Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGM4_LEIMA

TriTrypDb:

LmjF.12.0690 , LMJLV39_120012400 , LMJSD75_120012300

Length:

166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	9
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QGM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.651
CLV_NRD_NRD_1	149	151	PF00675	0.635
CLV_NRD_NRD_1	31	33	PF00675	0.603
CLV_PCSK_KEX2_1	140	142	PF00082	0.654
CLV_PCSK_KEX2_1	31	33	PF00082	0.603
CLV_PCSK_PC7_1	137	143	PF00082	0.656
CLV_PCSK_SKI1_1	52	56	PF00082	0.640
DEG_Nend_UBRbox_3	1	3	PF02207	0.656
DOC_CKS1_1	129	134	PF01111	0.475
DOC_CYCLIN_RxL_1	137	149	PF00134	0.486
DOC_MAPK_gen_1	137	145	PF00069	0.471
DOC_MAPK_gen_1	71	80	PF00069	0.470
DOC_MAPK_gen_1	8	16	PF00069	0.492
DOC_MAPK_MEF2A_6	113	120	PF00069	0.446
DOC_MAPK_MEF2A_6	65	72	PF00069	0.531
DOC_PP2B_PxIxI_1	88	94	PF00149	0.453
DOC_USP7_MATH_1	122	126	PF00917	0.549
DOC_WW_Pin1_4	128	133	PF00397	0.470
LIG_14-3-3_CanoR_1	41	45	PF00244	0.460
LIG_Actin_WH2_2	68	83	PF00022	0.388
LIG_FHA_1	19	25	PF00498	0.403
LIG_FHA_1	41	47	PF00498	0.464
LIG_LIR_Gen_1	43	51	PF02991	0.475
LIG_LIR_Gen_1	76	85	PF02991	0.455
LIG_LIR_Nem_3	50	54	PF02991	0.438
LIG_LIR_Nem_3	76	80	PF02991	0.440
LIG_SH2_CRK	51	55	PF00017	0.450
LIG_SH2_STAT5	138	141	PF00017	0.453
LIG_SH2_STAT5	44	47	PF00017	0.422
LIG_SH2_STAT5	77	80	PF00017	0.424
LIG_SUMO_SIM_par_1	89	94	PF11976	0.470
LIG_TYR_ITIM	75	80	PF00017	0.485
MOD_CK1_1	18	24	PF00069	0.378
MOD_CK1_1	40	46	PF00069	0.450
MOD_CK2_1	130	136	PF00069	0.518
MOD_GlcNHglycan	17	20	PF01048	0.355
MOD_GSK3_1	107	114	PF00069	0.482
MOD_GSK3_1	124	131	PF00069	0.434
MOD_GSK3_1	15	22	PF00069	0.397
MOD_GSK3_1	30	37	PF00069	0.360
MOD_NEK2_1	30	35	PF00069	0.462
MOD_PIKK_1	122	128	PF00454	0.472
MOD_PIKK_1	154	160	PF00454	0.371
MOD_PKA_2	30	36	PF00069	0.411
MOD_PKA_2	40	46	PF00069	0.466
MOD_PKA_2	80	86	PF00069	0.492
MOD_Plk_1	91	97	PF00069	0.465
MOD_Plk_2-3	73	79	PF00069	0.415
MOD_Plk_4	124	130	PF00069	0.435
MOD_Plk_4	19	25	PF00069	0.397
MOD_Plk_4	40	46	PF00069	0.438
MOD_Plk_4	73	79	PF00069	0.450
MOD_ProDKin_1	128	134	PF00069	0.467
MOD_SUMO_rev_2	146	153	PF00179	0.479
TRG_DiLeu_BaEn_1	50	55	PF01217	0.451
TRG_ENDOCYTIC_2	44	47	PF00928	0.419
TRG_ENDOCYTIC_2	51	54	PF00928	0.438
TRG_ENDOCYTIC_2	77	80	PF00928	0.438
TRG_ER_diArg_1	139	142	PF00400	0.457
TRG_ER_diArg_1	30	32	PF00400	0.391
TRG_ER_diArg_1	8	11	PF00400	0.634
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.711
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB87	Leptomonas seymouri	79%	96%
A0A0S4JEH6	Bodo saltans	51%	100%
A0A1X0NMA1	Trypanosomatidae	67%	100%
A0A3Q8I877	Leishmania donovani	98%	100%
A4H6Y2	Leishmania braziliensis	86%	100%
C9ZHY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	99%
C9ZHZ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
E9AGF6	Leishmania infantum	98%	100%
E9ANZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%