PriCT_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

primase 2, putative

Species:

Leishmania major

UniProt:

Q4QGM9_LEIMA

TriTrypDb:

LmjF.12.0640 , LMJLV39_120011900 , LMJSD75_120011800

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGM9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006260	DNA replication	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0003896	DNA primase activity	7	2
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016779	nucleotidyltransferase activity	4	2
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0034062	5'-3' RNA polymerase activity	5	2
GO:0097747	RNA polymerase activity	4	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	475	481	PF00089	0.343
CLV_NRD_NRD_1	198	200	PF00675	0.439
CLV_NRD_NRD_1	203	205	PF00675	0.437
CLV_NRD_NRD_1	326	328	PF00675	0.420
CLV_NRD_NRD_1	380	382	PF00675	0.476
CLV_NRD_NRD_1	403	405	PF00675	0.444
CLV_NRD_NRD_1	453	455	PF00675	0.445
CLV_NRD_NRD_1	512	514	PF00675	0.343
CLV_NRD_NRD_1	529	531	PF00675	0.442
CLV_PCSK_FUR_1	195	199	PF00082	0.205
CLV_PCSK_KEX2_1	197	199	PF00082	0.436
CLV_PCSK_KEX2_1	328	330	PF00082	0.360
CLV_PCSK_KEX2_1	382	384	PF00082	0.368
CLV_PCSK_KEX2_1	403	405	PF00082	0.509
CLV_PCSK_KEX2_1	453	455	PF00082	0.445
CLV_PCSK_KEX2_1	51	53	PF00082	0.443
CLV_PCSK_KEX2_1	529	531	PF00082	0.442
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.405
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.345
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.368
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.443
CLV_PCSK_SKI1_1	131	135	PF00082	0.368
CLV_PCSK_SKI1_1	174	178	PF00082	0.422
CLV_PCSK_SKI1_1	204	208	PF00082	0.385
CLV_PCSK_SKI1_1	270	274	PF00082	0.343
CLV_PCSK_SKI1_1	300	304	PF00082	0.368
CLV_PCSK_SKI1_1	353	357	PF00082	0.530
CLV_PCSK_SKI1_1	375	379	PF00082	0.594
CLV_PCSK_SKI1_1	453	457	PF00082	0.457
CLV_PCSK_SKI1_1	91	95	PF00082	0.426
DEG_APCC_DBOX_1	326	334	PF00400	0.443
DEG_Nend_Nbox_1	1	3	PF02207	0.405
DOC_CYCLIN_RxL_1	128	135	PF00134	0.480
DOC_CYCLIN_RxL_1	88	97	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	501	507	PF00134	0.480
DOC_MAPK_DCC_7	59	68	PF00069	0.428
DOC_MAPK_gen_1	327	333	PF00069	0.401
DOC_MAPK_gen_1	378	387	PF00069	0.323
DOC_MAPK_gen_1	513	519	PF00069	0.443
DOC_MAPK_MEF2A_6	59	68	PF00069	0.404
DOC_MAPK_RevD_3	499	515	PF00069	0.443
DOC_PP1_RVXF_1	260	267	PF00149	0.343
DOC_PP1_RVXF_1	513	520	PF00149	0.330
DOC_PP1_RVXF_1	89	96	PF00149	0.368
DOC_PP4_FxxP_1	149	152	PF00568	0.323
DOC_USP7_MATH_1	122	126	PF00917	0.419
DOC_USP7_MATH_1	160	164	PF00917	0.490
DOC_USP7_MATH_1	188	192	PF00917	0.323
DOC_USP7_MATH_1	395	399	PF00917	0.590
DOC_USP7_MATH_1	469	473	PF00917	0.428
DOC_USP7_UBL2_3	378	382	PF12436	0.563
DOC_USP7_UBL2_3	413	417	PF12436	0.537
DOC_USP7_UBL2_3	502	506	PF12436	0.343
DOC_WW_Pin1_4	257	262	PF00397	0.455
DOC_WW_Pin1_4	500	505	PF00397	0.443
