Putative surface antigen protein 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

promastigote surface antigen 38S

Species:

Leishmania major

UniProt:

Q4QGL4_LEIMA

TriTrypDb:

LmjF.12.0890 , LMJLV39_000011700 , LMJLV39_120012900 , LMJSD75_120012700 , LMJSD75_120012800

Length:

395

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 165

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 65, no: 9
NetGPI	no	yes: 0, no: 74

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	75
GO:0016020	membrane	2	26
GO:0042995	cell projection	2	75
GO:0043226	organelle	2	75
GO:0043227	membrane-bounded organelle	3	75
GO:0110165	cellular anatomical entity	1	75
GO:0120025	plasma membrane bounded cell projection	3	75
GO:0005886	plasma membrane	3	5

Expansion

Sequence features

Q4QGL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGL4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004672	protein kinase activity	3	3
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.336
CLV_NRD_NRD_1	205	207	PF00675	0.419
CLV_NRD_NRD_1	6	8	PF00675	0.720
CLV_PCSK_KEX2_1	6	8	PF00082	0.687
CLV_PCSK_SKI1_1	206	210	PF00082	0.457
CLV_PCSK_SKI1_1	7	11	PF00082	0.653
DOC_AGCK_PIF_2	69	74	PF00069	0.222
DOC_CYCLIN_RxL_1	105	116	PF00134	0.234
DOC_CYCLIN_RxL_1	3	13	PF00134	0.442
DOC_MAPK_gen_1	203	213	PF00069	0.281
DOC_MAPK_MEF2A_6	301	308	PF00069	0.300
DOC_PP1_RVXF_1	108	115	PF00149	0.238
DOC_USP7_MATH_1	371	375	PF00917	0.406
DOC_USP7_MATH_2	223	229	PF00917	0.253
DOC_USP7_MATH_2	271	277	PF00917	0.293
DOC_WW_Pin1_4	85	90	PF00397	0.351
LIG_14-3-3_CanoR_1	206	213	PF00244	0.264
LIG_14-3-3_CanoR_1	281	286	PF00244	0.278
LIG_14-3-3_CanoR_1	43	48	PF00244	0.433
LIG_Actin_WH2_2	177	192	PF00022	0.207
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BRCT_BRCA1_1	70	74	PF00533	0.241
LIG_deltaCOP1_diTrp_1	62	69	PF00928	0.393
LIG_FHA_1	207	213	PF00498	0.267
LIG_FHA_1	317	323	PF00498	0.307
LIG_FHA_1	42	48	PF00498	0.392
LIG_FHA_2	122	128	PF00498	0.329
LIG_FHA_2	155	161	PF00498	0.325
LIG_FHA_2	323	329	PF00498	0.318
LIG_FHA_2	92	98	PF00498	0.383
LIG_LIR_Gen_1	113	121	PF02991	0.364
LIG_LIR_Gen_1	127	135	PF02991	0.346
LIG_LIR_Gen_1	152	159	PF02991	0.315
LIG_LIR_Gen_1	231	242	PF02991	0.264
LIG_LIR_Gen_1	273	280	PF02991	0.321
LIG_LIR_Gen_1	71	80	PF02991	0.259
LIG_LIR_Nem_3	103	107	PF02991	0.407
LIG_LIR_Nem_3	127	132	PF02991	0.366
LIG_LIR_Nem_3	231	237	PF02991	0.259
LIG_LIR_Nem_3	255	261	PF02991	0.317
LIG_LIR_Nem_3	71	75	PF02991	0.281
LIG_PDZ_Class_2	390	395	PF00595	0.235
LIG_PTAP_UEV_1	323	328	PF05743	0.303
LIG_SH2_STAT3	238	241	PF00017	0.240
LIG_SH2_STAT5	234	237	PF00017	0.217
LIG_SH2_STAT5	238	241	PF00017	0.237
LIG_SH2_STAT5	258	261	PF00017	0.284
LIG_SH2_STAT5	354	357	PF00017	0.390
LIG_SH3_1	321	327	PF00018	0.299
LIG_SH3_3	321	327	PF00018	0.338
LIG_SH3_3	93	99	PF00018	0.387
LIG_Sin3_3	379	386	PF02671	0.206
LIG_SUMO_SIM_anti_2	182	188	PF11976	0.259
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.357
LIG_SUMO_SIM_par_1	304	310	PF11976	0.259
LIG_TYR_ITIM	102	107	PF00017	0.445
LIG_TYR_ITIM	232	237	PF00017	0.258
MOD_CK1_1	152	158	PF00069	0.357
MOD_CK1_1	179	185	PF00069	0.283
MOD_CK1_1	228	234	PF00069	0.280
MOD_CK1_1	251	257	PF00069	0.343
MOD_CK1_1	315	321	PF00069	0.319
MOD_CK2_1	127	133	PF00069	0.304
MOD_CK2_1	154	160	PF00069	0.406
MOD_CK2_1	322	328	PF00069	0.315
MOD_CK2_1	91	97	PF00069	0.421
MOD_GlcNHglycan	121	124	PF01048	0.578
MOD_GlcNHglycan	140	143	PF01048	0.453
MOD_GlcNHglycan	145	148	PF01048	0.506
MOD_GlcNHglycan	170	173	PF01048	0.474
MOD_GlcNHglycan	194	197	PF01048	0.496
MOD_GlcNHglycan	218	221	PF01048	0.533
MOD_GlcNHglycan	242	245	PF01048	0.572
MOD_GlcNHglycan	249	253	PF01048	0.534
MOD_GlcNHglycan	25	28	PF01048	0.685
MOD_GlcNHglycan	265	269	PF01048	0.528
MOD_GlcNHglycan	285	288	PF01048	0.487
MOD_GlcNHglycan	342	345	PF01048	0.661
MOD_GlcNHglycan	374	377	PF01048	0.238
MOD_GSK3_1	121	128	PF00069	0.351
MOD_GSK3_1	134	141	PF00069	0.274
MOD_GSK3_1	154	161	PF00069	0.322
MOD_GSK3_1	176	183	PF00069	0.331
MOD_GSK3_1	312	319	PF00069	0.390
MOD_GSK3_1	32	39	PF00069	0.537
MOD_GSK3_1	322	329	PF00069	0.486
MOD_GSK3_1	354	361	PF00069	0.436
MOD_GSK3_1	87	94	PF00069	0.376
MOD_N-GLC_2	262	264	PF02516	0.403
MOD_NEK2_1	10	15	PF00069	0.552
MOD_NEK2_1	121	126	PF00069	0.338
MOD_NEK2_1	138	143	PF00069	0.282
MOD_NEK2_1	189	194	PF00069	0.261
MOD_NEK2_1	21	26	PF00069	0.504
MOD_NEK2_1	213	218	PF00069	0.256
MOD_NEK2_1	237	242	PF00069	0.294
MOD_NEK2_1	266	271	PF00069	0.302
MOD_NEK2_1	283	288	PF00069	0.241
MOD_NEK2_2	134	139	PF00069	0.212
MOD_PIKK_1	237	243	PF00454	0.220
MOD_PK_1	166	172	PF00069	0.225
MOD_PKA_1	206	212	PF00069	0.210
MOD_PKA_2	189	195	PF00069	0.315
MOD_Plk_1	272	278	PF00069	0.324
MOD_Plk_1	358	364	PF00069	0.405
MOD_Plk_2-3	160	166	PF00069	0.350
MOD_Plk_2-3	68	74	PF00069	0.365
MOD_Plk_4	182	188	PF00069	0.330
MOD_Plk_4	213	219	PF00069	0.318
MOD_ProDKin_1	85	91	PF00069	0.348
TRG_DiLeu_BaEn_1	359	364	PF01217	0.256
TRG_ENDOCYTIC_2	104	107	PF00928	0.448
TRG_ENDOCYTIC_2	234	237	PF00928	0.209
TRG_ENDOCYTIC_2	258	261	PF00928	0.338
TRG_ER_diArg_1	5	7	PF00400	0.664
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L4	Leptomonas seymouri	35%	100%
A0A0N1I121	Leptomonas seymouri	30%	79%
A0A0N1I7S5	Leptomonas seymouri	35%	78%
A0A0S4IQ67	Bodo saltans	25%	100%
A0A0S4IQE4	Bodo saltans	22%	70%
A0A0S4IR61	Bodo saltans	29%	98%
A0A0S4JD35	Bodo saltans	28%	66%
A0A0S4JFC9	Bodo saltans	27%	82%
A0A0S4JFV3	Bodo saltans	24%	100%
A0A0S4JHM1	Bodo saltans	27%	100%
A0A0S4JQW3	Bodo saltans	26%	100%
A0A0S4KMV2	Bodo saltans	28%	100%
