LeishMANIAdb
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Putative surface antigen protein 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative surface antigen protein 2
Gene product:
surface antigen protein 2, putative
Species:
Leishmania major
UniProt:
Q4QGK0_LEIMA
TriTrypDb:
LmjF.12.0755 , LMJLV39_000011100 , LMJLV39_000016600 * , LMJSD75_120012800 , LMJSD75_120012900
Length:
570

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 130
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 50, no: 2
NetGPI no yes: 0, no: 52
Cellular components
Term Name Level Count
GO:0005929 cilium 4 53
GO:0016020 membrane 2 28
GO:0042995 cell projection 2 53
GO:0043226 organelle 2 53
GO:0043227 membrane-bounded organelle 3 53
GO:0110165 cellular anatomical entity 1 53
GO:0120025 plasma membrane bounded cell projection 3 53
GO:0005886 plasma membrane 3 6

Expansion

Sequence features

Q4QGK0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGK0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 124 128 PF00656 0.426
CLV_NRD_NRD_1 237 239 PF00675 0.453
CLV_NRD_NRD_1 310 312 PF00675 0.546
CLV_NRD_NRD_1 6 8 PF00675 0.719
CLV_PCSK_KEX2_1 157 159 PF00082 0.625
CLV_PCSK_KEX2_1 190 192 PF00082 0.458
CLV_PCSK_KEX2_1 310 312 PF00082 0.504
CLV_PCSK_KEX2_1 6 8 PF00082 0.719
CLV_PCSK_PC1ET2_1 157 159 PF00082 0.625
CLV_PCSK_PC1ET2_1 190 192 PF00082 0.445
CLV_PCSK_SKI1_1 157 161 PF00082 0.613
CLV_PCSK_SKI1_1 190 194 PF00082 0.631
CLV_PCSK_SKI1_1 238 242 PF00082 0.486
CLV_PCSK_SKI1_1 7 11 PF00082 0.737
DEG_SCF_FBW7_2 498 503 PF00400 0.496
DEG_SPOP_SBC_1 426 430 PF00917 0.477
DEG_SPOP_SBC_1 437 441 PF00917 0.457
DEG_SPOP_SBC_1 448 452 PF00917 0.468
DEG_SPOP_SBC_1 458 462 PF00917 0.456
DEG_SPOP_SBC_1 468 472 PF00917 0.579
DEG_SPOP_SBC_1 478 482 PF00917 0.580
DOC_AGCK_PIF_2 69 74 PF00069 0.292
DOC_CYCLIN_RxL_1 105 116 PF00134 0.305
DOC_CYCLIN_RxL_1 235 243 PF00134 0.241
DOC_CYCLIN_RxL_1 3 13 PF00134 0.584
DOC_CYCLIN_yCln2_LP_2 221 224 PF00134 0.263
DOC_CYCLIN_yCln2_LP_2 242 248 PF00134 0.243
DOC_MAPK_gen_1 157 164 PF00069 0.248
DOC_MAPK_MEF2A_6 397 404 PF00069 0.433
DOC_PP1_RVXF_1 108 115 PF00149 0.326
DOC_PP2B_LxvP_1 221 224 PF13499 0.404
DOC_USP7_MATH_1 276 280 PF00917 0.339
DOC_USP7_MATH_1 546 550 PF00917 0.429
DOC_USP7_MATH_2 175 181 PF00917 0.438
DOC_USP7_MATH_2 223 229 PF00917 0.424
DOC_USP7_MATH_2 295 301 PF00917 0.358
DOC_USP7_MATH_2 319 325 PF00917 0.262
DOC_USP7_MATH_2 367 373 PF00917 0.359
DOC_WW_Pin1_4 213 218 PF00397 0.395
DOC_WW_Pin1_4 429 434 PF00397 0.646
DOC_WW_Pin1_4 490 495 PF00397 0.673
DOC_WW_Pin1_4 496 501 PF00397 0.487
