LeishMANIAdb
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Surface antigen protein 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen protein 2
Gene product:
surface antigen protein 2 precursor
Species:
Leishmania major
UniProt:
Q4QGJ7_LEIMA
TriTrypDb:
LmjF.12.0780 , LMJLV39_120012900 , LMJSD75_120012600
Length:
375

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 120
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 46, no: 8
NetGPI no yes: 0, no: 54
Cellular components
Term Name Level Count
GO:0005929 cilium 4 55
GO:0016020 membrane 2 14
GO:0042995 cell projection 2 55
GO:0043226 organelle 2 55
GO:0043227 membrane-bounded organelle 3 55
GO:0110165 cellular anatomical entity 1 55
GO:0120025 plasma membrane bounded cell projection 3 55
GO:0005886 plasma membrane 3 3

Expansion

Sequence features

Q4QGJ7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGJ7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0004672 protein kinase activity 3 1
GO:0004674 protein serine/threonine kinase activity 4 1
GO:0016301 kinase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 1
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 6 8 PF00675 0.698
CLV_PCSK_KEX2_1 6 8 PF00082 0.698
CLV_PCSK_SKI1_1 7 11 PF00082 0.706
DEG_SCF_FBW7_1 272 278 PF00400 0.467
DEG_SCF_FBW7_2 303 308 PF00400 0.470
DEG_SPOP_SBC_1 275 279 PF00917 0.476
DEG_SPOP_SBC_1 281 285 PF00917 0.476
DOC_CKS1_1 272 277 PF01111 0.468
DOC_CYCLIN_RxL_1 105 116 PF00134 0.307
DOC_CYCLIN_RxL_1 182 193 PF00134 0.302
DOC_CYCLIN_RxL_1 3 13 PF00134 0.514
DOC_MAPK_MEF2A_6 229 236 PF00069 0.382
DOC_PP1_RVXF_1 108 115 PF00149 0.313
DOC_USP7_MATH_1 209 213 PF00917 0.323
DOC_USP7_MATH_1 351 355 PF00917 0.387
DOC_USP7_MATH_2 151 157 PF00917 0.303
DOC_USP7_UBL2_3 340 344 PF12436 0.325
DOC_USP7_UBL2_3 59 63 PF12436 0.322
DOC_WW_Pin1_4 262 267 PF00397 0.489
DOC_WW_Pin1_4 271 276 PF00397 0.549
DOC_WW_Pin1_4 295 300 PF00397 0.656
DOC_WW_Pin1_4 301 306 PF00397 0.479
DOC_WW_Pin1_4 85 90 PF00397 0.315
LIG_14-3-3_CanoR_1 276 281 PF00244 0.499
LIG_14-3-3_CanoR_1 43 48 PF00244 0.353
LIG_Actin_WH2_2 153 168 PF00022 0.297
LIG_BIR_II_1 1 5 PF00653 0.625
LIG_deltaCOP1_diTrp_1 62 69 PF00928 0.356
LIG_EVH1_1 271 275 PF00568 0.466
LIG_FHA_1 263 269 PF00498 0.569
LIG_FHA_1 277 283 PF00498 0.456
LIG_FHA_1 42 48 PF00498 0.380
LIG_FHA_2 131 137 PF00498 0.336
LIG_FHA_2 275 281 PF00498 0.505
LIG_FHA_2 283 289 PF00498 0.491
LIG_FHA_2 307 313 PF00498 0.411
LIG_FHA_2 92 98 PF00498 0.437
LIG_LIR_Gen_1 113 121 PF02991 0.423
LIG_LIR_Gen_1 128 135 PF02991 0.365
LIG_LIR_Gen_1 200 209 PF02991 0.415
LIG_LIR_Gen_1 71 80 PF02991 0.342
LIG_LIR_Nem_3 103 107 PF02991 0.420
LIG_LIR_Nem_3 200 205 PF02991 0.342
LIG_LIR_Nem_3 71 75 PF02991 0.403
LIG_PDZ_Class_2 370 375 PF00595 0.295
LIG_SH2_STAT5 334 337 PF00017 0.330
LIG_SH2_STAT5 83 86 PF00017 0.342
LIG_SH3_3 269 275 PF00018 0.467
LIG_SH3_3 287 293 PF00018 0.482
LIG_SH3_3 93 99 PF00018 0.408
LIG_Sin3_3 359 366 PF02671 0.266
LIG_SUMO_SIM_anti_2 158 164 PF11976 0.316
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.331
LIG_SUMO_SIM_par_1 232 238 PF11976 0.345
LIG_TYR_ITIM 102 107 PF00017 0.376
MOD_CDK_SPK_2 271 276 PF00069 0.467
MOD_CK1_1 128 134 PF00069 0.393
MOD_CK1_1 156 162 PF00069 0.351
MOD_CK1_1 179 185 PF00069 0.533
MOD_CK1_1 197 203 PF00069 0.336
MOD_CK1_1 259 265 PF00069 0.466
MOD_CK1_1 85 91 PF00069 0.353
MOD_CK2_1 130 136 PF00069 0.346
MOD_CK2_1 274 280 PF00069 0.472
MOD_CK2_1 282 288 PF00069 0.474
MOD_CK2_1 306 312 PF00069 0.439
MOD_CK2_1 91 97 PF00069 0.446
MOD_GlcNHglycan 121 124 PF01048 0.643
MOD_GlcNHglycan 146 149 PF01048 0.581
MOD_GlcNHglycan 170 173 PF01048 0.571
MOD_GlcNHglycan 178 181 PF01048 0.694
MOD_GlcNHglycan 193 197 PF01048 0.576
MOD_GlcNHglycan 202 205 PF01048 0.574
MOD_GlcNHglycan 25 28 PF01048 0.661
MOD_GlcNHglycan 258 261 PF01048 0.733
MOD_GlcNHglycan 322 325 PF01048 0.558
MOD_GlcNHglycan 354 357 PF01048 0.292
MOD_GlcNHglycan 84 87 PF01048 0.560
MOD_GSK3_1 121 128 PF00069 0.423
MOD_GSK3_1 130 137 PF00069 0.470
MOD_GSK3_1 142 149 PF00069 0.486
MOD_GSK3_1 179 186 PF00069 0.420
MOD_GSK3_1 194 201 PF00069 0.388
MOD_GSK3_1 249 256 PF00069 0.531
MOD_GSK3_1 258 265 PF00069 0.559
MOD_GSK3_1 271 278 PF00069 0.477
MOD_GSK3_1 280 287 PF00069 0.574
MOD_GSK3_1 291 298 PF00069 0.498
MOD_GSK3_1 32 39 PF00069 0.509
MOD_GSK3_1 334 341 PF00069 0.506
MOD_GSK3_1 87 94 PF00069 0.340
MOD_N-GLC_1 266 271 PF02516 0.731
MOD_NEK2_1 10 15 PF00069 0.674
MOD_NEK2_1 121 126 PF00069 0.412
MOD_NEK2_1 165 170 PF00069 0.324
MOD_NEK2_1 194 199 PF00069 0.507
MOD_NEK2_1 207 212 PF00069 0.403
MOD_NEK2_1 21 26 PF00069 0.577
MOD_NEK2_1 282 287 PF00069 0.556
MOD_NEK2_2 209 214 PF00069 0.290
MOD_PK_1 142 148 PF00069 0.315
MOD_PKA_2 165 171 PF00069 0.312
MOD_PKA_2 275 281 PF00069 0.491
MOD_Plk_1 338 344 PF00069 0.360
MOD_Plk_2-3 136 142 PF00069 0.345
MOD_Plk_2-3 68 74 PF00069 0.323
MOD_Plk_4 158 164 PF00069 0.368
MOD_ProDKin_1 262 268 PF00069 0.490
MOD_ProDKin_1 271 277 PF00069 0.550
MOD_ProDKin_1 295 301 PF00069 0.654
MOD_ProDKin_1 85 91 PF00069 0.311
MOD_SUMO_rev_2 224 230 PF00179 0.333
MOD_SUMO_rev_2 332 341 PF00179 0.339
TRG_ENDOCYTIC_2 104 107 PF00928 0.405
TRG_ER_diArg_1 5 7 PF00400 0.592
TRG_Pf-PMV_PEXEL_1 185 190 PF00026 0.503

