Putative surface antigen protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen protein 2, putative

Species:

Leishmania major

UniProt:

Q4QGK1_LEIMA

TriTrypDb:

LmjF.12.0755 , LmjF.12.1070 , LMJLV39_000011100 , LMJLV39_000013400 , LMJSD75_120013100

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 90

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 30, no: 7
NetGPI	no	yes: 0, no: 37

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	38
GO:0016020	membrane	2	26
GO:0042995	cell projection	2	38
GO:0043226	organelle	2	38
GO:0043227	membrane-bounded organelle	3	38
GO:0110165	cellular anatomical entity	1	38
GO:0120025	plasma membrane bounded cell projection	3	38
GO:0005886	plasma membrane	3	5

Expansion

Sequence features

Q4QGK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGK1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004672	protein kinase activity	3	3
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.385
CLV_NRD_NRD_1	282	284	PF00675	0.507
CLV_NRD_NRD_1	6	8	PF00675	0.729
CLV_PCSK_KEX2_1	282	284	PF00082	0.490
CLV_PCSK_KEX2_1	6	8	PF00082	0.769
CLV_PCSK_SKI1_1	190	194	PF00082	0.506
CLV_PCSK_SKI1_1	228	232	PF00082	0.644
CLV_PCSK_SKI1_1	351	355	PF00082	0.478
CLV_PCSK_SKI1_1	7	11	PF00082	0.745
DEG_SCF_FBW7_2	632	637	PF00400	0.486
DEG_SCF_TRCP1_1	142	148	PF00400	0.253
DEG_SPOP_SBC_1	475	479	PF00917	0.476
DEG_SPOP_SBC_1	490	494	PF00917	0.609
DEG_SPOP_SBC_1	500	504	PF00917	0.552
DEG_SPOP_SBC_1	510	514	PF00917	0.558
DEG_SPOP_SBC_1	525	529	PF00917	0.511
DEG_SPOP_SBC_1	535	539	PF00917	0.592
DEG_SPOP_SBC_1	545	549	PF00917	0.527
DEG_SPOP_SBC_1	556	560	PF00917	0.578
DEG_SPOP_SBC_1	570	574	PF00917	0.584
DEG_SPOP_SBC_1	580	584	PF00917	0.433
DEG_SPOP_SBC_1	590	594	PF00917	0.602
DEG_SPOP_SBC_1	600	604	PF00917	0.526
DEG_SPOP_SBC_1	611	615	PF00917	0.619
DOC_AGCK_PIF_2	69	74	PF00069	0.295
DOC_CYCLIN_RxL_1	105	116	PF00134	0.312
DOC_CYCLIN_RxL_1	3	13	PF00134	0.684
DOC_CYCLIN_yClb5_NLxxxL_5	406	415	PF00134	0.400
DOC_CYCLIN_yCln2_LP_2	267	273	PF00134	0.287
DOC_MAPK_gen_1	228	238	PF00069	0.247
DOC_MAPK_gen_1	240	249	PF00069	0.237
DOC_MAPK_gen_1	351	358	PF00069	0.254
DOC_MAPK_gen_1	445	453	PF00069	0.320
DOC_MAPK_MEF2A_6	182	191	PF00069	0.329
DOC_MAPK_MEF2A_6	231	238	PF00069	0.248
DOC_MAPK_MEF2A_6	445	453	PF00069	0.460
DOC_MAPK_NFAT4_5	231	239	PF00069	0.236
DOC_PP1_RVXF_1	108	115	PF00149	0.366
DOC_PP1_RVXF_1	180	187	PF00149	0.374
DOC_USP7_MATH_1	373	377	PF00917	0.433
DOC_USP7_MATH_1	426	430	PF00917	0.391
DOC_USP7_MATH_1	680	684	PF00917	0.463
DOC_USP7_MATH_2	175	181	PF00917	0.325
DOC_USP7_MATH_2	224	230	PF00917	0.426
DOC_USP7_MATH_2	320	326	PF00917	0.414
DOC_USP7_MATH_2	344	350	PF00917	0.334
DOC_USP7_UBL2_3	470	474	PF12436	0.377
DOC_USP7_UBL2_3	59	63	PF12436	0.252
DOC_WW_Pin1_4	262	267	PF00397	0.260
DOC_WW_Pin1_4	624	629	PF00397	0.620
DOC_WW_Pin1_4	630	635	PF00397	0.588
DOC_WW_Pin1_4	85	90	PF00397	0.304
LIG_14-3-3_CanoR_1	158	164	PF00244	0.391
LIG_14-3-3_CanoR_1	43	48	PF00244	0.438
LIG_Actin_WH2_2	201	216	PF00022	0.261
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_BRCT_BRCA1_1	182	186	PF00533	0.444
LIG_BRCT_BRCA1_1	70	74	PF00533	0.289
LIG_deltaCOP1_diTrp_1	62	69	PF00928	0.458
LIG_FHA_1	169	175	PF00498	0.393
LIG_FHA_1	208	214	PF00498	0.365
LIG_FHA_1	218	224	PF00498	0.384
LIG_FHA_1	352	358	PF00498	0.378
LIG_FHA_1	377	383	PF00498	0.336
LIG_FHA_1	42	48	PF00498	0.471
LIG_FHA_1	550	556	PF00498	0.426
LIG_FHA_1	605	611	PF00498	0.502
LIG_FHA_1	668	674	PF00498	0.431
LIG_FHA_2	122	128	PF00498	0.461
LIG_FHA_2	204	210	PF00498	0.396
LIG_FHA_2	254	260	PF00498	0.436
LIG_FHA_2	301	307	PF00498	0.383
LIG_FHA_2	612	618	PF00498	0.632
LIG_FHA_2	636	642	PF00498	0.440
LIG_FHA_2	92	98	PF00498	0.453
LIG_LIR_Gen_1	113	121	PF02991	0.467
LIG_LIR_Gen_1	127	135	PF02991	0.431
LIG_LIR_Gen_1	152	159	PF02991	0.331
LIG_LIR_Gen_1	177	186	PF02991	0.381
LIG_LIR_Gen_1	232	243	PF02991	0.342
LIG_LIR_Gen_1	250	257	PF02991	0.296
LIG_LIR_Gen_1	297	305	PF02991	0.298
LIG_LIR_Gen_1	322	330	PF02991	0.374
LIG_LIR_Gen_1	346	353	PF02991	0.291
LIG_LIR_Gen_1	370	378	PF02991	0.367
LIG_LIR_Gen_1	417	426	PF02991	0.379
LIG_LIR_Gen_1	71	79	PF02991	0.375
LIG_LIR_Nem_3	103	107	PF02991	0.441
LIG_LIR_Nem_3	127	132	PF02991	0.436
LIG_LIR_Nem_3	183	189	PF02991	0.391
LIG_LIR_Nem_3	232	238	PF02991	0.321
LIG_LIR_Nem_3	297	302	PF02991	0.358
LIG_LIR_Nem_3	370	374	PF02991	0.316
LIG_LIR_Nem_3	417	422	PF02991	0.359
LIG_LIR_Nem_3	71	75	PF02991	0.355
LIG_NRBOX	352	358	PF00104	0.276
LIG_PCNA_PIPBox_1	326	335	PF02747	0.230
LIG_PDZ_Class_2	699	704	PF00595	0.308
LIG_Pex14_1	72	76	PF04695	0.220
LIG_SH2_CRK	76	80	PF00017	0.235
LIG_SH2_SRC	235	238	PF00017	0.341
LIG_SH2_STAT5	235	238	PF00017	0.300
LIG_SH2_STAT5	285	288	PF00017	0.311
LIG_SH2_STAT5	663	666	PF00017	0.446
LIG_SH2_STAT5	674	677	PF00017	0.540
LIG_SH2_STAT5	76	79	PF00017	0.396
LIG_SH2_STAT5	83	86	PF00017	0.435
LIG_SH3_3	267	273	PF00018	0.412
LIG_SH3_3	616	622	PF00018	0.567
LIG_SH3_3	93	99	PF00018	0.431
LIG_Sin3_3	688	695	PF02671	0.304
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.416
LIG_SUMO_SIM_par_1	209	215	PF11976	0.377
LIG_SUMO_SIM_par_1	449	455	PF11976	0.459
LIG_TYR_ITIM	102	107	PF00017	0.457
LIG_TYR_ITIM	233	238	PF00017	0.380
LIG_UBA3_1	233	240	PF00899	0.222
MOD_CK1_1	152	158	PF00069	0.365
MOD_CK1_1	180	186	PF00069	0.371
MOD_CK1_1	203	209	PF00069	0.382
MOD_CK1_1	229	235	PF00069	0.343
MOD_CK1_1	241	247	PF00069	0.324
MOD_CK1_1	252	258	PF00069	0.360
MOD_CK1_1	277	283	PF00069	0.340
MOD_CK1_1	297	303	PF00069	0.319
MOD_CK1_1	325	331	PF00069	0.389
MOD_CK1_1	376	382	PF00069	0.371
MOD_CK1_1	385	391	PF00069	0.390
MOD_CK1_1	396	402	PF00069	0.360
MOD_CK1_1	414	420	PF00069	0.350
MOD_CK1_1	575	581	PF00069	0.461
MOD_CK2_1	127	133	PF00069	0.432
MOD_CK2_1	253	259	PF00069	0.439
MOD_CK2_1	611	617	PF00069	0.506
MOD_CK2_1	635	641	PF00069	0.457
MOD_CK2_1	91	97	PF00069	0.431
MOD_GlcNHglycan	121	124	PF01048	0.652
MOD_GlcNHglycan	142	145	PF01048	0.614
MOD_GlcNHglycan	194	197	PF01048	0.585
MOD_GlcNHglycan	243	246	PF01048	0.581
MOD_GlcNHglycan	25	28	PF01048	0.741
MOD_GlcNHglycan	290	294	PF01048	0.545
MOD_GlcNHglycan	315	318	PF01048	0.587
MOD_GlcNHglycan	363	366	PF01048	0.602
MOD_GlcNHglycan	370	374	PF01048	0.576
MOD_GlcNHglycan	387	390	PF01048	0.568
MOD_GlcNHglycan	395	398	PF01048	0.571
MOD_GlcNHglycan	411	414	PF01048	0.555
MOD_GlcNHglycan	419	422	PF01048	0.587
MOD_GlcNHglycan	651	654	PF01048	0.638
MOD_GlcNHglycan	683	686	PF01048	0.388
MOD_GSK3_1	121	128	PF00069	0.412
MOD_GSK3_1	134	141	PF00069	0.347
MOD_GSK3_1	145	152	PF00069	0.378
MOD_GSK3_1	176	183	PF00069	0.346
MOD_GSK3_1	200	207	PF00069	0.385
MOD_GSK3_1	249	256	PF00069	0.321
MOD_GSK3_1	258	265	PF00069	0.351
MOD_GSK3_1	273	280	PF00069	0.313
MOD_GSK3_1	291	298	PF00069	0.360
MOD_GSK3_1	32	39	PF00069	0.568
MOD_GSK3_1	369	376	PF00069	0.380
MOD_GSK3_1	381	388	PF00069	0.326
MOD_GSK3_1	396	403	PF00069	0.379
MOD_GSK3_1	411	418	PF00069	0.288
MOD_GSK3_1	466	473	PF00069	0.503
MOD_GSK3_1	474	481	PF00069	0.516
MOD_GSK3_1	485	492	PF00069	0.518
MOD_GSK3_1	495	502	PF00069	0.465
MOD_GSK3_1	505	512	PF00069	0.479
MOD_GSK3_1	513	520	PF00069	0.477
MOD_GSK3_1	524	531	PF00069	0.503
MOD_GSK3_1	534	541	PF00069	0.505
MOD_GSK3_1	544	551	PF00069	0.488
MOD_GSK3_1	554	561	PF00069	0.464
MOD_GSK3_1	565	572	PF00069	0.492
MOD_GSK3_1	575	582	PF00069	0.478
MOD_GSK3_1	585	592	PF00069	0.509
MOD_GSK3_1	595	602	PF00069	0.515
MOD_GSK3_1	605	612	PF00069	0.591
MOD_GSK3_1	620	627	PF00069	0.567
MOD_GSK3_1	663	670	PF00069	0.471
MOD_GSK3_1	87	94	PF00069	0.434
MOD_N-GLC_1	409	414	PF02516	0.522
MOD_N-GLC_1	77	82	PF02516	0.527
MOD_NEK2_1	10	15	PF00069	0.634
MOD_NEK2_1	121	126	PF00069	0.391
MOD_NEK2_1	140	145	PF00069	0.329
MOD_NEK2_1	170	175	PF00069	0.336
MOD_NEK2_1	192	197	PF00069	0.390
MOD_NEK2_1	21	26	PF00069	0.599
MOD_NEK2_1	236	241	PF00069	0.345
MOD_NEK2_1	310	315	PF00069	0.383
MOD_NEK2_1	332	337	PF00069	0.415
MOD_NEK2_1	358	363	PF00069	0.390
MOD_NEK2_1	380	385	PF00069	0.372
MOD_NEK2_1	411	416	PF00069	0.383
MOD_NEK2_1	424	429	PF00069	0.343
MOD_NEK2_2	134	139	PF00069	0.232
MOD_NEK2_2	426	431	PF00069	0.303
MOD_PIKK_1	351	357	PF00454	0.383
MOD_PKA_1	351	357	PF00069	0.240
MOD_PKA_2	157	163	PF00069	0.440
MOD_PKA_2	241	247	PF00069	0.247
MOD_Plk_1	176	182	PF00069	0.368
MOD_Plk_1	252	258	PF00069	0.331
MOD_Plk_1	345	351	PF00069	0.322
MOD_Plk_1	369	375	PF00069	0.358
MOD_Plk_1	667	673	PF00069	0.373
MOD_Plk_2-3	209	215	PF00069	0.436
MOD_Plk_2-3	253	259	PF00069	0.277
MOD_Plk_2-3	68	74	PF00069	0.385
MOD_Plk_4	229	235	PF00069	0.350
MOD_Plk_4	358	364	PF00069	0.350
MOD_Plk_4	373	379	PF00069	0.345
MOD_ProDKin_1	262	268	PF00069	0.261
MOD_ProDKin_1	624	630	PF00069	0.620
MOD_ProDKin_1	85	91	PF00069	0.301
TRG_DiLeu_BaEn_1	668	673	PF01217	0.347
TRG_ENDOCYTIC_2	104	107	PF00928	0.457
TRG_ENDOCYTIC_2	235	238	PF00928	0.347
TRG_ENDOCYTIC_2	76	79	PF00928	0.306
TRG_ER_diArg_1	281	283	PF00400	0.290
TRG_ER_diArg_1	5	7	PF00400	0.648
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IRQ2	Bodo saltans	32%	82%
A0A0S4J1D6	Bodo saltans	27%	72%
A0A0S4J206	Bodo saltans	35%	100%
A0A0S4J761	Bodo saltans	31%	70%
A0A0S4J7H0	Bodo saltans	28%	71%
A0A0S4J985	Bodo saltans	29%	71%
A0A0S4JAQ3	Bodo saltans	27%	78%
A0A0S4JG36	Bodo saltans	26%	67%
A0A0S4JLC0	Bodo saltans	29%	67%
A0A0S4JMQ7	Bodo saltans	33%	69%
A0A0S4JQZ4	Bodo saltans	32%	70%
A0A0S4KEG2	Bodo saltans	25%	84%
A0A0S4KF94	Bodo saltans	24%	80%
A0A3Q8IC27	Leishmania donovani	32%	100%
A0A3S5H6M3	Leishmania donovani	79%	100%
A0A3S5H6M4	Leishmania donovani	56%	100%
A0A3S7WS66	Leishmania donovani	54%	100%
A4H6Y8	Leishmania braziliensis	46%	77%
A4HZ93	Leishmania infantum	32%	100%
E9AGG2	Leishmania infantum	80%	100%
E9AGG7	Leishmania infantum	57%	100%
E9AGG9	Leishmania infantum	56%	100%
E9ANZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	99%
E9AP05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
F4HTV4	Arabidopsis thaliana	24%	72%
F4JGB6	Arabidopsis thaliana	23%	87%
F4JTU7	Arabidopsis thaliana	24%	87%
I1Z695	Oryza sativa subsp. japonica	25%	71%
Q4QGI0	Leishmania major	63%	100%
Q4QGI2	Leishmania major	50%	100%
Q4QGI4	Leishmania major	53%	100%
Q4QGI6	Leishmania major	58%	100%
Q4QGI8	Leishmania major	52%	93%
Q4QGJ0	Leishmania major	93%	100%
Q4QGJ2	Leishmania major	63%	100%
Q4QGJ9	Leishmania major	68%	100%
Q4QGK0	Leishmania major	63%	100%
Q4QGK2	Leishmania major	53%	100%
Q4QGK4	Leishmania major	64%	100%
Q4QGK8	Leishmania major	58%	100%
Q4QGL2	Leishmania major	58%	100%
Q4QGL8	Leishmania major	50%	100%
Q658G7	Oryza sativa subsp. japonica	25%	72%
Q9SHI4	Arabidopsis thaliana	22%	93%
Q9ZUI0	Arabidopsis thaliana	25%	72%