DOC_WW_Pin1_4 85 90 PF00397 0.475
LIG_14-3-3_CanoR_1 158 163 PF00244 0.449
LIG_14-3-3_CanoR_1 303 308 PF00244 0.384
LIG_14-3-3_CanoR_1 377 382 PF00244 0.282
LIG_14-3-3_CanoR_1 43 48 PF00244 0.363
LIG_Actin_WH2_2 180 195 PF00022 0.300
LIG_Actin_WH2_2 225 243 PF00022 0.251
LIG_Actin_WH2_2 297 312 PF00022 0.245
LIG_BIR_II_1 1 5 PF00653 0.666
LIG_BRCT_BRCA1_1 70 74 PF00533 0.290
LIG_deltaCOP1_diTrp_1 62 69 PF00928 0.422
LIG_FHA_1 158 164 PF00498 0.275
LIG_FHA_1 169 175 PF00498 0.403
LIG_FHA_1 217 223 PF00498 0.405
LIG_FHA_1 241 247 PF00498 0.309
LIG_FHA_1 304 310 PF00498 0.295
LIG_FHA_1 42 48 PF00498 0.480
LIG_FHA_1 534 540 PF00498 0.341
LIG_FHA_2 122 128 PF00498 0.356
LIG_FHA_2 438 444 PF00498 0.439
LIG_FHA_2 448 454 PF00498 0.448
LIG_FHA_2 458 464 PF00498 0.507
LIG_FHA_2 468 474 PF00498 0.569
LIG_FHA_2 478 484 PF00498 0.640
LIG_FHA_2 502 508 PF00498 0.444
LIG_FHA_2 92 98 PF00498 0.445
LIG_FXI_DFP_1 164 168 PF00024 0.437
LIG_LIR_Gen_1 113 121 PF02991 0.483
LIG_LIR_Gen_1 127 135 PF02991 0.386
LIG_LIR_Gen_1 152 159 PF02991 0.397
LIG_LIR_Gen_1 166 175 PF02991 0.351
LIG_LIR_Gen_1 177 186 PF02991 0.367
LIG_LIR_Gen_1 201 208 PF02991 0.324
LIG_LIR_Gen_1 225 232 PF02991 0.314
LIG_LIR_Gen_1 297 304 PF02991 0.287
LIG_LIR_Gen_1 321 330 PF02991 0.370
LIG_LIR_Gen_1 358 367 PF02991 0.410
LIG_LIR_Gen_1 369 376 PF02991 0.430
LIG_LIR_Gen_1 71 80 PF02991 0.468
LIG_LIR_Nem_3 103 107 PF02991 0.444
LIG_LIR_Nem_3 127 132 PF02991 0.383
LIG_LIR_Nem_3 166 170 PF02991 0.341
LIG_LIR_Nem_3 201 205 PF02991 0.364
LIG_LIR_Nem_3 225 229 PF02991 0.326
LIG_LIR_Nem_3 327 333 PF02991 0.285
LIG_LIR_Nem_3 358 362 PF02991 0.366
LIG_LIR_Nem_3 71 75 PF02991 0.377
LIG_PDZ_Class_2 565 570 PF00595 0.333
LIG_SH2_STAT3 334 337 PF00017 0.247
LIG_SH2_STAT5 258 261 PF00017 0.227
LIG_SH2_STAT5 330 333 PF00017 0.241
LIG_SH2_STAT5 334 337 PF00017 0.257
LIG_SH2_STAT5 354 357 PF00017 0.360
LIG_SH2_STAT5 359 362 PF00017 0.374
LIG_SH2_STAT5 529 532 PF00017 0.365
LIG_SH2_STAT5 540 543 PF00017 0.400
LIG_SH3_3 242 248 PF00018 0.251
LIG_SH3_3 430 436 PF00018 0.440
LIG_SH3_3 442 448 PF00018 0.432
LIG_SH3_3 452 458 PF00018 0.431
LIG_SH3_3 462 468 PF00018 0.426
LIG_SH3_3 472 478 PF00018 0.483
LIG_SH3_3 482 488 PF00018 0.481
LIG_SH3_3 93 99 PF00018 0.464
LIG_Sin3_3 554 561 PF02671 0.299
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.373
LIG_TYR_ITIM 102 107 PF00017 0.410
LIG_TYR_ITIM 256 261 PF00017 0.224
LIG_TYR_ITIM 328 333 PF00017 0.234
LIG_TYR_ITIM 357 362 PF00017 0.360
MOD_CDK_SPxK_1 429 435 PF00069 0.431
MOD_CK1_1 204 210 PF00069 0.344
MOD_CK1_1 323 329 PF00069 0.375
MOD_CK1_1 347 353 PF00069 0.433