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZ17 Leptomonas seymouri 31% 100%
A0A0S4JEJ4 Bodo saltans 25% 100%
A0A3Q8I9A6 Leishmania donovani 55% 97%
A0A3Q8I9D0 Leishmania donovani 56% 100%
A0A3Q8IC27 Leishmania donovani 31% 79%
A0A3Q8IIJ9 Leishmania donovani 31% 100%
A0A3S5H6D6 Leishmania donovani 32% 100%
A0A3S7WP69 Leishmania donovani 21% 100%
A0A3S7WPB2 Leishmania donovani 30% 100%
A0A3S7X4J4 Leishmania donovani 31% 100%
A4H4D2 Leishmania braziliensis 24% 100%
A4H4G6 Leishmania braziliensis 29% 100%
A4H5P0 Leishmania braziliensis 28% 100%
A4HBX3 Leishmania braziliensis 31% 83%
A4HJC8 Leishmania braziliensis 30% 100%
A4HSL2 Leishmania infantum 21% 100%
A4HTX9 Leishmania infantum 32% 100%
A4HVB0 Leishmania infantum 51% 93%
A4HZ93 Leishmania infantum 31% 79%
A4I6S4 Leishmania infantum 31% 100%
D1GJ51 Leishmania infantum 50% 81%
E8NHG5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 84%
E8NHP8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9ACQ0 Leishmania major 30% 100%
E9AG65 Leishmania infantum 30% 100%
E9AGG5 Leishmania infantum 57% 90%
E9AGG9 Leishmania infantum 56% 69%
E9AGH0 Leishmania infantum 56% 99%
E9AKJ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9AKM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AMQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AP02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 100%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 96%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 73%
E9AP07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 56% 89%
E9B1U4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B1U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 89%
E9B1U6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
P21978 Leishmania amazonensis 53% 79%
Q25331 Leishmania major 94% 100%
Q4Q6B6 Leishmania major 29% 100%
Q4Q6B7 Leishmania major 29% 100%
Q4QC79 Leishmania major 29% 82%
Q4QGI0 Leishmania major 60% 74%
Q4QGI2 Leishmania major 46% 67%
Q4QGI4 Leishmania major 47% 70%
Q4QGI6 Leishmania major 71% 69%
Q4QGJ4 Leishmania major 94% 100%
Q4QGK2 Leishmania major 52% 67%
Q4QGK6 Leishmania major 94% 97%
Q4QGL4 Leishmania major 63% 95%
Q4QHW6 Leishmania major 33% 100%
Q4QJB2 Leishmania major 21% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS