Flavin_Reduct domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QGK9_LEIMA

TriTrypDb:

LmjF.12.1015 , LMJLV39_120012700 , LMJSD75_120013200

Length:

422

Annotations

LeishMANIAdb annotations

This is a highly disordered Cys-rich prote8in with spurious hydrophobic segments. Very low conservation.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QGK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.507
CLV_C14_Caspase3-7	143	147	PF00656	0.810
CLV_C14_Caspase3-7	173	177	PF00656	0.774
CLV_NRD_NRD_1	136	138	PF00675	0.788
CLV_NRD_NRD_1	406	408	PF00675	0.772
CLV_NRD_NRD_1	86	88	PF00675	0.577
CLV_PCSK_FUR_1	402	406	PF00082	0.774
CLV_PCSK_KEX2_1	136	138	PF00082	0.788
CLV_PCSK_KEX2_1	404	406	PF00082	0.777
CLV_PCSK_KEX2_1	85	87	PF00082	0.579
CLV_PCSK_PC7_1	400	406	PF00082	0.775
CLV_PCSK_SKI1_1	139	143	PF00082	0.772
DEG_SPOP_SBC_1	41	45	PF00917	0.602
DOC_CDC14_PxL_1	127	135	PF14671	0.761
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.714
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.589
DOC_MAPK_gen_1	27	37	PF00069	0.598
DOC_MAPK_MEF2A_6	214	222	PF00069	0.724
DOC_MAPK_MEF2A_6	30	39	PF00069	0.592
DOC_PP2B_LxvP_1	180	183	PF13499	0.814
DOC_PP2B_LxvP_1	31	34	PF13499	0.580
DOC_PP2B_LxvP_1	37	40	PF13499	0.544
DOC_USP7_MATH_1	126	130	PF00917	0.765
DOC_USP7_MATH_1	140	144	PF00917	0.584
DOC_USP7_MATH_1	187	191	PF00917	0.841
DOC_USP7_MATH_1	244	248	PF00917	0.785
DOC_USP7_MATH_1	329	333	PF00917	0.821
DOC_USP7_MATH_1	347	351	PF00917	0.780
DOC_USP7_MATH_1	41	45	PF00917	0.637
DOC_WW_Pin1_4	234	239	PF00397	0.766
DOC_WW_Pin1_4	284	289	PF00397	0.734
DOC_WW_Pin1_4	29	34	PF00397	0.592
DOC_WW_Pin1_4	361	366	PF00397	0.813
DOC_WW_Pin1_4	54	59	PF00397	0.648
LIG_14-3-3_CanoR_1	152	160	PF00244	0.759
LIG_14-3-3_CanoR_1	308	314	PF00244	0.776
LIG_14-3-3_CanoR_1	363	372	PF00244	0.832
LIG_CtBP_PxDLS_1	288	292	PF00389	0.732
LIG_FHA_1	192	198	PF00498	0.817
LIG_FHA_1	235	241	PF00498	0.786
LIG_FHA_1	371	377	PF00498	0.645
LIG_FHA_1	392	398	PF00498	0.781
LIG_FHA_1	41	47	PF00498	0.608
LIG_FHA_1	413	419	PF00498	0.637
LIG_FHA_2	171	177	PF00498	0.805
LIG_FHA_2	285	291	PF00498	0.730
LIG_GBD_Chelix_1	344	352	PF00786	0.778
LIG_LIR_Apic_2	360	365	PF02991	0.814
LIG_LIR_Gen_1	247	256	PF02991	0.551
LIG_LIR_Nem_3	247	251	PF02991	0.605
LIG_MYND_1	54	58	PF01753	0.569
LIG_OCRL_FandH_1	247	259	PF00620	0.694
LIG_SH3_2	131	136	PF14604	0.770
LIG_SH3_2	50	55	PF14604	0.581
LIG_SH3_3	128	134	PF00018	0.775
LIG_SH3_3	221	227	PF00018	0.707
LIG_SH3_3	235	241	PF00018	0.556
LIG_SH3_3	47	53	PF00018	0.607
LIG_SH3_3	65	71	PF00018	0.571
LIG_SH3_CIN85_PxpxPR_1	408	413	PF14604	0.770
LIG_SH3_CIN85_PxpxPR_1	50	55	PF14604	0.581
LIG_Sin3_3	177	184	PF02671	0.794
LIG_SUMO_SIM_par_1	287	292	PF11976	0.732
LIG_WW_3	52	56	PF00397	0.576
MOD_CDK_SPK_2	361	366	PF00069	0.813
MOD_CK1_1	129	135	PF00069	0.797
MOD_CK1_1	153	159	PF00069	0.760
MOD_CK1_1	328	334	PF00069	0.819
MOD_CK1_1	364	370	PF00069	0.831
MOD_CK1_1	44	50	PF00069	0.640
MOD_Cter_Amidation	402	405	PF01082	0.772
MOD_GlcNHglycan	152	155	PF01048	0.786
MOD_GlcNHglycan	156	159	PF01048	0.726
MOD_GlcNHglycan	188	192	PF01048	0.836
MOD_GlcNHglycan	260	263	PF01048	0.699
MOD_GlcNHglycan	293	296	PF01048	0.548
MOD_GlcNHglycan	327	330	PF01048	0.787
MOD_GlcNHglycan	331	334	PF01048	0.726
MOD_GlcNHglycan	349	352	PF01048	0.809
MOD_GlcNHglycan	366	369	PF01048	0.506
MOD_GlcNHglycan	375	379	PF01048	0.671
MOD_GlcNHglycan	46	49	PF01048	0.640
MOD_GSK3_1	112	119	PF00069	0.704
MOD_GSK3_1	150	157	PF00069	0.768
MOD_GSK3_1	187	194	PF00069	0.810
MOD_GSK3_1	232	239	PF00069	0.781
MOD_GSK3_1	325	332	PF00069	0.717
MOD_GSK3_1	370	377	PF00069	0.658
MOD_GSK3_1	40	47	PF00069	0.606
MOD_NEK2_1	289	294	PF00069	0.579
MOD_NEK2_1	35	40	PF00069	0.595
MOD_NEK2_2	140	145	PF00069	0.772
MOD_OFUCOSY	159	165	PF10250	0.757
MOD_PIKK_1	112	118	PF00454	0.632
MOD_PIKK_1	196	202	PF00454	0.797
MOD_PIKK_1	77	83	PF00454	0.582
MOD_PKA_2	116	122	PF00069	0.769
MOD_PKA_2	154	160	PF00069	0.756
MOD_PKA_2	208	214	PF00069	0.713
MOD_PKA_2	329	335	PF00069	0.815
MOD_PKA_2	412	418	PF00069	0.796
MOD_PKA_2	75	81	PF00069	0.584
MOD_PKB_1	137	145	PF00069	0.776
MOD_PKB_1	234	242	PF00069	0.768
MOD_Plk_1	187	193	PF00069	0.842
MOD_Plk_1	289	295	PF00069	0.590
MOD_Plk_1	374	380	PF00069	0.773
MOD_ProDKin_1	234	240	PF00069	0.767
MOD_ProDKin_1	284	290	PF00069	0.733
MOD_ProDKin_1	29	35	PF00069	0.595
MOD_ProDKin_1	361	367	PF00069	0.811
MOD_ProDKin_1	54	60	PF00069	0.648
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.817
TRG_ER_diArg_1	136	139	PF00400	0.787
TRG_ER_diArg_1	402	405	PF00400	0.786
TRG_ER_diArg_1	406	408	PF00400	0.506
TRG_ER_diArg_1	85	87	PF00400	0.603
TRG_ER_diArg_1	98	101	PF00400	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H6Y6	Leishmania braziliensis	50%	81%
Q4QGI5	Leishmania major	99%	100%
Q4QGI7	Leishmania major	96%	100%
Q4QGL1	Leishmania major	98%	98%