LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein
Species:
Leishmania major
UniProt:
Q4QGL1_LEIMA
TriTrypDb:
LmjF.12.0905 , LMJLV39_120012700 , LMJSD75_120013200
Length:
431

Annotations

LeishMANIAdb annotations

This is a highly disordered Cys-rich prote8in with spurious hydrophobic segments. Very low conservation.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

Q4QGL1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGL1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 143 147 PF00656 0.803
CLV_C14_Caspase3-7 173 177 PF00656 0.807
CLV_NRD_NRD_1 136 138 PF00675 0.809
CLV_NRD_NRD_1 392 394 PF00675 0.541
CLV_NRD_NRD_1 401 403 PF00675 0.707
CLV_NRD_NRD_1 86 88 PF00675 0.590
CLV_PCSK_KEX2_1 136 138 PF00082 0.809
CLV_PCSK_KEX2_1 392 394 PF00082 0.572
CLV_PCSK_KEX2_1 401 403 PF00082 0.738
CLV_PCSK_KEX2_1 85 87 PF00082 0.590
CLV_PCSK_SKI1_1 139 143 PF00082 0.800
DEG_SPOP_SBC_1 41 45 PF00917 0.611
DOC_CDC14_PxL_1 127 135 PF14671 0.790
DOC_CYCLIN_yCln2_LP_2 240 246 PF00134 0.802
DOC_CYCLIN_yCln2_LP_2 31 37 PF00134 0.605
DOC_MAPK_gen_1 27 37 PF00069 0.613
DOC_MAPK_MEF2A_6 214 222 PF00069 0.719
DOC_MAPK_MEF2A_6 30 39 PF00069 0.607
DOC_PP2B_LxvP_1 180 183 PF13499 0.841
DOC_PP2B_LxvP_1 31 34 PF13499 0.599
DOC_PP2B_LxvP_1 37 40 PF13499 0.565
DOC_USP7_MATH_1 126 130 PF00917 0.783
DOC_USP7_MATH_1 140 144 PF00917 0.553
DOC_USP7_MATH_1 187 191 PF00917 0.839
DOC_USP7_MATH_1 244 248 PF00917 0.786
DOC_USP7_MATH_1 329 333 PF00917 0.808
DOC_USP7_MATH_1 347 351 PF00917 0.503
DOC_USP7_MATH_1 41 45 PF00917 0.611
DOC_USP7_MATH_1 427 431 PF00917 0.481
DOC_WW_Pin1_4 234 239 PF00397 0.806
DOC_WW_Pin1_4 284 289 PF00397 0.728
DOC_WW_Pin1_4 29 34 PF00397 0.609
DOC_WW_Pin1_4 361 366 PF00397 0.838
DOC_WW_Pin1_4 54 59 PF00397 0.647
LIG_14-3-3_CanoR_1 152 160 PF00244 0.784
LIG_14-3-3_CanoR_1 308 314 PF00244 0.729
LIG_14-3-3_CanoR_1 363 372 PF00244 0.828
LIG_CtBP_PxDLS_1 288 292 PF00389 0.721
LIG_FHA_1 192 198 PF00498 0.852
LIG_FHA_1 235 241 PF00498 0.805
LIG_FHA_1 41 47 PF00498 0.617
LIG_FHA_2 104 110 PF00498 0.661
LIG_FHA_2 171 177 PF00498 0.806
LIG_FHA_2 285 291 PF00498 0.721
LIG_GBD_Chelix_1 344 352 PF00786 0.817
LIG_LIR_Apic_2 360 365 PF02991 0.835
LIG_LIR_Gen_1 247 256 PF02991 0.723
LIG_LIR_Nem_3 247 251 PF02991 0.742
LIG_MYND_1 54 58 PF01753 0.584
LIG_OCRL_FandH_1 247 259 PF00620 0.726
LIG_PCNA_yPIPBox_3 376 384 PF02747 0.441
LIG_PDZ_Class_2 426 431 PF00595 0.482
LIG_SH3_2 131 136 PF14604 0.797
