LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative surface antigen protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative surface antigen protein
Gene product:
surface antigen protein, putative
Species:
Leishmania major
UniProt:
Q4QGL8_LEIMA
TriTrypDb:
LmjF.12.0990 , LMJLV39_000019000 , LMJLV39_120012900 , LMJSD75_120013500
Length:
610

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 120
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 63, no: 10
NetGPI no yes: 0, no: 73
Cellular components
Term Name Level Count
GO:0005929 cilium 4 74
GO:0016020 membrane 2 30
GO:0042995 cell projection 2 74
GO:0043226 organelle 2 74
GO:0043227 membrane-bounded organelle 3 74
GO:0110165 cellular anatomical entity 1 74
GO:0120025 plasma membrane bounded cell projection 3 74
GO:0005886 plasma membrane 3 6

Expansion

Sequence features

Q4QGL8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGL8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 123 127 PF00656 0.365
CLV_NRD_NRD_1 421 423 PF00675 0.459
CLV_NRD_NRD_1 6 8 PF00675 0.718
CLV_PCSK_KEX2_1 421 423 PF00082 0.485
CLV_PCSK_KEX2_1 6 8 PF00082 0.718
CLV_PCSK_SKI1_1 421 425 PF00082 0.427
CLV_PCSK_SKI1_1 7 11 PF00082 0.671
DOC_CYCLIN_RxL_1 3 13 PF00134 0.615
DOC_MAPK_gen_1 130 139 PF00069 0.175
DOC_MAPK_gen_1 421 428 PF00069 0.184
DOC_MAPK_MEF2A_6 516 523 PF00069 0.301
DOC_PP1_RVXF_1 108 115 PF00149 0.220
DOC_PP1_RVXF_1 131 137 PF00149 0.316
DOC_PP1_RVXF_1 179 186 PF00149 0.190
DOC_USP7_MATH_1 191 195 PF00917 0.297
DOC_USP7_MATH_1 239 243 PF00917 0.232
DOC_USP7_MATH_1 443 447 PF00917 0.307
DOC_USP7_MATH_1 496 500 PF00917 0.304
DOC_USP7_MATH_1 586 590 PF00917 0.220
DOC_USP7_MATH_1 76 80 PF00917 0.333
LIG_14-3-3_CanoR_1 421 428 PF00244 0.213
LIG_Actin_WH2_2 272 287 PF00022 0.193
LIG_Actin_WH2_2 344 359 PF00022 0.420
LIG_BIR_II_1 1 5 PF00653 0.622
LIG_BRCT_BRCA1_1 181 185 PF00533 0.194
LIG_deltaCOP1_diTrp_1 61 69 PF00928 0.375
LIG_FHA_1 207 213 PF00498 0.294
LIG_FHA_1 42 48 PF00498 0.425
LIG_FHA_1 422 428 PF00498 0.185
LIG_FHA_1 447 453 PF00498 0.263
LIG_FHA_1 532 538 PF00498 0.344
LIG_FHA_2 121 127 PF00498 0.377
LIG_FHA_2 154 160 PF00498 0.269
LIG_FHA_2 326 332 PF00498 0.272
LIG_FHA_2 374 380 PF00498 0.224
LIG_FHA_2 538 544 PF00498 0.471
LIG_FHA_2 63 69 PF00498 0.332
LIG_FHA_2 92 98 PF00498 0.337
LIG_LIR_Gen_1 126 136 PF02991 0.326
LIG_LIR_Gen_1 151 158 PF02991 0.247
LIG_LIR_Gen_1 182 193 PF02991 0.319
