Putative surface antigen protein 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen protein 2, putative

Species:

Leishmania major

UniProt:

Q4QGL5_LEIMA

TriTrypDb:

LmjF.12.0765 , LmjF.12.0870 , LMJLV39_000011100 , LMJLV39_000017700 , LMJSD75_120012700 , LMJSD75_120012800

Length:

547

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 90

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 30, no: 0
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	31
GO:0016020	membrane	2	10
GO:0042995	cell projection	2	31
GO:0043226	organelle	2	31
GO:0043227	membrane-bounded organelle	3	31
GO:0110165	cellular anatomical entity	1	31
GO:0120025	plasma membrane bounded cell projection	3	31
GO:0005886	plasma membrane	3	2

Expansion

Sequence features

Q4QGL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGL5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004672	protein kinase activity	3	2
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.308
CLV_NRD_NRD_1	189	191	PF00675	0.472
CLV_NRD_NRD_1	236	238	PF00675	0.470
CLV_NRD_NRD_1	6	8	PF00675	0.701
CLV_PCSK_FUR_1	187	191	PF00082	0.447
CLV_PCSK_KEX2_1	189	191	PF00082	0.462
CLV_PCSK_KEX2_1	6	8	PF00082	0.701
CLV_PCSK_SKI1_1	189	193	PF00082	0.477
CLV_PCSK_SKI1_1	237	241	PF00082	0.517
CLV_PCSK_SKI1_1	7	11	PF00082	0.707
DEG_SCF_FBW7_2	475	480	PF00400	0.479
DEG_SPOP_SBC_1	354	358	PF00917	0.485
DEG_SPOP_SBC_1	363	367	PF00917	0.465
DEG_SPOP_SBC_1	373	377	PF00917	0.500
DEG_SPOP_SBC_1	383	387	PF00917	0.463
DEG_SPOP_SBC_1	393	397	PF00917	0.461
DEG_SPOP_SBC_1	403	407	PF00917	0.463
DEG_SPOP_SBC_1	413	417	PF00917	0.454
DEG_SPOP_SBC_1	433	437	PF00917	0.465
DEG_SPOP_SBC_1	454	458	PF00917	0.486
DEG_SPOP_SBC_1	86	90	PF00917	0.257
DOC_AGCK_PIF_2	69	74	PF00069	0.308
DOC_CYCLIN_RxL_1	186	196	PF00134	0.290
DOC_CYCLIN_RxL_1	253	263	PF00134	0.249
DOC_CYCLIN_RxL_1	3	13	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	220	223	PF00134	0.259
DOC_MAPK_MEF2A_6	324	331	PF00069	0.394
DOC_PP2B_LxvP_1	220	223	PF13499	0.259
DOC_USP7_MATH_1	523	527	PF00917	0.472
DOC_USP7_MATH_2	198	204	PF00917	0.250
DOC_USP7_MATH_2	222	228	PF00917	0.270
DOC_USP7_UBL2_3	59	63	PF12436	0.265
DOC_WW_Pin1_4	212	217	PF00397	0.245
DOC_WW_Pin1_4	467	472	PF00397	0.530
DOC_WW_Pin1_4	473	478	PF00397	0.554
LIG_14-3-3_CanoR_1	275	284	PF00244	0.288
LIG_14-3-3_CanoR_1	304	309	PF00244	0.323
LIG_14-3-3_CanoR_1	31	35	PF00244	0.468
LIG_14-3-3_CanoR_1	43	48	PF00244	0.361
LIG_14-3-3_CanoR_1	76	84	PF00244	0.251
LIG_14-3-3_CanoR_1	85	95	PF00244	0.252
LIG_Actin_WH2_2	179	194	PF00022	0.274
LIG_Actin_WH2_2	224	242	PF00022	0.254