LIG_SH3_2 50 55 PF14604 0.592
LIG_SH3_3 128 134 PF00018 0.787
LIG_SH3_3 221 227 PF00018 0.702
LIG_SH3_3 235 241 PF00018 0.559
LIG_SH3_3 47 53 PF00018 0.618
LIG_SH3_3 65 71 PF00018 0.583
LIG_SH3_CIN85_PxpxPR_1 50 55 PF14604 0.592
LIG_Sin3_3 177 184 PF02671 0.830
LIG_SUMO_SIM_par_1 287 292 PF11976 0.720
LIG_WW_3 52 56 PF00397 0.587
MOD_CDK_SPK_2 361 366 PF00069 0.838
MOD_CK1_1 129 135 PF00069 0.793
MOD_CK1_1 153 159 PF00069 0.783
MOD_CK1_1 328 334 PF00069 0.807
MOD_CK1_1 364 370 PF00069 0.833
MOD_CK1_1 44 50 PF00069 0.619
MOD_CK2_1 103 109 PF00069 0.660
MOD_GlcNHglycan 152 155 PF01048 0.779
MOD_GlcNHglycan 156 159 PF01048 0.716
MOD_GlcNHglycan 188 192 PF01048 0.845
MOD_GlcNHglycan 260 263 PF01048 0.780
MOD_GlcNHglycan 293 296 PF01048 0.705
MOD_GlcNHglycan 327 330 PF01048 0.803
MOD_GlcNHglycan 331 334 PF01048 0.738
MOD_GlcNHglycan 349 352 PF01048 0.509
MOD_GlcNHglycan 366 369 PF01048 0.542
MOD_GlcNHglycan 386 389 PF01048 0.540
MOD_GlcNHglycan 412 415 PF01048 0.503
MOD_GlcNHglycan 46 49 PF01048 0.623
MOD_GSK3_1 111 118 PF00069 0.681
MOD_GSK3_1 150 157 PF00069 0.783
MOD_GSK3_1 187 194 PF00069 0.845
MOD_GSK3_1 232 239 PF00069 0.806
MOD_GSK3_1 325 332 PF00069 0.801
MOD_GSK3_1 40 47 PF00069 0.616
MOD_GSK3_1 99 106 PF00069 0.704
MOD_NEK2_1 112 117 PF00069 0.520
MOD_NEK2_1 289 294 PF00069 0.710
MOD_NEK2_1 35 40 PF00069 0.608
MOD_NEK2_1 384 389 PF00069 0.446
MOD_NEK2_1 407 412 PF00069 0.505
MOD_NEK2_2 140 145 PF00069 0.799
MOD_OFUCOSY 159 165 PF10250 0.793
MOD_PIKK_1 196 202 PF00454 0.834
MOD_PIKK_1 77 83 PF00454 0.595
MOD_PKA_2 116 122 PF00069 0.781
MOD_PKA_2 154 160 PF00069 0.784
MOD_PKA_2 208 214 PF00069 0.744
MOD_PKA_2 329 335 PF00069 0.810
MOD_PKA_2 407 413 PF00069 0.768
MOD_PKA_2 75 81 PF00069 0.596
MOD_PKB_1 137 145 PF00069 0.804
MOD_PKB_1 234 242 PF00069 0.807
MOD_Plk_1 187 193 PF00069 0.842
MOD_Plk_1 289 295 PF00069 0.707
MOD_ProDKin_1 234 240 PF00069 0.806
MOD_ProDKin_1 284 290 PF00069 0.726
MOD_ProDKin_1 29 35 PF00069 0.610
MOD_ProDKin_1 361 367 PF00069 0.839
MOD_ProDKin_1 54 60 PF00069 0.647
TRG_DiLeu_BaLyEn_6 193 198 PF01217 0.852
TRG_ER_diArg_1 136 139 PF00400 0.811
TRG_ER_diArg_1 391 393 PF00400 0.586
TRG_ER_diArg_1 401 404 PF00400 0.769
TRG_ER_diArg_1 85 87 PF00400 0.617
TRG_ER_diArg_1 98 101 PF00400 0.637

Homologs

Protein Taxonomy Sequence identity Coverage
Q4QGI5 Leishmania major 99% 100%
Q4QGI7 Leishmania major 92% 100%
Q4QGK9 Leishmania major 98% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS