Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGK3_LEIMA

TriTrypDb:

LmjF.12.0970 , LMJSD75_120013000

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 21
NetGPI	no	yes: 0, no: 22

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGK3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.660
CLV_NRD_NRD_1	229	231	PF00675	0.607
CLV_NRD_NRD_1	307	309	PF00675	0.759
CLV_NRD_NRD_1	318	320	PF00675	0.677
CLV_NRD_NRD_1	395	397	PF00675	0.635
CLV_NRD_NRD_1	522	524	PF00675	0.536
CLV_NRD_NRD_1	569	571	PF00675	0.487
CLV_PCSK_FUR_1	393	397	PF00082	0.601
CLV_PCSK_FUR_1	566	570	PF00082	0.486
CLV_PCSK_KEX2_1	103	105	PF00082	0.471
CLV_PCSK_KEX2_1	229	231	PF00082	0.607
CLV_PCSK_KEX2_1	243	245	PF00082	0.635
CLV_PCSK_KEX2_1	307	309	PF00082	0.713
CLV_PCSK_KEX2_1	395	397	PF00082	0.632
CLV_PCSK_KEX2_1	497	499	PF00082	0.481
CLV_PCSK_KEX2_1	522	524	PF00082	0.532
CLV_PCSK_KEX2_1	568	570	PF00082	0.489
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.471
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.635
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.481
CLV_PCSK_SKI1_1	395	399	PF00082	0.630
CLV_PCSK_SKI1_1	453	457	PF00082	0.425
CLV_PCSK_SKI1_1	474	478	PF00082	0.536
CLV_Separin_Metazoa	226	230	PF03568	0.600
DEG_APCC_DBOX_1	473	481	PF00400	0.432
DEG_APCC_DBOX_1	485	493	PF00400	0.449
DEG_Nend_Nbox_1	1	3	PF02207	0.669
DOC_CDC14_PxL_1	477	485	PF14671	0.434
DOC_CKS1_1	518	523	PF01111	0.435
DOC_CYCLIN_RxL_1	392	402	PF00134	0.638
DOC_CYCLIN_yClb3_PxF_3	466	474	PF00134	0.426
DOC_CYCLIN_yCln2_LP_2	472	478	PF00134	0.436
DOC_MAPK_DCC_7	474	482	PF00069	0.433
DOC_MAPK_gen_1	319	327	PF00069	0.721
DOC_MAPK_gen_1	34	44	PF00069	0.571
DOC_MAPK_gen_1	486	494	PF00069	0.458
DOC_MAPK_gen_1	532	540	PF00069	0.453
DOC_MAPK_gen_1	8	18	PF00069	0.658
DOC_MAPK_MEF2A_6	11	18	PF00069	0.602
DOC_MAPK_MEF2A_6	474	482	PF00069	0.433
DOC_MAPK_MEF2A_6	532	540	PF00069	0.453
DOC_PP1_SILK_1	554	559	PF00149	0.467
DOC_PP2B_LxvP_1	476	479	PF13499	0.431
DOC_PP4_FxxP_1	148	151	PF00568	0.614
DOC_PP4_FxxP_1	446	449	PF00568	0.424
DOC_PP4_FxxP_1	482	485	PF00568	0.440
DOC_PP4_FxxP_1	515	518	PF00568	0.447
DOC_USP7_MATH_1	321	325	PF00917	0.748
DOC_USP7_MATH_1	426	430	PF00917	0.660
DOC_USP7_MATH_1	439	443	PF00917	0.630
DOC_USP7_MATH_1	534	538	PF00917	0.453
DOC_USP7_MATH_1	539	543	PF00917	0.449
DOC_USP7_MATH_1	550	554	PF00917	0.428
DOC_USP7_MATH_1	577	581	PF00917	0.438
DOC_WW_Pin1_4	10	15	PF00397	0.599
DOC_WW_Pin1_4	103	108	PF00397	0.585
DOC_WW_Pin1_4	352	357	PF00397	0.688
DOC_WW_Pin1_4	445	450	PF00397	0.690
DOC_WW_Pin1_4	517	522	PF00397	0.434
DOC_WW_Pin1_4	548	553	PF00397	0.429
DOC_WW_Pin1_4	61	66	PF00397	0.578
LIG_14-3-3_CanoR_1	30	34	PF00244	0.704
LIG_14-3-3_CanoR_1	431	440	PF00244	0.732
LIG_14-3-3_CanoR_1	453	463	PF00244	0.426
LIG_14-3-3_CanoR_1	509	515	PF00244	0.526
LIG_14-3-3_CanoR_1	522	527	PF00244	0.471
LIG_14-3-3_CanoR_1	568	577	PF00244	0.469
LIG_BRCT_BRCA1_1	323	327	PF00533	0.716
LIG_BRCT_BRCA1_1	441	445	PF00533	0.446