LIG_BIR_II_1	1	5	PF00653	0.575
LIG_BRCT_BRCA1_1	207	211	PF00533	0.234
LIG_BRCT_BRCA1_1	70	74	PF00533	0.340
LIG_deltaCOP1_diTrp_1	176	179	PF00928	0.268
LIG_deltaCOP1_diTrp_1	200	204	PF00928	0.260
LIG_deltaCOP1_diTrp_1	62	69	PF00928	0.328
LIG_FHA_1	183	189	PF00498	0.374
LIG_FHA_1	216	222	PF00498	0.301
LIG_FHA_1	240	246	PF00498	0.347
LIG_FHA_1	348	354	PF00498	0.416
LIG_FHA_1	42	48	PF00498	0.398
LIG_FHA_1	448	454	PF00498	0.491
LIG_FHA_1	511	517	PF00498	0.340
LIG_FHA_2	121	127	PF00498	0.320
LIG_FHA_2	455	461	PF00498	0.471
LIG_FHA_2	479	485	PF00498	0.440
LIG_FHA_2	92	98	PF00498	0.415
LIG_LIR_Gen_1	126	134	PF02991	0.305
LIG_LIR_Gen_1	151	160	PF02991	0.310
LIG_LIR_Gen_1	176	183	PF02991	0.355
LIG_LIR_Gen_1	272	281	PF02991	0.304
LIG_LIR_Nem_3	103	107	PF02991	0.358
LIG_LIR_Nem_3	126	131	PF02991	0.327
LIG_LIR_Nem_3	159	163	PF02991	0.286
LIG_LIR_Nem_3	176	180	PF02991	0.362
LIG_LIR_Nem_3	202	207	PF02991	0.261
LIG_LIR_Nem_3	224	228	PF02991	0.262
LIG_LIR_Nem_3	278	284	PF02991	0.321
LIG_LIR_Nem_3	71	75	PF02991	0.320
LIG_PCNA_yPIPBox_3	248	256	PF02747	0.262
LIG_PDZ_Class_2	542	547	PF00595	0.319
LIG_SH2_PTP2	83	86	PF00017	0.242
LIG_SH2_STAT5	113	116	PF00017	0.268
LIG_SH2_STAT5	160	163	PF00017	0.258
LIG_SH2_STAT5	281	284	PF00017	0.268
LIG_SH2_STAT5	302	305	PF00017	0.298
LIG_SH2_STAT5	506	509	PF00017	0.361
LIG_SH2_STAT5	517	520	PF00017	0.405
LIG_SH2_STAT5	83	86	PF00017	0.300
LIG_SH3_3	241	247	PF00018	0.249
LIG_SH3_3	459	465	PF00018	0.484
LIG_SH3_3	93	99	PF00018	0.361
LIG_Sin3_3	531	538	PF02671	0.269
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.334
LIG_SUMO_SIM_par_1	256	263	PF11976	0.291
LIG_TYR_ITIM	102	107	PF00017	0.359
MOD_CK1_1	151	157	PF00069	0.366
MOD_CK1_1	203	209	PF00069	0.316
MOD_CK1_1	274	280	PF00069	0.455
MOD_CK2_1	126	132	PF00069	0.311
MOD_CK2_1	454	460	PF00069	0.471
MOD_CK2_1	478	484	PF00069	0.471
MOD_CK2_1	91	97	PF00069	0.325
MOD_CMANNOS	201	204	PF00535	0.442
MOD_GlcNHglycan	120	123	PF01048	0.541
MOD_GlcNHglycan	139	142	PF01048	0.543
MOD_GlcNHglycan	144	147	PF01048	0.596
MOD_GlcNHglycan	165	168	PF01048	0.521
MOD_GlcNHglycan	193	196	PF01048	0.585
MOD_GlcNHglycan	25	28	PF01048	0.673
MOD_GlcNHglycan	265	268	PF01048	0.693
MOD_GlcNHglycan	288	292	PF01048	0.531
MOD_GlcNHglycan	494	497	PF01048	0.585
MOD_GlcNHglycan	526	529	PF01048	0.325
MOD_GSK3_1	120	127	PF00069	0.347
MOD_GSK3_1	133	140	PF00069	0.291
MOD_GSK3_1	144	151	PF00069	0.378
MOD_GSK3_1	199	206	PF00069	0.364
MOD_GSK3_1	259	266	PF00069	0.297
MOD_GSK3_1	271	278	PF00069	0.365
MOD_GSK3_1	32	39	PF00069	0.497
MOD_GSK3_1	344	351	PF00069	0.488
MOD_GSK3_1	352	359	PF00069	0.602
MOD_GSK3_1	362	369	PF00069	0.574
MOD_GSK3_1	372	379	PF00069	0.643
MOD_GSK3_1	382	389	PF00069	0.515
MOD_GSK3_1	392	399	PF00069	0.484
MOD_GSK3_1	402	409	PF00069	0.513
MOD_GSK3_1	412	419	PF00069	0.473
MOD_GSK3_1	423	430	PF00069	0.484
MOD_GSK3_1	432	439	PF00069	0.536
MOD_GSK3_1	442	449	PF00069	0.478
MOD_GSK3_1	452	459	PF00069	0.473
MOD_GSK3_1	463	470	PF00069	0.556
MOD_GSK3_1	506	513	PF00069	0.373
MOD_GSK3_1	87	94	PF00069	0.369
MOD_N-GLC_2	285	287	PF02516	0.462
MOD_NEK2_1	10	15	PF00069	0.687
MOD_NEK2_1	120	125	PF00069	0.334
MOD_NEK2_1	137	142	PF00069	0.396
MOD_NEK2_1	191	196	PF00069	0.409
MOD_NEK2_1	21	26	PF00069	0.507
MOD_NEK2_1	239	244	PF00069	0.399
MOD_NEK2_1	260	265	PF00069	0.460
MOD_NEK2_1	289	294	PF00069	0.450
MOD_PIKK_1	75	81	PF00454	0.257
MOD_PKA_2	274	280	PF00069	0.274
MOD_PKA_2	30	36	PF00069	0.439
MOD_PKA_2	75	81	PF00069	0.257
MOD_Plk_1	175	181	PF00069	0.384
MOD_Plk_1	199	205	PF00069	0.278
MOD_Plk_1	271	277	PF00069	0.320
MOD_Plk_1	510	516	PF00069	0.366
MOD_Plk_2-3	224	230	PF00069	0.267
MOD_Plk_2-3	68	74	PF00069	0.322
MOD_ProDKin_1	212	218	PF00069	0.249
MOD_ProDKin_1	467	473	PF00069	0.526
TRG_DiLeu_BaEn_1	511	516	PF01217	0.339
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.264
TRG_ENDOCYTIC_2	104	107	PF00928	0.358
TRG_ENDOCYTIC_2	160	163	PF00928	0.269
TRG_ENDOCYTIC_2	281	284	PF00928	0.289
TRG_ENDOCYTIC_2	83	86	PF00928	0.243
TRG_ER_diArg_1	186	189	PF00400	0.242
TRG_ER_diArg_1	5	7	PF00400	0.600
TRG_Pf-PMV_PEXEL_1	256	261	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J206	Bodo saltans	31%	89%
A0A3Q8I9A6	Leishmania donovani	49%	100%
A0A3Q8IC27	Leishmania donovani	30%	100%
A0A3Q8IFC2	Leishmania donovani	34%	100%
A0A3S5H6M4	Leishmania donovani	49%	83%
A0A3S7WS66	Leishmania donovani	49%	83%
A4HVB0	Leishmania infantum	52%	100%
A4HZ93	Leishmania infantum	29%	100%
A4I6S2	Leishmania infantum	33%	100%
D1GJ51	Leishmania infantum	58%	100%
E8NHG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AEF4	Leishmania major	32%	100%
E9AGG5	Leishmania infantum	49%	100%
E9AGH0	Leishmania infantum	51%	100%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AP05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9AVA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B1U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4QC79	Leishmania major	32%	100%
Q4QGI0	Leishmania major	59%	100%
Q4QGI6	Leishmania major	51%	100%
Q4QGJ0	Leishmania major	47%	87%
Q4QGK0	Leishmania major	62%	96%
Q4QGK8	Leishmania major	60%	100%
Q4QGL2	Leishmania major	60%	100%
Q4QGL4	Leishmania major	65%	100%
Q9C9H6	Arabidopsis thaliana	23%	70%
Q9T0K5	Arabidopsis thaliana	22%	72%