DOC_WW_Pin1_4	58	63	PF00397	0.426
DOC_WW_Pin1_4	74	79	PF00397	0.323
LIG_14-3-3_CanoR_1	174	183	PF00244	0.428
LIG_14-3-3_CanoR_1	300	308	PF00244	0.343
LIG_14-3-3_CanoR_1	344	352	PF00244	0.559
LIG_14-3-3_CanoR_1	353	358	PF00244	0.523
LIG_14-3-3_CanoR_1	383	388	PF00244	0.561
LIG_14-3-3_CanoR_1	498	502	PF00244	0.345
LIG_Actin_WH2_2	46	61	PF00022	0.405
LIG_Actin_WH2_2	490	508	PF00022	0.480
LIG_AP2alpha_1	149	153	PF02296	0.443
LIG_AP2alpha_2	151	153	PF02296	0.443
LIG_APCC_ABBA_1	92	97	PF00400	0.443
LIG_APCC_ABBAyCdc20_2	91	97	PF00400	0.443
LIG_BIR_III_2	371	375	PF00653	0.438
LIG_BIR_III_4	436	440	PF00653	0.564
LIG_BRCT_BRCA1_1	8	12	PF00533	0.343
LIG_deltaCOP1_diTrp_1	494	499	PF00928	0.343
LIG_eIF4E_1	269	275	PF01652	0.368
LIG_FHA_1	156	162	PF00498	0.362
LIG_FHA_1	258	264	PF00498	0.445
LIG_FHA_1	346	352	PF00498	0.569
LIG_FHA_1	365	371	PF00498	0.518
LIG_FHA_1	428	434	PF00498	0.610
LIG_FHA_1	457	463	PF00498	0.538
LIG_FHA_2	130	136	PF00498	0.479
LIG_FHA_2	216	222	PF00498	0.305
LIG_FHA_2	333	339	PF00498	0.438
LIG_FHA_2	352	358	PF00498	0.261
LIG_HCF-1_HBM_1	312	315	PF13415	0.430
LIG_LIR_Gen_1	114	122	PF02991	0.343
LIG_LIR_Gen_1	151	162	PF02991	0.366
LIG_LIR_Gen_1	175	184	PF02991	0.480
LIG_LIR_Gen_1	230	240	PF02991	0.446
LIG_LIR_Gen_1	474	483	PF02991	0.343
LIG_LIR_Gen_1	494	504	PF02991	0.155
LIG_LIR_Gen_1	9	19	PF02991	0.343
LIG_LIR_Nem_3	114	119	PF02991	0.343
LIG_LIR_Nem_3	150	156	PF02991	0.369
LIG_LIR_Nem_3	230	236	PF02991	0.446
LIG_LIR_Nem_3	268	272	PF02991	0.343
LIG_LIR_Nem_3	434	438	PF02991	0.540
LIG_LIR_Nem_3	474	479	PF02991	0.343
LIG_LIR_Nem_3	494	499	PF02991	0.155
LIG_LIR_Nem_3	537	543	PF02991	0.487
LIG_LIR_Nem_3	83	87	PF02991	0.443
LIG_LIR_Nem_3	9	15	PF02991	0.343
LIG_LYPXL_yS_3	84	87	PF13949	0.443
LIG_Pex14_1	528	532	PF04695	0.428
LIG_Pex14_2	149	153	PF04695	0.443
LIG_RPA_C_Fungi	376	388	PF08784	0.466
LIG_SH2_CRK	269	273	PF00017	0.368
LIG_SH2_CRK	438	442	PF00017	0.622
LIG_SH2_GRB2like	534	537	PF00017	0.414
LIG_SH2_NCK_1	116	120	PF00017	0.405
LIG_SH2_SRC	116	119	PF00017	0.405
LIG_SH2_SRC	139	142	PF00017	0.343
LIG_SH2_SRC	534	537	PF00017	0.470
LIG_SH2_STAP1	473	477	PF00017	0.343
LIG_SH2_STAP1	507	511	PF00017	0.443
LIG_SH2_STAT3	315	318	PF00017	0.446
LIG_SH2_STAT5	139	142	PF00017	0.343
LIG_SH2_STAT5	534	537	PF00017	0.414
LIG_SH2_STAT5	57	60	PF00017	0.443
LIG_SH3_3	139	145	PF00018	0.413
LIG_SH3_3	438	444	PF00018	0.599
LIG_Sin3_3	153	160	PF02671	0.443
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.330
LIG_SUMO_SIM_par_1	359	364	PF11976	0.540
LIG_SxIP_EBH_1	55	69	PF03271	0.461
LIG_TRAF2_1	3	6	PF00917	0.443
LIG_TYR_ITIM	137	142	PF00017	0.343
LIG_WW_3	465	469	PF00397	0.368
MOD_CDC14_SPxK_1	503	506	PF00782	0.443
MOD_CDK_SPK_2	257	262	PF00069	0.427
MOD_CDK_SPxK_1	500	506	PF00069	0.443
MOD_CK1_1	250	256	PF00069	0.497
MOD_CK1_1	257	263	PF00069	0.366
MOD_CK1_1	500	506	PF00069	0.373
