Putative surface antigen protein 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen protein 2, putative

Species:

Leishmania major

UniProt:

Q4QGJ6_LEIMA

TriTrypDb:

LmjF.12.0765 , LMJLV39_000011100 , LMJLV39_000017300 , LMJSD75_120012700 , LMJSD75_120012800

Length:

572

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 100

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 33, no: 2
NetGPI	no	yes: 0, no: 35

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	36
GO:0016020	membrane	2	16
GO:0042995	cell projection	2	36
GO:0043226	organelle	2	36
GO:0043227	membrane-bounded organelle	3	36
GO:0110165	cellular anatomical entity	1	36
GO:0120025	plasma membrane bounded cell projection	3	36
GO:0005886	plasma membrane	3	2

Expansion

Sequence features

Q4QGJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGJ6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004672	protein kinase activity	3	2
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.319
CLV_NRD_NRD_1	189	191	PF00675	0.480
CLV_NRD_NRD_1	6	8	PF00675	0.701
CLV_PCSK_KEX2_1	156	158	PF00082	0.480
CLV_PCSK_KEX2_1	189	191	PF00082	0.488
CLV_PCSK_KEX2_1	6	8	PF00082	0.701
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.480
CLV_PCSK_SKI1_1	189	193	PF00082	0.518
CLV_PCSK_SKI1_1	7	11	PF00082	0.672
DEG_SCF_FBW7_2	500	505	PF00400	0.503
DEG_SPOP_SBC_1	354	358	PF00917	0.486
DEG_SPOP_SBC_1	363	367	PF00917	0.600
DEG_SPOP_SBC_1	378	382	PF00917	0.535
DEG_SPOP_SBC_1	388	392	PF00917	0.549
DEG_SPOP_SBC_1	398	402	PF00917	0.453
DEG_SPOP_SBC_1	408	412	PF00917	0.509
DEG_SPOP_SBC_1	419	423	PF00917	0.591
DEG_SPOP_SBC_1	428	432	PF00917	0.594
DEG_SPOP_SBC_1	458	462	PF00917	0.664
DEG_SPOP_SBC_1	479	483	PF00917	0.495
DOC_CYCLIN_RxL_1	186	196	PF00134	0.301
DOC_CYCLIN_RxL_1	3	13	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	220	223	PF00134	0.299
DOC_CYCLIN_yCln2_LP_2	241	247	PF00134	0.291
DOC_MAPK_gen_1	156	163	PF00069	0.329
DOC_MAPK_gen_1	76	84	PF00069	0.275
DOC_MAPK_MEF2A_6	205	212	PF00069	0.287
DOC_MAPK_MEF2A_6	324	331	PF00069	0.399
DOC_MAPK_MEF2A_6	76	84	PF00069	0.275
DOC_PP1_RVXF_1	154	161	PF00149	0.264
DOC_PP2B_LxvP_1	220	223	PF13499	0.291
DOC_USP7_MATH_1	263	267	PF00917	0.459
DOC_USP7_MATH_1	548	552	PF00917	0.373
DOC_USP7_MATH_2	174	180	PF00917	0.394
DOC_USP7_MATH_2	198	204	PF00917	0.265
DOC_USP7_MATH_2	222	228	PF00917	0.337
DOC_WW_Pin1_4	212	217	PF00397	0.272
DOC_WW_Pin1_4	492	497	PF00397	0.651
DOC_WW_Pin1_4	498	503	PF00397	0.491
DOC_WW_Pin1_4	85	90	PF00397	0.358
LIG_14-3-3_CanoR_1	157	161	PF00244	0.289
LIG_14-3-3_CanoR_1	253	258	PF00244	0.354
LIG_14-3-3_CanoR_1	304	309	PF00244	0.395
LIG_14-3-3_CanoR_1	43	48	PF00244	0.359
LIG_Actin_WH2_2	179	194	PF00022	0.307
LIG_APCC_ABBA_1	208	213	PF00400	0.256
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_deltaCOP1_diTrp_1	111	115	PF00928	0.258
LIG_deltaCOP1_diTrp_1	200	204	PF00928	0.275
LIG_deltaCOP1_diTrp_1	61	69	PF00928	0.435
LIG_DLG_GKlike_1	253	260	PF00625	0.275
LIG_FHA_1	168	174	PF00498	0.348
LIG_FHA_1	183	189	PF00498	0.430
LIG_FHA_1	216	222	PF00498	0.360
LIG_FHA_1	240	246	PF00498	0.406
LIG_FHA_1	348	354	PF00498	0.429
LIG_FHA_1	413	419	PF00498	0.465
LIG_FHA_1	42	48	PF00498	0.388
LIG_FHA_1	473	479	PF00498	0.482
LIG_FHA_1	536	542	PF00498	0.346
LIG_FHA_2	121	127	PF00498	0.325
LIG_FHA_2	480	486	PF00498	0.527
LIG_FHA_2	504	510	PF00498	0.464
LIG_FHA_2	92	98	PF00498	0.490
LIG_LIR_Gen_1	151	160	PF02991	0.366
LIG_LIR_Gen_1	176	183	PF02991	0.350
LIG_LIR_Gen_1	71	80	PF02991	0.357
LIG_LIR_Nem_3	103	107	PF02991	0.433
LIG_LIR_Nem_3	126	131	PF02991	0.394
LIG_LIR_Nem_3	159	163	PF02991	0.299
LIG_LIR_Nem_3	202	207	PF02991	0.287
LIG_LIR_Nem_3	224	228	PF02991	0.389
LIG_LIR_Nem_3	71	75	PF02991	0.383
LIG_PDZ_Class_2	567	572	PF00595	0.323
LIG_SH2_STAT5	281	284	PF00017	0.290
LIG_SH2_STAT5	531	534	PF00017	0.370
LIG_SH2_STAT5	542	545	PF00017	0.419
LIG_SH2_STAT5	83	86	PF00017	0.307
LIG_SH3_3	241	247	PF00018	0.294
LIG_SH3_3	484	490	PF00018	0.564
LIG_SH3_3	93	99	PF00018	0.371
LIG_Sin3_3	556	563	PF02671	0.291
LIG_SUMO_SIM_anti_2	254	259	PF11976	0.338
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.340
LIG_TYR_ITIM	102	107	PF00017	0.364
LIG_UBA3_1	257	264	PF00899	0.299
MOD_CK1_1	118	124	PF00069	0.310
MOD_CK1_1	151	157	PF00069	0.363
MOD_CK1_1	203	209	PF00069	0.373
MOD_CK1_1	239	245	PF00069	0.339
MOD_CK1_1	251	257	PF00069	0.380
MOD_CK1_1	274	280	PF00069	0.422
MOD_CK2_1	479	485	PF00069	0.493
MOD_CK2_1	503	509	PF00069	0.519
MOD_CK2_1	91	97	PF00069	0.441
MOD_CMANNOS	201	204	PF00535	0.460
MOD_GlcNHglycan	120	123	PF01048	0.625
MOD_GlcNHglycan	139	142	PF01048	0.518
MOD_GlcNHglycan	144	147	PF01048	0.583
MOD_GlcNHglycan	164	168	PF01048	0.568
MOD_GlcNHglycan	193	196	PF01048	0.622
MOD_GlcNHglycan	25	28	PF01048	0.744
MOD_GlcNHglycan	265	268	PF01048	0.612
MOD_GlcNHglycan	272	276	PF01048	0.598
MOD_GlcNHglycan	288	292	PF01048	0.593
MOD_GlcNHglycan	519	522	PF01048	0.627
MOD_GlcNHglycan	551	554	PF01048	0.327
MOD_GSK3_1	120	127	PF00069	0.486
MOD_GSK3_1	133	140	PF00069	0.334
MOD_GSK3_1	144	151	PF00069	0.360
MOD_GSK3_1	163	170	PF00069	0.339
MOD_GSK3_1	199	206	PF00069	0.367
MOD_GSK3_1	247	254	PF00069	0.327
MOD_GSK3_1	32	39	PF00069	0.530
MOD_GSK3_1	344	351	PF00069	0.499
MOD_GSK3_1	352	359	PF00069	0.551
MOD_GSK3_1	362	369	PF00069	0.537
MOD_GSK3_1	373	380	PF00069	0.492
MOD_GSK3_1	383	390	PF00069	0.504
MOD_GSK3_1	393	400	PF00069	0.501
MOD_GSK3_1	403	410	PF00069	0.498
MOD_GSK3_1	413	420	PF00069	0.480
MOD_GSK3_1	423	430	PF00069	0.514
MOD_GSK3_1	431	438	PF00069	0.507
MOD_GSK3_1	439	446	PF00069	0.482
MOD_GSK3_1	448	455	PF00069	0.513
MOD_GSK3_1	457	464	PF00069	0.503
MOD_GSK3_1	467	474	PF00069	0.563
MOD_GSK3_1	477	484	PF00069	0.569
MOD_GSK3_1	488	495	PF00069	0.609
MOD_GSK3_1	531	538	PF00069	0.552
MOD_GSK3_1	87	94	PF00069	0.455
MOD_N-GLC_1	115	120	PF02516	0.636
MOD_N-GLC_2	285	287	PF02516	0.484
MOD_NEK2_1	10	15	PF00069	0.577
MOD_NEK2_1	120	125	PF00069	0.488
MOD_NEK2_1	137	142	PF00069	0.309
MOD_NEK2_1	191	196	PF00069	0.399
MOD_NEK2_1	21	26	PF00069	0.502
MOD_NEK2_1	236	241	PF00069	0.368
MOD_NEK2_1	289	294	PF00069	0.453
MOD_NEK2_2	133	138	PF00069	0.279
MOD_PKA_1	156	162	PF00069	0.273
MOD_PKA_2	156	162	PF00069	0.394
MOD_Plk_1	115	121	PF00069	0.479
MOD_Plk_1	175	181	PF00069	0.353
MOD_Plk_1	199	205	PF00069	0.337
MOD_Plk_1	535	541	PF00069	0.544
MOD_Plk_2-3	224	230	PF00069	0.299
MOD_Plk_2-3	68	74	PF00069	0.337
MOD_Plk_4	115	121	PF00069	0.278
MOD_Plk_4	156	162	PF00069	0.357
MOD_Plk_4	203	209	PF00069	0.316
MOD_Plk_4	253	259	PF00069	0.320
MOD_ProDKin_1	212	218	PF00069	0.276
MOD_ProDKin_1	492	498	PF00069	0.649
MOD_ProDKin_1	85	91	PF00069	0.352
MOD_SUMO_rev_2	59	65	PF00179	0.311
TRG_DiLeu_BaEn_1	536	541	PF01217	0.346
TRG_ENDOCYTIC_2	104	107	PF00928	0.365
TRG_ENDOCYTIC_2	281	284	PF00928	0.344
TRG_ER_diArg_1	188	190	PF00400	0.281
TRG_ER_diArg_1	5	7	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4ILC9	Bodo saltans	32%	100%
A0A0S4IRQ2	Bodo saltans	32%	67%
A0A0S4J206	Bodo saltans	32%	93%
A0A0S4JEE7	Bodo saltans	27%	72%
A0A3Q8I9A6	Leishmania donovani	50%	100%
A0A3Q8IC27	Leishmania donovani	31%	100%
A0A3Q8IFC2	Leishmania donovani	36%	100%
A4HBX3	Leishmania braziliensis	34%	100%
A4HJX1	Leishmania braziliensis	33%	100%
A4HVB0	Leishmania infantum	53%	100%
A4HZ93	Leishmania infantum	31%	100%
A4I6S2	Leishmania infantum	31%	100%
D1GJ51	Leishmania infantum	61%	100%
E8NHG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AEF4	Leishmania major	35%	100%
E9AGG5	Leishmania infantum	49%	100%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9AP05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9AVA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B1U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
Q4Q6B8	Leishmania major	29%	100%
Q4QC79	Leishmania major	33%	100%
Q4QGI0	Leishmania major	63%	100%
Q4QGI6	Leishmania major	54%	100%
Q4QGJ0	Leishmania major	51%	91%
Q4QGJ2	Leishmania major	51%	88%
Q4QGJ9	Leishmania major	55%	97%
Q4QGK0	Leishmania major	61%	100%
Q4QGK6	Leishmania major	51%	100%
Q4QGK8	Leishmania major	60%	100%
Q4QGL2	Leishmania major	60%	100%
Q4QGL4	Leishmania major	69%	100%
Q9C9H6	Arabidopsis thaliana	24%	73%