishmania major	24%	100%
Q54K95	Dictyostelium discoideum	21%	100%
Q54MJ7	Dictyostelium discoideum	44%	93%
Q58874	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	23%	100%
Q58CZ9	Bos taurus	22%	100%
Q59228	Geobacillus stearothermophilus	24%	100%
Q5F4K8	Pinus pinaster	26%	100%
Q60013	Streptomyces virginiae	25%	100%
Q67Y55	Arabidopsis thaliana	25%	100%
Q6GM82	Xenopus laevis	40%	92%
Q6NYL5	Danio rerio	42%	91%
Q795M6	Bacillus subtilis (strain 168)	26%	100%
Q82DR2	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	26%	100%
Q8BGT5	Mus musculus	42%	95%
Q8QZR1	Mus musculus	25%	100%
Q8QZR5	Mus musculus	42%	100%
Q8TD30	Homo sapiens	42%	95%
Q8YP73	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	23%	100%
Q93703	Caenorhabditis elegans	23%	100%
Q972A2	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	25%	100%
Q9C969	Arabidopsis thaliana	23%	100%
Q9LDV4	Arabidopsis thaliana	44%	92%
Q9LR30	Arabidopsis thaliana	41%	100%
Q9LVY1	Arabidopsis thaliana	23%	100%
Q9S7E9	Arabidopsis thaliana	41%	100%
Q9SIE1	Arabidopsis thaliana	26%	100%
Q9SIV0	Arabidopsis thaliana	24%	100%
Q9SK47	Arabidopsis thaliana	23%	100%
Q9ST02	Hordeum vulgare	25%	100%
Q9ST03	Hordeum vulgare	24%	90%
Q9V0L2	Pyrococcus abyssi (strain GE5 / Orsay)	25%	100%
Q9X0Y2	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	26%	100%
V5BJS7	Trypanosoma cruzi	64%	99%