LeishMANIAdb
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Putative surface antigen protein 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative surface antigen protein 2
Gene product:
surface antigen protein 2, putative
Species:
Leishmania major
UniProt:
Q4QGJ9_LEIMA
TriTrypDb:
LmjF.12.0760 , LMJLV39_000011100 , LMJLV39_000013700 * , LMJSD75_120012800 , LMJSD75_120012900
Length:
587

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 120
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 45, no: 5
NetGPI no yes: 0, no: 50
Cellular components
Term Name Level Count
GO:0005929 cilium 4 51
GO:0016020 membrane 2 28
GO:0042995 cell projection 2 51
GO:0043226 organelle 2 51
GO:0043227 membrane-bounded organelle 3 51
GO:0110165 cellular anatomical entity 1 51
GO:0120025 plasma membrane bounded cell projection 3 51
GO:0005886 plasma membrane 3 6

Expansion

Sequence features

Q4QGJ9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGJ9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 124 128 PF00656 0.426
CLV_NRD_NRD_1 277 279 PF00675 0.596
CLV_NRD_NRD_1 6 8 PF00675 0.645
CLV_PCSK_KEX2_1 6 8 PF00082 0.645
CLV_PCSK_SKI1_1 278 282 PF00082 0.571
CLV_PCSK_SKI1_1 326 330 PF00082 0.583
CLV_PCSK_SKI1_1 7 11 PF00082 0.720
DEG_SCF_FBW7_1 474 480 PF00400 0.414
DEG_SCF_FBW7_2 515 520 PF00400 0.448
DEG_SPOP_SBC_1 462 466 PF00917 0.581
DEG_SPOP_SBC_1 477 481 PF00917 0.429
DEG_SPOP_SBC_1 483 487 PF00917 0.562
DEG_SPOP_SBC_1 495 499 PF00917 0.461
DOC_CKS1_1 474 479 PF01111 0.413
DOC_CYCLIN_RxL_1 107 115 PF00134 0.265
DOC_CYCLIN_RxL_1 3 13 PF00134 0.647
DOC_CYCLIN_RxL_1 374 385 PF00134 0.258
DOC_MAPK_gen_1 278 285 PF00069 0.349
DOC_MAPK_gen_1 326 333 PF00069 0.255
DOC_MAPK_MEF2A_6 421 428 PF00069 0.508
DOC_PP1_RVXF_1 108 115 PF00149 0.293
DOC_PP1_RVXF_1 132 138 PF00149 0.230
DOC_PP1_RVXF_1 180 187 PF00149 0.369
DOC_PP1_RVXF_1 228 235 PF00149 0.283
DOC_USP7_MATH_1 192 196 PF00917 0.334
DOC_USP7_MATH_1 300 304 PF00917 0.415
DOC_USP7_MATH_1 348 352 PF00917 0.366
DOC_USP7_MATH_1 401 405 PF00917 0.327
DOC_USP7_MATH_1 563 567 PF00917 0.410
DOC_USP7_UBL2_3 59 63 PF12436 0.382
DOC_WW_Pin1_4 473 478 PF00397 0.609
DOC_WW_Pin1_4 507 512 PF00397 0.600
DOC_WW_Pin1_4 513 518 PF00397 0.553
DOC_WW_Pin1_4 85 90 PF00397 0.414
LIG_14-3-3_CanoR_1 278 285 PF00244 0.263
LIG_14-3-3_CanoR_1 43 48 PF00244 0.420
LIG_Actin_WH2_2 201 216 PF00022 0.254
LIG_BIR_II_1 1 5 PF00653 0.643
LIG_BRCT_BRCA1_1 182 186 PF00533 0.257
LIG_BRCT_BRCA1_1 230 234 PF00533 0.312
LIG_deltaCOP1_diTrp_1 62 69 PF00928 0.385
LIG_EVH1_1 473 477 PF00568 0.411
LIG_FHA_1 104 110 PF00498 0.277
LIG_FHA_1 279 285 PF00498 0.351
LIG_FHA_1 304 310 PF00498 0.235
LIG_FHA_1 327 333 PF00498 0.299
LIG_FHA_1 352 358 PF00498 0.372
LIG_FHA_1 42 48 PF00498 0.474
LIG_FHA_1 479 485 PF00498 0.422
LIG_FHA_2 122 128 PF00498 0.423
LIG_FHA_2 477 483 PF00498 0.422
LIG_FHA_2 485 491 PF00498 0.446
LIG_FHA_2 495 501 PF00498 0.461
LIG_FHA_2 519 525 PF00498 0.394
LIG_FHA_2 63 69 PF00498 0.362
LIG_FHA_2 92 98 PF00498 0.403
LIG_LIR_Gen_1 103 112 PF02991 0.418
LIG_LIR_Gen_1 113 121 PF02991 0.436
LIG_LIR_Gen_1 127 137 PF02991 0.363
LIG_LIR_Gen_1 152 159 PF02991 0.371
LIG_LIR_Gen_1 183 194 PF02991 0.344
LIG_LIR_Gen_1 231 242 PF02991 0.317
LIG_LIR_Gen_1 297 304 PF02991 0.268
LIG_LIR_Gen_1 345 352 PF02991 0.329
LIG_LIR_Gen_1 392 401 PF02991 0.397
LIG_LIR_Gen_1 71 80 PF02991 0.321
LIG_LIR_Nem_3 103 107 PF02991 0.432
LIG_LIR_Nem_3 127 132 PF02991 0.415
LIG_LIR_Nem_3 136 140 PF02991 0.393
LIG_LIR_Nem_3 183 189 PF02991 0.319
LIG_LIR_Nem_3 231 237 PF02991 0.307
LIG_LIR_Nem_3 297 301 PF02991 0.297
LIG_LIR_Nem_3 345 349 PF02991 0.340
LIG_LIR_Nem_3 71 75 PF02991 0.365
LIG_NRBOX 279 285 PF00104 0.228
LIG_NRBOX 327 333 PF00104 0.325
LIG_PDZ_Class_2 582 587 PF00595 0.269
LIG_SH2_CRK 104 108 PF00017 0.408
LIG_SH2_STAP1 104 108 PF00017 0.252
LIG_SH2_STAT5 104 107 PF00017 0.256
LIG_SH2_STAT5 546 549 PF00017 0.481
LIG_SH2_STAT5 83 86 PF00017 0.251
LIG_SH3_3 471 477 PF00018 0.531
LIG_SH3_3 489 495 PF00018 0.658
LIG_SH3_3 499 505 PF00018 0.496
LIG_SH3_3 93 99 PF00018 0.454
LIG_Sin3_3 571 578 PF02671 0.255
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.323
LIG_TYR_ITIM 102 107 PF00017 0.473
LIG_UBA3_1 108 116 PF00899 0.229
MOD_CK1_1 152 158 PF00069 0.437
MOD_CK1_1 180 186 PF00069 0.336
MOD_CK1_1 203 209 PF00069 0.360
MOD_CK1_1 228 234 PF00069 0.342
MOD_CK1_1 251 257 PF00069 0.351
MOD_CK1_1 303 309 PF00069 0.301
MOD_CK1_1 312 318 PF00069 0.341
MOD_CK1_1 351 357 PF00069 0.356
MOD_CK1_1 360 366 PF00069 0.403
MOD_CK1_1 371 377 PF00069 0.394
MOD_CK1_1 389 395 PF00069 0.332
MOD_CK1_1 85 91 PF00069 0.293
MOD_CK2_1 127 133 PF00069 0.424
MOD_CK2_1 476 482 PF00069 0.426
MOD_CK2_1 484 490 PF00069 0.476
MOD_CK2_1 494 500 PF00069 0.462
MOD_CK2_1 518 524 PF00069 0.432
MOD_CK2_1 91 97 PF00069 0.449
MOD_GlcNHglycan 121 124 PF01048 0.597
MOD_GlcNHglycan 140 143 PF01048 0.540
MOD_GlcNHglycan 145 148 PF01048 0.596
MOD_GlcNHglycan 170 173 PF01048 0.570
MOD_GlcNHglycan 194 197 PF01048 0.576
MOD_GlcNHglycan 218 221 PF01048 0.498
MOD_GlcNHglycan 242 245 PF01048 0.566
MOD_GlcNHglycan 25 28 PF01048 0.730
MOD_GlcNHglycan 266 269 PF01048 0.554
MOD_GlcNHglycan 290 293 PF01048 0.504
MOD_GlcNHglycan 297 301 PF01048 0.515
MOD_GlcNHglycan 309 312 PF01048 0.611
MOD_GlcNHglycan 314 317 PF01048 0.606
MOD_GlcNHglycan 338 341 PF01048 0.581
MOD_GlcNHglycan 345 349 PF01048 0.560
MOD_GlcNHglycan 357 360 PF01048 0.490
MOD_GlcNHglycan 362 365 PF01048 0.561
MOD_GlcNHglycan 370 373 PF01048 0.564
MOD_GlcNHglycan 385 389 PF01048 0.599
MOD_GlcNHglycan 394 397 PF01048 0.563
MOD_GlcNHglycan 534 537 PF01048 0.628
MOD_GlcNHglycan 566 569 PF01048 0.470
MOD_GlcNHglycan 84 87 PF01048 0.550
MOD_GSK3_1 121 128 PF00069 0.399
MOD_GSK3_1 145 152 PF00069 0.388
MOD_GSK3_1 166 173 PF00069 0.326
MOD_GSK3_1 200 207 PF00069 0.367
MOD_GSK3_1 214 221 PF00069 0.332
MOD_GSK3_1 296 303 PF00069 0.331
MOD_GSK3_1 32 39 PF00069 0.552
MOD_GSK3_1 344 351 PF00069 0.362
MOD_GSK3_1 371 378 PF00069 0.368
MOD_GSK3_1 386 393 PF00069 0.345
MOD_GSK3_1 441 448 PF00069 0.568
MOD_GSK3_1 449 456 PF00069 0.608
MOD_GSK3_1 458 465 PF00069 0.588
MOD_GSK3_1 473 480 PF00069 0.483
MOD_GSK3_1 482 489 PF00069 0.501
MOD_GSK3_1 503 510 PF00069 0.535
MOD_GSK3_1 546 553 PF00069 0.489
MOD_GSK3_1 87 94 PF00069 0.342
MOD_NEK2_1 10 15 PF00069 0.532
MOD_NEK2_1 112 117 PF00069 0.351
MOD_NEK2_1 121 126 PF00069 0.360
MOD_NEK2_1 138 143 PF00069 0.336
MOD_NEK2_1 21 26 PF00069 0.559
MOD_NEK2_1 213 218 PF00069 0.345
MOD_NEK2_1 237 242 PF00069 0.358
MOD_NEK2_1 285 290 PF00069 0.294
MOD_NEK2_1 307 312 PF00069 0.359
MOD_NEK2_1 314 319 PF00069 0.334
MOD_NEK2_1 333 338 PF00069 0.376
MOD_NEK2_1 355 360 PF00069 0.408
MOD_NEK2_1 386 391 PF00069 0.349
MOD_NEK2_1 399 404 PF00069 0.347
MOD_NEK2_1 453 458 PF00069 0.523
MOD_NEK2_1 484 489 PF00069 0.486
MOD_NEK2_2 401 406 PF00069 0.268
MOD_PIKK_1 261 267 PF00454 0.466
MOD_PIKK_1 326 332 PF00454 0.322
MOD_PK_1 166 172 PF00069 0.267
MOD_PK_1 214 220 PF00069 0.251
MOD_PKA_1 278 284 PF00069 0.238
MOD_PKA_1 326 332 PF00069 0.250
MOD_PKA_2 213 219 PF00069 0.359
MOD_PKA_2 307 313 PF00069 0.345
MOD_PKA_2 355 361 PF00069 0.386
MOD_Plk_1 102 108 PF00069 0.319
MOD_Plk_1 296 302 PF00069 0.284
MOD_Plk_1 333 339 PF00069 0.293
MOD_Plk_1 344 350 PF00069 0.345
MOD_Plk_1 550 556 PF00069 0.540
MOD_Plk_2-3 160 166 PF00069 0.439
MOD_Plk_2-3 68 74 PF00069 0.320
MOD_Plk_4 103 109 PF00069 0.278
MOD_Plk_4 133 139 PF00069 0.341
MOD_Plk_4 182 188 PF00069 0.335
MOD_Plk_4 230 236 PF00069 0.350
MOD_Plk_4 251 257 PF00069 0.324
MOD_Plk_4 285 291 PF00069 0.286
MOD_Plk_4 333 339 PF00069 0.297
MOD_ProDKin_1 473 479 PF00069 0.611
MOD_ProDKin_1 507 513 PF00069 0.600
MOD_ProDKin_1 85 91 PF00069 0.410
MOD_SUMO_rev_2 416 422 PF00179 0.295
TRG_DiLeu_BaEn_1 551 556 PF01217 0.338
TRG_ENDOCYTIC_2 104 107 PF00928 0.464
TRG_ER_diArg_1 5 7 PF00400 0.543
TRG_Pf-PMV_PEXEL_1 377 382 PF00026 0.465

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I661 Leptomonas seymouri 37% 100%