MOD_CK2_1 127 133 PF00069 0.425
MOD_CK2_1 323 329 PF00069 0.468
MOD_CK2_1 437 443 PF00069 0.440
MOD_CK2_1 447 453 PF00069 0.435
MOD_CK2_1 457 463 PF00069 0.433
MOD_CK2_1 467 473 PF00069 0.435
MOD_CK2_1 477 483 PF00069 0.620
MOD_CK2_1 501 507 PF00069 0.607
MOD_CK2_1 91 97 PF00069 0.459
MOD_GlcNHglycan 121 124 PF01048 0.696
MOD_GlcNHglycan 140 143 PF01048 0.624
MOD_GlcNHglycan 145 148 PF01048 0.582
MOD_GlcNHglycan 194 197 PF01048 0.567
MOD_GlcNHglycan 25 28 PF01048 0.763
MOD_GlcNHglycan 266 269 PF01048 0.541
MOD_GlcNHglycan 274 277 PF01048 0.524
MOD_GlcNHglycan 289 293 PF01048 0.624
MOD_GlcNHglycan 314 317 PF01048 0.595
MOD_GlcNHglycan 338 341 PF01048 0.551
MOD_GlcNHglycan 345 349 PF01048 0.542
MOD_GlcNHglycan 361 365 PF01048 0.643
MOD_GlcNHglycan 381 384 PF01048 0.594
MOD_GlcNHglycan 517 520 PF01048 0.733
MOD_GlcNHglycan 549 552 PF01048 0.453
MOD_GSK3_1 121 128 PF00069 0.477
MOD_GSK3_1 134 141 PF00069 0.395
MOD_GSK3_1 145 152 PF00069 0.389
MOD_GSK3_1 166 173 PF00069 0.371
MOD_GSK3_1 200 207 PF00069 0.353
MOD_GSK3_1 257 264 PF00069 0.307
MOD_GSK3_1 272 279 PF00069 0.333
MOD_GSK3_1 299 306 PF00069 0.324
MOD_GSK3_1 32 39 PF00069 0.579
MOD_GSK3_1 320 327 PF00069 0.372
MOD_GSK3_1 417 424 PF00069 0.508
MOD_GSK3_1 425 432 PF00069 0.580
MOD_GSK3_1 486 493 PF00069 0.629
MOD_GSK3_1 529 536 PF00069 0.469
MOD_GSK3_1 87 94 PF00069 0.381
MOD_NEK2_1 10 15 PF00069 0.554
MOD_NEK2_1 121 126 PF00069 0.492
MOD_NEK2_1 138 143 PF00069 0.436
MOD_NEK2_1 192 197 PF00069 0.364
MOD_NEK2_1 21 26 PF00069 0.597
MOD_NEK2_1 240 245 PF00069 0.352
MOD_NEK2_1 261 266 PF00069 0.338
MOD_NEK2_1 309 314 PF00069 0.417
MOD_NEK2_1 333 338 PF00069 0.399
MOD_NEK2_1 362 367 PF00069 0.378
MOD_NEK2_2 276 281 PF00069 0.253
MOD_PIKK_1 261 267 PF00454 0.426
MOD_PIKK_1 333 339 PF00454 0.368
MOD_PKA_1 157 163 PF00069 0.241
MOD_PKA_2 157 163 PF00069 0.441
MOD_PKA_2 309 315 PF00069 0.254
MOD_Plk_1 176 182 PF00069 0.373
MOD_Plk_1 200 206 PF00069 0.329
MOD_Plk_1 320 326 PF00069 0.350
MOD_Plk_1 368 374 PF00069 0.474
MOD_Plk_1 533 539 PF00069 0.494
MOD_Plk_2-3 225 231 PF00069 0.263
MOD_Plk_2-3 68 74 PF00069 0.410
MOD_Plk_4 158 164 PF00069 0.352
MOD_ProDKin_1 213 219 PF00069 0.399
MOD_ProDKin_1 429 435 PF00069 0.646
MOD_ProDKin_1 490 496 PF00069 0.673
MOD_ProDKin_1 85 91 PF00069 0.471
MOD_SUMO_rev_2 392 398 PF00179 0.321
TRG_DiLeu_BaEn_1 534 539 PF01217 0.345
TRG_ENDOCYTIC_2 104 107 PF00928 0.413
TRG_ENDOCYTIC_2 258 261 PF00928 0.243
TRG_ENDOCYTIC_2 330 333 PF00928 0.382
TRG_ENDOCYTIC_2 354 357 PF00928 0.362
TRG_ENDOCYTIC_2 359 362 PF00928 0.374
TRG_ER_diArg_1 309 311 PF00400 0.269
TRG_ER_diArg_1 5 7 PF00400 0.635
TRG_Pf-PMV_PEXEL_1 281 286 PF00026 0.444
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.561

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I661 Leptomonas seymouri 32% 100%
A0A0S4IHI7 Bodo saltans 27% 74%
A0A0S4IJN2 Bodo saltans 24% 85%
A0A0S4IRQ2 Bodo saltans 30% 67%
A0A0S4IVQ8 Bodo saltans 33% 95%
A0A0S4IW93 Bodo saltans 26% 94%
A0A0S4J014 Bodo saltans 25% 80%
A0A0S4J2H8 Bodo saltans 25% 97%
A0A0S4J954 Bodo saltans 24% 77%
A0A0S4JAQ6 Bodo saltans 26% 100%
A0A0S4JBI6 Bodo saltans 24% 67%
A0A0S4JHE0 Bodo saltans 29% 68%
A0A0S4JL29 Bodo saltans 29% 100%
A0A0S4JTM6 Bodo saltans 25% 77%
A0A0S4JTQ7 Bodo saltans 36% 100%
A0A0S4JVI0 Bodo saltans 26% 80%
A0A0S4KEG2 Bodo saltans 25% 68%
A0A0S4KK37 Bodo saltans 28% 98%
A0A3Q8I9A6 Leishmania donovani 51% 100%
A0A3Q8I9B4 Leishmania donovani 48% 100%
A0A3Q8IC27 Leishmania donovani 32% 100%
A0A3S5H6L9 Leishmania donovani 48% 100%
A0A3S5H6M3 Leishmania donovani 58% 83%
A0A3S5H6M4 Leishmania donovani 53% 87%
A0A3S7WS66 Leishmania donovani 52% 87%
A4HBX3 Leishmania braziliensis 32% 100%
A4HVB0 Leishmania infantum 53% 100%
A4HZ93 Leishmania infantum 32% 100%
D1GJ51 Leishmania infantum 55% 100%
E8NHG5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9AGG2 Leishmania infantum 57% 86%
E9AGG7 Leishmania infantum 61% 91%
E9AGG9 Leishmania infantum 60% 100%
E9AGH0 Leishmania infantum 53% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 81%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 52% 100%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 82%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
F4JGB6 Arabidopsis thaliana 26% 70%
Q1PEN0 Arabidopsis thaliana 23% 79%
Q4QC79 Leishmania major 32% 100%
Q4QGI0 Leishmania major 64% 100%
Q4QGI2 Leishmania major 61% 100%
Q4QGI4 Leishmania major 62% 100%
Q4QGI6 Leishmania major 61% 100%
Q4QGI8 Leishmania major 52% 75%
Q4QGJ0 Leishmania major 61% 100%
Q4QGJ2 Leishmania major 68% 100%
Q4QGJ6 Leishmania major 61% 100%
Q4QGJ9 Leishmania major 63% 100%
Q4QGK1 Leishmania major 63% 81%
Q4QGK2 Leishmania major 55% 100%
Q4QGK4 Leishmania major 69% 85%
Q4QGK6 Leishmania major 56% 100%
Q4QGK8 Leishmania major 55% 100%
Q4QGL2 Leishmania major 55% 100%
Q4QGL4 Leishmania major 70% 100%
Q4QGL5 Leishmania major 62% 100%
Q4QGL8 Leishmania major 51% 93%
Q4QGM1 Leishmania major 62% 73%
Q9C9H6 Arabidopsis thaliana 22% 73%
Q9LJW7 Arabidopsis thaliana 24% 80%
Q9SHI4 Arabidopsis thaliana 22% 75%
Q9SVM3 Arabidopsis thaliana 25% 68%
Q9SVN2 Arabidopsis thaliana 26% 71%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS