Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGJ5_LEIMA

TriTrypDb:

LmjF.12.0930 , LMJSD75_120013000

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 22
NetGPI	no	yes: 0, no: 23

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGJ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	360	364	PF00656	0.705
CLV_NRD_NRD_1	229	231	PF00675	0.582
CLV_NRD_NRD_1	307	309	PF00675	0.800
CLV_NRD_NRD_1	318	320	PF00675	0.699
CLV_NRD_NRD_1	390	392	PF00675	0.686
CLV_NRD_NRD_1	472	474	PF00675	0.536
CLV_PCSK_FUR_1	388	392	PF00082	0.643
CLV_PCSK_KEX2_1	103	105	PF00082	0.475
CLV_PCSK_KEX2_1	229	231	PF00082	0.582
CLV_PCSK_KEX2_1	243	245	PF00082	0.622
CLV_PCSK_KEX2_1	307	309	PF00082	0.749
CLV_PCSK_KEX2_1	390	392	PF00082	0.683
CLV_PCSK_KEX2_1	471	473	PF00082	0.541
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.475
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.622
CLV_PCSK_SKI1_1	390	394	PF00082	0.678
CLV_Separin_Metazoa	226	230	PF03568	0.583
DEG_Nend_Nbox_1	1	3	PF02207	0.617
DOC_CYCLIN_RxL_1	387	397	PF00134	0.684
DOC_MAPK_gen_1	319	327	PF00069	0.741
DOC_MAPK_gen_1	34	44	PF00069	0.572
DOC_MAPK_gen_1	72	81	PF00069	0.379
DOC_MAPK_gen_1	8	18	PF00069	0.629
DOC_MAPK_MEF2A_6	11	18	PF00069	0.588
DOC_PP4_FxxP_1	148	151	PF00568	0.572
DOC_USP7_MATH_1	321	325	PF00917	0.727
DOC_USP7_MATH_1	421	425	PF00917	0.697
DOC_USP7_MATH_1	434	438	PF00917	0.689
DOC_WW_Pin1_4	10	15	PF00397	0.567
DOC_WW_Pin1_4	103	108	PF00397	0.577
DOC_WW_Pin1_4	61	66	PF00397	0.561
LIG_14-3-3_CanoR_1	30	34	PF00244	0.696
LIG_14-3-3_CanoR_1	426	435	PF00244	0.764
LIG_14-3-3_CanoR_1	466	471	PF00244	0.548
LIG_BRCT_BRCA1_1	323	327	PF00533	0.729
LIG_BRCT_BRCA1_1	6	10	PF00533	0.647
LIG_Clathr_ClatBox_1	130	134	PF01394	0.492
LIG_deltaCOP1_diTrp_1	310	315	PF00928	0.662
LIG_EVH1_1	148	152	PF00568	0.573
LIG_FHA_1	11	17	PF00498	0.613
LIG_FHA_1	243	249	PF00498	0.627
LIG_LIR_Apic_2	146	151	PF02991	0.591
LIG_LIR_Apic_2	250	255	PF02991	0.636
LIG_LIR_Apic_2	298	303	PF02991	0.646
LIG_LIR_Apic_2	59	65	PF02991	0.552
LIG_LIR_Apic_2	93	97	PF02991	0.574
LIG_LIR_Gen_1	236	247	PF02991	0.614
LIG_LIR_Gen_1	289	300	PF02991	0.597
LIG_LIR_Nem_3	182	188	PF02991	0.556
LIG_LIR_Nem_3	236	242	PF02991	0.628
LIG_LIR_Nem_3	289	295	PF02991	0.589
LIG_LIR_Nem_3	31	36	PF02991	0.598
LIG_LIR_Nem_3	310	314	PF02991	0.661
LIG_LIR_Nem_3	353	359	PF02991	0.544
LIG_LIR_Nem_3	85	90	PF02991	0.570
LIG_PCNA_PIPBox_1	116	125	PF02747	0.651
LIG_PDZ_Wminus1_1	475	477	PF00595	0.535
LIG_Pex14_2	327	331	PF04695	0.762
LIG_SH2_CRK	292	296	PF00017	0.601
LIG_SH2_CRK	87	91	PF00017	0.566
LIG_SH2_NCK_1	292	296	PF00017	0.631
LIG_SH2_NCK_1	352	356	PF00017	0.776
LIG_SH2_NCK_1	359	363	PF00017	0.713
LIG_SH2_PTP2	300	303	PF00017	0.657
LIG_SH2_SRC	300	303	PF00017	0.657
LIG_SH2_SRC	359	362	PF00017	0.682
LIG_SH2_STAT3	210	213	PF00017	0.710
LIG_SH2_STAT3	70	73	PF00017	0.565
LIG_SH2_STAT5	300	303	PF00017	0.657
LIG_SH2_STAT5	70	73	PF00017	0.565
LIG_SH2_STAT5	94	97	PF00017	0.584