MOD_CK2_1	129	135	PF00069	0.483
MOD_CK2_1	215	221	PF00069	0.370
MOD_CK2_1	343	349	PF00069	0.491
MOD_CK2_1	353	359	PF00069	0.390
MOD_GlcNHglycan	186	189	PF01048	0.471
MOD_GlcNHglycan	192	195	PF01048	0.427
MOD_GlcNHglycan	240	243	PF01048	0.438
MOD_GlcNHglycan	249	252	PF01048	0.365
MOD_GlcNHglycan	256	259	PF01048	0.301
MOD_GlcNHglycan	303	306	PF01048	0.443
MOD_GlcNHglycan	308	311	PF01048	0.443
MOD_GlcNHglycan	320	323	PF01048	0.443
MOD_GlcNHglycan	397	400	PF01048	0.617
MOD_GSK3_1	184	191	PF00069	0.324
MOD_GSK3_1	234	241	PF00069	0.448
MOD_GSK3_1	250	257	PF00069	0.471
MOD_GSK3_1	343	350	PF00069	0.606
MOD_GSK3_1	47	54	PF00069	0.405
MOD_GSK3_1	6	13	PF00069	0.339
MOD_LATS_1	172	178	PF00433	0.443
MOD_N-GLC_1	279	284	PF02516	0.343
MOD_N-GLC_1	484	489	PF02516	0.343
MOD_N-GLC_1	535	540	PF02516	0.426
MOD_NEK2_1	155	160	PF00069	0.443
MOD_NEK2_1	361	366	PF00069	0.397
MOD_NEK2_1	408	413	PF00069	0.559
MOD_NEK2_1	535	540	PF00069	0.426
MOD_NEK2_2	64	69	PF00069	0.443
MOD_PKA_1	51	57	PF00069	0.434
MOD_PKA_1	7	13	PF00069	0.443
MOD_PKA_2	343	349	PF00069	0.550
MOD_PKA_2	497	503	PF00069	0.345
MOD_PKA_2	51	57	PF00069	0.434
MOD_PKB_1	381	389	PF00069	0.324
MOD_Plk_1	129	135	PF00069	0.330
MOD_Plk_1	215	221	PF00069	0.261
MOD_Plk_1	279	285	PF00069	0.343
MOD_Plk_1	361	367	PF00069	0.458
MOD_Plk_1	535	541	PF00069	0.438
MOD_Plk_4	129	135	PF00069	0.330
MOD_Plk_4	27	33	PF00069	0.345
MOD_Plk_4	347	353	PF00069	0.600
MOD_Plk_4	361	367	PF00069	0.320
MOD_Plk_4	383	389	PF00069	0.592
MOD_Plk_4	535	541	PF00069	0.438
MOD_Plk_4	64	70	PF00069	0.432
MOD_ProDKin_1	257	263	PF00069	0.455
MOD_ProDKin_1	500	506	PF00069	0.443
MOD_ProDKin_1	58	64	PF00069	0.426
MOD_ProDKin_1	74	80	PF00069	0.301
MOD_SUMO_rev_2	371	377	PF00179	0.581
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.386
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.346
TRG_ENDOCYTIC_2	116	119	PF00928	0.480
TRG_ENDOCYTIC_2	139	142	PF00928	0.343
TRG_ENDOCYTIC_2	233	236	PF00928	0.443
TRG_ENDOCYTIC_2	269	272	PF00928	0.368
TRG_ENDOCYTIC_2	438	441	PF00928	0.635
TRG_ENDOCYTIC_2	84	87	PF00928	0.443
TRG_ER_diArg_1	198	200	PF00400	0.205
TRG_ER_diArg_1	327	330	PF00400	0.415
TRG_ER_diArg_1	402	404	PF00400	0.627
TRG_ER_diArg_1	419	422	PF00400	0.524
TRG_ER_diArg_1	452	454	PF00400	0.464
TRG_ER_diArg_1	528	530	PF00400	0.446
TRG_NLS_MonoExtN_4	195	201	PF00514	0.424
TRG_NLS_MonoExtN_4	202	208	PF00514	0.367
TRG_NLS_MonoExtN_4	378	385	PF00514	0.318
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	368	373	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T3	Leptomonas seymouri	67%	71%
A0A1X0NMZ0	Trypanosomatidae	47%	71%
A0A3R7JWW2	Trypanosoma rangeli	48%	77%
A0A3S7WS08	Leishmania donovani	94%	100%
A4H6X7	Leishmania braziliensis	81%	94%
E9AGF1	Leishmania infantum	93%	100%
E9ANZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DG34	Trypanosoma cruzi	46%	90%