LIG_BRCT_BRCA1_1	6	10	PF00533	0.676
LIG_Clathr_ClatBox_1	130	134	PF01394	0.512
LIG_deltaCOP1_diTrp_1	310	315	PF00928	0.645
LIG_EVH1_1	148	152	PF00568	0.608
LIG_EVH1_1	465	469	PF00568	0.414
LIG_EVH1_1	477	481	PF00568	0.422
LIG_EVH1_1	517	521	PF00568	0.428
LIG_EVH1_2	478	482	PF00568	0.427
LIG_FHA_1	11	17	PF00498	0.628
LIG_FHA_1	243	249	PF00498	0.627
LIG_FHA_1	573	579	PF00498	0.452
LIG_LIR_Apic_2	146	151	PF02991	0.620
LIG_LIR_Apic_2	250	255	PF02991	0.643
LIG_LIR_Apic_2	298	303	PF02991	0.640
LIG_LIR_Apic_2	513	518	PF02991	0.452
LIG_LIR_Apic_2	59	65	PF02991	0.567
LIG_LIR_Apic_2	93	97	PF02991	0.594
LIG_LIR_Gen_1	236	247	PF02991	0.609
LIG_LIR_Gen_1	289	300	PF02991	0.573
LIG_LIR_Nem_3	182	188	PF02991	0.604
LIG_LIR_Nem_3	236	242	PF02991	0.644
LIG_LIR_Nem_3	289	295	PF02991	0.567
LIG_LIR_Nem_3	31	36	PF02991	0.615
LIG_LIR_Nem_3	310	314	PF02991	0.639
LIG_LIR_Nem_3	85	90	PF02991	0.589
LIG_LYPXL_L_2	464	473	PF13949	0.426
LIG_MYND_1	475	479	PF01753	0.428
LIG_MYND_1	481	485	PF01753	0.433
LIG_PCNA_PIPBox_1	116	125	PF02747	0.683
LIG_PDZ_Class_2	579	584	PF00595	0.436
LIG_Pex14_2	327	331	PF04695	0.746
LIG_Pex14_2	452	456	PF04695	0.429
LIG_SH2_CRK	292	296	PF00017	0.600
LIG_SH2_CRK	87	91	PF00017	0.593
LIG_SH2_NCK_1	292	296	PF00017	0.630
LIG_SH2_NCK_1	364	368	PF00017	0.658
LIG_SH2_PTP2	300	303	PF00017	0.637
LIG_SH2_SRC	300	303	PF00017	0.662
LIG_SH2_SRC	364	367	PF00017	0.675
LIG_SH2_STAT3	210	213	PF00017	0.741
LIG_SH2_STAT3	70	73	PF00017	0.566
LIG_SH2_STAT5	300	303	PF00017	0.637
LIG_SH2_STAT5	70	73	PF00017	0.602
LIG_SH2_STAT5	94	97	PF00017	0.591
LIG_SH3_1	420	426	PF00018	0.737
LIG_SH3_2	518	523	PF14604	0.435
LIG_SH3_3	135	141	PF00018	0.604
LIG_SH3_3	146	152	PF00018	0.612
LIG_SH3_3	186	192	PF00018	0.614
LIG_SH3_3	245	251	PF00018	0.645
LIG_SH3_3	342	348	PF00018	0.667
LIG_SH3_3	402	408	PF00018	0.665
LIG_SH3_3	420	426	PF00018	0.744
LIG_SH3_3	463	469	PF00018	0.420
LIG_SH3_3	472	478	PF00018	0.432
LIG_SH3_3	489	495	PF00018	0.454
LIG_SH3_3	515	521	PF00018	0.438
LIG_SH3_3	533	539	PF00018	0.449
LIG_SH3_3	544	550	PF00018	0.438
LIG_SUMO_SIM_anti_2	457	463	PF11976	0.424
LIG_SUMO_SIM_anti_2	553	558	PF11976	0.460
LIG_TRAF2_1	20	23	PF00917	0.632
LIG_TRAF2_1	223	226	PF00917	0.658
LIG_TRAF2_1	247	250	PF00917	0.742
LIG_TRAF2_1	65	68	PF00917	0.701
LIG_TRFH_1	471	475	PF08558	0.435
LIG_WW_2	425	428	PF00397	0.791
LIG_WW_2	478	481	PF00397	0.424
MOD_CDC14_SPxK_1	106	109	PF00782	0.581
MOD_CDK_SPK_2	352	357	PF00069	0.688
MOD_CDK_SPK_2	517	522	PF00069	0.434
MOD_CDK_SPxK_1	103	109	PF00069	0.587
MOD_CDK_SPxK_1	517	523	PF00069	0.438
MOD_CDK_SPxxK_3	10	17	PF00069	0.627
MOD_CK1_1	429	435	PF00069	0.778
MOD_CK1_1	525	531	PF00069	0.510
MOD_CK2_1	158	164	PF00069	0.578
MOD_CK2_1	383	389	PF00069	0.544
MOD_Cter_Amidation	305	308	PF01082	0.730
MOD_Cter_Amidation	317	320	PF01082	0.484
MOD_GlcNHglycan	23	29	PF01048	0.741
MOD_GlcNHglycan	316	319	PF01048	0.716
MOD_GlcNHglycan	400	404	PF01048	0.651
MOD_GlcNHglycan	405	408	PF01048	0.635
