LeishMANIAdb
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Putative surface antigen protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative surface antigen protein
Gene product:
surface antigen protein, putative
Species:
Leishmania major
UniProt:
Q4QGK2_LEIMA
TriTrypDb:
LmjF.12.1060 , LMJLV39_000018600 , LMJSD75_120013500
Length:
560

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 145
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 64, no: 8
NetGPI no yes: 0, no: 72
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 7
GO:0005929 cilium 4 73
GO:0016020 membrane 2 34
GO:0042995 cell projection 2 73
GO:0043226 organelle 2 73
GO:0043227 membrane-bounded organelle 3 73
GO:0110165 cellular anatomical entity 1 73
GO:0120025 plasma membrane bounded cell projection 3 73

Expansion

Sequence features

Q4QGK2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGK2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 123 127 PF00656 0.502
CLV_NRD_NRD_1 254 256 PF00675 0.269
CLV_NRD_NRD_1 280 282 PF00675 0.283
CLV_NRD_NRD_1 6 8 PF00675 0.742
CLV_PCSK_KEX2_1 254 256 PF00082 0.267
CLV_PCSK_KEX2_1 6 8 PF00082 0.742
CLV_PCSK_SKI1_1 159 163 PF00082 0.491
CLV_PCSK_SKI1_1 167 171 PF00082 0.509
CLV_PCSK_SKI1_1 205 209 PF00082 0.480
CLV_PCSK_SKI1_1 230 234 PF00082 0.321
CLV_PCSK_SKI1_1 281 285 PF00082 0.463
CLV_PCSK_SKI1_1 329 333 PF00082 0.395
CLV_PCSK_SKI1_1 398 402 PF00082 0.539
CLV_PCSK_SKI1_1 7 11 PF00082 0.694
DOC_CYCLIN_RxL_1 186 196 PF00134 0.325
DOC_CYCLIN_RxL_1 3 13 PF00134 0.700
DOC_CYCLIN_yCln2_LP_2 290 296 PF00134 0.253
DOC_MAPK_gen_1 203 212 PF00069 0.291
DOC_MAPK_gen_1 254 261 PF00069 0.240
DOC_MAPK_gen_1 281 290 PF00069 0.256
DOC_MAPK_MEF2A_6 254 261 PF00069 0.235
DOC_MAPK_MEF2A_6 516 524 PF00069 0.509
DOC_PP1_RVXF_1 108 115 PF00149 0.523
DOC_USP7_MATH_1 214 218 PF00917 0.597
DOC_USP7_MATH_1 76 80 PF00917 0.458
DOC_USP7_MATH_2 223 229 PF00917 0.539
DOC_USP7_MATH_2 247 253 PF00917 0.277
DOC_USP7_MATH_2 271 277 PF00917 0.262
DOC_USP7_MATH_2 319 325 PF00917 0.548
DOC_USP7_MATH_2 439 445 PF00917 0.364
DOC_USP7_UBL2_3 332 336 PF12436 0.277
DOC_WW_Pin1_4 546 551 PF00397 0.571
DOC_WW_Pin1_4 552 557 PF00397 0.551
LIG_14-3-3_CanoR_1 159 164 PF00244 0.447
LIG_14-3-3_CanoR_1 43 48 PF00244 0.555
LIG_14-3-3_CanoR_1 468 477 PF00244 0.452
LIG_14-3-3_CanoR_1 540 544 PF00244 0.761
LIG_Actin_WH2_1 105 121 PF00022 0.226
LIG_Actin_WH2_2 297 312 PF00022 0.553
LIG_BIR_II_1 1 5 PF00653 0.663
LIG_Clathr_ClatBox_1 352 356 PF01394 0.401
LIG_Clathr_ClatBox_1 521 525 PF01394 0.310
LIG_deltaCOP1_diTrp_1 176 179 PF00928 0.483
LIG_deltaCOP1_diTrp_1 200 206 PF00928 0.264
LIG_deltaCOP1_diTrp_1 61 69 PF00928 0.547
LIG_FHA_1 168 174 PF00498 0.451
LIG_FHA_1 183 189 PF00498 0.343
LIG_FHA_1 207 213 PF00498 0.424
LIG_FHA_1 217 223 PF00498 0.554
LIG_FHA_1 275 281 PF00498 0.413
LIG_FHA_1 304 310 PF00498 0.424
LIG_FHA_1 376 382 PF00498 0.353
LIG_FHA_1 42 48 PF00498 0.583
LIG_FHA_1 448 454 PF00498 0.509
LIG_FHA_2 121 127 PF00498 0.364
LIG_FHA_2 206 212 PF00498 0.351
LIG_FHA_2 63 69 PF00498 0.460
LIG_FHA_2 92 98 PF00498 0.505
LIG_GBD_Chelix_1 349 357 PF00786 0.230
LIG_LIR_Gen_1 126 134 PF02991 0.400
LIG_LIR_Gen_1 151 160 PF02991 0.385
LIG_LIR_Gen_1 175 183 PF02991 0.405
LIG_LIR_Gen_1 200 207 PF02991 0.348
LIG_LIR_Gen_1 321 328 PF02991 0.418
LIG_LIR_Gen_1 441 448 PF02991 0.420
LIG_LIR_Gen_1 465 472 PF02991 0.468
LIG_LIR_Gen_1 489 498 PF02991 0.526
LIG_LIR_Gen_1 71 80 PF02991 0.568
LIG_LIR_Nem_3 126 131 PF02991 0.470
LIG_LIR_Nem_3 175 180 PF02991 0.408
LIG_LIR_Nem_3 71 75 PF02991 0.418
LIG_PCNA_PIPBox_1 229 238 PF02747 0.273
LIG_PCNA_PIPBox_1 253 262 PF02747 0.230
LIG_PCNA_PIPBox_1 397 406 PF02747 0.312
LIG_PCNA_PIPBox_1 421 430 PF02747 0.262
LIG_SH2_CRK 532 536 PF00017 0.355
LIG_SH2_SRC 404 407 PF00017 0.424
LIG_SH2_SRC 428 431 PF00017 0.446
LIG_SH2_STAT5 236 239 PF00017 0.282
LIG_SH2_STAT5 260 263 PF00017 0.235
LIG_SH2_STAT5 404 407 PF00017 0.311
LIG_SH2_STAT5 428 431 PF00017 0.424
LIG_SH2_STAT5 532 535 PF00017 0.406
LIG_SH3_3 290 296 PF00018 0.470
LIG_SH3_3 93 99 PF00018 0.518
LIG_SUMO_SIM_anti_2 135 141 PF11976 0.414
LIG_SUMO_SIM_anti_2 347 353 PF11976 0.407
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.442
LIG_SUMO_SIM_par_1 305 312 PF11976 0.399
LIG_SUMO_SIM_par_1 377 382 PF11976 0.480
LIG_SUMO_SIM_par_1 449 454 PF11976 0.396
LIG_TYR_ITIM 102 107 PF00017 0.469
LIG_UBA3_1 520 529 PF00899 0.311
MOD_CK1_1 151 157 PF00069 0.419
MOD_CK1_1 172 178 PF00069 0.445
MOD_CK1_1 372 378 PF00069 0.392
MOD_CK1_1 420 426 PF00069 0.434
MOD_CK1_1 444 450 PF00069 0.405
MOD_CK2_1 126 132 PF00069 0.510
MOD_CK2_1 205 211 PF00069 0.409
MOD_CK2_1 91 97 PF00069 0.505