A0A0S4IHI7 Bodo saltans 28% 76%
A0A0S4IN27 Bodo saltans 37% 100%
A0A0S4IRQ2 Bodo saltans 31% 69%
A0A0S4ISU4 Bodo saltans 36% 89%
A0A0S4IT62 Bodo saltans 36% 79%
A0A0S4IU91 Bodo saltans 26% 67%
A0A0S4IW93 Bodo saltans 30% 97%
A0A0S4IWB9 Bodo saltans 32% 71%
A0A0S4J014 Bodo saltans 29% 82%
A0A0S4J2H8 Bodo saltans 25% 100%
A0A0S4J4L7 Bodo saltans 25% 80%
A0A0S4J954 Bodo saltans 25% 79%
A0A0S4JB95 Bodo saltans 28% 97%
A0A0S4JNU2 Bodo saltans 36% 71%
A0A0S4KEC2 Bodo saltans 36% 67%
A0A0S4KEG2 Bodo saltans 26% 70%
A0A0S4KF94 Bodo saltans 24% 67%
A0A0S4KK37 Bodo saltans 31% 100%
A0A3Q8IC27 Leishmania donovani 35% 100%
A0A3S5H6M3 Leishmania donovani 61% 86%
A0A3S5H6M4 Leishmania donovani 57% 89%
A0A3S7WS66 Leishmania donovani 57% 89%
A4HBX3 Leishmania braziliensis 37% 100%
A4HVB0 Leishmania infantum 44% 90%
A4HZ93 Leishmania infantum 34% 100%
D1GJ51 Leishmania infantum 55% 100%
E8NHG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 77%
E9AGG2 Leishmania infantum 62% 88%
E9AGG5 Leishmania infantum 51% 100%
E9AGG7 Leishmania infantum 58% 94%
E9AGG9 Leishmania infantum 59% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 83%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 88%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 56% 84%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B1U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
F4J7T6 Arabidopsis thaliana 22% 66%
F4J8G2 Arabidopsis thaliana 27% 67%
F4JTU7 Arabidopsis thaliana 24% 72%
Q1PEN0 Arabidopsis thaliana 23% 82%
Q40235 Solanum pimpinellifolium 22% 68%
Q4QC79 Leishmania major 36% 100%
Q4QGI0 Leishmania major 57% 100%
Q4QGI2 Leishmania major 58% 100%
Q4QGI4 Leishmania major 57% 100%
Q4QGI6 Leishmania major 60% 100%
Q4QGI8 Leishmania major 49% 100%
Q4QGJ0 Leishmania major 64% 100%
Q4QGJ2 Leishmania major 67% 100%
Q4QGJ6 Leishmania major 55% 100%
Q4QGK0 Leishmania major 63% 100%
Q4QGK1 Leishmania major 68% 83%
Q4QGK2 Leishmania major 51% 100%
Q4QGK4 Leishmania major 55% 88%
Q4QGK8 Leishmania major 54% 100%
Q4QGL2 Leishmania major 54% 100%
Q4QGL4 Leishmania major 68% 100%
Q4QGL8 Leishmania major 64% 96%
Q4QGM1 Leishmania major 54% 76%
Q8RX63 Arabidopsis thaliana 26% 68%
Q8TF66 Homo sapiens 22% 100%
Q9C9H6 Arabidopsis thaliana 24% 75%
Q9C9H7 Arabidopsis thaliana 24% 69%
Q9FYK0 Arabidopsis thaliana 23% 66%
Q9LS79 Arabidopsis thaliana 21% 75%
Q9LS80 Arabidopsis thaliana 24% 70%
Q9M9X0 Arabidopsis thaliana 25% 68%
Q9SHI3 Arabidopsis thaliana 22% 81%
Q9SVM3 Arabidopsis thaliana 24% 70%
Q9SVN2 Arabidopsis thaliana 22% 73%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS