LeishMANIAdb
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Promastigote surface antigen protein PSA

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Promastigote surface antigen protein PSA
Gene product:
promastigote surface antigen protein PSA
Species:
Leishmania major
UniProt:
Q4QGL2_LEIMA
TriTrypDb:
LmjF.12.0910 , LMJLV39_000018600 , LMJSD75_120013500
Length:
512

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 140
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 69, no: 14
NetGPI no yes: 0, no: 83
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 7
GO:0005929 cilium 4 84
GO:0016020 membrane 2 33
GO:0042995 cell projection 2 84
GO:0043226 organelle 2 84
GO:0043227 membrane-bounded organelle 3 84
GO:0110165 cellular anatomical entity 1 84
GO:0120025 plasma membrane bounded cell projection 3 84

Expansion

Sequence features

Q4QGL2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGL2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 4
GO:0004672 protein kinase activity 3 4
GO:0004674 protein serine/threonine kinase activity 4 4
GO:0016301 kinase activity 4 4
GO:0016740 transferase activity 2 4
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 4
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 4
GO:0140096 catalytic activity, acting on a protein 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 123 127 PF00656 0.541
CLV_NRD_NRD_1 257 259 PF00675 0.227
CLV_NRD_NRD_1 6 8 PF00675 0.744
CLV_PCSK_FUR_1 255 259 PF00082 0.223
CLV_PCSK_KEX2_1 257 259 PF00082 0.220
CLV_PCSK_KEX2_1 6 8 PF00082 0.744
CLV_PCSK_SKI1_1 159 163 PF00082 0.450
CLV_PCSK_SKI1_1 167 171 PF00082 0.429
CLV_PCSK_SKI1_1 205 209 PF00082 0.495
CLV_PCSK_SKI1_1 230 234 PF00082 0.534
CLV_PCSK_SKI1_1 257 261 PF00082 0.465
CLV_PCSK_SKI1_1 7 11 PF00082 0.714
DEG_APCC_DBOX_1 446 454 PF00400 0.275
DOC_CYCLIN_RxL_1 186 196 PF00134 0.321
DOC_CYCLIN_RxL_1 3 13 PF00134 0.734
DOC_CYCLIN_RxL_1 326 336 PF00134 0.233
DOC_CYCLIN_yCln2_LP_2 266 272 PF00134 0.496
DOC_MAPK_gen_1 203 212 PF00069 0.238
DOC_MAPK_gen_1 257 266 PF00069 0.261
DOC_MAPK_MEF2A_6 468 476 PF00069 0.481
DOC_PP1_RVXF_1 108 115 PF00149 0.309
DOC_PP1_RVXF_1 396 403 PF00149 0.235
DOC_USP7_MATH_1 214 218 PF00917 0.474
DOC_USP7_MATH_1 76 80 PF00917 0.445
DOC_USP7_MATH_2 223 229 PF00917 0.506
DOC_USP7_MATH_2 247 253 PF00917 0.368
DOC_USP7_MATH_2 295 301 PF00917 0.327
DOC_WW_Pin1_4 498 503 PF00397 0.756
DOC_WW_Pin1_4 504 509 PF00397 0.574
LIG_14-3-3_CanoR_1 133 138 PF00244 0.331
LIG_14-3-3_CanoR_1 159 164 PF00244 0.475
LIG_14-3-3_CanoR_1 43 48 PF00244 0.538
LIG_14-3-3_CanoR_1 492 496 PF00244 0.726
LIG_Actin_WH2_2 273 288 PF00022 0.565
LIG_Actin_WH2_2 297 312 PF00022 0.414
LIG_Actin_WH2_2 321 336 PF00022 0.268
LIG_BIR_II_1 1 5 PF00653 0.685
LIG_BRCT_BRCA1_1 299 303 PF00533 0.377
LIG_BRCT_BRCA1_1 323 327 PF00533 0.392
LIG_Clathr_ClatBox_1 354 358 PF01394 0.369
LIG_Clathr_ClatBox_1 473 477 PF01394 0.313
LIG_deltaCOP1_diTrp_1 176 179 PF00928 0.462
LIG_deltaCOP1_diTrp_1 200 206 PF00928 0.517
LIG_deltaCOP1_diTrp_1 297 303 PF00928 0.405
LIG_deltaCOP1_diTrp_1 61 69 PF00928 0.550
LIG_FHA_1 168 174 PF00498 0.450
LIG_FHA_1 183 189 PF00498 0.353
LIG_FHA_1 207 213 PF00498 0.397
LIG_FHA_1 217 223 PF00498 0.433
LIG_FHA_1 280 286 PF00498 0.341
LIG_FHA_1 42 48 PF00498 0.571
LIG_FHA_2 121 127 PF00498 0.510
LIG_FHA_2 206 212 PF00498 0.426
LIG_FHA_2 303 309 PF00498 0.427
LIG_FHA_2 63 69 PF00498 0.485
LIG_FHA_2 92 98 PF00498 0.478
LIG_LIR_Gen_1 126 135 PF02991 0.432
LIG_LIR_Gen_1 175 183 PF02991 0.390
LIG_LIR_Gen_1 200 207 PF02991 0.444
LIG_LIR_Gen_1 297 304 PF02991 0.337
LIG_LIR_Gen_1 350 359 PF02991 0.320
LIG_LIR_Gen_1 417 426 PF02991 0.347
LIG_LIR_Gen_1 441 450 PF02991 0.486
LIG_LIR_Gen_1 71 80 PF02991 0.539
LIG_LIR_Nem_3 126 131 PF02991 0.467
LIG_LIR_Nem_3 175 180 PF02991 0.370
LIG_LIR_Nem_3 350 354 PF02991 0.308
LIG_LIR_Nem_3 425 429 PF02991 0.385
LIG_LIR_Nem_3 71 75 PF02991 0.403
LIG_PCNA_PIPBox_1 229 238 PF02747 0.503
LIG_SH2_STAT5 236 239 PF00017 0.424
LIG_SH2_STAT5 356 359 PF00017 0.332
LIG_SH3_3 266 272 PF00018 0.464
LIG_SH3_3 93 99 PF00018 0.512
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.540
LIG_SUMO_SIM_par_1 132 138 PF11976 0.406
LIG_SUMO_SIM_par_1 281 288 PF11976 0.480
LIG_TYR_ITIM 102 107 PF00017 0.516
LIG_TYR_ITIM 354 359 PF00017 0.336
LIG_UBA3_1 472 481 PF00899 0.335
MOD_CK1_1 151 157 PF00069 0.452
MOD_CK1_1 172 178 PF00069 0.371
MOD_CK1_1 299 305 PF00069 0.335
MOD_CK1_1 347 353 PF00069 0.353
MOD_CK1_1 371 377 PF00069 0.461
MOD_CK2_1 126 132 PF00069 0.499
MOD_CK2_1 205 211 PF00069 0.424
MOD_CK2_1 91 97 PF00069 0.496
MOD_GlcNHglycan 120 123 PF01048 0.466
MOD_GlcNHglycan 139 142 PF01048 0.469
MOD_GlcNHglycan 144 147 PF01048 0.448
MOD_GlcNHglycan 193 196 PF01048 0.502
MOD_GlcNHglycan 25 28 PF01048 0.642
MOD_GlcNHglycan 290 293 PF01048 0.447
MOD_GlcNHglycan 314 317 PF01048 0.383
MOD_GlcNHglycan 338 341 PF01048 0.426
MOD_GlcNHglycan 346 349 PF01048 0.373
MOD_GlcNHglycan 362 365 PF01048 0.438
MOD_GlcNHglycan 386 389 PF01048 0.408
MOD_GlcNHglycan 410 413 PF01048 0.476
MOD_GlcNHglycan 433 437 PF01048 0.411
MOD_GlcNHglycan 441 445 PF01048 0.420
MOD_GSK3_1 120 127 PF00069 0.438
MOD_GSK3_1 133 140 PF00069 0.402
MOD_GSK3_1 144 151 PF00069 0.439
MOD_GSK3_1 214 221 PF00069 0.381
MOD_GSK3_1 281 288 PF00069 0.305
MOD_GSK3_1 310 317 PF00069 0.370
MOD_GSK3_1 32 39 PF00069 0.628
MOD_GSK3_1 490 497 PF00069 0.720
MOD_GSK3_1 498 505 PF00069 0.727
MOD_GSK3_1 87 94 PF00069 0.472
MOD_N-GLC_1 288 293 PF02516 0.321
MOD_N-GLC_2 489 491 PF02516 0.675
MOD_NEK2_1 10 15 PF00069 0.607
MOD_NEK2_1 120 125 PF00069 0.409
MOD_NEK2_1 137 142 PF00069 0.477
MOD_NEK2_1 169 174 PF00069 0.304
MOD_NEK2_1 191 196 PF00069 0.432
MOD_NEK2_1 21 26 PF00069 0.598
MOD_NEK2_1 218 223 PF00069 0.366
MOD_NEK2_1 285 290 PF00069 0.367
MOD_NEK2_1 333 338 PF00069 0.490
MOD_NEK2_1 357 362 PF00069 0.398
MOD_NEK2_1 381 386 PF00069 0.413
MOD_NEK2_1 405 410 PF00069 0.354
MOD_NEK2_1 434 439 PF00069 0.428
MOD_NEK2_1 86 91 PF00069 0.454
MOD_PIKK_1 126 132 PF00454 0.340
MOD_PIKK_1 357 363 PF00454 0.482
MOD_PIKK_1 381 387 PF00454 0.534
MOD_PIKK_1 405 411 PF00454 0.433
MOD_PK_1 310 316 PF00069 0.554
MOD_PKA_1 62 68 PF00069 0.355
MOD_PKA_2 285 291 PF00069 0.441
MOD_PKA_2 333 339 PF00069 0.538
MOD_PKA_2 491 497 PF00069 0.739
MOD_PKB_1 157 165 PF00069 0.245
MOD_Plk_1 175 181 PF00069 0.389
MOD_Plk_1 199 205 PF00069 0.441
MOD_Plk_1 296 302 PF00069 0.353
MOD_Plk_1 357 363 PF00069 0.359
MOD_Plk_1 416 422 PF00069 0.411
MOD_Plk_1 440 446 PF00069 0.508
MOD_Plk_1 86 92 PF00069 0.405
MOD_Plk_2-3 281 287 PF00069 0.240
MOD_Plk_2-3 68 74 PF00069 0.504
MOD_Plk_4 151 157 PF00069 0.460
MOD_Plk_4 182 188 PF00069 0.408
MOD_Plk_4 249 255 PF00069 0.348
MOD_Plk_4 299 305 PF00069 0.374
MOD_Plk_4 347 353 PF00069 0.361
MOD_Plk_4 417 423 PF00069 0.302
MOD_ProDKin_1 498 504 PF00069 0.758
MOD_SUMO_rev_2 59 65 PF00179 0.308
TRG_DiLeu_BaLyEn_6 115 120 PF01217 0.550
TRG_DiLeu_BaLyEn_6 130 135 PF01217 0.227
TRG_ENDOCYTIC_2 104 107 PF00928 0.511
TRG_ENDOCYTIC_2 356 359 PF00928 0.413
TRG_ER_diArg_1 156 159 PF00400 0.267
TRG_ER_diArg_1 254 257 PF00400 0.269
TRG_ER_diArg_1 446 449 PF00400 0.560
TRG_ER_diArg_1 5 7 PF00400 0.746
TRG_Pf-PMV_PEXEL_1 377 382 PF00026 0.448
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.562

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6A5 Leptomonas seymouri 28% 80%
A0A0N1I121 Leptomonas seymouri 26% 100%
A0A0N1I661 Leptomonas seymouri 36% 90%
A0A0N1I7S5 Leptomonas seymouri 33% 100%
A0A0N1II82 Leptomonas seymouri 30% 74%
A0A0S4IHI7 Bodo saltans 29% 66%
A0A0S4IJN2 Bodo saltans 32% 76%
A0A0S4ILC9 Bodo saltans 34% 93%
A0A0S4IN27 Bodo saltans 41% 95%
A0A0S4IQE4 Bodo saltans 27% 90%
A0A0S4ISU4 Bodo saltans 39% 78%
A0A0S4IT62 Bodo saltans 35% 69%
A0A0S4IU23 Bodo saltans 31% 86%
A0A0S4IU73 Bodo saltans 36% 100%
A0A0S4IV96 Bodo saltans 39% 84%
A0A0S4IVQ8 Bodo saltans 37% 85%
A0A0S4IW93 Bodo saltans 26% 84%
A0A0S4IY44 Bodo saltans 28% 77%
A0A0S4IZC7 Bodo saltans 27% 100%
A0A0S4J014 Bodo saltans 27% 72%
A0A0S4J1A6 Bodo saltans 26% 100%
A0A0S4J206 Bodo saltans 35% 83%
A0A0S4J2H8 Bodo saltans 28% 88%
A0A0S4J3T7 Bodo saltans 33% 100%
A0A0S4J4L7 Bodo saltans 30% 69%
A0A0S4J5A0 Bodo saltans 39% 90%
A0A0S4J954 Bodo saltans 25% 69%
A0A0S4JAQ6 Bodo saltans 27% 99%
A0A0S4JAS1 Bodo saltans 35% 81%
A0A0S4JAW7 Bodo saltans 25% 100%
A0A0S4JB95 Bodo saltans 25% 84%
A0A0S4JBV9 Bodo saltans 28% 100%
A0A0S4JD35 Bodo saltans 29% 86%
A0A0S4JDS1 Bodo saltans 24% 96%
A0A0S4JDT0 Bodo saltans 35% 78%
A0A0S4JEK1 Bodo saltans 27% 100%
A0A0S4JEP2 Bodo saltans 25% 88%
A0A0S4JL29 Bodo saltans 29% 100%
A0A0S4JMF9 Bodo saltans 32% 100%
A0A0S4JQZ0 Bodo saltans 24% 68%
A0A0S4JS89 Bodo saltans 27% 100%
A0A0S4JTM6 Bodo saltans 35% 69%
A0A0S4JTQ7 Bodo saltans 35% 97%
A0A0S4JU95 Bodo saltans 32% 67%
A0A0S4JVI0 Bodo saltans 26% 72%
A0A0S4KGV4 Bodo saltans 25% 94%
A0A0S4KH41 Bodo saltans 30% 74%
A0A0S4KJA7 Bodo saltans 28% 76%
A0A0S4KK37 Bodo saltans 34% 88%
A0A3Q8I9A6 Leishmania donovani 52% 100%
A0A3Q8I9B4 Leishmania donovani 41% 100%
A0A3Q8I9D9 Leishmania donovani 41% 100%
A0A3Q8IC27 Leishmania donovani 35% 100%
A0A3S5H6L9 Leishmania donovani 42% 100%
A0A3S5H6M3 Leishmania donovani 54% 75%
A0A3S5H6M4 Leishmania donovani 55% 78%
A0A3S7WS66 Leishmania donovani 55% 78%
A4HBX3 Leishmania braziliensis 32% 100%
A4HVB0 Leishmania infantum 47% 100%
A4HZ93 Leishmania infantum 35% 100%
D1GJ51 Leishmania infantum 55% 100%
E8NHG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 67%
E9AGG2 Leishmania infantum 54% 77%
E9AGG7 Leishmania infantum 54% 82%
E9AGG9 Leishmania infantum 60% 95%
E9AGH0 Leishmania infantum 50% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 72%
E9AP02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 73%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 100%
E9AP07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
O48851 Arabidopsis thaliana 26% 66%
O80809 Arabidopsis thaliana 24% 71%
Q1PEN0 Arabidopsis thaliana 21% 71%
Q4QC79 Leishmania major 36% 100%
Q4QGI0 Leishmania major 64% 100%
Q4QGI2 Leishmania major 65% 100%
Q4QGI4 Leishmania major 73% 100%
Q4QGI6 Leishmania major 55% 100%
Q4QGI8 Leishmania major 62% 100%
Q4QGJ0 Leishmania major 58% 100%
Q4QGJ2 Leishmania major 56% 100%
Q4QGJ6 Leishmania major 60% 90%
Q4QGJ9 Leishmania major 54% 100%
Q4QGK0 Leishmania major 55% 100%
Q4QGK1 Leishmania major 58% 100%
Q4QGK2 Leishmania major 70% 100%
Q4QGK4 Leishmania major 57% 100%
Q4QGK8 Leishmania major 100% 100%
Q4QGL4 Leishmania major 51% 100%
Q4QGL5 Leishmania major 60% 94%
Q4QGL8 Leishmania major 59% 84%
Q54AX5 Dictyostelium discoideum 24% 100%
Q5M8G4 Xenopus tropicalis 25% 85%
Q5ZLN0 Gallus gallus 26% 85%
Q940E8 Zea mays 26% 84%
Q9LJW7 Arabidopsis thaliana 25% 72%
Q9SHI3 Arabidopsis thaliana 22% 70%
Q9SHI4 Arabidopsis thaliana 25% 68%
Q9SJH6 Arabidopsis thaliana 26% 100%
Q9SKK5 Arabidopsis thaliana 23% 76%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS