Lipoprotein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Lipoprotein

Gene product:

Protein of unknown function (DUF962), putative

Species:

Leishmania major

UniProt:

Q4QGM2_LEIMA

TriTrypDb:

LmjF.12.0710 , LMJLV39_120012600 , LMJSD75_120012500

Length:

108

Annotations

LeishMANIAdb annotations

This small protein is closely similar to a large group of poorly-studied prokaryotic proteins (annotated as DUF962 domain proteins). Some members are also found in plants and slime molds.. Duplicated in Leishmaniids

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QGM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.275
CLV_PCSK_KEX2_1	32	34	PF00082	0.275
DOC_ANK_TNKS_1	51	58	PF00023	0.298
DOC_PP4_FxxP_1	84	87	PF00568	0.507
DOC_USP7_MATH_1	24	28	PF00917	0.544
DOC_USP7_MATH_1	46	50	PF00917	0.469
DOC_USP7_MATH_1	58	62	PF00917	0.248
LIG_BRCT_BRCA1_1	4	8	PF00533	0.625
LIG_FHA_2	72	78	PF00498	0.428
LIG_GBD_Chelix_1	98	106	PF00786	0.330
LIG_LIR_Apic_2	82	87	PF02991	0.499
LIG_LIR_Nem_3	17	22	PF02991	0.473
LIG_LIR_Nem_3	93	98	PF02991	0.505
LIG_SH2_STAT5	19	22	PF00017	0.467
MOD_CK1_1	90	96	PF00069	0.522
MOD_CK2_1	71	77	PF00069	0.428
MOD_GlcNHglycan	10	13	PF01048	0.362
MOD_GlcNHglycan	4	7	PF01048	0.440
MOD_GlcNHglycan	48	51	PF01048	0.424
MOD_GSK3_1	24	31	PF00069	0.520
MOD_GSK3_1	76	83	PF00069	0.502
MOD_LATS_1	26	32	PF00433	0.506
MOD_N-GLC_1	2	7	PF02516	0.503
MOD_NEK2_1	36	41	PF00069	0.362
MOD_NEK2_1	8	13	PF00069	0.679
MOD_NEK2_1	97	102	PF00069	0.502
MOD_PIKK_1	76	82	PF00454	0.499
MOD_Plk_4	71	77	PF00069	0.315
MOD_Plk_4	97	103	PF00069	0.517
TRG_ER_diArg_1	32	34	PF00400	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C1	Leptomonas seymouri	69%	100%
A0A0N1HYH1	Leptomonas seymouri	36%	100%
A0A0S4IVD1	Bodo saltans	32%	96%
A0A1X0NMC7	Trypanosomatidae	47%	99%
A0A3Q8IHQ7	Leishmania donovani	40%	100%
A0A3R7N4G9	Trypanosoma rangeli	43%	99%
A0A3S5H6L3	Leishmania donovani	99%	100%
A4H6Y4	Leishmania braziliensis	84%	100%
A4H6Y5	Leishmania braziliensis	40%	100%
E9AGF8	Leishmania infantum	99%	100%
E9AGF9	Leishmania infantum	39%	100%
E9ANZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%