LIG_LIR_Gen_1 232 241 PF02991 0.245
LIG_LIR_Gen_1 440 448 PF02991 0.224
LIG_LIR_Gen_1 487 497 PF02991 0.352
LIG_LIR_Gen_1 71 80 PF02991 0.405
LIG_LIR_Nem_3 103 107 PF02991 0.353
LIG_LIR_Nem_3 126 131 PF02991 0.336
LIG_LIR_Nem_3 135 139 PF02991 0.251
LIG_LIR_Nem_3 182 188 PF02991 0.281
LIG_LIR_Nem_3 232 236 PF02991 0.242
LIG_LIR_Nem_3 440 444 PF02991 0.228
LIG_LIR_Nem_3 487 492 PF02991 0.306
LIG_LIR_Nem_3 71 75 PF02991 0.293
LIG_NRBOX 422 428 PF00104 0.239
LIG_PDZ_Class_2 605 610 PF00595 0.207
LIG_PTAP_UEV_1 538 543 PF05743 0.285
LIG_SH2_STAT5 569 572 PF00017 0.247
LIG_SH3_1 536 542 PF00018 0.290
LIG_SH3_3 536 542 PF00018 0.390
LIG_SH3_3 93 99 PF00018 0.386
LIG_Sin3_3 594 601 PF02671 0.190
LIG_SUMO_SIM_anti_2 135 141 PF11976 0.179
LIG_SUMO_SIM_anti_2 253 259 PF11976 0.200
LIG_SUMO_SIM_anti_2 278 283 PF11976 0.287
LIG_SUMO_SIM_anti_2 301 307 PF11976 0.245
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.270
LIG_SUMO_SIM_par_1 208 215 PF11976 0.399
LIG_SUMO_SIM_par_1 253 259 PF11976 0.344
LIG_SUMO_SIM_par_1 519 525 PF11976 0.423
LIG_TYR_ITIM 102 107 PF00017 0.407
LIG_WRC_WIRS_1 230 235 PF05994 0.200
MOD_CK1_1 151 157 PF00069 0.278
MOD_CK1_1 179 185 PF00069 0.298
MOD_CK1_1 203 209 PF00069 0.269
MOD_CK1_1 226 232 PF00069 0.262
MOD_CK1_1 250 256 PF00069 0.253
MOD_CK1_1 275 281 PF00069 0.358
MOD_CK1_1 298 304 PF00069 0.284
MOD_CK1_1 322 328 PF00069 0.301
MOD_CK1_1 346 352 PF00069 0.266
MOD_CK1_1 370 376 PF00069 0.283
MOD_CK1_1 394 400 PF00069 0.258
MOD_CK1_1 446 452 PF00069 0.275
MOD_CK1_1 455 461 PF00069 0.310
MOD_CK1_1 466 472 PF00069 0.327
MOD_CK1_1 484 490 PF00069 0.303
MOD_CK1_1 530 536 PF00069 0.322
MOD_CK2_1 126 132 PF00069 0.212
MOD_CK2_1 153 159 PF00069 0.269
MOD_CK2_1 537 543 PF00069 0.467
MOD_CK2_1 91 97 PF00069 0.379
MOD_GlcNHglycan 120 123 PF01048 0.530
MOD_GlcNHglycan 144 147 PF01048 0.494
MOD_GlcNHglycan 169 172 PF01048 0.566
MOD_GlcNHglycan 193 196 PF01048 0.509
MOD_GlcNHglycan 217 220 PF01048 0.457
MOD_GlcNHglycan 241 244 PF01048 0.490
MOD_GlcNHglycan 25 28 PF01048 0.675
MOD_GlcNHglycan 265 268 PF01048 0.621
MOD_GlcNHglycan 289 292 PF01048 0.491
MOD_GlcNHglycan 313 316 PF01048 0.512
MOD_GlcNHglycan 337 340 PF01048 0.518
MOD_GlcNHglycan 361 364 PF01048 0.510
MOD_GlcNHglycan 385 388 PF01048 0.484
MOD_GlcNHglycan 409 412 PF01048 0.549
MOD_GlcNHglycan 433 436 PF01048 0.455
MOD_GlcNHglycan 440 444 PF01048 0.441
MOD_GlcNHglycan 457 460 PF01048 0.510
MOD_GlcNHglycan 465 468 PF01048 0.493
MOD_GlcNHglycan 480 484 PF01048 0.536
MOD_GlcNHglycan 489 492 PF01048 0.562
MOD_GlcNHglycan 557 560 PF01048 0.666
MOD_GlcNHglycan 589 592 PF01048 0.450
MOD_GSK3_1 120 127 PF00069 0.319
MOD_GSK3_1 144 151 PF00069 0.295
MOD_GSK3_1 153 160 PF00069 0.295
MOD_GSK3_1 175 182 PF00069 0.275
MOD_GSK3_1 199 206 PF00069 0.310
MOD_GSK3_1 271 278 PF00069 0.357
MOD_GSK3_1 285 292 PF00069 0.254
MOD_GSK3_1 295 302 PF00069 0.299
MOD_GSK3_1 319 326 PF00069 0.271
MOD_GSK3_1 32 39 PF00069 0.513
MOD_GSK3_1 343 350 PF00069 0.289
MOD_GSK3_1 367 374 PF00069 0.333
MOD_GSK3_1 391 398 PF00069 0.285
MOD_GSK3_1 439 446 PF00069 0.240
MOD_GSK3_1 451 458 PF00069 0.247
MOD_GSK3_1 466 473 PF00069 0.318
MOD_GSK3_1 481 488 PF00069 0.270
MOD_GSK3_1 527 534 PF00069 0.364
MOD_GSK3_1 537 544 PF00069 0.441
MOD_GSK3_1 569 576 PF00069 0.452
MOD_GSK3_1 82 89 PF00069 0.288
MOD_NEK2_1 10 15 PF00069 0.509
MOD_NEK2_1 120 125 PF00069 0.288
MOD_NEK2_1 21 26 PF00069 0.489
MOD_NEK2_1 212 217 PF00069 0.341
MOD_NEK2_1 284 289 PF00069 0.282
MOD_NEK2_1 323 328 PF00069 0.276
MOD_NEK2_1 356 361 PF00069 0.328
MOD_NEK2_1 428 433 PF00069 0.216
MOD_NEK2_1 450 455 PF00069 0.354
MOD_NEK2_1 481 486 PF00069 0.281
MOD_NEK2_1 86 91 PF00069 0.252
MOD_NEK2_2 496 501 PF00069 0.349
MOD_PIKK_1 212 218 PF00454 0.256
MOD_PIKK_1 260 266 PF00454 0.232
MOD_PIKK_1 308 314 PF00454 0.331
MOD_PIKK_1 332 338 PF00454 0.387
MOD_PIKK_1 356 362 PF00454 0.416
MOD_PIKK_1 380 386 PF00454 0.407
MOD_PIKK_1 404 410 PF00454 0.364
MOD_PK_1 165 171 PF00069 0.204
MOD_PK_1 277 283 PF00069 0.185
MOD_PK_1 285 291 PF00069 0.193
MOD_PKA_1 421 427 PF00069 0.186
MOD_PKA_1 62 68 PF00069 0.253
MOD_PKA_2 284 290 PF00069 0.287
MOD_PKA_2 356 362 PF00069 0.308
MOD_PKA_2 421 427 PF00069 0.209
MOD_Plk_1 439 445 PF00069 0.233
MOD_Plk_1 573 579 PF00069 0.443
MOD_Plk_1 86 92 PF00069 0.319
MOD_Plk_2-3 159 165 PF00069 0.184
MOD_Plk_2-3 68 74 PF00069 0.378
MOD_Plk_4 132 138 PF00069 0.298
MOD_Plk_4 181 187 PF00069 0.270
MOD_Plk_4 226 232 PF00069 0.248
MOD_Plk_4 250 256 PF00069 0.268
MOD_Plk_4 277 283 PF00069 0.277
MOD_Plk_4 428 434 PF00069 0.213
MOD_Plk_4 443 449 PF00069 0.272
MOD_SUMO_rev_2 511 517 PF00179 0.230
MOD_SUMO_rev_2 59 65 PF00179 0.226
TRG_DiLeu_BaEn_1 574 579 PF01217 0.250
TRG_DiLeu_BaEn_2 131 137 PF01217 0.173
TRG_DiLeu_BaLyEn_6 115 120 PF01217 0.406
TRG_ENDOCYTIC_2 104 107 PF00928 0.406
TRG_ER_diArg_1 420 422 PF00400 0.261
TRG_ER_diArg_1 5 7 PF00400 0.669
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.611

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6A5 Leptomonas seymouri 28% 96%
A0A0N1I121 Leptomonas seymouri 27% 100%
A0A0N1I661 Leptomonas seymouri 37% 100%
A0A0S4IHI7 Bodo saltans 29% 79%
A0A0S4IJN2 Bodo saltans 30% 91%
A0A0S4IN27 Bodo saltans 39% 100%
A0A0S4IQE4 Bodo saltans 26% 100%
A0A0S4IRQ2 Bodo saltans 33% 71%
A0A0S4ISU4 Bodo saltans 35% 93%
A0A0S4IT62 Bodo saltans 38% 82%
A0A0S4ITE7 Bodo saltans 37% 68%
A0A0S4IU73 Bodo saltans 38% 100%
A0A0S4IU91 Bodo saltans 28% 69%
A0A0S4IVQ8 Bodo saltans 34% 100%
A0A0S4IW93 Bodo saltans 28% 100%
A0A0S4IY44 Bodo saltans 26% 92%
A0A0S4J014 Bodo saltans 27% 85%
A0A0S4J0N5 Bodo saltans 26% 71%
A0A0S4J2H8 Bodo saltans 28% 100%
A0A0S4J542 Bodo saltans 27% 67%
A0A0S4J5A0 Bodo saltans 39% 100%
A0A0S4J7S2 Bodo saltans 26% 67%
A0A0S4J954 Bodo saltans 25% 82%
A0A0S4JAQ6 Bodo saltans 28% 100%
A0A0S4JAS1 Bodo saltans 37% 96%
A0A0S4JB95 Bodo saltans 26% 100%
A0A0S4JD35 Bodo saltans 31% 100%
A0A0S4JDT0 Bodo saltans 34% 93%
A0A0S4JJV0 Bodo saltans 29% 71%
A0A0S4JL29 Bodo saltans 34% 100%
A0A0S4JNU2 Bodo saltans 41% 74%
A0A0S4JQZ0 Bodo saltans 26% 81%
A0A0S4JTM6 Bodo saltans 35% 83%
A0A0S4JTQ7 Bodo saltans 42% 100%
A0A0S4JVI0 Bodo saltans 30% 86%
A0A0S4KEC2 Bodo saltans 39% 69%
A0A0S4KEG2 Bodo saltans 31% 73%
A0A0S4KF94 Bodo saltans 25% 70%
A0A0S4KGV4 Bodo saltans 25% 100%
A0A0S4KH41 Bodo saltans 27% 88%
A0A0S4KIR5 Bodo saltans 27% 73%
A0A0S4KJA7 Bodo saltans 28% 91%
A0A0S4KK37 Bodo saltans 30% 100%
A0A3Q8I9B4 Leishmania donovani 42% 100%
A0A3Q8I9D9 Leishmania donovani 41% 99%
A0A3Q8IC27 Leishmania donovani 35% 100%
A0A3S5H6L9 Leishmania donovani 44% 100%
A0A3S5H6M3 Leishmania donovani 54% 89%
A0A3S5H6M4 Leishmania donovani 54% 93%
A0A3S7WS66 Leishmania donovani 54% 93%
A4H6Y8 Leishmania braziliensis 50% 67%
A4HBX3 Leishmania braziliensis 36% 100%
A4HM88 Leishmania braziliensis 31% 71%
A4HVB0 Leishmania infantum 53% 100%
A4HZ93 Leishmania infantum 36% 100%
A6QLV3 Bos taurus 23% 100%
D1GJ51 Leishmania infantum 63% 100%
E8NHG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 80%
E9AGG2 Leishmania infantum 54% 92%
E9AGG5 Leishmania infantum 56% 100%
E9AGG7 Leishmania infantum 58% 97%
E9AGG9 Leishmania infantum 59% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 86%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 88%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B1U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