MOD_GlcNHglycan	428	431	PF01048	0.746
MOD_GlcNHglycan	434	437	PF01048	0.747
MOD_GlcNHglycan	441	444	PF01048	0.692
MOD_GlcNHglycan	498	501	PF01048	0.477
MOD_GlcNHglycan	528	531	PF01048	0.511
MOD_GlcNHglycan	84	87	PF01048	0.567
MOD_GSK3_1	24	31	PF00069	0.777
MOD_GSK3_1	399	406	PF00069	0.649
MOD_GSK3_1	522	529	PF00069	0.516
MOD_GSK3_1	548	555	PF00069	0.435
MOD_GSK3_1	564	571	PF00069	0.470
MOD_GSK3_1	99	106	PF00069	0.571
MOD_NEK2_1	314	319	PF00069	0.635
MOD_NEK2_1	398	403	PF00069	0.573
MOD_NEK2_1	454	459	PF00069	0.472
MOD_NEK2_1	540	545	PF00069	0.461
MOD_NEK2_1	99	104	PF00069	0.594
MOD_NEK2_2	29	34	PF00069	0.726
MOD_NEK2_2	510	515	PF00069	0.461
MOD_PK_1	522	528	PF00069	0.467
MOD_PKA_1	522	528	PF00069	0.467
MOD_PKA_1	568	574	PF00069	0.481
MOD_PKA_2	29	35	PF00069	0.700
MOD_PKA_2	432	438	PF00069	0.734
MOD_PKA_2	508	514	PF00069	0.507
MOD_PKA_2	522	528	PF00069	0.522
MOD_PKA_2	534	540	PF00069	0.443
MOD_PKA_2	568	574	PF00069	0.481
MOD_PKB_1	566	574	PF00069	0.481
MOD_Plk_1	158	164	PF00069	0.595
MOD_Plk_1	383	389	PF00069	0.496
MOD_Plk_4	447	453	PF00069	0.511
MOD_Plk_4	510	516	PF00069	0.463
MOD_Plk_4	552	558	PF00069	0.455
MOD_Plk_4	577	583	PF00069	0.436
MOD_ProDKin_1	10	16	PF00069	0.602
MOD_ProDKin_1	103	109	PF00069	0.587
MOD_ProDKin_1	352	358	PF00069	0.685
MOD_ProDKin_1	445	451	PF00069	0.688
MOD_ProDKin_1	517	523	PF00069	0.438
MOD_ProDKin_1	548	554	PF00069	0.433
MOD_ProDKin_1	61	67	PF00069	0.583
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.608
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.565
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.439
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.593
TRG_ENDOCYTIC_2	176	179	PF00928	0.582
TRG_ENDOCYTIC_2	292	295	PF00928	0.584
TRG_ENDOCYTIC_2	87	90	PF00928	0.593
TRG_ER_diArg_1	228	230	PF00400	0.606
TRG_ER_diArg_1	258	261	PF00400	0.724
TRG_ER_diArg_1	393	396	PF00400	0.597
TRG_ER_diArg_1	48	51	PF00400	0.550
TRG_ER_diArg_1	485	488	PF00400	0.448
TRG_ER_diArg_1	521	523	PF00400	0.493
TRG_ER_diArg_1	566	569	PF00400	0.485
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	395	400	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9T4	Leptomonas seymouri	79%	100%
A0A1X0NP12	Trypanosomatidae	72%	100%
A0A381ME06	Leishmania infantum	95%	100%
A0A3Q8IHT5	Leishmania donovani	94%	100%
A0A3S7WS51	Leishmania donovani	95%	100%
A4H6Y7	Leishmania braziliensis	82%	100%
C9ZHZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AGG3	Leishmania infantum	95%	100%
E9AGG8	Leishmania infantum	95%	100%
E9AP06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QGI1	Leishmania major	98%	100%
Q4QGI3	Leishmania major	99%	100%
Q4QGJ3	Leishmania major	99%	100%
Q4QGJ5	Leishmania major	98%	100%
Q4QGJ8	Leishmania major	98%	100%
Q4QGK5	Leishmania major	99%	100%
Q4QGK7	Leishmania major	99%	100%
Q4QGL3	Leishmania major	99%	100%
Q4QGL6	Leishmania major	99%	100%
Q4QGM0	Leishmania major	98%	100%
V5BF60	Trypanosoma cruzi	72%	100%