MOD_Cter_Amidation 334 337 PF01082 0.304
MOD_GlcNHglycan 144 147 PF01048 0.409
MOD_GlcNHglycan 193 196 PF01048 0.446
MOD_GlcNHglycan 25 28 PF01048 0.632
MOD_GlcNHglycan 314 317 PF01048 0.511
MOD_GlcNHglycan 338 341 PF01048 0.416
MOD_GlcNHglycan 362 365 PF01048 0.405
MOD_GlcNHglycan 386 389 PF01048 0.480
MOD_GlcNHglycan 409 413 PF01048 0.410
MOD_GlcNHglycan 434 437 PF01048 0.475
MOD_GlcNHglycan 458 461 PF01048 0.554
MOD_GlcNHglycan 470 473 PF01048 0.491
MOD_GlcNHglycan 481 485 PF01048 0.455
MOD_GlcNHglycan 489 493 PF01048 0.430
MOD_GSK3_1 120 127 PF00069 0.563
MOD_GSK3_1 144 151 PF00069 0.369
MOD_GSK3_1 214 221 PF00069 0.400
MOD_GSK3_1 305 312 PF00069 0.417
MOD_GSK3_1 32 39 PF00069 0.581
MOD_GSK3_1 392 399 PF00069 0.475
MOD_GSK3_1 416 423 PF00069 0.358
MOD_GSK3_1 440 447 PF00069 0.479
MOD_GSK3_1 464 471 PF00069 0.524
MOD_GSK3_1 538 545 PF00069 0.721
MOD_GSK3_1 546 553 PF00069 0.752
MOD_GSK3_1 87 94 PF00069 0.450
MOD_N-GLC_1 312 317 PF02516 0.338
MOD_N-GLC_1 86 91 PF02516 0.390
MOD_N-GLC_2 537 539 PF02516 0.479
MOD_NEK2_1 10 15 PF00069 0.631
MOD_NEK2_1 120 125 PF00069 0.545
MOD_NEK2_1 169 174 PF00069 0.343
MOD_NEK2_1 191 196 PF00069 0.429
MOD_NEK2_1 21 26 PF00069 0.566
MOD_NEK2_1 218 223 PF00069 0.404
MOD_NEK2_1 309 314 PF00069 0.561
MOD_NEK2_1 338 343 PF00069 0.374
MOD_NEK2_1 357 362 PF00069 0.451
MOD_NEK2_1 381 386 PF00069 0.436
MOD_NEK2_1 429 434 PF00069 0.318
MOD_NEK2_1 453 458 PF00069 0.488
MOD_NEK2_1 482 487 PF00069 0.489
MOD_NEK2_1 86 91 PF00069 0.348
MOD_PIKK_1 357 363 PF00454 0.459
MOD_PIKK_1 381 387 PF00454 0.317
MOD_PIKK_1 429 435 PF00454 0.591
MOD_PIKK_1 453 459 PF00454 0.581
MOD_PKA_1 336 342 PF00069 0.266
MOD_PKA_1 62 68 PF00069 0.364
MOD_PKA_2 309 315 PF00069 0.567
MOD_PKA_2 539 545 PF00069 0.773
MOD_PKB_1 157 165 PF00069 0.260
MOD_Plk_1 175 181 PF00069 0.454
MOD_Plk_1 199 205 PF00069 0.382
MOD_Plk_1 320 326 PF00069 0.480
MOD_Plk_1 440 446 PF00069 0.460
MOD_Plk_1 464 470 PF00069 0.510
MOD_Plk_1 488 494 PF00069 0.551
MOD_Plk_1 86 92 PF00069 0.443
MOD_Plk_2-3 68 74 PF00069 0.505
MOD_Plk_4 135 141 PF00069 0.368
MOD_Plk_4 151 157 PF00069 0.370
MOD_Plk_4 182 188 PF00069 0.443
MOD_Plk_4 297 303 PF00069 0.390
MOD_Plk_4 423 429 PF00069 0.312
MOD_ProDKin_1 546 552 PF00069 0.572
MOD_SUMO_rev_2 395 400 PF00179 0.268
MOD_SUMO_rev_2 59 65 PF00179 0.319
TRG_ENDOCYTIC_2 104 107 PF00928 0.466
TRG_ENDOCYTIC_2 532 535 PF00928 0.486
TRG_ER_diArg_1 156 159 PF00400 0.283
TRG_ER_diArg_1 253 255 PF00400 0.269
TRG_ER_diArg_1 5 7 PF00400 0.740
TRG_NES_CRM1_1 396 409 PF08389 0.280
TRG_Pf-PMV_PEXEL_1 377 382 PF00026 0.268
TRG_Pf-PMV_PEXEL_1 449 454 PF00026 0.285
TRG_Pf-PMV_PEXEL_1 468 473 PF00026 0.614
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.411

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6A5 Leptomonas seymouri 29% 88%
A0A0N1I121 Leptomonas seymouri 28% 100%
A0A0N1I661 Leptomonas seymouri 34% 98%
A0A0N1I7S5 Leptomonas seymouri 32% 100%
A0A0N1II82 Leptomonas seymouri 31% 81%
A0A0S4IHI7 Bodo saltans 28% 72%
A0A0S4IJN2 Bodo saltans 25% 83%
A0A0S4ILC9 Bodo saltans 34% 100%
A0A0S4IN27 Bodo saltans 38% 100%
A0A0S4IQE4 Bodo saltans 26% 99%
A0A0S4ISU4 Bodo saltans 41% 85%
A0A0S4IT62 Bodo saltans 36% 76%
A0A0S4IU23 Bodo saltans 27% 95%
A0A0S4IU73 Bodo saltans 38% 100%
A0A0S4IV96 Bodo saltans 37% 92%
A0A0S4IVQ8 Bodo saltans 36% 93%
A0A0S4IW93 Bodo saltans 28% 92%
A0A0S4IY44 Bodo saltans 27% 84%
A0A0S4IZC7 Bodo saltans 24% 100%
A0A0S4J014 Bodo saltans 26% 78%
A0A0S4J100 Bodo saltans 28% 67%
A0A0S4J206 Bodo saltans 34% 91%
A0A0S4J2H8 Bodo saltans 28% 96%
A0A0S4J3T7 Bodo saltans 33% 100%
A0A0S4J4L7 Bodo saltans 28% 76%
A0A0S4J5A0 Bodo saltans 38% 98%
A0A0S4J954 Bodo saltans 25% 76%
A0A0S4JAQ6 Bodo saltans 26% 100%
A0A0S4JAS1 Bodo saltans 38% 88%
A0A0S4JAW7 Bodo saltans 26% 100%
A0A0S4JB95 Bodo saltans 25% 92%
A0A0S4JBV9 Bodo saltans 28% 100%
A0A0S4JD35 Bodo saltans 26% 94%
A0A0S4JDS1 Bodo saltans 25% 100%
A0A0S4JDT0 Bodo saltans 34% 85%
A0A0S4JEK1 Bodo saltans 26% 100%
A0A0S4JL29 Bodo saltans 31% 100%
A0A0S4JMF9 Bodo saltans 33% 100%
A0A0S4JN05 Bodo saltans 36% 67%
A0A0S4JNU2 Bodo saltans 40% 68%
A0A0S4JQZ0 Bodo saltans 26% 74%
A0A0S4JS89 Bodo saltans 28% 100%
A0A0S4JSB8 Bodo saltans 35% 100%
A0A0S4JTM6 Bodo saltans 33% 76%
A0A0S4JTQ7 Bodo saltans 39% 100%
A0A0S4JVI0 Bodo saltans 27% 79%
A0A0S4KEG2 Bodo saltans 26% 67%
A0A0S4KGV4 Bodo saltans 24% 100%
A0A0S4KH41 Bodo saltans 29% 80%
A0A0S4KIR5 Bodo saltans 23% 67%
A0A0S4KJA7 Bodo saltans 27% 83%
A0A0S4KK37 Bodo saltans 29% 96%
A0A3Q8I9A6 Leishmania donovani 52% 100%
A0A3Q8I9B4 Leishmania donovani 38% 100%
A0A3Q8I9D9 Leishmania donovani 38% 100%
A0A3Q8IC27 Leishmania donovani 32% 100%
A0A3S5H6L9 Leishmania donovani 43% 100%
A0A3S5H6M3 Leishmania donovani 53% 82%
A0A3S5H6M4 Leishmania donovani 53% 85%
A0A3S7WS66 Leishmania donovani 51% 85%
A4HBX3 Leishmania braziliensis 32% 100%
A4HVB0 Leishmania infantum 50% 100%
A4HZ93 Leishmania infantum 32% 100%
A7SFP1 Nematostella vectensis 25% 97%
D1GJ51 Leishmania infantum 54% 100%
E8NHG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 73%
E9AGG2 Leishmania infantum 54% 84%
E9AGG5 Leishmania infantum 51% 100%
E9AGG7 Leishmania infantum 57% 89%
E9AGG9 Leishmania infantum 57% 100%
E9AGH0 Leishmania infantum 51% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 56% 79%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 56% 80%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
F4IUU1 Arabidopsis thaliana 24% 69%
F4JGB6 Arabidopsis thaliana 27% 69%
F4JTU7 Arabidopsis thaliana 24% 69%
F4KHA2 Arabidopsis thaliana 24% 71%
O48851 Arabidopsis thaliana 26% 73%
O49325 Arabidopsis thaliana 25% 72%
O49328 Arabidopsis thaliana 25% 70%
O49879 Solanum lycopersicum 25% 66%
O80809 Arabidopsis thaliana 25% 78%
Q1PEN0 Arabidopsis thaliana 23% 78%
Q25331 Leishmania major 52% 100%
Q4QC79 Leishmania major 35% 100%
Q4QGI0 Leishmania major 62% 94%
Q4QGI2 Leishmania major 77% 100%
Q4QGI4 Leishmania major 75% 99%
Q4QGI6 Leishmania major 51% 100%
Q4QGI8 Leishmania major 75% 100%
Q4QGJ0 Leishmania major 54% 100%
Q4QGJ2 Leishmania major 53% 100%
Q4QGJ4 Leishmania major 53% 100%
Q4QGJ7 Leishmania major 52% 100%
Q4QGJ9 Leishmania major 51% 100%
Q4QGK0 Leishmania major 55% 100%
Q4QGK1 Leishmania major 53% 100%
Q4QGK4 Leishmania major 46% 84%
Q4QGK6 Leishmania major 52% 100%
Q4QGK8 Leishmania major 70% 100%
Q4QGL2 Leishmania major 70% 100%
Q4QGL4 Leishmania major 50% 100%
Q4QGL8 Leishmania major 57% 92%
Q4QGM1 Leishmania major 69% 72%
Q7FZR1 Arabidopsis thaliana 23% 69%
Q940E8 Zea mays 29% 91%
Q9C9H6 Arabidopsis thaliana 25% 71%
Q9C9H7 Arabidopsis thaliana 26% 66%
Q9LJW7 Arabidopsis thaliana 25% 79%
Q9LS79 Arabidopsis thaliana 24% 71%
Q9LS80 Arabidopsis thaliana 24% 67%
Q9MA83 Arabidopsis thaliana 25% 71%
Q9SHI3 Arabidopsis thaliana 25% 77%
Q9SHI4 Arabidopsis thaliana 24% 74%
Q9SKK5 Arabidopsis thaliana 20% 83%
Q9SVM3 Arabidopsis thaliana 24% 66%
Q9SVN2 Arabidopsis thaliana 24% 70%
Q9ZUK7 Arabidopsis thaliana 24% 68%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS