WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGK7_LEIMA

TriTrypDb:

LmjF.12.0930 , LMJSD75_120013000

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 22
NetGPI	no	yes: 0, no: 23

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGK7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.694
CLV_NRD_NRD_1	229	231	PF00675	0.572
CLV_NRD_NRD_1	307	309	PF00675	0.794
CLV_NRD_NRD_1	318	320	PF00675	0.694
CLV_NRD_NRD_1	395	397	PF00675	0.665
CLV_NRD_NRD_1	477	479	PF00675	0.538
CLV_PCSK_FUR_1	393	397	PF00082	0.621
CLV_PCSK_KEX2_1	229	231	PF00082	0.572
CLV_PCSK_KEX2_1	243	245	PF00082	0.623
CLV_PCSK_KEX2_1	307	309	PF00082	0.743
CLV_PCSK_KEX2_1	395	397	PF00082	0.661
CLV_PCSK_KEX2_1	476	478	PF00082	0.542
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.623
CLV_PCSK_SKI1_1	395	399	PF00082	0.658
CLV_Separin_Metazoa	226	230	PF03568	0.578
DEG_Nend_Nbox_1	1	3	PF02207	0.628
DOC_CYCLIN_RxL_1	392	402	PF00134	0.665
DOC_MAPK_gen_1	319	327	PF00069	0.735
DOC_MAPK_gen_1	34	44	PF00069	0.548
DOC_MAPK_gen_1	8	18	PF00069	0.650
DOC_MAPK_MEF2A_6	11	18	PF00069	0.610
DOC_PP4_FxxP_1	148	151	PF00568	0.563
DOC_USP7_MATH_1	321	325	PF00917	0.720
DOC_USP7_MATH_1	426	430	PF00917	0.696
DOC_USP7_MATH_1	439	443	PF00917	0.689
DOC_WW_Pin1_4	10	15	PF00397	0.592
DOC_WW_Pin1_4	103	108	PF00397	0.566
DOC_WW_Pin1_4	352	357	PF00397	0.673
DOC_WW_Pin1_4	61	66	PF00397	0.555
LIG_14-3-3_CanoR_1	30	34	PF00244	0.691
LIG_14-3-3_CanoR_1	431	440	PF00244	0.762
LIG_14-3-3_CanoR_1	471	476	PF00244	0.548
LIG_BRCT_BRCA1_1	323	327	PF00533	0.723
LIG_BRCT_BRCA1_1	6	10	PF00533	0.657
LIG_Clathr_ClatBox_1	130	134	PF01394	0.495
LIG_deltaCOP1_diTrp_1	310	315	PF00928	0.664
LIG_EVH1_1	148	152	PF00568	0.564
LIG_FHA_1	11	17	PF00498	0.637
LIG_FHA_1	243	249	PF00498	0.628
LIG_LIR_Apic_2	146	151	PF02991	0.581
LIG_LIR_Apic_2	250	255	PF02991	0.644
LIG_LIR_Apic_2	298	303	PF02991	0.658
LIG_LIR_Apic_2	59	65	PF02991	0.544
LIG_LIR_Apic_2	93	97	PF02991	0.571
LIG_LIR_Gen_1	236	247	PF02991	0.613
LIG_LIR_Gen_1	289	300	PF02991	0.631
LIG_LIR_Nem_3	182	188	PF02991	0.544
LIG_LIR_Nem_3	236	242	PF02991	0.626
LIG_LIR_Nem_3	289	295	PF02991	0.628
LIG_LIR_Nem_3	31	36	PF02991	0.586
LIG_LIR_Nem_3	310	314	PF02991	0.663
LIG_LIR_Nem_3	85	90	PF02991	0.558
LIG_PCNA_PIPBox_1	116	125	PF02747	0.642
LIG_PDZ_Wminus1_1	480	482	PF00595	0.534
LIG_Pex14_2	327	331	PF04695	0.758
LIG_SH2_CRK	292	296	PF00017	0.633
LIG_SH2_CRK	87	91	PF00017	0.567
LIG_SH2_NCK_1	292	296	PF00017	0.664
LIG_SH2_NCK_1	364	368	PF00017	0.702
LIG_SH2_PTP2	300	303	PF00017	0.668
LIG_SH2_SRC	300	303	PF00017	0.668
LIG_SH2_SRC	364	367	PF00017	0.672
LIG_SH2_STAT3	210	213	PF00017	0.713
LIG_SH2_STAT3	70	73	PF00017	0.549
LIG_SH2_STAT5	300	303	PF00017	0.668
LIG_SH2_STAT5	70	73	PF00017	0.549
LIG_SH2_STAT5	94	97	PF00017	0.570
LIG_SH3_1	420	426	PF00018	0.749
LIG_SH3_3	135	141	PF00018	0.589
LIG_SH3_3	146	152	PF00018	0.572
LIG_SH3_3	186	192	PF00018	0.582