F4IUU1 Arabidopsis thaliana 24% 75%
F4J7T6 Arabidopsis thaliana 25% 69%
F4J8G2 Arabidopsis thaliana 24% 70%
F4JGB6 Arabidopsis thaliana 24% 75%
F4JTU7 Arabidopsis thaliana 24% 75%
F4KHA2 Arabidopsis thaliana 23% 77%
O22938 Arabidopsis thaliana 25% 69%
O48849 Arabidopsis thaliana 20% 69%
O48851 Arabidopsis thaliana 24% 79%
O49325 Arabidopsis thaliana 23% 78%
O49328 Arabidopsis thaliana 22% 76%
O49329 Arabidopsis thaliana 23% 71%
O49879 Solanum lycopersicum 24% 72%
O80809 Arabidopsis thaliana 25% 85%
O88520 Mus musculus 23% 100%
P0DO05 Solanum pimpinellifolium 25% 71%
P0DO06 Solanum pimpinellifolium 25% 71%
P35859 Rattus norvegicus 21% 100%
P70389 Mus musculus 20% 100%
Q1L8Y7 Danio rerio 23% 100%
Q1PEN0 Arabidopsis thaliana 24% 85%
Q22875 Caenorhabditis elegans 23% 100%
Q40235 Solanum pimpinellifolium 26% 71%
Q4QC79 Leishmania major 35% 100%
Q4QGI0 Leishmania major 64% 93%
Q4QGI2 Leishmania major 60% 98%
Q4QGI4 Leishmania major 64% 98%
Q4QGI6 Leishmania major 59% 85%
Q4QGI8 Leishmania major 65% 100%
Q4QGJ0 Leishmania major 51% 100%
Q4QGJ2 Leishmania major 48% 100%
Q4QGJ9 Leishmania major 64% 100%
Q4QGK0 Leishmania major 51% 89%
Q4QGK1 Leishmania major 50% 100%
Q4QGK2 Leishmania major 57% 98%
Q4QGK4 Leishmania major 50% 100%
Q4QGK8 Leishmania major 59% 94%
Q4QGL2 Leishmania major 59% 94%
Q4QGM1 Leishmania major 60% 79%
Q5MR23 Solanum pimpinellifolium 26% 71%
Q5RAV5 Pongo abelii 23% 100%
Q5ZLN0 Gallus gallus 24% 100%
Q6AYI5 Rattus norvegicus 23% 100%
Q7FZR1 Arabidopsis thaliana 24% 75%
Q7SXW3 Danio rerio 24% 100%
Q8AVI4 Xenopus laevis 24% 100%
Q8C0R9 Mus musculus 22% 72%
Q8RX63 Arabidopsis thaliana 26% 71%
Q93YT3 Arabidopsis thaliana 25% 68%
Q9C9H6 Arabidopsis thaliana 23% 78%
Q9C9H7 Arabidopsis thaliana 25% 72%
Q9FL51 Arabidopsis thaliana 24% 70%
Q9FYK0 Arabidopsis thaliana 22% 69%
Q9LJS0 Arabidopsis thaliana 23% 69%
Q9LJS2 Arabidopsis thaliana 27% 69%
Q9LJW7 Arabidopsis thaliana 25% 86%
Q9LRW9 Arabidopsis thaliana 23% 69%
Q9LS79 Arabidopsis thaliana 23% 78%
Q9LS80 Arabidopsis thaliana 25% 73%
Q9M9X0 Arabidopsis thaliana 24% 70%
Q9MA83 Arabidopsis thaliana 25% 78%
Q9SHI3 Arabidopsis thaliana 25% 84%
Q9SHI4 Arabidopsis thaliana 23% 81%
Q9SKK5 Arabidopsis thaliana 21% 91%
Q9SVM3 Arabidopsis thaliana 25% 72%
Q9SVN2 Arabidopsis thaliana 24% 76%
Q9UQ13 Homo sapiens 23% 100%
Q9ZUK7 Arabidopsis thaliana 25% 74%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS