ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGM3_LEIMA

TriTrypDb:

LmjF.12.0700 , LMJLV39_120012500 , LMJSD75_120012400

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	13
GO:0042995	cell projection	2	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0110165	cellular anatomical entity	1	13
GO:0120025	plasma membrane bounded cell projection	3	13

Expansion

Sequence features

Q4QGM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGM3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.573
CLV_NRD_NRD_1	52	54	PF00675	0.383
CLV_NRD_NRD_1	805	807	PF00675	0.500
CLV_NRD_NRD_1	839	841	PF00675	0.726
CLV_PCSK_KEX2_1	145	147	PF00082	0.573
CLV_PCSK_KEX2_1	181	183	PF00082	0.424
CLV_PCSK_KEX2_1	219	221	PF00082	0.549
CLV_PCSK_KEX2_1	33	35	PF00082	0.583
CLV_PCSK_KEX2_1	52	54	PF00082	0.522
CLV_PCSK_KEX2_1	686	688	PF00082	0.578
CLV_PCSK_KEX2_1	705	707	PF00082	0.450
CLV_PCSK_KEX2_1	788	790	PF00082	0.524
CLV_PCSK_KEX2_1	839	841	PF00082	0.687
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.424
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.406
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.583
CLV_PCSK_PC1ET2_1	686	688	PF00082	0.466
CLV_PCSK_PC1ET2_1	705	707	PF00082	0.465
CLV_PCSK_PC1ET2_1	788	790	PF00082	0.504
CLV_PCSK_PC1ET2_1	839	841	PF00082	0.687
CLV_PCSK_PC7_1	784	790	PF00082	0.517
CLV_PCSK_SKI1_1	216	220	PF00082	0.478
CLV_PCSK_SKI1_1	397	401	PF00082	0.757
CLV_PCSK_SKI1_1	48	52	PF00082	0.456
CLV_PCSK_SKI1_1	496	500	PF00082	0.465
CLV_PCSK_SKI1_1	534	538	PF00082	0.350
CLV_PCSK_SKI1_1	842	846	PF00082	0.539
CLV_Separin_Metazoa	657	661	PF03568	0.517
DEG_APCC_DBOX_1	788	796	PF00400	0.514
DEG_Nend_Nbox_1	1	3	PF02207	0.475
DEG_ODPH_VHL_1	64	76	PF01847	0.392
DEG_SCF_FBW7_1	416	423	PF00400	0.568
DEG_SPOP_SBC_1	420	424	PF00917	0.682
DOC_CDC14_PxL_1	95	103	PF14671	0.383
DOC_CKS1_1	280	285	PF01111	0.541
DOC_CYCLIN_RxL_1	216	224	PF00134	0.385
DOC_CYCLIN_RxL_1	528	538	PF00134	0.327
DOC_MAPK_gen_1	181	188	PF00069	0.349
DOC_MAPK_HePTP_8	571	583	PF00069	0.408
DOC_MAPK_MEF2A_6	458	466	PF00069	0.565
DOC_MAPK_MEF2A_6	574	583	PF00069	0.311
DOC_MAPK_MEF2A_6	752	759	PF00069	0.469
DOC_USP7_MATH_1	149	153	PF00917	0.620
DOC_USP7_MATH_1	155	159	PF00917	0.550
DOC_USP7_MATH_1	160	164	PF00917	0.411
DOC_USP7_MATH_1	319	323	PF00917	0.422
DOC_USP7_MATH_1	393	397	PF00917	0.481
DOC_USP7_MATH_1	420	424	PF00917	0.686
DOC_USP7_MATH_1	445	449	PF00917	0.721
DOC_USP7_MATH_1	801	805	PF00917	0.612
DOC_USP7_MATH_1	830	834	PF00917	0.644
DOC_USP7_UBL2_3	838	842	PF12436	0.609
DOC_WW_Pin1_4	134	139	PF00397	0.566
DOC_WW_Pin1_4	231	236	PF00397	0.587
DOC_WW_Pin1_4	26	31	PF00397	0.478
DOC_WW_Pin1_4	279	284	PF00397	0.536
DOC_WW_Pin1_4	416	421	PF00397	0.573
DOC_WW_Pin1_4	458	463	PF00397	0.648
DOC_WW_Pin1_4	512	517	PF00397	0.417
LIG_14-3-3_CanoR_1	161	167	PF00244	0.571
LIG_14-3-3_CanoR_1	292	298	PF00244	0.436
LIG_14-3-3_CanoR_1	34	44	PF00244	0.532
LIG_14-3-3_CanoR_1	397	406	PF00244	0.772
LIG_14-3-3_CanoR_1	409	418	PF00244	0.651
LIG_14-3-3_CanoR_1	496	504	PF00244	0.524
LIG_14-3-3_CanoR_1	593	599	PF00244	0.556
LIG_14-3-3_CanoR_1	723	731	PF00244	0.601
LIG_14-3-3_CanoR_1	752	756	PF00244	0.567
LIG_Actin_WH2_2	288	305	PF00022	0.399
LIG_Actin_WH2_2	69	86	PF00022	0.348
LIG_Actin_WH2_2	9	24	PF00022	0.373
LIG_Clathr_ClatBox_1	561	565	PF01394	0.445
LIG_Clathr_ClatBox_1	632	636	PF01394	0.388
LIG_Clathr_ClatBox_1	73	77	PF01394	0.462
LIG_EH_1	225	229	PF12763	0.523
LIG_eIF4E_1	663	669	PF01652	0.363
LIG_FHA_1	116	122	PF00498	0.479
LIG_FHA_1	16	22	PF00498	0.554
LIG_FHA_1	27	33	PF00498	0.530
LIG_FHA_1	35	41	PF00498	0.496
LIG_FHA_1	475	481	PF00498	0.497
LIG_FHA_1	811	817	PF00498	0.656
LIG_FHA_2	100	106	PF00498	0.446
LIG_FHA_2	259	265	PF00498	0.611
LIG_FHA_2	36	42	PF00498	0.527
LIG_FHA_2	436	442	PF00498	0.587
LIG_FHA_2	694	700	PF00498	0.451
LIG_FHA_2	734	740	PF00498	0.457
LIG_LIR_Gen_1	102	111	PF02991	0.339
LIG_LIR_Gen_1	606	611	PF02991	0.369
LIG_LIR_Nem_3	102	106	PF02991	0.340
LIG_LIR_Nem_3	606	610	PF02991	0.404
LIG_NRBOX	531	537	PF00104	0.327
LIG_SH2_CRK	2	6	PF00017	0.593
LIG_SH2_GRB2like	166	169	PF00017	0.413
LIG_SH2_GRB2like	196	199	PF00017	0.356
LIG_SH2_SRC	166	169	PF00017	0.413
LIG_SH2_STAP1	17	21	PF00017	0.460
LIG_SH2_STAP1	36	40	PF00017	0.516
LIG_SH2_STAT3	196	199	PF00017	0.498
LIG_SH2_STAT3	616	619	PF00017	0.336
LIG_SH2_STAT3	724	727	PF00017	0.571
LIG_SH2_STAT5	103	106	PF00017	0.287
LIG_SH2_STAT5	166	169	PF00017	0.436
LIG_SH2_STAT5	17	20	PF00017	0.390
LIG_SH2_STAT5	196	199	PF00017	0.448
LIG_SH2_STAT5	36	39	PF00017	0.526
LIG_SH2_STAT5	616	619	PF00017	0.420
LIG_SH2_STAT5	724	727	PF00017	0.571
LIG_SH3_1	277	283	PF00018	0.605
LIG_SH3_3	237	243	PF00018	0.471
LIG_SH3_3	277	283	PF00018	0.581
LIG_SH3_3	554	560	PF00018	0.374
LIG_SUMO_SIM_anti_2	563	569	PF11976	0.326
LIG_SUMO_SIM_par_1	184	191	PF11976	0.337
LIG_SUMO_SIM_par_1	205	210	PF11976	0.466
LIG_SUMO_SIM_par_1	466	471	PF11976	0.500
LIG_SUMO_SIM_par_1	477	483	PF11976	0.418
LIG_SUMO_SIM_par_1	560	565	PF11976	0.449
LIG_TYR_ITIM	101	106	PF00017	0.309
MOD_CDK_SPxxK_3	26	33	PF00069	0.474
MOD_CK1_1	115	121	PF00069	0.649
MOD_CK1_1	258	264	PF00069	0.723
MOD_CK1_1	422	428	PF00069	0.755
MOD_CK1_1	497	503	PF00069	0.503
MOD_CK2_1	187	193	PF00069	0.562
MOD_CK2_1	35	41	PF00069	0.530
MOD_CK2_1	435	441	PF00069	0.583
MOD_CK2_1	733	739	PF00069	0.481
MOD_GlcNHglycan	118	121	PF01048	0.656
MOD_GlcNHglycan	151	154	PF01048	0.762
MOD_GlcNHglycan	157	160	PF01048	0.705
MOD_GlcNHglycan	222	226	PF01048	0.472
MOD_GlcNHglycan	257	260	PF01048	0.605
MOD_GlcNHglycan	271	274	PF01048	0.658
MOD_GlcNHglycan	277	280	PF01048	0.585
MOD_GlcNHglycan	330	333	PF01048	0.414
MOD_GlcNHglycan	447	450	PF01048	0.764
MOD_GlcNHglycan	537	540	PF01048	0.327
MOD_GlcNHglycan	842	845	PF01048	0.494
MOD_GSK3_1	1	8	PF00069	0.449
MOD_GSK3_1	111	118	PF00069	0.578
MOD_GSK3_1	251	258	PF00069	0.658
MOD_GSK3_1	275	282	PF00069	0.564
MOD_GSK3_1	291	298	PF00069	0.287
MOD_GSK3_1	301	308	PF00069	0.343
MOD_GSK3_1	393	400	PF00069	0.492
MOD_GSK3_1	410	417	PF00069	0.717
MOD_GSK3_1	435	442	PF00069	0.803
MOD_GSK3_1	445	452	PF00069	0.762
MOD_GSK3_1	486	493	PF00069	0.454
MOD_GSK3_1	826	833	PF00069	0.713
MOD_N-GLC_1	328	333	PF02516	0.526
MOD_N-GLC_1	411	416	PF02516	0.526
MOD_N-GLC_1	512	517	PF02516	0.400
MOD_N-GLC_1	641	646	PF02516	0.449
MOD_N-GLC_1	680	685	PF02516	0.411
MOD_NEK2_1	1	6	PF00069	0.460
MOD_NEK2_1	214	219	PF00069	0.406
MOD_NEK2_1	221	226	PF00069	0.361
MOD_NEK2_1	290	295	PF00069	0.361
MOD_NEK2_1	328	333	PF00069	0.441
MOD_NEK2_1	35	40	PF00069	0.517
MOD_NEK2_1	359	364	PF00069	0.496
MOD_NEK2_1	421	426	PF00069	0.666
MOD_NEK2_1	475	480	PF00069	0.478
MOD_NEK2_1	486	491	PF00069	0.397
MOD_NEK2_1	494	499	PF00069	0.301
MOD_NEK2_1	522	527	PF00069	0.415
MOD_NEK2_1	535	540	PF00069	0.251
MOD_NEK2_1	566	571	PF00069	0.362
MOD_NEK2_1	60	65	PF00069	0.445
MOD_NEK2_1	622	627	PF00069	0.434
MOD_PIKK_1	258	264	PF00454	0.589
MOD_PIKK_1	443	449	PF00454	0.627
MOD_PIKK_1	801	807	PF00454	0.596
MOD_PKA_1	840	846	PF00069	0.715
MOD_PKA_2	160	166	PF00069	0.621
MOD_PKA_2	21	27	PF00069	0.548
MOD_PKA_2	291	297	PF00069	0.434
MOD_PKA_2	384	390	PF00069	0.763
MOD_PKA_2	592	598	PF00069	0.469
MOD_PKA_2	636	642	PF00069	0.412
MOD_PKA_2	722	728	PF00069	0.595
MOD_PKA_2	751	757	PF00069	0.568
MOD_Plk_1	411	417	PF00069	0.538
MOD_Plk_1	486	492	PF00069	0.463
MOD_Plk_1	744	750	PF00069	0.437
MOD_Plk_1	772	778	PF00069	0.677
MOD_Plk_2-3	751	757	PF00069	0.430
MOD_Plk_4	112	118	PF00069	0.553
MOD_Plk_4	162	168	PF00069	0.479
MOD_Plk_4	362	368	PF00069	0.376
MOD_Plk_4	475	481	PF00069	0.439
MOD_Plk_4	566	572	PF00069	0.440
MOD_Plk_4	584	590	PF00069	0.376
MOD_Plk_4	69	75	PF00069	0.431
MOD_Plk_4	744	750	PF00069	0.437
MOD_Plk_4	772	778	PF00069	0.481
MOD_Plk_4	99	105	PF00069	0.357
MOD_ProDKin_1	134	140	PF00069	0.568
MOD_ProDKin_1	231	237	PF00069	0.590
MOD_ProDKin_1	26	32	PF00069	0.474
MOD_ProDKin_1	279	285	PF00069	0.532
MOD_ProDKin_1	416	422	PF00069	0.569
MOD_ProDKin_1	458	464	PF00069	0.632
MOD_ProDKin_1	512	518	PF00069	0.417
MOD_SUMO_for_1	654	657	PF00179	0.469
MOD_SUMO_for_1	729	732	PF00179	0.567
MOD_SUMO_rev_2	26	35	PF00179	0.521
MOD_SUMO_rev_2	41	50	PF00179	0.479
MOD_SUMO_rev_2	680	688	PF00179	0.524
MOD_SUMO_rev_2	721	729	PF00179	0.518
TRG_DiLeu_BaEn_1	342	347	PF01217	0.384
TRG_DiLeu_BaLyEn_6	531	536	PF01217	0.283
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.405
TRG_DiLeu_LyEn_5	342	347	PF01217	0.384
TRG_ENDOCYTIC_2	103	106	PF00928	0.289
TRG_ENDOCYTIC_2	13	16	PF00928	0.361
TRG_ENDOCYTIC_2	2	5	PF00928	0.541
TRG_ENDOCYTIC_2	666	669	PF00928	0.363
TRG_ER_diArg_1	144	146	PF00400	0.510
TRG_ER_diArg_1	51	53	PF00400	0.510
TRG_NES_CRM1_1	199	210	PF08389	0.394
TRG_NES_CRM1_1	745	756	PF08389	0.567
TRG_NLS_MonoCore_2	837	842	PF00514	0.751
TRG_NLS_MonoExtC_3	837	842	PF00514	0.646
TRG_NLS_MonoExtN_4	838	844	PF00514	0.637
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.727
TRG_Pf-PMV_PEXEL_1	708	712	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P337	Leptomonas seymouri	56%	94%
A0A0S4JDM4	Bodo saltans	26%	100%
A0A1X0NMB3	Trypanosomatidae	32%	100%
A0A3Q8IBH7	Leishmania donovani	94%	100%
A0A3R7RCX5	Trypanosoma rangeli	32%	100%
A0A422NEU0	Trypanosoma rangeli	23%	100%
A4H6Y3	Leishmania braziliensis	79%	100%
C9ZHZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AGF7	Leishmania infantum	94%	100%
E9ANZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AZQ5	Trypanosoma cruzi	33%	100%