LIG_SH3_3	245	251	PF00018	0.628
LIG_SH3_3	342	348	PF00018	0.656
LIG_SH3_3	402	408	PF00018	0.677
LIG_SH3_3	420	426	PF00018	0.736
LIG_TRAF2_1	20	23	PF00917	0.619
LIG_TRAF2_1	223	226	PF00917	0.656
LIG_TRAF2_1	247	250	PF00917	0.730
LIG_TRAF2_1	65	68	PF00917	0.657
LIG_WW_2	425	428	PF00397	0.816
MOD_CDC14_SPxK_1	106	109	PF00782	0.554
MOD_CDK_SPK_2	352	357	PF00069	0.673
MOD_CDK_SPxK_1	103	109	PF00069	0.566
MOD_CDK_SPxxK_3	10	17	PF00069	0.609
MOD_CK1_1	429	435	PF00069	0.805
MOD_CK2_1	158	164	PF00069	0.577
MOD_CK2_1	383	389	PF00069	0.570
MOD_CK2_1	452	458	PF00069	0.582
MOD_Cter_Amidation	305	308	PF01082	0.741
MOD_Cter_Amidation	317	320	PF01082	0.557
MOD_GlcNHglycan	23	29	PF01048	0.702
MOD_GlcNHglycan	316	319	PF01048	0.746
MOD_GlcNHglycan	400	404	PF01048	0.677
MOD_GlcNHglycan	405	408	PF01048	0.660
MOD_GlcNHglycan	428	431	PF01048	0.775
MOD_GlcNHglycan	434	437	PF01048	0.794
MOD_GlcNHglycan	441	444	PF01048	0.820
MOD_GlcNHglycan	84	87	PF01048	0.539
MOD_GSK3_1	24	31	PF00069	0.686
MOD_GSK3_1	399	406	PF00069	0.724
MOD_GSK3_1	99	106	PF00069	0.564
MOD_NEK2_1	314	319	PF00069	0.629
MOD_NEK2_1	398	403	PF00069	0.631
MOD_NEK2_1	99	104	PF00069	0.561
MOD_NEK2_2	29	34	PF00069	0.726
MOD_PKA_2	29	35	PF00069	0.689
MOD_PKA_2	432	438	PF00069	0.763
MOD_Plk_1	158	164	PF00069	0.577
MOD_Plk_1	383	389	PF00069	0.525
MOD_Plk_2-3	452	458	PF00069	0.582
MOD_ProDKin_1	10	16	PF00069	0.594
MOD_ProDKin_1	103	109	PF00069	0.566
MOD_ProDKin_1	352	358	PF00069	0.670
MOD_ProDKin_1	61	67	PF00069	0.562
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.615
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.563
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.575
TRG_ENDOCYTIC_2	176	179	PF00928	0.560
TRG_ENDOCYTIC_2	292	295	PF00928	0.631
TRG_ENDOCYTIC_2	87	90	PF00928	0.560
TRG_ER_diArg_1	228	230	PF00400	0.580
TRG_ER_diArg_1	258	261	PF00400	0.726
TRG_ER_diArg_1	393	396	PF00400	0.616
TRG_ER_diArg_1	475	478	PF00400	0.546
TRG_ER_diArg_1	48	51	PF00400	0.526
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	395	400	PF00026	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9T4	Leptomonas seymouri	80%	100%
A0A0S4IRN8	Bodo saltans	72%	100%
A0A1X0NP12	Trypanosomatidae	72%	100%
A0A381ME06	Leishmania infantum	96%	100%
A0A3Q8IHT5	Leishmania donovani	95%	100%
A0A3S7WS51	Leishmania donovani	96%	100%
A4H6Y7	Leishmania braziliensis	82%	100%
C9ZHZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AGG3	Leishmania infantum	96%	100%
E9AGG8	Leishmania infantum	96%	100%
E9AP06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QGI1	Leishmania major	99%	100%
Q4QGI3	Leishmania major	99%	100%
Q4QGJ3	Leishmania major	99%	100%
Q4QGJ5	Leishmania major	99%	99%
Q4QGJ8	Leishmania major	99%	100%
Q4QGK3	Leishmania major	99%	100%
Q4QGK5	Leishmania major	99%	100%
Q4QGL3	Leishmania major	99%	100%
Q4QGL6	Leishmania major	98%	100%
Q4QGM0	Leishmania major	99%	100%
V5BF60	Trypanosoma cruzi	73%	98%