LIG_SH3_1	415	421	PF00018	0.753
LIG_SH3_3	135	141	PF00018	0.592
LIG_SH3_3	146	152	PF00018	0.581
LIG_SH3_3	186	192	PF00018	0.591
LIG_SH3_3	245	251	PF00018	0.625
LIG_SH3_3	342	348	PF00018	0.656
LIG_SH3_3	397	403	PF00018	0.693
LIG_SH3_3	415	421	PF00018	0.739
LIG_TRAF2_1	20	23	PF00917	0.643
LIG_TRAF2_1	223	226	PF00917	0.658
LIG_TRAF2_1	247	250	PF00917	0.731
LIG_TRAF2_1	65	68	PF00917	0.663
LIG_WW_2	420	423	PF00397	0.820
MOD_CDC14_SPxK_1	106	109	PF00782	0.560
MOD_CDK_SPxK_1	103	109	PF00069	0.576
MOD_CDK_SPxxK_3	10	17	PF00069	0.584
MOD_CK1_1	424	430	PF00069	0.806
MOD_CK2_1	158	164	PF00069	0.589
MOD_CK2_1	378	384	PF00069	0.600
MOD_CK2_1	447	453	PF00069	0.593
MOD_Cter_Amidation	305	308	PF01082	0.739
MOD_Cter_Amidation	317	320	PF01082	0.561
MOD_GlcNHglycan	23	29	PF01048	0.717
MOD_GlcNHglycan	316	319	PF01048	0.748
MOD_GlcNHglycan	395	399	PF01048	0.692
MOD_GlcNHglycan	400	403	PF01048	0.676
MOD_GlcNHglycan	423	426	PF01048	0.773
MOD_GlcNHglycan	429	432	PF01048	0.799
MOD_GlcNHglycan	436	439	PF01048	0.819
MOD_GlcNHglycan	84	87	PF01048	0.553
MOD_GSK3_1	24	31	PF00069	0.698
MOD_GSK3_1	394	401	PF00069	0.736
MOD_GSK3_1	99	106	PF00069	0.583
MOD_NEK2_1	314	319	PF00069	0.630
MOD_NEK2_1	393	398	PF00069	0.646
MOD_NEK2_1	99	104	PF00069	0.582
MOD_NEK2_2	29	34	PF00069	0.732
MOD_PKA_2	29	35	PF00069	0.698
MOD_PKA_2	427	433	PF00069	0.766
MOD_Plk_1	158	164	PF00069	0.589
MOD_Plk_1	378	384	PF00069	0.554
MOD_Plk_2-3	447	453	PF00069	0.593
MOD_ProDKin_1	10	16	PF00069	0.567
MOD_ProDKin_1	103	109	PF00069	0.576
MOD_ProDKin_1	61	67	PF00069	0.567
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.590
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.587
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.589
TRG_ENDOCYTIC_2	176	179	PF00928	0.575
TRG_ENDOCYTIC_2	292	295	PF00928	0.596
TRG_ENDOCYTIC_2	87	90	PF00928	0.567
TRG_ER_diArg_1	228	230	PF00400	0.586
TRG_ER_diArg_1	258	261	PF00400	0.729
TRG_ER_diArg_1	388	391	PF00400	0.639
TRG_ER_diArg_1	470	473	PF00400	0.541
TRG_ER_diArg_1	48	51	PF00400	0.530
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	390	395	PF00026	0.685

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9T4	Leptomonas seymouri	79%	100%
A0A0S4IRN8	Bodo saltans	71%	100%
A0A1X0NP12	Trypanosomatidae	72%	100%
A0A381ME06	Leishmania infantum	94%	100%
A0A3Q8IHT5	Leishmania donovani	94%	100%
A0A3S7WS51	Leishmania donovani	94%	100%
A4H6Y7	Leishmania braziliensis	81%	100%
C9ZHZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AGG3	Leishmania infantum	94%	100%
E9AGG8	Leishmania infantum	94%	100%
E9AP06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QGI1	Leishmania major	97%	100%
Q4QGI3	Leishmania major	98%	100%
Q4QGJ3	Leishmania major	98%	100%
Q4QGJ8	Leishmania major	99%	99%
Q4QGK3	Leishmania major	98%	82%
Q4QGK5	Leishmania major	98%	99%
Q4QGK7	Leishmania major	99%	99%
Q4QGL3	Leishmania major	98%	99%
Q4QGL6	Leishmania major	98%	100%
Q4QGM0	Leishmania major	98%	99%
V5BF60	Trypanosoma cruzi	72%	97%