LeishMANIAdb
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Serine/threonine-protein phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein phosphatase
Gene product:
ser/thr protein phosphatase, putative
Species:
Leishmania major
UniProt:
Q4QGM7_LEIMA
TriTrypDb:
LmjF.12.0660 , LMJLV39_120012100 , LMJSD75_120012000
Length:
954

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005654 nucleoplasm 2 2
GO:0005737 cytoplasm 2 2
GO:0005829 cytosol 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4QGM7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGM7

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016311 dephosphorylation 5 1
GO:0019538 protein metabolic process 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 14
GO:0004721 phosphoprotein phosphatase activity 3 14
GO:0004722 protein serine/threonine phosphatase activity 4 14
GO:0005488 binding 1 9
GO:0005509 calcium ion binding 5 9
GO:0016787 hydrolase activity 2 14
GO:0016788 hydrolase activity, acting on ester bonds 3 14
GO:0016791 phosphatase activity 5 14
GO:0017018 myosin phosphatase activity 5 14
GO:0042578 phosphoric ester hydrolase activity 4 14
GO:0043167 ion binding 2 9
GO:0043169 cation binding 3 9
GO:0046872 metal ion binding 4 9
GO:0140096 catalytic activity, acting on a protein 2 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 607 611 PF00656 0.612
CLV_MEL_PAP_1 330 336 PF00089 0.546
CLV_NRD_NRD_1 116 118 PF00675 0.602
CLV_NRD_NRD_1 183 185 PF00675 0.683
CLV_NRD_NRD_1 33 35 PF00675 0.768
CLV_NRD_NRD_1 466 468 PF00675 0.339
CLV_NRD_NRD_1 649 651 PF00675 0.522
CLV_NRD_NRD_1 666 668 PF00675 0.321
CLV_NRD_NRD_1 71 73 PF00675 0.601
CLV_NRD_NRD_1 877 879 PF00675 0.506
CLV_NRD_NRD_1 917 919 PF00675 0.608
CLV_PCSK_KEX2_1 116 118 PF00082 0.650
CLV_PCSK_KEX2_1 183 185 PF00082 0.683
CLV_PCSK_KEX2_1 255 257 PF00082 0.607
CLV_PCSK_KEX2_1 33 35 PF00082 0.781
CLV_PCSK_KEX2_1 465 467 PF00082 0.318
CLV_PCSK_KEX2_1 649 651 PF00082 0.509
CLV_PCSK_KEX2_1 666 668 PF00082 0.323
CLV_PCSK_KEX2_1 917 919 PF00082 0.653
CLV_PCSK_PC1ET2_1 255 257 PF00082 0.641
CLV_PCSK_PC7_1 662 668 PF00082 0.376
CLV_PCSK_SKI1_1 163 167 PF00082 0.573
CLV_PCSK_SKI1_1 210 214 PF00082 0.499
CLV_PCSK_SKI1_1 293 297 PF00082 0.467
CLV_PCSK_SKI1_1 298 302 PF00082 0.406
CLV_PCSK_SKI1_1 308 312 PF00082 0.263
CLV_PCSK_SKI1_1 403 407 PF00082 0.360
CLV_PCSK_SKI1_1 433 437 PF00082 0.352
CLV_PCSK_SKI1_1 558 562 PF00082 0.365
CLV_PCSK_SKI1_1 644 648 PF00082 0.618
CLV_PCSK_SKI1_1 695 699 PF00082 0.383
CLV_PCSK_SKI1_1 879 883 PF00082 0.471
CLV_PCSK_SKI1_1 89 93 PF00082 0.469
DEG_APCC_DBOX_1 707 715 PF00400 0.532
DEG_APCC_DBOX_1 844 852 PF00400 0.469
DEG_SPOP_SBC_1 268 272 PF00917 0.615
DOC_ANK_TNKS_1 183 190 PF00023 0.548
DOC_CDC14_PxL_1 720 728 PF14671 0.492
DOC_CYCLIN_RxL_1 638 651 PF00134 0.589
DOC_CYCLIN_yCln2_LP_2 700 706 PF00134 0.414
DOC_MAPK_gen_1 293 301 PF00069 0.538
DOC_MAPK_gen_1 465 471 PF00069 0.325
DOC_MAPK_gen_1 476 485 PF00069 0.325
DOC_MAPK_MEF2A_6 383 392 PF00069 0.300
DOC_MAPK_MEF2A_6 695 702 PF00069 0.419
DOC_MAPK_NFAT4_5 695 703 PF00069 0.422
DOC_PP1_RVXF_1 166 172 PF00149 0.665
DOC_PP2B_LxvP_1 614 617 PF13499 0.542
DOC_PP2B_LxvP_1 700 703 PF13499 0.413
DOC_PP4_FxxP_1 185 188 PF00568 0.560
DOC_USP7_MATH_1 15 19 PF00917 0.658
DOC_USP7_MATH_1 254 258 PF00917 0.600
DOC_USP7_MATH_1 268 272 PF00917 0.536
DOC_USP7_MATH_1 332 336 PF00917 0.547
DOC_USP7_MATH_1 368 372 PF00917 0.384
DOC_USP7_MATH_1 586 590 PF00917 0.364
DOC_USP7_MATH_1 59 63 PF00917 0.651
DOC_USP7_UBL2_3 159 163 PF12436 0.592
DOC_USP7_UBL2_3 241 245 PF12436 0.583
DOC_USP7_UBL2_3 73 77 PF12436 0.620
DOC_WW_Pin1_4 324 329 PF00397 0.440
LIG_14-3-3_CanoR_1 256 261 PF00244 0.677
LIG_14-3-3_CanoR_1 308 317 PF00244 0.366
LIG_14-3-3_CanoR_1 621 626 PF00244 0.618
LIG_14-3-3_CanoR_1 742 746 PF00244 0.467
LIG_14-3-3_CanoR_1 853 861 PF00244 0.576
LIG_14-3-3_CanoR_1 878 884 PF00244 0.520
LIG_14-3-3_CanoR_1 917 921 PF00244 0.634
LIG_14-3-3_CanoR_1 943 948 PF00244 0.654
LIG_Actin_WH2_2 348 365 PF00022 0.453
LIG_BRCT_BRCA1_1 271 275 PF00533 0.494
LIG_BRCT_BRCA1_1 630 634 PF00533 0.753
LIG_BRCT_BRCA1_1 762 766 PF00533 0.550
LIG_BRCT_BRCA1_2 762 768 PF00533 0.549
LIG_CaM_IQ_9 202 217 PF13499 0.456
LIG_Clathr_ClatBox_1 711 715 PF01394 0.528
LIG_deltaCOP1_diTrp_1 701 706 PF00928 0.411
LIG_deltaCOP1_diTrp_1 735 741 PF00928 0.546
LIG_DLG_GKlike_1 943 950 PF00625 0.672
LIG_EH1_1 285 293 PF00400 0.445
LIG_FHA_1 176 182 PF00498 0.499
LIG_FHA_1 624 630 PF00498 0.658
LIG_FHA_2 427 433 PF00498 0.308
LIG_FHA_2 784 790 PF00498 0.407
LIG_FHA_2 853 859 PF00498 0.577
LIG_Integrin_isoDGR_2 336 338 PF01839 0.550
LIG_LIR_Apic_2 499 505 PF02991 0.322
LIG_LIR_Apic_2 566 571 PF02991 0.436
LIG_LIR_Apic_2 718 724 PF02991 0.459
LIG_LIR_Gen_1 235 242 PF02991 0.547
LIG_LIR_Gen_1 494 505 PF02991 0.322
LIG_LIR_Gen_1 592 600 PF02991 0.566
LIG_LIR_Gen_1 775 783 PF02991 0.399
LIG_LIR_Gen_1 887 898 PF02991 0.464
LIG_LIR_Gen_1 902 913 PF02991 0.437
LIG_LIR_Nem_3 220 226 PF02991 0.479
LIG_LIR_Nem_3 235 240 PF02991 0.551
LIG_LIR_Nem_3 271 277 PF02991 0.570
LIG_LIR_Nem_3 370 376 PF02991 0.341
LIG_LIR_Nem_3 573 578 PF02991 0.395
LIG_LIR_Nem_3 587 593 PF02991 0.382
LIG_LIR_Nem_3 701 707 PF02991 0.410
LIG_LIR_Nem_3 775 779 PF02991 0.401
LIG_LIR_Nem_3 902 908 PF02991 0.423
LIG_LIR_Nem_3 945 950 PF02991 0.559
LIG_MLH1_MIPbox_1 271 275 PF16413 0.494
LIG_PCNA_PIPBox_1 104 113 PF02747 0.562
LIG_Pex14_1 721 725 PF04695 0.394
LIG_Pex14_2 725 729 PF04695 0.353
LIG_PTB_Apo_2 170 177 PF02174 0.636
LIG_PTB_Apo_2 374 381 PF02174 0.300
LIG_PTB_Apo_2 415 422 PF02174 0.322
LIG_PTB_Apo_2 941 948 PF02174 0.593
LIG_PTB_Phospho_1 374 380 PF10480 0.460
LIG_PTB_Phospho_1 415 421 PF10480 0.322
LIG_SH2_CRK 568 572 PF00017 0.506
LIG_SH2_CRK 575 579 PF00017 0.409
LIG_SH2_GRB2like 416 419 PF00017 0.318
LIG_SH2_NCK_1 488 492 PF00017 0.360
LIG_SH2_PTP2 404 407 PF00017 0.334
LIG_SH2_SRC 551 554 PF00017 0.428
LIG_SH2_SRC 600 603 PF00017 0.585
LIG_SH2_STAP1 431 435 PF00017 0.322
LIG_SH2_STAT5 274 277 PF00017 0.413
LIG_SH2_STAT5 374 377 PF00017 0.349
LIG_SH2_STAT5 380 383 PF00017 0.343
LIG_SH2_STAT5 404 407 PF00017 0.334
LIG_SH2_STAT5 673 676 PF00017 0.396
LIG_SH2_STAT5 705 708 PF00017 0.389
LIG_SH2_STAT5 710 713 PF00017 0.364
LIG_SH2_STAT5 785 788 PF00017 0.418
LIG_SH2_STAT5 913 916 PF00017 0.488
LIG_SH3_3 248 254 PF00018 0.613
LIG_SH3_3 262 268 PF00018 0.483
LIG_SH3_3 296 302 PF00018 0.425
LIG_SH3_4 144 151 PF00018 0.612
LIG_SH3_5 75 79 PF00018 0.553
LIG_SUMO_SIM_anti_2 389 396 PF11976 0.325
LIG_SUMO_SIM_par_1 128 133 PF11976 0.561
LIG_SUMO_SIM_par_1 344 350 PF11976 0.314
LIG_SUMO_SIM_par_1 389 396 PF11976 0.340
LIG_SUMO_SIM_par_1 558 564 PF11976 0.377
LIG_SUMO_SIM_par_1 601 611 PF11976 0.639
LIG_SUMO_SIM_par_1 710 716 PF11976 0.546
LIG_TRAF2_1 26 29 PF00917 0.508
LIG_UBA3_1 291 296 PF00899 0.523
LIG_UBA3_1 358 363 PF00899 0.329
LIG_UBA3_1 394 403 PF00899 0.340
LIG_UBA3_1 889 894 PF00899 0.473
LIG_WRC_WIRS_1 578 583 PF05994 0.503
LIG_WRC_WIRS_1 622 627 PF05994 0.612
LIG_WRC_WIRS_1 796 801 PF05994 0.536
LIG_WW_3 462 466 PF00397 0.304
MOD_CK1_1 16 22 PF00069 0.733
MOD_CK1_1 37 43 PF00069 0.742
MOD_CK1_1 47 53 PF00069 0.735
MOD_CK1_1 525 531 PF00069 0.376
MOD_CK1_1 589 595 PF00069 0.516
MOD_CK1_1 623 629 PF00069 0.693
MOD_CK1_1 925 931 PF00069 0.559
MOD_CK2_1 2 8 PF00069 0.618
MOD_CK2_1 486 492 PF00069 0.331
MOD_CK2_1 508 514 PF00069 0.231
MOD_CK2_1 546 552 PF00069 0.472
MOD_CK2_1 795 801 PF00069 0.508
MOD_CK2_1 805 811 PF00069 0.552
MOD_CMANNOS 94 97 PF00535 0.530
MOD_Cter_Amidation 114 117 PF01082 0.649
MOD_Cter_Amidation 31 34 PF01082 0.621
MOD_GlcNHglycan 15 18 PF01048 0.673
MOD_GlcNHglycan 364 367 PF01048 0.417
MOD_GlcNHglycan 46 49 PF01048 0.776
MOD_GlcNHglycan 548 551 PF01048 0.492
MOD_GlcNHglycan 563 566 PF01048 0.273
MOD_GlcNHglycan 762 765 PF01048 0.562
MOD_GlcNHglycan 807 810 PF01048 0.482
MOD_GlcNHglycan 947 950 PF01048 0.607
MOD_GSK3_1 218 225 PF00069 0.622
MOD_GSK3_1 34 41 PF00069 0.667
MOD_GSK3_1 362 369 PF00069 0.449
MOD_GSK3_1 508 515 PF00069 0.231
MOD_GSK3_1 59 66 PF00069 0.598
MOD_GSK3_1 600 607 PF00069 0.627
MOD_GSK3_1 608 615 PF00069 0.543
MOD_GSK3_1 621 628 PF00069 0.609
MOD_GSK3_1 636 643 PF00069 0.634
MOD_GSK3_1 677 684 PF00069 0.407
MOD_GSK3_1 756 763 PF00069 0.566
MOD_GSK3_1 843 850 PF00069 0.538
MOD_GSK3_1 89 96 PF00069 0.486
MOD_GSK3_1 9 16 PF00069 0.658
MOD_GSK3_1 923 930 PF00069 0.652
MOD_GSK3_1 938 945 PF00069 0.397
MOD_N-GLC_1 37 42 PF02516 0.635
MOD_N-GLC_1 486 491 PF02516 0.460
MOD_N-GLC_1 943 948 PF02516 0.628
MOD_NEK2_1 152 157 PF00069 0.530
MOD_NEK2_1 198 203 PF00069 0.597
MOD_NEK2_1 362 367 PF00069 0.477
MOD_NEK2_1 563 568 PF00069 0.375
MOD_NEK2_1 608 613 PF00069 0.559
MOD_NEK2_1 625 630 PF00069 0.538
MOD_NEK2_1 634 639 PF00069 0.594
MOD_NEK2_1 677 682 PF00069 0.406
MOD_NEK2_1 852 857 PF00069 0.518
MOD_NEK2_1 923 928 PF00069 0.678
MOD_NEK2_1 942 947 PF00069 0.706
MOD_NEK2_2 690 695 PF00069 0.475
MOD_NMyristoyl 1 7 PF02799 0.586
MOD_OFUCOSY 86 93 PF10250 0.492
MOD_PIKK_1 486 492 PF00454 0.340
MOD_PIKK_1 512 518 PF00454 0.404
MOD_PIKK_1 600 606 PF00454 0.716
MOD_PIKK_1 756 762 PF00454 0.528
MOD_PIKK_1 843 849 PF00454 0.496
MOD_PIKK_1 879 885 PF00454 0.475
MOD_PK_1 256 262 PF00069 0.587
MOD_PK_1 467 473 PF00069 0.417
MOD_PKA_2 137 143 PF00069 0.621
MOD_PKA_2 19 25 PF00069 0.633
MOD_PKA_2 32 38 PF00069 0.754
MOD_PKA_2 332 338 PF00069 0.571
MOD_PKA_2 512 518 PF00069 0.325
MOD_PKA_2 620 626 PF00069 0.649
MOD_PKA_2 648 654 PF00069 0.549
MOD_PKA_2 741 747 PF00069 0.491
MOD_PKA_2 852 858 PF00069 0.600
MOD_PKA_2 916 922 PF00069 0.640
MOD_PKA_2 942 948 PF00069 0.724
MOD_PKB_1 465 473 PF00069 0.376
MOD_Plk_1 198 204 PF00069 0.578
MOD_Plk_1 218 224 PF00069 0.450
MOD_Plk_1 472 478 PF00069 0.360
MOD_Plk_1 525 531 PF00069 0.328
MOD_Plk_1 59 65 PF00069 0.647
MOD_Plk_1 600 606 PF00069 0.670
MOD_Plk_1 715 721 PF00069 0.455
MOD_Plk_1 89 95 PF00069 0.476
MOD_Plk_1 901 907 PF00069 0.532
MOD_Plk_1 943 949 PF00069 0.626
MOD_Plk_2-3 508 514 PF00069 0.231
MOD_Plk_2-3 901 907 PF00069 0.555
MOD_Plk_4 161 167 PF00069 0.626
MOD_Plk_4 218 224 PF00069 0.479
MOD_Plk_4 447 453 PF00069 0.312
MOD_Plk_4 558 564 PF00069 0.353
MOD_Plk_4 577 583 PF00069 0.372
MOD_Plk_4 681 687 PF00069 0.405
MOD_Plk_4 775 781 PF00069 0.379
MOD_Plk_4 80 86 PF00069 0.566
MOD_Plk_4 847 853 PF00069 0.510
MOD_ProDKin_1 324 330 PF00069 0.451
MOD_SPalmitoyl_4 1 7 PF01529 0.646
MOD_SUMO_for_1 196 199 PF00179 0.475
MOD_SUMO_for_1 232 235 PF00179 0.490
MOD_SUMO_rev_2 503 511 PF00179 0.231
TRG_DiLeu_BaLyEn_6 434 439 PF01217 0.376
TRG_DiLeu_BaLyEn_6 666 671 PF01217 0.438
TRG_ENDOCYTIC_2 227 230 PF00928 0.560
TRG_ENDOCYTIC_2 274 277 PF00928 0.545
TRG_ENDOCYTIC_2 373 376 PF00928 0.351
TRG_ENDOCYTIC_2 404 407 PF00928 0.334
TRG_ENDOCYTIC_2 575 578 PF00928 0.445
TRG_ENDOCYTIC_2 593 596 PF00928 0.362
TRG_ENDOCYTIC_2 722 725 PF00928 0.345
TRG_ENDOCYTIC_2 773 776 PF00928 0.373
TRG_ER_diArg_1 183 185 PF00400 0.569
TRG_ER_diArg_1 464 467 PF00400 0.325
TRG_ER_diArg_1 666 669 PF00400 0.461
TRG_NES_CRM1_1 220 235 PF08389 0.511
TRG_NES_CRM1_1 350 364 PF08389 0.325
TRG_NLS_MonoExtN_4 254 259 PF00514 0.608
TRG_Pf-PMV_PEXEL_1 109 113 PF00026 0.490
TRG_Pf-PMV_PEXEL_1 657 661 PF00026 0.404
TRG_Pf-PMV_PEXEL_1 748 752 PF00026 0.528

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IGT4 Leptomonas seymouri 82% 98%
A0A0S4JAH8 Bodo saltans 31% 76%
A0A0S4JE35 Bodo saltans 58% 100%
A0A1X0NNZ8 Trypanosomatidae 62% 100%
A0A3Q8I989 Leishmania donovani 97% 99%
A0A422MRT7 Trypanosoma rangeli 59% 100%
A4H6X9 Leishmania braziliensis 90% 100%
C9ZHY0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 100%
C9ZUN2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 67%
E9AGF3 Leishmania infantum 97% 99%
E9ANZ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 99%
V5BP95 Trypanosoma cruzi 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS