LeishMANIAdb
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Putative surface antigen protein 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative surface antigen protein 2
Gene product:
surface antigen protein 2, putative
Species:
Leishmania major
UniProt:
Q4QGJ2_LEIMA
TriTrypDb:
LmjF.12.0830 * , LMJLV39_000010000 * , LMJLV39_000016300 * , LMJSD75_120012800 , LMJSD75_120012900
Length:
648

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 110
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 40, no: 3
NetGPI no yes: 0, no: 43
Cellular components
Term Name Level Count
GO:0005929 cilium 4 44
GO:0016020 membrane 2 26
GO:0042995 cell projection 2 44
GO:0043226 organelle 2 44
GO:0043227 membrane-bounded organelle 3 44
GO:0110165 cellular anatomical entity 1 44
GO:0120025 plasma membrane bounded cell projection 3 44
GO:0005886 plasma membrane 3 6

Expansion

Sequence features

Q4QGJ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGJ2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 212 214 PF00675 0.469
CLV_NRD_NRD_1 285 287 PF00675 0.479
CLV_NRD_NRD_1 6 8 PF00675 0.729
CLV_PCSK_KEX2_1 132 134 PF00082 0.632
CLV_PCSK_KEX2_1 165 167 PF00082 0.465
CLV_PCSK_KEX2_1 285 287 PF00082 0.478
CLV_PCSK_KEX2_1 6 8 PF00082 0.729
CLV_PCSK_PC1ET2_1 132 134 PF00082 0.624
CLV_PCSK_PC1ET2_1 165 167 PF00082 0.455
CLV_PCSK_SKI1_1 132 136 PF00082 0.532
CLV_PCSK_SKI1_1 165 169 PF00082 0.508
CLV_PCSK_SKI1_1 213 217 PF00082 0.615
CLV_PCSK_SKI1_1 232 236 PF00082 0.571
CLV_PCSK_SKI1_1 325 329 PF00082 0.488
CLV_PCSK_SKI1_1 7 11 PF00082 0.720
DEG_SCF_FBW7_1 539 546 PF00400 0.425
DEG_SCF_FBW7_2 576 581 PF00400 0.498
DEG_SPOP_SBC_1 449 453 PF00917 0.483
DEG_SPOP_SBC_1 464 468 PF00917 0.608
DEG_SPOP_SBC_1 474 478 PF00917 0.567
DEG_SPOP_SBC_1 489 493 PF00917 0.612
DEG_SPOP_SBC_1 499 503 PF00917 0.587
DEG_SPOP_SBC_1 514 518 PF00917 0.423
DEG_SPOP_SBC_1 524 528 PF00917 0.447
DEG_SPOP_SBC_1 543 547 PF00917 0.435
DEG_SPOP_SBC_1 556 560 PF00917 0.606
DOC_CKS1_1 540 545 PF01111 0.527
DOC_CYCLIN_RxL_1 226 237 PF00134 0.290
DOC_CYCLIN_RxL_1 3 13 PF00134 0.594
DOC_CYCLIN_RxL_1 373 384 PF00134 0.277
DOC_CYCLIN_yClb5_NLxxxL_5 236 245 PF00134 0.258
DOC_CYCLIN_yCln2_LP_2 196 199 PF00134 0.263
DOC_CYCLIN_yCln2_LP_2 76 82 PF00134 0.246
DOC_MAPK_gen_1 132 139 PF00069 0.261
DOC_MAPK_gen_1 325 332 PF00069 0.249
DOC_MAPK_MEF2A_6 420 427 PF00069 0.445
DOC_PP1_RVXF_1 227 234 PF00149 0.265
DOC_PP2B_LxvP_1 196 199 PF13499 0.263
DOC_PP2B_LxvP_1 76 79 PF13499 0.249
DOC_USP7_MATH_1 251 255 PF00917 0.263
DOC_USP7_MATH_1 347 351 PF00917 0.421
DOC_USP7_MATH_1 400 404 PF00917 0.465
DOC_USP7_MATH_1 556 560 PF00917 0.625
DOC_USP7_MATH_1 624 628 PF00917 0.314
DOC_USP7_MATH_2 150 156 PF00917 0.350
DOC_USP7_MATH_2 198 204 PF00917 0.299
DOC_USP7_MATH_2 270 276 PF00917 0.305
DOC_USP7_MATH_2 294 300 PF00917 0.285
DOC_WW_Pin1_4 223 228 PF00397 0.384
DOC_WW_Pin1_4 539 544 PF00397 0.462
DOC_WW_Pin1_4 568 573 PF00397 0.582
DOC_WW_Pin1_4 574 579 PF00397 0.557
LIG_14-3-3_CanoR_1 133 138 PF00244 0.302
LIG_14-3-3_CanoR_1 232 237 PF00244 0.349
LIG_14-3-3_CanoR_1 278 283 PF00244 0.340
LIG_14-3-3_CanoR_1 43 48 PF00244 0.438
LIG_14-3-3_CanoR_1 85 95 PF00244 0.300
LIG_Actin_WH2_2 155 170 PF00022 0.299
LIG_Actin_WH2_2 200 218 PF00022 0.265
LIG_Actin_WH2_2 272 287 PF00022 0.284
LIG_BIR_II_1 1 5 PF00653 0.705
LIG_deltaCOP1_diTrp_1 62 69 PF00928 0.354
LIG_FHA_1 133 139 PF00498 0.438
LIG_FHA_1 144 150 PF00498 0.359
LIG_FHA_1 192 198 PF00498 0.371
LIG_FHA_1 216 222 PF00498 0.350
LIG_FHA_1 279 285 PF00498 0.295
LIG_FHA_1 326 332 PF00498 0.291
LIG_FHA_1 42 48 PF00498 0.443
LIG_FHA_1 612 618 PF00498 0.511
LIG_FHA_1 81 87 PF00498 0.349
LIG_FHA_2 556 562 PF00498 0.501
LIG_FHA_2 580 586 PF00498 0.495
LIG_FHA_2 92 98 PF00498 0.410
LIG_FXI_DFP_1 139 143 PF00024 0.445
LIG_GSK3_LRP6_1 539 545 PF00069 0.423
LIG_LIR_Gen_1 127 134 PF02991 0.359
LIG_LIR_Gen_1 141 150 PF02991 0.407
LIG_LIR_Gen_1 152 161 PF02991 0.389
LIG_LIR_Gen_1 176 183 PF02991 0.371
LIG_LIR_Gen_1 272 279 PF02991 0.383
LIG_LIR_Gen_1 296 304 PF02991 0.292
LIG_LIR_Gen_1 344 353 PF02991 0.320
LIG_LIR_Gen_1 391 400 PF02991 0.413
LIG_LIR_Gen_1 71 80 PF02991 0.424
LIG_LIR_Nem_3 103 107 PF02991 0.403
LIG_LIR_Nem_3 141 145 PF02991 0.387
LIG_LIR_Nem_3 176 180 PF02991 0.373
LIG_LIR_Nem_3 200 204 PF02991 0.329
LIG_LIR_Nem_3 344 348 PF02991 0.344
LIG_LIR_Nem_3 391 396 PF02991 0.383
LIG_LIR_Nem_3 71 75 PF02991 0.367
LIG_NRBOX 326 332 PF00104 0.244
LIG_PDZ_Class_2 643 648 PF00595 0.309
LIG_SH2_STAT5 607 610 PF00017 0.381
LIG_SH2_STAT5 618 621 PF00017 0.406
LIG_SH3_3 214 220 PF00018 0.416
LIG_SH3_3 537 543 PF00018 0.427
LIG_SH3_3 560 566 PF00018 0.476
LIG_SH3_3 93 99 PF00018 0.457
LIG_Sin3_3 632 639 PF02671 0.299
LIG_SUMO_SIM_anti_2 350 355 PF11976 0.266
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.465
LIG_SUMO_SIM_par_1 423 429 PF11976 0.342
LIG_SUMO_SIM_par_1 78 83 PF11976 0.353
LIG_TYR_ITIM 102 107 PF00017 0.458
LIG_UBA3_1 353 360 PF00899 0.265
MOD_CDC14_SPxK_1 226 229 PF00782 0.268
MOD_CDK_SPxK_1 223 229 PF00069 0.266
MOD_CK1_1 179 185 PF00069 0.441
MOD_CK1_1 254 260 PF00069 0.368
MOD_CK1_1 299 305 PF00069 0.478
MOD_CK1_1 359 365 PF00069 0.419
MOD_CK1_1 370 376 PF00069 0.411
MOD_CK1_1 388 394 PF00069 0.349
MOD_CK2_1 555 561 PF00069 0.452
MOD_CK2_1 579 585 PF00069 0.638
MOD_CK2_1 91 97 PF00069 0.413
MOD_GlcNHglycan 169 172 PF01048 0.617
MOD_GlcNHglycan 241 244 PF01048 0.636
MOD_GlcNHglycan 249 252 PF01048 0.614
MOD_GlcNHglycan 25 28 PF01048 0.756
MOD_GlcNHglycan 264 268 PF01048 0.624
MOD_GlcNHglycan 289 292 PF01048 0.617
MOD_GlcNHglycan 313 316 PF01048 0.638
MOD_GlcNHglycan 337 340 PF01048 0.615
MOD_GlcNHglycan 344 348 PF01048 0.578
MOD_GlcNHglycan 356 359 PF01048 0.552
MOD_GlcNHglycan 361 364 PF01048 0.634
MOD_GlcNHglycan 369 372 PF01048 0.605
MOD_GlcNHglycan 384 388 PF01048 0.598
MOD_GlcNHglycan 393 396 PF01048 0.598
MOD_GlcNHglycan 595 598 PF01048 0.743
MOD_GlcNHglycan 627 630 PF01048 0.446
MOD_GSK3_1 120 127 PF00069 0.369
MOD_GSK3_1 141 148 PF00069 0.426
MOD_GSK3_1 175 182 PF00069 0.422
MOD_GSK3_1 232 239 PF00069 0.356
MOD_GSK3_1 247 254 PF00069 0.415
MOD_GSK3_1 274 281 PF00069 0.375
MOD_GSK3_1 295 302 PF00069 0.383
MOD_GSK3_1 32 39 PF00069 0.553
MOD_GSK3_1 343 350 PF00069 0.408
MOD_GSK3_1 370 377 PF00069 0.432
MOD_GSK3_1 385 392 PF00069 0.319
MOD_GSK3_1 440 447 PF00069 0.564
MOD_GSK3_1 448 455 PF00069 0.574
MOD_GSK3_1 459 466 PF00069 0.499
MOD_GSK3_1 469 476 PF00069 0.575
MOD_GSK3_1 477 484 PF00069 0.535
MOD_GSK3_1 488 495 PF00069 0.479
MOD_GSK3_1 498 505 PF00069 0.498
MOD_GSK3_1 509 516 PF00069 0.469
MOD_GSK3_1 519 526 PF00069 0.476
MOD_GSK3_1 527 534 PF00069 0.485
MOD_GSK3_1 538 545 PF00069 0.530
MOD_GSK3_1 564 571 PF00069 0.625
MOD_GSK3_1 607 614 PF00069 0.524
MOD_GSK3_1 87 94 PF00069 0.430
MOD_N-GLC_1 239 244 PF02516 0.513
MOD_NEK2_1 10 15 PF00069 0.610
MOD_NEK2_1 167 172 PF00069 0.454
MOD_NEK2_1 21 26 PF00069 0.551
MOD_NEK2_1 215 220 PF00069 0.366
MOD_NEK2_1 236 241 PF00069 0.430
MOD_NEK2_1 284 289 PF00069 0.410
MOD_NEK2_1 306 311 PF00069 0.423
MOD_NEK2_1 332 337 PF00069 0.321
MOD_NEK2_1 354 359 PF00069 0.402
MOD_NEK2_1 361 366 PF00069 0.359
MOD_NEK2_1 385 390 PF00069 0.401
MOD_NEK2_1 398 403 PF00069 0.375
MOD_NEK2_1 80 85 PF00069 0.336
MOD_NEK2_1 87 92 PF00069 0.327
MOD_NEK2_2 400 405 PF00069 0.295
MOD_PIKK_1 308 314 PF00454 0.308
MOD_PIKK_1 325 331 PF00454 0.303
MOD_PKA_1 132 138 PF00069 0.250
MOD_PKA_1 325 331 PF00069 0.252
MOD_PKA_2 132 138 PF00069 0.274
MOD_PKA_2 284 290 PF00069 0.494
MOD_Plk_1 151 157 PF00069 0.372
MOD_Plk_1 175 181 PF00069 0.359
MOD_Plk_1 295 301 PF00069 0.400
MOD_Plk_1 343 349 PF00069 0.374
MOD_Plk_1 611 617 PF00069 0.397
MOD_Plk_2-3 200 206 PF00069 0.281
MOD_Plk_2-3 68 74 PF00069 0.435
MOD_Plk_4 133 139 PF00069 0.264
MOD_Plk_4 251 257 PF00069 0.277
MOD_Plk_4 332 338 PF00069 0.349
MOD_Plk_4 347 353 PF00069 0.291
MOD_ProDKin_1 223 229 PF00069 0.389
MOD_ProDKin_1 539 545 PF00069 0.464
MOD_ProDKin_1 568 574 PF00069 0.580
MOD_SUMO_rev_2 415 421 PF00179 0.334
MOD_SUMO_rev_2 605 614 PF00179 0.349
TRG_DiLeu_BaEn_1 612 617 PF01217 0.378
TRG_ENDOCYTIC_2 104 107 PF00928 0.455
TRG_ER_diArg_1 284 286 PF00400 0.274
TRG_ER_diArg_1 5 7 PF00400 0.639
TRG_Pf-PMV_PEXEL_1 232 237 PF00026 0.464
TRG_Pf-PMV_PEXEL_1 376 381 PF00026 0.493

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I661 Leptomonas seymouri 35% 100%
A0A0S4IWB9 Bodo saltans 29% 78%
A0A0S4J206 Bodo saltans 32% 100%
A0A0S4J954 Bodo saltans 21% 87%
A0A0S4JTM6 Bodo saltans 27% 88%
A0A0S4KK37 Bodo saltans 30% 100%
A0A1X0ND37 Trypanosomatidae 26% 68%
A0A3Q8I9B4 Leishmania donovani 43% 100%
A0A3Q8I9D9 Leishmania donovani 43% 100%
A0A3Q8IC27 Leishmania donovani 32% 100%
A0A3S5H6L9 Leishmania donovani 43% 100%
A0A3S5H6M3 Leishmania donovani 59% 94%
A0A3S5H6M4 Leishmania donovani 51% 99%
A0A3S7WS66 Leishmania donovani 51% 98%
A4H6Y8 Leishmania braziliensis 50% 71%
A4HBX3 Leishmania braziliensis 37% 100%
A4HZ93 Leishmania infantum 32% 100%
D1GJ51 Leishmania infantum 51% 100%
E8NHG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 85%
E9AGG2 Leishmania infantum 59% 98%
E9AGG7 Leishmania infantum 54% 100%
E9AGG9 Leishmania infantum 51% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 92%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 93%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
Q4QC79 Leishmania major 34% 100%
Q4QGI0 Leishmania major 58% 100%
Q4QGI2 Leishmania major 55% 100%
Q4QGI4 Leishmania major 51% 100%
Q4QGI6 Leishmania major 58% 100%
Q4QGI8 Leishmania major 53% 85%
Q4QGJ0 Leishmania major 66% 100%
Q4QGJ6 Leishmania major 51% 100%
Q4QGJ9 Leishmania major 67% 100%
Q4QGK0 Leishmania major 68% 100%
Q4QGK1 Leishmania major 63% 92%
Q4QGK2 Leishmania major 53% 100%
Q4QGK4 Leishmania major 97% 97%
Q4QGK8 Leishmania major 56% 100%
Q4QGL2 Leishmania major 56% 100%
Q4QGL8 Leishmania major 48% 100%
Q4QGM1 Leishmania major 56% 84%
Q9SRL7 Arabidopsis thaliana 20% 69%
Q9SVN2 Arabidopsis thaliana 22% 81%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS