Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGM8_LEIMA

TriTrypDb:

LmjF.12.0650 , LMJLV39_120012000 , LMJSD75_120011900

Length:

818

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGM8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004843	cysteine-type deubiquitinase activity	5	7
GO:0008233	peptidase activity	3	7
GO:0008234	cysteine-type peptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0019783	ubiquitin-like protein peptidase activity	4	7
GO:0101005	deubiquitinase activity	5	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1990380	K48-linked deubiquitinase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.501
CLV_C14_Caspase3-7	335	339	PF00656	0.593
CLV_C14_Caspase3-7	391	395	PF00656	0.677
CLV_C14_Caspase3-7	475	479	PF00656	0.755
CLV_NRD_NRD_1	154	156	PF00675	0.490
CLV_NRD_NRD_1	234	236	PF00675	0.598
CLV_NRD_NRD_1	366	368	PF00675	0.649
CLV_NRD_NRD_1	376	378	PF00675	0.605
CLV_NRD_NRD_1	429	431	PF00675	0.805
CLV_NRD_NRD_1	439	441	PF00675	0.661
CLV_NRD_NRD_1	482	484	PF00675	0.747
CLV_NRD_NRD_1	807	809	PF00675	0.682
CLV_NRD_NRD_1	811	813	PF00675	0.676
CLV_PCSK_FUR_1	374	378	PF00082	0.590
CLV_PCSK_KEX2_1	109	111	PF00082	0.453
CLV_PCSK_KEX2_1	154	156	PF00082	0.490
CLV_PCSK_KEX2_1	234	236	PF00082	0.598
CLV_PCSK_KEX2_1	312	314	PF00082	0.730
CLV_PCSK_KEX2_1	374	376	PF00082	0.643
CLV_PCSK_KEX2_1	382	384	PF00082	0.691
CLV_PCSK_KEX2_1	429	431	PF00082	0.732
CLV_PCSK_KEX2_1	438	440	PF00082	0.638
CLV_PCSK_KEX2_1	482	484	PF00082	0.809
CLV_PCSK_KEX2_1	811	813	PF00082	0.672
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.453
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.730
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.627
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.752
CLV_PCSK_SKI1_1	134	138	PF00082	0.384
CLV_PCSK_SKI1_1	262	266	PF00082	0.536
CLV_PCSK_SKI1_1	341	345	PF00082	0.565
CLV_PCSK_SKI1_1	483	487	PF00082	0.802
CLV_PCSK_SKI1_1	522	526	PF00082	0.636
CLV_PCSK_SKI1_1	62	66	PF00082	0.491
CLV_PCSK_SKI1_1	811	815	PF00082	0.684
DEG_SCF_FBW7_1	96	102	PF00400	0.453
DEG_SPOP_SBC_1	280	284	PF00917	0.717
DEG_SPOP_SBC_1	549	553	PF00917	0.720
DOC_AGCK_PIF_1	84	89	PF00069	0.456
DOC_CKS1_1	15	20	PF01111	0.426
DOC_CKS1_1	96	101	PF01111	0.451
DOC_CYCLIN_RxL_1	131	141	PF00134	0.385
DOC_MAPK_DCC_7	110	120	PF00069	0.420
DOC_MAPK_gen_1	109	120	PF00069	0.422
DOC_MAPK_gen_1	805	815	PF00069	0.683
DOC_MAPK_MEF2A_6	113	122	PF00069	0.399
DOC_MAPK_MEF2A_6	262	269	PF00069	0.596
DOC_MAPK_MEF2A_6	808	817	PF00069	0.683
DOC_PP2B_LxvP_1	21	24	PF13499	0.464
DOC_PP2B_LxvP_1	265	268	PF13499	0.591
DOC_PP2B_PxIxI_1	671	677	PF00149	0.654
DOC_USP7_MATH_1	16	20	PF00917	0.432
DOC_USP7_MATH_1	175	179	PF00917	0.461
DOC_USP7_MATH_1	199	203	PF00917	0.579
DOC_USP7_MATH_1	278	282	PF00917	0.617
DOC_USP7_MATH_1	343	347	PF00917	0.676
DOC_USP7_MATH_1	395	399	PF00917	0.639
DOC_USP7_MATH_1	547	551	PF00917	0.842
DOC_USP7_MATH_1	609	613	PF00917	0.736
DOC_USP7_MATH_1	666	670	PF00917	0.754
DOC_USP7_MATH_1	704	708	PF00917	0.680
DOC_USP7_MATH_1	710	714	PF00917	0.622
DOC_USP7_MATH_1	759	763	PF00917	0.789
DOC_USP7_MATH_1	787	791	PF00917	0.817
DOC_USP7_MATH_1	804	808	PF00917	0.538
DOC_USP7_MATH_1	99	103	PF00917	0.459
DOC_USP7_UBL2_3	368	372	PF12436	0.671
DOC_USP7_UBL2_3	378	382	PF12436	0.557
DOC_USP7_UBL2_3	805	809	PF12436	0.787
DOC_WW_Pin1_4	113	118	PF00397	0.423
DOC_WW_Pin1_4	14	19	PF00397	0.416
DOC_WW_Pin1_4	171	176	PF00397	0.485
DOC_WW_Pin1_4	189	194	PF00397	0.422
DOC_WW_Pin1_4	35	40	PF00397	0.512
DOC_WW_Pin1_4	607	612	PF00397	0.733
DOC_WW_Pin1_4	66	71	PF00397	0.486
DOC_WW_Pin1_4	72	77	PF00397	0.481
DOC_WW_Pin1_4	722	727	PF00397	0.780
DOC_WW_Pin1_4	735	740	PF00397	0.714
DOC_WW_Pin1_4	745	750	PF00397	0.679
DOC_WW_Pin1_4	92	97	PF00397	0.411
LIG_14-3-3_CanoR_1	134	139	PF00244	0.388
LIG_14-3-3_CanoR_1	154	160	PF00244	0.446
LIG_14-3-3_CanoR_1	253	261	PF00244	0.612
LIG_14-3-3_CanoR_1	482	488	PF00244	0.815
LIG_14-3-3_CanoR_1	584	590	PF00244	0.713
LIG_14-3-3_CanoR_1	651	661	PF00244	0.541
LIG_Actin_WH2_2	225	240	PF00022	0.671
LIG_AP2alpha_2	513	515	PF02296	0.647
LIG_BIR_II_1	1	5	PF00653	0.407
LIG_BRCT_BRCA1_1	609	613	PF00533	0.791
LIG_BRCT_BRCA1_1	657	661	PF00533	0.779
LIG_BRCT_BRCA1_1	737	741	PF00533	0.727
LIG_BRCT_BRCA1_1	789	793	PF00533	0.745
LIG_Clathr_ClatBox_1	357	361	PF01394	0.470
LIG_CtBP_PxDLS_1	117	121	PF00389	0.381
LIG_FHA_1	131	137	PF00498	0.476
LIG_FHA_1	205	211	PF00498	0.664
LIG_FHA_1	490	496	PF00498	0.808
LIG_FHA_1	67	73	PF00498	0.491
LIG_FHA_1	96	102	PF00498	0.453
LIG_FHA_2	166	172	PF00498	0.499
LIG_FHA_2	289	295	PF00498	0.576
LIG_FHA_2	45	51	PF00498	0.520
LIG_FHA_2	473	479	PF00498	0.833
LIG_FHA_2	779	785	PF00498	0.809
LIG_LIR_Apic_2	607	611	PF02991	0.713
LIG_LIR_Gen_1	353	360	PF02991	0.598
LIG_LIR_Gen_1	738	749	PF02991	0.576
LIG_LIR_Gen_1	85	94	PF02991	0.627
LIG_LIR_Nem_3	305	309	PF02991	0.656
LIG_LIR_Nem_3	353	357	PF02991	0.601
LIG_LIR_Nem_3	82	87	PF02991	0.455
LIG_LIR_Nem_3	88	94	PF02991	0.539
LIG_PCNA_yPIPBox_3	221	232	PF02747	0.531
LIG_SH2_CRK	608	612	PF00017	0.713
LIG_SH2_CRK	87	91	PF00017	0.460
LIG_SH2_GRB2like	657	660	PF00017	0.543
LIG_SH2_NCK_1	424	428	PF00017	0.745
LIG_SH2_NCK_1	608	612	PF00017	0.694
LIG_SH2_STAP1	354	358	PF00017	0.531
LIG_SH2_STAP1	698	702	PF00017	0.789
LIG_SH2_STAP1	87	91	PF00017	0.630
LIG_SH2_STAT5	71	74	PF00017	0.504
LIG_SH2_STAT5	77	80	PF00017	0.460
LIG_SH2_STAT5	87	90	PF00017	0.429
LIG_SH3_3	284	290	PF00018	0.746
LIG_SH3_3	93	99	PF00018	0.448
LIG_SH3_4	805	812	PF00018	0.784
LIG_SUMO_SIM_par_1	116	121	PF11976	0.383
LIG_SUMO_SIM_par_1	355	362	PF11976	0.468
LIG_SxIP_EBH_1	635	645	PF03271	0.722
LIG_TRAF2_1	359	362	PF00917	0.553
LIG_WRC_WIRS_1	241	246	PF05994	0.698
LIG_WRC_WIRS_1	86	91	PF05994	0.459
MOD_CDK_SPK_2	35	40	PF00069	0.512
MOD_CDK_SPxK_1	171	177	PF00069	0.485
MOD_CDK_SPxxK_3	35	42	PF00069	0.517
MOD_CDK_SPxxK_3	66	73	PF00069	0.490
MOD_CK1_1	116	122	PF00069	0.381
MOD_CK1_1	141	147	PF00069	0.443
MOD_CK1_1	189	195	PF00069	0.449
MOD_CK1_1	281	287	PF00069	0.654
MOD_CK1_1	305	311	PF00069	0.688
MOD_CK1_1	406	412	PF00069	0.737
MOD_CK1_1	425	431	PF00069	0.721
MOD_CK1_1	442	448	PF00069	0.640
MOD_CK1_1	481	487	PF00069	0.727
MOD_CK1_1	489	495	PF00069	0.746
MOD_CK1_1	518	524	PF00069	0.612
MOD_CK1_1	550	556	PF00069	0.810
MOD_CK1_1	564	570	PF00069	0.781
MOD_CK1_1	655	661	PF00069	0.755
MOD_CK1_1	670	676	PF00069	0.510
MOD_CK1_1	717	723	PF00069	0.754
MOD_CK1_1	742	748	PF00069	0.803
MOD_CK1_1	75	81	PF00069	0.472
MOD_CK1_1	779	785	PF00069	0.809
MOD_CK1_1	789	795	PF00069	0.652
MOD_CK1_1	85	91	PF00069	0.438
MOD_CK1_1	95	101	PF00069	0.412
MOD_CK2_1	167	173	PF00069	0.503
MOD_CK2_1	199	205	PF00069	0.522
MOD_CK2_1	212	218	PF00069	0.446
MOD_CK2_1	288	294	PF00069	0.552
MOD_CK2_1	323	329	PF00069	0.596
MOD_CK2_1	395	401	PF00069	0.767
MOD_CK2_1	44	50	PF00069	0.527
MOD_CK2_1	503	509	PF00069	0.746
MOD_CK2_1	778	784	PF00069	0.770
MOD_CK2_1	804	810	PF00069	0.684
MOD_Cter_Amidation	310	313	PF01082	0.705
MOD_Cter_Amidation	436	439	PF01082	0.752
MOD_DYRK1A_RPxSP_1	724	728	PF00069	0.655
MOD_GlcNHglycan	177	180	PF01048	0.463
MOD_GlcNHglycan	283	286	PF01048	0.602
MOD_GlcNHglycan	29	33	PF01048	0.495
MOD_GlcNHglycan	345	348	PF01048	0.516
MOD_GlcNHglycan	441	444	PF01048	0.697
MOD_GlcNHglycan	446	449	PF01048	0.642
MOD_GlcNHglycan	464	467	PF01048	0.804
MOD_GlcNHglycan	475	478	PF01048	0.756
MOD_GlcNHglycan	483	486	PF01048	0.807
MOD_GlcNHglycan	488	491	PF01048	0.789
MOD_GlcNHglycan	517	520	PF01048	0.628
MOD_GlcNHglycan	589	592	PF01048	0.793
MOD_GlcNHglycan	59	62	PF01048	0.498
MOD_GlcNHglycan	613	616	PF01048	0.768
MOD_GlcNHglycan	617	620	PF01048	0.795
MOD_GlcNHglycan	662	665	PF01048	0.768
MOD_GlcNHglycan	669	672	PF01048	0.600
MOD_GlcNHglycan	679	682	PF01048	0.629
MOD_GlcNHglycan	706	709	PF01048	0.786
MOD_GlcNHglycan	712	715	PF01048	0.714
MOD_GlcNHglycan	716	719	PF01048	0.722
MOD_GlcNHglycan	761	764	PF01048	0.725
MOD_GlcNHglycan	767	770	PF01048	0.699
MOD_GlcNHglycan	781	784	PF01048	0.478
MOD_GlcNHglycan	789	792	PF01048	0.733
MOD_GSK3_1	116	123	PF00069	0.375
MOD_GSK3_1	130	137	PF00069	0.324
MOD_GSK3_1	167	174	PF00069	0.500
MOD_GSK3_1	189	196	PF00069	0.545
MOD_GSK3_1	276	283	PF00069	0.674
MOD_GSK3_1	295	302	PF00069	0.654
MOD_GSK3_1	384	391	PF00069	0.553
MOD_GSK3_1	499	506	PF00069	0.721
MOD_GSK3_1	561	568	PF00069	0.787
MOD_GSK3_1	587	594	PF00069	0.740
MOD_GSK3_1	607	614	PF00069	0.787
MOD_GSK3_1	62	69	PF00069	0.586
MOD_GSK3_1	666	673	PF00069	0.752
MOD_GSK3_1	694	701	PF00069	0.725
MOD_GSK3_1	71	78	PF00069	0.499
MOD_GSK3_1	710	717	PF00069	0.610
MOD_GSK3_1	731	738	PF00069	0.672
MOD_GSK3_1	739	746	PF00069	0.756
MOD_GSK3_1	775	782	PF00069	0.721
MOD_GSK3_1	783	790	PF00069	0.697
MOD_GSK3_1	95	102	PF00069	0.453
MOD_LATS_1	633	639	PF00433	0.557
MOD_N-GLC_1	604	609	PF02516	0.708
MOD_N-GLC_2	729	731	PF02516	0.568
MOD_NEK2_1	118	123	PF00069	0.365
MOD_NEK2_1	138	143	PF00069	0.488
MOD_NEK2_1	210	215	PF00069	0.538
MOD_NEK2_1	237	242	PF00069	0.595
MOD_NEK2_1	28	33	PF00069	0.494
MOD_NEK2_1	515	520	PF00069	0.713
MOD_NEK2_1	613	618	PF00069	0.798
MOD_NEK2_1	634	639	PF00069	0.712
MOD_NEK2_1	653	658	PF00069	0.769
MOD_NEK2_1	709	714	PF00069	0.754
MOD_NEK2_1	733	738	PF00069	0.736
MOD_NEK2_1	776	781	PF00069	0.712
MOD_PIKK_1	193	199	PF00454	0.430
MOD_PIKK_1	44	50	PF00454	0.527
MOD_PIKK_1	62	68	PF00454	0.488
MOD_PK_1	155	161	PF00069	0.479
MOD_PK_1	635	641	PF00069	0.707
MOD_PKA_1	439	445	PF00069	0.743
MOD_PKA_2	141	147	PF00069	0.443
MOD_PKA_2	237	243	PF00069	0.675
MOD_PKA_2	271	277	PF00069	0.668
MOD_PKA_2	299	305	PF00069	0.586
MOD_PKA_2	384	390	PF00069	0.628
MOD_PKA_2	43	49	PF00069	0.531
MOD_PKA_2	439	445	PF00069	0.750
MOD_PKA_2	481	487	PF00069	0.817
MOD_PKA_2	704	710	PF00069	0.746
MOD_PKA_2	776	782	PF00069	0.710
MOD_PKB_1	528	536	PF00069	0.669
MOD_Plk_1	251	257	PF00069	0.624
MOD_Plk_1	698	704	PF00069	0.782
MOD_Plk_2-3	323	329	PF00069	0.604
MOD_Plk_2-3	401	407	PF00069	0.741
MOD_Plk_2-3	507	513	PF00069	0.759
MOD_Plk_4	16	22	PF00069	0.440
MOD_Plk_4	288	294	PF00069	0.589
MOD_Plk_4	561	567	PF00069	0.575
MOD_Plk_4	670	676	PF00069	0.654
MOD_Plk_4	85	91	PF00069	0.660
MOD_ProDKin_1	113	119	PF00069	0.413
MOD_ProDKin_1	14	20	PF00069	0.421
MOD_ProDKin_1	171	177	PF00069	0.485
MOD_ProDKin_1	189	195	PF00069	0.425
MOD_ProDKin_1	35	41	PF00069	0.515
MOD_ProDKin_1	607	613	PF00069	0.735
MOD_ProDKin_1	66	72	PF00069	0.488
MOD_ProDKin_1	722	728	PF00069	0.774
MOD_ProDKin_1	735	741	PF00069	0.716
MOD_ProDKin_1	745	751	PF00069	0.691
MOD_ProDKin_1	92	98	PF00069	0.450
MOD_SUMO_rev_2	49	54	PF00179	0.501
TRG_DiLeu_BaEn_1	218	223	PF01217	0.519
TRG_DiLeu_BaEn_1	353	358	PF01217	0.664
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.458
TRG_ENDOCYTIC_2	306	309	PF00928	0.668
TRG_ENDOCYTIC_2	354	357	PF00928	0.566
TRG_ENDOCYTIC_2	87	90	PF00928	0.630
TRG_ER_diArg_1	154	156	PF00400	0.490
TRG_ER_diArg_1	374	377	PF00400	0.592
TRG_ER_diArg_1	429	431	PF00400	0.732
TRG_ER_diArg_1	439	441	PF00400	0.626
TRG_ER_diArg_1	811	813	PF00400	0.658
TRG_NLS_MonoExtN_4	435	442	PF00514	0.706
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	258	263	PF00026	0.695
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	439	444	PF00026	0.743

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E7	Leptomonas seymouri	40%	100%
A0A3S7WRY5	Leishmania donovani	88%	100%
A4H6X8	Leishmania braziliensis	68%	100%
E9AGF2	Leishmania infantum	88%	100%
E9ANZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%