A0A3Q8I9A6	Leishmania donovani	59%	100%
A0A3Q8I9D0	Leishmania donovani	61%	100%
A0A3Q8IC27	Leishmania donovani	36%	83%
A0A3Q8IFC2	Leishmania donovani	40%	91%
A0A3Q8IIJ9	Leishmania donovani	35%	100%
A0A3Q8IK15	Leishmania donovani	33%	75%
A0A3S5H6D6	Leishmania donovani	30%	100%
A0A3S5H6L9	Leishmania donovani	59%	68%
A0A3S7WP69	Leishmania donovani	22%	96%
A0A3S7WPB2	Leishmania donovani	28%	100%
A0A3S7X4J4	Leishmania donovani	35%	100%
A4H4G6	Leishmania braziliensis	26%	100%
A4H5P0	Leishmania braziliensis	31%	100%
A4HBX3	Leishmania braziliensis	34%	87%
A4HJC8	Leishmania braziliensis	32%	100%
A4HJX1	Leishmania braziliensis	36%	90%
A4HSL2	Leishmania infantum	22%	96%
A4HTX9	Leishmania infantum	31%	100%
A4HVB0	Leishmania infantum	52%	98%
A4HZ93	Leishmania infantum	36%	83%
A4I6S2	Leishmania infantum	32%	90%
A4I6S3	Leishmania infantum	39%	79%
A4I6S4	Leishmania infantum	35%	100%
D1GJ51	Leishmania infantum	60%	85%
E8NHG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	89%
E8NHP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ACQ0	Leishmania major	28%	100%
E9AEF4	Leishmania major	38%	86%
E9AG65	Leishmania infantum	28%	100%
E9AGG5	Leishmania infantum	55%	95%
E9AGG9	Leishmania infantum	56%	73%
E9AGH0	Leishmania infantum	64%	100%
E9AKJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9AKM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AMQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AP00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9AP05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	77%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	94%
E9AVA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	86%
E9B1U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	87%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	94%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
P21978	Leishmania amazonensis	42%	83%
Q05091	Pyrus communis	23%	100%
Q25331	Leishmania major	63%	94%
Q4PSE6	Arabidopsis thaliana	25%	91%
Q4Q6B6	Leishmania major	33%	100%
Q4Q6B7	Leishmania major	33%	100%
Q4Q6B8	Leishmania major	34%	75%
Q4QC79	Leishmania major	33%	100%
Q4QGI0	Leishmania major	63%	78%
Q4QGI2	Leishmania major	52%	71%
Q4QGI4	Leishmania major	52%	74%
Q4QGI6	Leishmania major	65%	72%
Q4QGJ4	Leishmania major	62%	94%
Q4QGJ6	Leishmania major	69%	69%
Q4QGJ7	Leishmania major	63%	84%
Q4QGJ9	Leishmania major	68%	67%
Q4QGK0	Leishmania major	70%	69%
Q4QGK2	Leishmania major	50%	71%
Q4QGK6	Leishmania major	60%	84%
Q4QGK8	Leishmania major	51%	77%
Q4QGL2	Leishmania major	51%	77%
Q4QGL5	Leishmania major	65%	72%
Q4QHW6	Leishmania major	30%	100%
Q4QJB2	Leishmania major	22%	100%
Q8GT95	Oryza sativa subsp. japonica	23%	100%
Q8W3M4	Arabidopsis thaliana	24%	98%
Q9LHF1	Arabidopsis thaliana	23%	80%