Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGJ1_LEIMA

TriTrypDb:

LmjF.12.0840

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGJ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	229	231	PF00675	0.592
CLV_NRD_NRD_1	307	309	PF00675	0.767
CLV_PCSK_KEX2_1	229	231	PF00082	0.592
CLV_PCSK_KEX2_1	243	245	PF00082	0.623
CLV_PCSK_KEX2_1	307	309	PF00082	0.715
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.623
CLV_Separin_Metazoa	226	230	PF03568	0.585
DEG_Nend_Nbox_1	1	3	PF02207	0.610
DOC_MAPK_gen_1	34	44	PF00069	0.547
DOC_MAPK_gen_1	8	18	PF00069	0.647
DOC_MAPK_MEF2A_6	11	18	PF00069	0.616
DOC_PP4_FxxP_1	148	151	PF00568	0.537
DOC_WW_Pin1_4	10	15	PF00397	0.596
DOC_WW_Pin1_4	103	108	PF00397	0.564
DOC_WW_Pin1_4	61	66	PF00397	0.551
LIG_14-3-3_CanoR_1	30	34	PF00244	0.683
LIG_BRCT_BRCA1_1	6	10	PF00533	0.654
LIG_Clathr_ClatBox_1	130	134	PF01394	0.564
LIG_EVH1_1	148	152	PF00568	0.537
LIG_FHA_1	11	17	PF00498	0.617
LIG_FHA_1	243	249	PF00498	0.610
LIG_LIR_Apic_2	146	151	PF02991	0.558
LIG_LIR_Apic_2	250	255	PF02991	0.641
LIG_LIR_Apic_2	298	303	PF02991	0.646
LIG_LIR_Apic_2	59	65	PF02991	0.540
LIG_LIR_Apic_2	93	97	PF02991	0.578
LIG_LIR_Gen_1	236	247	PF02991	0.597
LIG_LIR_Gen_1	289	300	PF02991	0.577
LIG_LIR_Nem_3	182	188	PF02991	0.515
LIG_LIR_Nem_3	236	242	PF02991	0.633
LIG_LIR_Nem_3	289	295	PF02991	0.582
LIG_LIR_Nem_3	31	36	PF02991	0.582
LIG_LIR_Nem_3	310	314	PF02991	0.630
LIG_LIR_Nem_3	85	90	PF02991	0.573
LIG_PCNA_PIPBox_1	116	125	PF02747	0.625
LIG_SH2_CRK	292	296	PF00017	0.597
LIG_SH2_CRK	87	91	PF00017	0.567
LIG_SH2_NCK_1	292	296	PF00017	0.632
LIG_SH2_PTP2	300	303	PF00017	0.640
LIG_SH2_SRC	300	303	PF00017	0.640
LIG_SH2_STAT3	210	213	PF00017	0.717
LIG_SH2_STAT3	70	73	PF00017	0.556
LIG_SH2_STAT5	300	303	PF00017	0.640
LIG_SH2_STAT5	70	73	PF00017	0.566
LIG_SH2_STAT5	94	97	PF00017	0.575
LIG_SH3_3	135	141	PF00018	0.577
LIG_SH3_3	146	152	PF00018	0.553
LIG_SH3_3	186	192	PF00018	0.575
LIG_SH3_3	245	251	PF00018	0.632
LIG_TRAF2_1	20	23	PF00917	0.645
LIG_TRAF2_1	223	226	PF00917	0.687
LIG_TRAF2_1	247	250	PF00917	0.720
LIG_TRAF2_1	65	68	PF00917	0.636
MOD_CDC14_SPxK_1	106	109	PF00782	0.547
MOD_CDK_SPxK_1	103	109	PF00069	0.561
MOD_CDK_SPxxK_3	10	17	PF00069	0.615
MOD_CK2_1	158	164	PF00069	0.565
MOD_Cter_Amidation	305	308	PF01082	0.712
MOD_GlcNHglycan	23	29	PF01048	0.750
MOD_GlcNHglycan	84	87	PF01048	0.550
MOD_GSK3_1	24	31	PF00069	0.736
MOD_GSK3_1	99	106	PF00069	0.560
MOD_NEK2_1	99	104	PF00069	0.584
MOD_NEK2_2	29	34	PF00069	0.713
MOD_PKA_2	29	35	PF00069	0.680
MOD_Plk_1	158	164	PF00069	0.565
MOD_ProDKin_1	10	16	PF00069	0.597
MOD_ProDKin_1	103	109	PF00069	0.561
MOD_ProDKin_1	61	67	PF00069	0.557
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.622
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.566
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.583
TRG_ENDOCYTIC_2	176	179	PF00928	0.545
TRG_ENDOCYTIC_2	292	295	PF00928	0.589
TRG_ENDOCYTIC_2	87	90	PF00928	0.573
TRG_ER_diArg_1	228	230	PF00400	0.590
TRG_ER_diArg_1	258	261	PF00400	0.712
TRG_ER_diArg_1	48	51	PF00400	0.522
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9T4	Leptomonas seymouri	84%	71%
A0A0S4IRN8	Bodo saltans	76%	78%
A0A1X0NP12	Trypanosomatidae	81%	73%
A0A381ME06	Leishmania infantum	97%	72%
A0A3Q8IHT5	Leishmania donovani	97%	72%
A0A3S7WS51	Leishmania donovani	97%	72%
A4H6Y7	Leishmania braziliensis	87%	72%
C9ZHZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	74%
E9AGG3	Leishmania infantum	97%	72%
E9AGG8	Leishmania infantum	97%	72%
E9AP06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	72%
Q4QGI1	Leishmania major	99%	100%
Q4QGI3	Leishmania major	100%	72%
Q4QGL6	Leishmania major	99%	69%